Laurence de Leval

Publications | Mémoires et thèses

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441 publications

Sous presse | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | ...
 
Clinical use of circulating tumor DNA analysis in patients with lymphoma.
Bisig B., Lefort K., Carras S., de Leval L. Human pathology. Peer-reviewed.
 
HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin Lymphoma.
Chantziou A., Brenna C., Ioannidou K., Chen O.Y., Korkolopoulou P.A., Antoniadou A., Psichogiou M., Papaioannou M., Tsirigotis P., Foukas P.G. et al. Blood advances. Peer-reviewed.
 
Deep phenotyping of nodal T-cell lymphomas reveals immune alterations and therapeutic targets.
Stephan P., Perrot J., Voisin A., Barbery M., Andrieu T., Grimont M., Caramel J., Bardou M., Tondeur G., Missiaglia E. et al. Haematologica. Peer-reviewed.
 
Long-Term Follow-Up of the Prospective Randomized AATT Study (Autologous or Allogeneic Transplantation in Patients With Peripheral T-Cell Lymphoma).
Tournilhac O., Altmann B., Friedrichs B., Bouabdallah K., Leclerc M., Cartron G., Turlure P., Reimer P., Wagner-Drouet E., Sanhes L. et al., 2024/11/10. Journal of clinical oncology, 42 (32) pp. 3788-3794. Peer-reviewed.
 
Hematological Oncology journal women in lymphoma special issue: Latest updates in nodal peripheral T-cell lymphoma.
Poon L., de Leval L., Ng S.B., Song Y., Pro B., Savage K.J., Ruan J., Mehta-Shah N., Vose J.M., 2024/11. Hematological oncology, 42 (6) pp. e3191. Peer-reviewed.
 
A practical approach to the modern diagnosis and classification of T- and NK-cell lymphomas.
de Leval L., Gaulard P., Dogan A., 2024/10/31. Blood, 144 (18) pp. 1855-1872. Peer-reviewed.
 
Modeling NK-cell lymphoma in mice reveals its cell-of-origin and microenvironmental changes and identifies therapeutic targets.
Koya J., Tanigawa T., Mizuno K., Kim H., Ito Y., Yuasa M., Yamaguchi K., Kogure Y., Saito Y., Shingaki S. et al., 2024/10/22. Nature communications, 15 (1) p. 9106. Peer-reviewed.
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas.
Fischer A., Albert T.K., Moreno N., Interlandi M., Mormann J., Glaser S., Patil P., de Faria F.W., Richter M., Verma A. et al., 2024/10/03. Nature communications, 15 (1) p. 8571. Peer-reviewed.
Immune Phenotype-Genotype Associations in Primary Clear Cell Renal Cell Carcinoma and Matched Metastatic Tissue.
Sobottka B., Vetter V., Banaei-Esfahani A., Nowak M., Lorch A., Sirek A., Mertz K.D., Brunelli M., Berthold D., de Leval L. et al., 2024/10. Modern pathology, 37 (10) p. 100558. Peer-reviewed.
Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma.
Özoğul E., Montaner A., Pol M., Frigola G., Balagué O., Syrykh C., Bousquets-Muñoz P., Royo R., Fontaine J., Traverse-Glehen A. et al., 2024/09/23. Blood cancer journal, 14 (1) p. 166. Peer-reviewed.
 
Inducible CXCL12/CXCR4-dependent extramedullary hematopoietic niches in the adrenal gland.
Schyrr F., Alonso-Calleja A., Vijaykumar A., Sordet-Dessimoz J., Gebhard S., Sarkis R., Bataclan C., Ferreira Lopes S., Oggier A., de Leval L. et al., 2024/08/29. Blood, 144 (9) pp. 964-976. Peer-reviewed.
 
Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells
Moysi Eirini, Sharma Ashish A., O'Dell Sijy, Georgakis Spiros, Del Rio Estrada Perla Mariana, Torres-Ruiz Fernanda, Navarro Mauricio González, Villalobos Yara Andrea Luna, Rios Santiago Avila, Reyes-Teran Gustavo et al., 2024/08/03..
Primary diffuse large B-cell lymphoma of the central nervous system identified with CSF biomarkers.
Loser V., Segot A., de Leval L., Bisig B., Brouland J.P., Hewer E., Barcena C., Hottinger A.F., Pot C., 2024/07/22. BMC neurology, 24 (1) p. 250. Peer-reviewed.
 
Comprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes on the X Chromosome in Extranodal NK/T-cell Lymphoma.
Ito Y., Marouf A., Kogure Y., Koya J., Liévin R., Bruneau J., Tabata M., Saito Y., Shingaki S., Yuasa M. et al., 2024/07/02. Cancer research, 84 (13) pp. 2181-2201. Peer-reviewed.
 
Anémie aplasique [Aplastic anemia]
Dewarrat N., Costanza M., Royer-Chardon C., Zermatten M.G., De Leval L., Naveiras O., Blum S., 2024/06/26. Revue medicale suisse, 20 (880) pp. 1271-1275. Peer-reviewed.
PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation.
Chmiest D., Podavini S., Ioannidou K., Vallois D., Décaillet C., Gonzalez M., Quadroni M., Blackney K., Schairer R., de Leval L. et al., 2024/06/11. Blood advances, 8 (11) pp. 2908-2923. Peer-reviewed.
Cytokine-pathway blockers worsen mycosis fungoides masquerading as psoriasis.
Blanchard G., Bisig B., de Leval L., Hohl D., Guenova E., 2024/06. JAAD case reports, 48 pp. 98-102. Peer-reviewed.
 
Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study.
Dupuis J., Bachy E., Morschhauser F., Cartron G., Fukuhara N., Daguindau N., Casasnovas R.O., Snauwaert S., Gressin R., Fox C.P. et al., 2024/06. The Lancet. Haematology, 11 (6) pp. e406-e414. Peer-reviewed.
 
Romidepsin Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Versus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of the Ro-CHOP Trial.
Camus V., Thieblemont C., Gaulard P., Cheminant M., Casasnovas R.O., Ysebaert L., Damaj G.L., Guidez S., Pica G.M., Kim W.S. et al., 2024/05/10. Journal of clinical oncology, 42 (14) pp. 1612-1618. Peer-reviewed.
 
Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases.
Sarro R., Bisig B., Guey B., Missiaglia E., Cairoli A., Omoumi P., Letovanec I., Ferry J.A., Hasserjian R.P., de Leval L., 2024/04. Modern pathology, 37 (4) p. 100440. Peer-reviewed.
Angioimmunoblastic T-cell lymphoma and Kaposi sarcoma: A fortuitous collision?
Poullot E., Milowich D., Lemonnier F., Bisig B., Robe C., Pelletier L., Letourneau A., Dupuy A., Sako N., Ketterer N. et al., 2024/02. Histopathology, 84 (3) pp. 556-564. Peer-reviewed.
Erratum to: Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization.
Savage K.J., De Leval L., 2024/02/01. Haematologica, 109 (2) pp. 693-694. Peer-reviewed.
 
B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L., Fadle N., Regitz E., Roth S., Cetin O., Kos I.A., Hess S.M., Bein J., Bohle R.M., Vornanen M. et al., 2023/12/01. Haematologica, 108 (12) pp. 3347-3358. Peer-reviewed.
Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization.
Savage K.J., De Leval L., 2023/12/01. Haematologica, 108 (12) pp. 3204-3210. Peer-reviewed.
 
Invariant finding of non-clonal bone marrow lymphocytosis, with increased B cell component, in indolent systemic mastocytosis.
Papadopoulou V., Barcena-Garcia C., Basset V., Schoumans J., de Leval L., Schaller M., 2023/12. International journal of laboratory hematology, 45 (6) pp. 1007-1010. Peer-reviewed.
Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions.
Bisig B., Savage K.J., De Leval L., 2023/12/01. Haematologica, 108 (12) pp. 3227-3243. Peer-reviewed.
Was gibt es Neues bei der Klassifikation der peripheren T-Zell-Lymphomen? [What is new in the classification of peripheral T cell lymphomas?]
de Leval L., Bisig B., 2023/12. Pathologie, 44 (Suppl 3) pp. 128-135. Peer-reviewed.
Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio.
Straub M., Auderset A., de Leval L., Piazzon N., Maison D., Vozenin M.C., Ollivier J., Petit B., Sigman D.M., Martínez-García A., 2023/11/13. Scientific reports, 13 (1) p. 19796. Peer-reviewed.
 
Gene Expression Profiling Reveals Two Overarching Types of Anaplastic Large Cell Lymphoma with Distinct Targetable Biology: An L.L.M.P.P. Study
Feldman Andrew L., Dasari Surendra, Rimsza Lisa M., Scott David W., Oishi Naoki, Amador Catalina, Campo Elias, Chan Wing C., Cook James R., Delabie Jan et al., 2023/11/02., 65th ASH Annual Meeting December 9-12, 2023 pp. 847-847 dans Blood.
 
Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma
Bouska Alyssa, Zhang Weiwei, Sharma Sunandini, Holte Harald, Shah Ab Rauf, Lone Waseem Gul, Cappelli Luca Vincenzo, Fiore Danilo, Gong Qiang, Heavican-Foral Tayla et al., 2023/11/02., 65th ASH Annual Meeting December 9-12, 2023 pp. 2993-2993 dans Blood.
KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma.
Decroos A., Cheminant M., Bruneau J., Carras S., Parinet V., Pelletier L., Lacroix L., Martin N., Giustiniani J., Lhermitte L. et al., 2023/10/01. Haematologica, 108 (10) pp. 2830-2836. Peer-reviewed.
Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe.
Hofman P., Calabrese F., Kern I., Adam J., Alarcão A., Alborelli I., Anton N.T., Arndt A., Avdalyan A., Barberis M. et al., 2023/10. ESMO open, 8 (5) p. 101628. Peer-reviewed.
Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop.
Di Napoli A., Soma L., Quintanilla-Martinez L., de Leval L., Leoncini L., Zamò A., Ng S.B., Ondrejka S.L., Climent F., Wotherspoon A. et al., 2023/09. Virchows Archiv, 483 (3) pp. 299-316. Peer-reviewed.
Correction to: Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop.
Di Napoli A., Soma L., Quintanilla-Martinez L., de Leval L., Leoncini L., Zamò A., Ng S.B., Ondrejka S.L., Climent F., Wotherspoon A. et al., 2023/09. Virchows Archiv, 483 (3) p. 435. Peer-reviewed.
Correction to: The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Zamò A., van den Brand M., Climent F., de Leval L., Dirnhofer S., Leoncini L., Ng S.B., Ondrejka S.L., Quintanilla-Martinez L., Soma L. et al., 2023/09. Virchows Archiv, 483 (3) p. 437. Peer-reviewed.
Cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases: emerging concepts, recent advances, and the putative role of clonal hematopoiesis. A report of the 2022 EA4HP/SH lymphoma workshop.
Climent F., Nicolae A., de Leval L., Dirnhofer S., Leoncini L., Ondrejka S.L., Soma L., Wotherspoon A., Zamo A., Quintanilla-Martinez L. et al., 2023/09. Virchows Archiv, 483 (3) pp. 333-348. Peer-reviewed.
Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L., Laurent C., Soma L., Ng S.B., Climent F., Ondrejka S.L., Zamo A., Wotherspoon A., de Leval L., Dirnhofer S. et al., 2023/09. Virchows Archiv, 483 (3) pp. 281-298. Peer-reviewed.
 
EXABS-214-TCL New Insights Into the Pathogenesis of T-Cell Lymphoma and How This May Guide Treatment
de Leval Laurence, Bisig Bettina, 2023/09. Clinical Lymphoma Myeloma and Leukemia, 23 pp. S105-S106.
Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop.
Ondrejka S.L., Amador C., Climent F., Ng S.B., Soma L., Zamo A., Dirnhofer S., Quintanilla-Martinez L., Wotherspoon A., Leoncini L. et al., 2023/09. Virchows Archiv, 483 (3) pp. 349-365. Peer-reviewed.
 
POSTER: TCL-330 RHOA G17V Potentiates CD28-Induced NFAT Transcriptional Activity by Modulating p300 Activity: A Step Further in the Understanding of Follicular Helper T-Cell Lymphoma
Vallois David, Juilland Mélanie, Kalliopi Ioannidou, Lemmonier François, Missiaglia Edoardo, Bisig Bettina, Thome Margot, de Leval Laurence, 2023/09. pp. S214 dans Clinical Lymphoma Myeloma and Leukemia, Elsevier BV.
The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Zamò A., van den Brand M., Climent F., de Leval L., Dirnhofer S., Leoncini L., Ng S.B., Ondrejka S.L., Quintanilla-Martinez L., Soma L. et al., 2023/09. Virchows Archiv, 483 (3) pp. 317-331. Peer-reviewed.
Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches.
Oyler B.L., Valencia-Dávila J.A., Moysi E., Molyvdas A., Ioannidou K., March K., Ambrozak D., De Leval L., Fabozzi G., Woods A.S. et al., 2023/08/18. iScience, 26 (8) p. 107261. Peer-reviewed.
ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.
Sibon D., Bisig B., Bonnet C., Poullot E., Bachy E., Cavalieri D., Fataccioli V., Bregnard C., Drieux F., Bruneau J. et al., 2023/06/01. Haematologica, 108 (6) pp. 1590-1603. Peer-reviewed.
 
Cell-free DNA sequencing allows the identification of the mutational profile of TFH lymphomas and has a predictive value: a LYSA study.
Sako N., Delfau M., Bachy E., Morschhauser F., Cartron G., Casasnovas O., Gressin R., Daguindau N., Tournilhac O., Bouabdallah K. et al., 2023/06., 17th International Conference on Malignant Lymphoma, Palazzo dei Congressi, 13 ‐ 17 June, 2023 pp. 338-339 dans Hematological oncology. Peer-reviewed.
 
Lack of smarcb1 expression characterizes a subset of peripheral t‐cell lymphomas enriched in children and young adults.
Fischer A., Moreno N., Interlandi M., Albert T. K., Mormann J., Glaser S., Patil P., Balbach S., Wagener R., Bens S. et al., 2023/06. pp. 192-192 dans Hematological Oncology, Wiley.
 
Romidepsin Plus Chop versus Chop in Patients with Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of the Ro-Chop Trial.
Camus V., Thieblemont C., Gaulard P., Cheminant M., Casasnovas R., Ysebaert L., Damaj G.L., Guidez S., Pica G.M., Kim W.S. et al., 2023/06., 17th International Conference on Malignant Lymphoma, Palazzo dei Congressi, 13 ‐ 17 June, 2023 pp. 77-78 dans Hematological oncology. Peer-reviewed.
MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology.
Sarkis R., Burri O., Royer-Chardon C., Schyrr F., Blum S., Costanza M., Cherix S., Piazzon N., Barcena C., Bisig B. et al., 2023/04. Modern pathology, 36 (4) p. 100088. Peer-reviewed.
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.
Leca J., Lemonnier F., Meydan C., Foox J., El Ghamrasni S., Mboumba D.L., Duncan G.S., Fortin J., Sakamoto T., Tobin C. et al., 2023/02/13. Cancer cell, 41 (2) pp. 323-339.e10. Peer-reviewed.
 
Combined Reverse-Transcriptase Multiplex Ligation-Dependent Probe Amplification and Next-Generation Sequencing Analyses to Assign Unclassified BCL2−/BCL6− Nonrearranged Small B-Cell Lymphoid Neoplasms as Follicular or Nodal Marginal Zone Lymphoma.
Sesboue C., Galtier J., Jeanneau M., Chauvel A., Laharanne E., Amintas S., Merlio J.P., Bouabdallah K., Gros F.X., de Leval L. et al., 2023/02. Modern pathology, 36 (2) p. 100043. Peer-reviewed.
A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells.
Joo V., Petrovas C., de Leval L., Noto A., Obeid M., Fenwick C., Pantaleo G., 2023. Frontiers in immunology, 14 p. 1213375. Peer-reviewed.
 
Classification and diagnostic evaluation of nodal T- and NK-cell lymphomas.
Feldman A.L., Laurent C., Narbaitz M., Nakamura S., Chan W.C., de Leval L., Gaulard P., 2023/01. Virchows Archiv, 482 (1) pp. 265-279. Peer-reviewed.
Extranodal T- and NK-cell lymphomas.
de Leval L., Feldman A.L., Pileri S., Nakamura S., Gaulard P., 2023/01. Virchows Archiv, 482 (1) pp. 245-264. Peer-reviewed.
Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome.
Veloza L., Cavalieri D., Missiaglia E., Ledoux-Pilon A., Bisig B., Pereira B., Bonnet C., Poullot E., Quintanilla-Martinez L., Dubois R. et al., 2023/01/01. Haematologica, 108 (1) pp. 181-195. Peer-reviewed.
 
HHV8-negative primary effusion-based large B-cell lymphoma in a patient with chronic myeloid leukemia, BCR::ABL1-positive under dasatinib treatment: Report of a new case and literature review.
Christe L., Veloza L., Gros L., Bisig B., Blum S., Hewer E., de Leval L., 2022/12. Diagnostic cytopathology, 50 (12) pp. E351-E356. Peer-reviewed.
 
Genomic profiling for clinical decision making in lymphoid neoplasms.
de Leval L., Alizadeh A.A., Bergsagel P.L., Campo E., Davies A., Dogan A., Fitzgibbon J., Horwitz S.M., Melnick A.M., Morice W.G. et al., 2022/11/24. Blood, 140 (21) pp. 2193-2227. Peer-reviewed.
 
Cutaneous presentation of enteropathy-associated T-cell lymphoma masquerading as a DUSP22-rearranged CD30+ lymphoproliferation.
Bisig B., Cairoli A., Gaide O., Somja J., Bregnard C., Gaulard P., Xerri L., Lefort K., Missiaglia E., Gilliet M. et al., 2022/10. Virchows Archiv, 481 (4) pp. 653-657. Peer-reviewed.
Towards a national strategy for digital pathology in Switzerland.
Janowczyk A., Baumhoer D., Dirnhofer S., Grobholz R., Kipar A., de Leval L., Merkler D., Michielin O., Moch H., Perren A. et al., 2022/10. Virchows Archiv, 481 (4) pp. 647-652. Peer-reviewed.
The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee.
Campo E., Jaffe E.S., Cook J.R., Quintanilla-Martinez L., Swerdlow S.H., Anderson K.C., Brousset P., Cerroni L., de Leval L., Dirnhofer S. et al., 2022/09/15. Blood, 140 (11) pp. 1229-1253. Peer-reviewed.
EBV-associated NK and T-cell lymphoid neoplasms.
Kimura H., de Leval L., Cai Q., Kim W.S., 2022/09/01. Current opinion in oncology, 34 (5) pp. 422-431. Peer-reviewed.
 
Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations.
Nicolae A., Bouilly J., Lara D., Fataccioli V., Lemonnier F., Drieux F., Parrens M., Robe C., Poullot E., Bisig B. et al., 2022/08. Modern pathology, 35 (8) pp. 1126-1136. Peer-reviewed.
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis.
Evangelou K., Veroutis D., Paschalaki K., Foukas P.G., Lagopati N., Dimitriou M., Papaspyropoulos A., Konda B., Hazapis O., Polyzou A. et al., 2022/08. The European respiratory journal, 60 (2) p. 2102951. Peer-reviewed.
The EHA Research Roadmap: Malignant Lymphoid Diseases.
Dreyling M., André M., Gökbuget N., Tilly H., Jerkeman M., Gribben J., Ferreri A., Morel P., Stilgenbauer S., Fox C. et al., 2022/06. HemaSphere, 6 (6) pp. e726. Peer-reviewed.
 
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
Wu W., Nelson G.M., Koch R., Donovan K.A., Nowak R.P., Heavican-Foral T.B., Nirmal A.J., Liu H., Yang L., Duffy J. et al., 2022/03/31. Blood, 139 (13) pp. 2024-2037. Peer-reviewed.
EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disorders.
Veloza L., Tsai C.Y., Bisig B., Pantet O., Alberio L., Sempoux C., Cavassini M., de Leval L., 2022/03. Virchows Archiv, 480 (3) pp. 699-705. Peer-reviewed.
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
Domizio J.D., Gulen M.F., Saidoune F., Thacker V.V., Yatim A., Sharma K., Nass T., Guenova E., Schaller M., Conrad C. et al., 2022/03. Nature, 603 (7899) pp. 145-151. Peer-reviewed.
Venetoclax combined with FLAG-based chemotherapy induces an early and deep response in mixed-phenotype-acute leukemia.
Ségot A., Stalder G., de Leval L., Solly F., Schoumans J., Basset V., Blum S., Spertini O., 2022/03/01. American journal of hematology, 97 (3) pp. E91-E93. Peer-reviewed.
Genetic and phenotypic attributes of splenic marginal zone lymphoma.
Bonfiglio F., Bruscaggin A., Guidetti F., Terzi di Bergamo L., Faderl M., Spina V., Condoluci A., Bonomini L., Forestieri G., Koch R. et al., 2022/02/03. Blood, 139 (5) pp. 732-747. Peer-reviewed.
Azacytidine and Venetoclax in Relapsed and Refractory Patients With Angioimmunoblastic T-cell Lymphoma.
Laribi K., Baugier de Materre A., Touileb Y., Boursot C., Sandrini J., Cavalieri D., Pastoret C., de Leval L., Tournilhac O., 2022/02. HemaSphere, 6 (2) pp. e675. Peer-reviewed.
Prolonged Remissions After Nivolumab Plus Gemcitabine/Oxaliplatin in Relapsed/Refractory T-cell Lymphoma.
Houot R., Poeschel V., Altmann B., Angel S., Thurner L., Illmer T., Andre M., Dreyling M., Maisonneuve H., Tilly H. et al., 2022/02. HemaSphere, 6 (2) pp. e672. Peer-reviewed.
 
Romidepsin Plus CHOP Versus CHOP in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Results of the Ro-CHOP Phase III Study (Conducted by LYSA).
Bachy E., Camus V., Thieblemont C., Sibon D., Casasnovas R.O., Ysebaert L., Damaj G., Guidez S., Pica G.M., Kim W.S. et al., 2022/01/20. Journal of clinical oncology, 40 (3) pp. 242-251. Peer-reviewed.
COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic.
Fortarezza F., Pezzuto F., Hofman P., Kern I., Panizo A., von der Thüsen J., Timofeev S., Gorkiewicz G., Berezowska S., de Leval L. et al., 2022/01/01. Diagnostics, 12 (1) p. 95. Peer-reviewed.
Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript.
Voruz S., Blum S., de Leval L., Schoumans J., Solly F., Spertini O., 2021/12/20. Biomarker research, 9 (1) p. 92. Peer-reviewed.
Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.
Favre G., Mazzetti S., Gengler C., Bertelli C., Schneider J., Laubscher B., Capoccia R., Pakniyat F., Ben Jazia I., Eggel-Hort B. et al., 2021/12/15. Viruses, 13 (12) p. 2517. Peer-reviewed.
A stone in the bone.
Halfon M., Cochat P., Kissling S., Dattner N., de Leval L., Fakhouri F., Pruijm M., Bonny O., 2021/11. JIMD reports, 62 (1) pp. 6-8. Peer-reviewed.
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Liang H.C., Costanza M., Prutsch N., Zimmerman M.W., Gurnhofer E., Montes-Mojarro I.A., Abraham B.J., Prokoph N., Stoiber S., Tangermann S. et al., 2021/09/22. Nature communications, 12 (1) p. 5577. Peer-reviewed.
 
Hepatosplenic T-cell lymphoma: treatment challenges.
Bron D., De Leval L., Michiels S., Wittnebel S., EuroBloodNet for rare diseases, 2021/09/01. Current opinion in oncology, 33 (5) pp. 406-411. Peer-reviewed.
 
Molecular characterization of Burkitt lymphoma in the breast or ovary.
Elgaafary S., López C., Nagel I., Vater I., Bens S., Szczepanowski M., Aukema S.M., Wagener R., Hopp L., Binder H. et al., 2021/09. Leukemia & lymphoma, 62 (9) pp. 2120-2129. Peer-reviewed.
 
Detection of Gene Fusion Transcripts in Peripheral T-Cell Lymphoma Using a Multiplexed Targeted Sequencing Assay.
Drieux F., Ruminy P., Sater V., Marchand V., Fataccioli V., Lanic M.D., Viennot M., Viailly P.J., Sako N., Robe C. et al., 2021/08. The Journal of molecular diagnostics, 23 (8) pp. 929-940. Peer-reviewed.
Postmortem Cardiopulmonary Pathology in Patients with COVID-19 Infection: Single-Center Report of 12 Autopsies from Lausanne, Switzerland.
Berezowska S., Lefort K., Ioannidou K., Ndiaye D.R., Maison D., Petrovas C., Rotman S., Piazzon N., Milowich D., Sala N. et al., 2021/07/28. Diagnostics, 11 (8) p. 1357. Peer-reviewed.
CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas.
Monteiro I., Missiaglia E., Sciarra A., Santos J.V., Bouilly J., Romero P., Sempoux C., de Leval L., 2021/07. Virchows Archiv, 479 (1) pp. 209-214. Peer-reviewed.
Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming.
Carras S., Chartoire D., Mareschal S., Heiblig M., Marçais A., Robinot R., Urb M., Pommier R.M., Julia E., Chebel A. et al., 2021/07/01. The Journal of clinical investigation, 131 (13) pp. e139675. Peer-reviewed.
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Debackere K., Marcelis L., Demeyer S., Vanden Bempt M., Mentens N., Gielen O., Jacobs K., Broux M., Verhoef G., Michaux L. et al., 2021/06/17. Nature communications, 12 (1) p. 3705. Peer-reviewed.
 
Periphere T-Zell Lymphome: Hinweise zu COVID-19 finden Sie in der COVID-19-Leitlinie
Hopfinger G., Herling M., De Leval L., Krasniqi F., Reimer P., Schmitz N., Wulf G., 2021/06/14. Onkopedia.
 
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M., Letourneau A., Missiaglia E., De Prijck B., Nagy-Hulliger M., Somja J., Vivario M., Gaulard P., Lambert F., Bisig B. et al., 2021/06/01. The American journal of surgical pathology, 45 (6) pp. 773-786. Peer-reviewed.
Lymph node involvement by enteropathy-like indolent NK-cell proliferation.
Dargent J.L., Tinton N., Trimech M., de Leval L., 2021/06. Virchows Archiv, 478 (6) pp. 1197-1202. Peer-reviewed.
 
A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL.
Schmitz N., Truemper L., Bouabdallah K., Ziepert M., Leclerc M., Cartron G., Jaccard A., Reimer P., Wagner E., Wilhelm M. et al., 2021/05/13. Blood, 137 (19) pp. 2646-2656. Peer-reviewed.
Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine.
Voruz S., de Leval L., Cairoli A., 2021/05/13. Experimental hematology & oncology, 10 (1) p. 32. Peer-reviewed.
SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancy.
Gengler C., Dubruc E., Favre G., Greub G., de Leval L., Baud D., 2021/03. Clinical microbiology and infection, 27 (3) pp. 489-490. Peer-reviewed.
In Situ Characterization of Follicular Helper CD4 T Cells Using Multiplexed Imaging.
Ioannidou K., Ndiaye D.R., Noto A., Fenwick C., Fortis S.P., Pantaleo G., Petrovas C., de Leval L., 2021/02/28. Frontiers in immunology, 11 p. 607626. Peer-reviewed.
 
Solute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis.
Merli A.M., Vieujean S., Massot C., Blétard N., Quesada Calvo F., Baiwir D., Mazzucchelli G., Servais L., Wéra O., Oury C. et al., 2021/02/28. Journal of Crohn's & colitis, 15 (2) pp. 287–298. Peer-reviewed.
Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.
Hofman P., Ilié M., Chamorey E., Brest P., Schiappa R., Nakache V., Antoine M., Barberis M., Begueret H., Bibeau F. et al., 2021/02. ESMO open, 6 (1) p. 100024. Peer-reviewed.
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Cachot A., Bilous M., Liu Y.C., Li X., Saillard M., Cenerenti M., Rockinger G.A., Wyss T., Guillaume P., Schmidt J. et al., 2021/02. Science advances, 7 (9) pp. eabe3348. Peer-reviewed.
Integrative analysis of a phase 2 trial combining lenalidomide with CHOP in angioimmunoblastic T-cell lymphoma.
Lemonnier F., Safar V., Beldi-Ferchiou A., Cottereau A.S., Bachy E., Cartron G., Fataccioli V., Pelletier L., Robe C., Letourneau A. et al., 2021/01/26. Blood advances, 5 (2) pp. 539-548. Peer-reviewed.
Case Report: Spontaneous Remission of an Infraorbital Follicular B-Cell Lymphoma: Case Report and Review of the Literature.
Peeters M., Geusens J., Van der Cruyssen F., Michaux L., de Leval L., Tousseyn T., Vandenberghe P., Politis C., 2021. Pathology oncology research, 27 p. 642433. Peer-reviewed.
Recent advances upper gastrointestinal lymphomas: molecular updates and diagnostic implications.
Foukas P.G., Bisig B., de Leval L., 2021/01. Histopathology, 78 (1) pp. 187-214. Peer-reviewed.
Chromosomes in breast lymphoma.
de Leval L., 2020/12/17. Blood, 136 (25) pp. 2848-2849. Peer-reviewed.
 
Cytokine-directed therapy with tocilizumab for immune checkpoint inhibitor-related hemophagocytic lymphohistiocytosis.
Özdemir B.C., Latifyan S., Perreau M., Fenwick C., Alberio L., Waeber G., Spertini F., de Leval L., Michielin O., Obeid M., 2020/12. Annals of oncology, 31 (12) pp. 1775-1778. Peer-reviewed.
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows SETD2 Alterations.
Tomita S., Kikuti Y.Y., Carreras J., Sakai R., Takata K., Yoshino T., Bea S., Campo E., Missiaglia E., Bouilly J. et al., 2020/11/27. Cancers, 12 (12) p. 3539. Peer-reviewed.
Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult.
Othenin-Girard A., Regamey J., Lamoth F., Horisberger A., Glampedakis E., Epiney J.B., Kuntzer T., de Leval L., Carballares M., Hurni C.A. et al., 2020/11/02. Swiss medical weekly, 150 pp. w20387. Peer-reviewed.
Controversies in the Treatment of Peripheral T-cell Lymphoma.
Bachy E., Broccoli A., Dearden C., de Leval L., Gaulard P., Koch R., Morschhauser F., Trümper L., Zinzani P.L., 2020/10. HemaSphere, 4 (5) pp. e461. Peer-reviewed.
MarrowQuant Across Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections.
Tratwal J., Bekri D., Boussema C., Sarkis R., Kunz N., Koliqi T., Rojas-Sutterlin S., Schyrr F., Tavakol D.N., Campos V. et al., 2020/09/24. Frontiers in endocrinology, 11 p. 480. Peer-reviewed.
Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report.
Salvioni Chiabotti P., Bisig B., Cairoli A., Hajdu S.D., Lovey P.Y., Milowich D., Ziadi S., Du Pasquier R., Brouland J.P., de Leval L., 2020/09/14. Frontiers in oncology, 10 p. 1745. Peer-reviewed.
Management of Patients With Hematologic Malignancies During the COVID-19 Pandemic: Practical Considerations and Lessons to Be Learned.
Isidori A., de Leval L., Gergis U., Musto P., Porcu P., 2020/08/01. Frontiers in oncology, 10 p. 1439. Peer-reviewed.
Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract.
Soderquist C.R., Patel N., Murty V.V., Betman S., Aggarwal N., Young K.H., Xerri L., Leeman-Neill R., Lewis S.K., Green P.H. et al., 2020/07. Haematologica, 105 (7) pp. 1895-1906. Peer-reviewed.
Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay.
Drieux F., Ruminy P., Abdel-Sater A., Lemonnier F., Viailly P.J., Fataccioli V., Marchand V., Bisig B., Letourneau A., Parrens M. et al., 2020/06. Haematologica, 105 (6) pp. 1582-1592. Peer-reviewed.
Lymphoma Classification.
de Leval L., Jaffe E.S., 2020/05/31. Cancer journal, 26 (3) pp. 176-185. Peer-reviewed.
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L., Hartmann S., Fadle N., Regitz E., Kemele M., Kim Y.J., Bohle R.M., Nimmesgern A., von Müller L., Kempf VAJ et al., 2020/05/18. Nature communications, 11 (1) p. 2465. Peer-reviewed.
 
A Diffuse Medullary Hypercaptation With No Bone Lesion.
Christin A., de Leval L., Obeid M., 2020/02/01. JAMA oncology, 6 (2) pp. 291-292. Peer-reviewed.
Approach to nodal-based T-cell lymphomas.
de Leval L., 2020/01. Pathology, 52 (1) pp. 78-99. Peer-reviewed.
 
Molecular Heterogeneity within Brain Metastatic Prostate Cancer: A Multicenter Study of 50 Patients
Rodriguez Antonio, Sanoyan Dilara Akhoundova, Ferguson Alison, Maletti Sina, Selimovic-Hamza Senija, Comoglio Federico, Bruggmann Remy, Hewer Ekkehard, Genitsch Vera, Fleischmann Achim et al., 2020., 109th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), FEB 29-MAR 05, 2020 pp. 961-962 dans Modern Pathology.
 
Molecular Heterogeneity within Brain Metastatic Prostate Cancer: A Multicenter Study of 50 Patients.
Rodriguez Antonio, Sanoyan Dilara Akhoundova, Ferguson Alison, Maletti Sina, Selimovic-Hamza Senija, Comoglio Federico, Bruggmann Remy, Hewer Ekkehard, Genitsch Vera, Fleischmann Achim et al., 2020., 109th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), FEB 29-MAR 05, 2020 pp. 961-962 dans Modern Pathology.
 
Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry.
Amador C., Greiner T.C., Heavican T.B., Smith L.M., Galvis K.T., Lone W., Bouska A., D'Amore F., Pedersen M.B., Pileri S. et al., 2019/12/12. Blood, 134 (24) pp. 2159-2170. Peer-reviewed.
 
The Romand Network of Oncology: bridging the gap of personalised oncology
Michielin O., Tsantoulis P., Homicsko K., Christinat Y., De Leval L., Bisig B., Missiaglia E., Zoete V., Krebs F., Fortin A. et al., 2019/10/18. Swiss Medical Weekly.
New Data in the Molecular Pathology of T-Cell Lymphomas
De Leval L., 2019/09/30. Leading Opinions Hämatologie und Onkologie, 15 (5) pp. 43-45.
Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study.
Aimi F., Procopio M.G., Alvarez Flores M.T., Brouland J.P., Piazzon N., Brajkovic S., Dupouy D.G., Gijs M., de Leval L., 2019/09. Virchows Archiv, 475 (3) pp. 313-323. Peer-reviewed.
 
F-18-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.
Jreige M., Letovanec I., Chaba K., Renaud S., Rusakiewicz S., Cristina V., Peters S., Krueger T., de Leval L., Kandalaft L.E. et al., 2019/08. European journal of nuclear medicine and molecular imaging, 46 (9) pp. 1859-1868. Peer-reviewed.
 
Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma.
Crickx E., Poullot E., Moulis G., Goulabchand R., Fieschi C., Galicier L., Meignin V., Coppo P., Delarue R., Casasnovas O. et al., 2019/07. European journal of haematology, 103 (1) pp. 35-42. Peer-reviewed.
Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement.
Banga R., Rebecchini C., Procopio F.A., Noto A., Munoz O., Ioannidou K., Fenwick C., Ohmiti K., Cavassini M., Corpataux J.M. et al., 2019/07. PLoS pathogens, 15 (7) pp. e1007918. Peer-reviewed.
Breast implant-associated anaplastic large cell lymphoma and other rare T-cell lymphomas.
de Leval L., 2019/06. Hematological oncology, 37 Suppl 1 pp. 24-29. Peer-reviewed.
 
Crystal-Storing Histiocytosis.
Rebecchini C., Trimeche M., Rosselet A., de Leval L., 2019/06. International journal of surgical pathology, 27 (4) pp. 399-400. Peer-reviewed.
 
Primary hepatic marginal B cell lymphoma of mucosa-associated lymphoid tissue (MALT) and non-alcoholic steatohepatitis (NASH): more than a coincidence?
Haefliger S., Milowich D., Sciarra A., Trimeche M., Bouilly J., Kaiser J., Volpi S., Brouland J.P., Sempoux C., de Leval L., 2019/06. Annals of hematology, 98 (6) pp. 1513-1516. Peer-reviewed.
 
High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer.
Nguyen H.T., Migliozzi D., Bisig B., de Leval L., Gijs MAM, 2019/05. Laboratory investigation; a journal of technical methods and pathology, 99 (5) pp. 722-732. Peer-reviewed.
 
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.
Heavican T.B., Bouska A., Yu J., Lone W., Amador C., Gong Q., Zhang W., Li Y., Dave B.J., Nairismägi M.L. et al., 2019/04/11. Blood, 133 (15) pp. 1664-1676. Peer-reviewed.
CD73 expression in normal and pathological human hepatobiliopancreatic tissues.
Sciarra A., Monteiro I., Ménétrier-Caux C., Caux C., Gilbert B., Halkic N., La Rosa S., Romero P., Sempoux C., de Leval L., 2019/03. Cancer immunology, immunotherapy, 68 (3) pp. 467-478. Peer-reviewed.
 
Correction to: CD73 expression in normal and pathological human hepatobiliopancreatic tissues
Sciarra Amedeo, Monteiro Inês, Ménétrier-Caux Christine, Caux Christophe, Gilbert Benoit, Halkic Nermin, La Rosa Stefano, Romero Pedro, Sempoux Christine, de Leval Laurence, 2019/03. 1.
 
CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1<sup>-</sup> mantle cell lymphoma.
Martín-Garcia D., Navarro A., Valdés-Mas R., Clot G., Gutiérrez-Abril J., Prieto M., Ribera-Cortada I., Woroniecka R., Rymkiewicz G., Bens S. et al., 2019/02/28. Blood, 133 (9) pp. 940-951. Peer-reviewed.
The Need for a Consensus Next-generation Sequencing Panel for Mature Lymphoid Malignancies
Sujobert P., Le Bris Y., de Leval L., Gros A., Merlio JP, Pastoret C., Huet S., Sarkozy C., Davi F., Callanan M. et al., 2019/02. HemaSphere, 3 (1) pp. e169. Peer-reviewed.
 
Pathology and Molecular Pathogenesis of T-Cell Lymphoma
Iqbal J., De Leval L., 2019/01/31. pp. 95-141 dans Agressive Lymphomas chap. 4, Springer.
 
Cyclin D1-positive Mediastinal Large B-Cell Lymphoma With Copy Number Gains of CCND1 Gene: A Study of 3 Cases With Nonmediastinal Disease.
Chen B.J., Ruminy P., Roth C.G., Bisig B., Mankel B., Steinhilber J., Bohers E., Jardin F., Fend F., Swerdlow S.H. et al., 2019/01. The American journal of surgical pathology, 43 (1) pp. 110-120. Peer-reviewed.
 
Fetal Anthropometric Features: A Postmortem Study of Fetuses After the Termination of Pregnancy for Psychosocial Reasons Between 12 and 20 Gestational Weeks.
Muller Brochut A.C., Taffe P., Piaget-Rossel R., de Leval L., Rougemont A.L., 2019. Pediatric and developmental pathology, 22 (3) pp. 243-251. Peer-reviewed.
 
IG-MYC+ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas
Wagener R., López C., Kleinheinz K., Bausinger J., Aukema S.M., Nagel I., Toprak U.H., Seufert J., Altmüller J., Thiele H. et al., 2018/11/22. Blood, 132 (21) pp. 2280-2285. Peer-reviewed.
Advancing synoptic cancer reports beyond English: the University of Bern/PathoLink approach.
Banz Y., Berezowska S., de Leval L., Rubbia-Brandt L., Tolnay M., Moch H., Perren A., Hewer E., 2018/11. Virchows Archiv, 473 (5) pp. 655-656. Peer-reviewed.
Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma.
Letourneau A., Maerevoet M., Milowich D., Dewind R., Bisig B., Missiaglia E., de Leval L., 2018/10. Virchows Archiv, 473 (4) pp. 505-511. Peer-reviewed.
 
Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing.
Dupuy A., Lemonnier F., Fataccioli V., Martin-Garcia N., Robe C., Pelletier R., Poullot E., Moktefi A., Mokhtari K., Rousselet M.C. et al., 2018/09. The Journal of molecular diagnostics, 20 (5) pp. 677-685. Peer-reviewed.
New insights in the pathogenesis of T-cell lymphomas.
Lemonnier F., Gaulard P., de Leval L., 2018/09. Current opinion in oncology, 30 (5) pp. 277-284. Peer-reviewed.
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells.
Vallois D., Dupuy A., Lemonnier F., Allen G., Missiaglia E., Fataccioli V., Ortonne N., Clavert A., Delarue R., Rousselet M.C. et al., 2018/08. Haematologica, 103 (8) pp. e360-e363. Peer-reviewed.
CD73 expression and clinical significance in human metastatic melanoma.
Monteiro I., Vigano S., Faouzi M., Treilleux I., Michielin O., Ménétrier-Caux C., Caux C., Romero P., de Leval L., 2018/06/01. Oncotarget, 9 (42) pp. 26659-26669. Peer-reviewed.
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.
Herfs M., Roncarati P., Koopmansch B., Peulen O., Bruyere D., Lebeau A., Hendrick E., Hubert P., Poncin A., Penny W. et al., 2018/05. British journal of cancer, 118 (10) pp. 1302-1312. Peer-reviewed.
 
AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress.
Kfoury A., Armaro M., Collodet C., Sordet-Dessimoz J., Giner M.P., Christen S., Moco S., Leleu M., de Leval L., Koch U. et al., 2018/03/01. The EMBO journal, 37 (5) pp. e97673. Peer-reviewed.
Comment on "MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma".
Voruz S., Martins F., Cairoli A., Naveiras O., Homicsko K., Missiaglia E., de Leval L., Bisig B., Michielin O., Blum S., 2018/03. Haematologica, 103 (3) pp. e130. Peer-reviewed.
Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.
Lemonnier F., Poullot E., Dupuy A., Couronné L., Martin N., Scourzic L., Fataccioli V., Bruneau J., Cairns R.A., Mak T.W. et al., 2018/03. Haematologica, 103 (3) pp. e115-e118. Peer-reviewed.
 
Definition of a minimal genes set for mature lymphoid blood diseases [Définition d'un panel minimal de gènes pour la· prise en charge des hémopathies lymphoïdes matures]
Sujobert P., Le Bris Y., de Leval L., Gros A., Merlio JP, Pastoret C., Huet S., Sarkozy C., Davi F., Callanan M. et al., 2018/02/28. Hématologie, 24 (1) pp. 27-59. Peer-reviewed.
 
Angioimmunoblastic T-Cell Lymphoma
de Leval L., Bisig B., 2018. dans Encyclopedia of Pathology, Springer.
 
Breast Implant-Associated Malignant Lymphoma
De Leval Laurence, Milowich Dina, 2018. pp. 1-6 dans Encyclopedia of Pathology, Springer International Publishing.
Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland.
Steiner R., Kridel R., Giostra E., McKee T., Achermann R., Mueller N., Manuel O., Dickenmann M., Schuurmans M.M., de Leval L. et al., 2018. Swiss medical weekly, 148 pp. w14596. Peer-reviewed.
 
Non-Hodgkin Lymphomas: Pathology and Genetics
de Leval L., 2018. pp. 48-75 dans Encyclopedia of Cancer, Elsevier.
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma.
Voruz S., Cairoli A., Naveiras O., de Leval L., Missiaglia E., Homicsko K., Michielin O., Blum S., 2018/01. Haematologica, 103 (1) pp. e39-e41. Peer-reviewed.
Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation.
Van Hede D., Polese B., Humblet C., Wilharm A., Renoux V., Dortu E., de Leval L., Delvenne P., Desmet C.J., Bureau F. et al., 2017/10/24. Proceedings of the National Academy of Sciences of the United States of America, 114 (43) pp. E9056-E9065. Peer-reviewed.
 
P 14: RNA fusions involving CD28 contribute to mutations-induced TCR signaling activation in peripheral T-cell lymphomas of TFH derivation
Vallois D., Dupuy A., Lemonnier F., Fataccioli V., Ortonne N., Allen G., Tournilhac O., Delarue R., Rousselet MC, Fabiani B. et al., 2017/10/20. pp. 578-579 dans Swiss Pathology Days, Der Pathologe.
 
P13: Breast implant-associated anaplastic large-cell lymphoma presenting as a tumor mass and recurring as a seroma, with dual JAK1 and STAT3 mutations
Bisig B., Letourneau A., Maerevoet M., Millowich D., Dewind R., Missiaglia E., de Leval L., 2017/10/20. p. 578 dans Swiss Pathology Days, Der Pathologe.
B-cell lymphomas with discordance between pathological features and clinical behavior
de Leval Laurence, Copie-Bergman Christiane, Rosenwald Andreas, Rimsza Lisa, Pittaluga Stefania, Bisig Bettina, Dirnhofer Stefan, Facchetti Fabio, Pileri Stefano, Fend Falko et al., 2017/10. Virchows Archiv, 471 (4) pp. 439-451. Peer-reviewed.
 
Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery.
Broglie M.A., Stoeckli S.J., Sauter R., Pasche P., Reinhard A., de Leval L., Huber G.F., Pezier T.F., Soltermann A., Giger R. et al., 2017/10. Head & neck, 39 (10) pp. 2004-2015. Peer-reviewed.
 
Analyse mutationnelle de BRCA1/2 et inhibiteurs de PARP chez les ­patientes atteintes de cancer de l'ovaire
Mertz Kirsten D., Bisig Bettina, Azzarello-Burri Silvia, Rauch Anita, Röthlisberger Benno, de Leval Laurence, Cathomas Gieri, Terracciano Luigi, Jochum Wolfram, Perren Aurel et al., 2017/09/20. Forum Médical Suisse ‒ Swiss Medical Forum, 17 (38) pp. 816-818.
 
A standardized quantification tool for bone marrow components in histological sections
Tratwal J., Boussema C., Burri O., Koliqi T., Campos V., Nardi V., Bárcena C., Sarro R., Bisig B., De Leval L., 2017/09. pp. S62-S63 dans Experimental Hematology, Elsevier BV.
 
The clinicopathologic spectrum of mature aggressive B cell lymphomas.
Rimsza L., Pittaluga S., Dirnhofer S., Copie-Bergman C., de Leval L., Facchetti F., Pileri S., Rosenwald A., Wotherspoon A., Fend F., 2017/08/26. Virchows Archiv, 471 (4) pp. 453-466. Peer-reviewed.
Microfluidics for rapid cytokeratin immunohistochemical staining in frozen sections.
Brajkovic S., Dupouy D.G., de Leval L., Gijs M.A., 2017/08. Laboratory investigation; a journal of technical methods and pathology, 97 (8) pp. 983-991. Peer-reviewed.
 
Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.
Facchetti F., Pileri S.A., Lorenzi L., Tabanelli V., Rimsza L., Pittaluga S., Dirnhofer S., Copie-Bergman C., de Leval L., Rosenwald A. et al., 2017/07/10. Virchows Archiv, 471 (4) pp. 467-489. Peer-reviewed.
Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy.
Darcis G., Van der Auwera G., Giot J.B., Hayette M.P., Tassin F., Arrese Estrada J., Cnops L., Moutschen M., de Leval L., Leonard P., 2017/07/07. BMC infectious diseases, 17 (1) p. 478. Peer-reviewed.
Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer.
Chevalier M.F., Bohner P., Pieraerts C., Lhermitte B., Gourmaud J., Nobile A., Rotman S., Cesson V., Martin V., Legris A.S. et al., 2017/06. European urology, 71 (6) pp. 854-857. Peer-reviewed.
Very low expression of PD-L1 in medullary thyroid carcinoma.
Bongiovanni M., Rebecchini C., Saglietti C., Bulliard J.L., Marino L., de Leval L., Sykiotis G.P., 2017/06. Endocrine-related cancer, 24 (6) pp. L35-L38. Peer-reviewed.
Du neuf dans l’oncogenèse moléculaire des lymphomes : rôle du gène SETD2 dans les lymphomes T de l’intestin [Molecular oncogenesis of lymphomas: role of the SETD2 gene in intestinal T-cell lymphomas]
Vallois D., Roberti A., Bisig B., Gaulard P., de Leval L., 2017/05. Medecine sciences, 33 (5) pp. 469-473. Peer-reviewed.
 
Fibrin-Associated EBV plus Large B-Cell Lymphoma: An Indolent Neoplasm Distinct from DLBCL-CI [1363]
Boyer D., McKelvie P., de Leval L., Edlefsen KL, Ko YH, Aberman Z., Kovach A., Masih A., Nishino A., Weiss L. et al., 2017/04/30., 106th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) pp. 339A-340A dans Modern Pathology.
 
Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation.
Boyer D.F., McKelvie P.A., de Leval L., Edlefsen K.L., Ko Y.H., Aberman Z.A., Kovach A.E., Masih A., Nishino H.T., Weiss L.M. et al., 2017/04. The American journal of surgical pathology, 41 (3) pp. 299-312. Peer-reviewed.
Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin.
Dobay M.P., Lemonnier F., Missiaglia E., Bastard C., Vallois D., Jais J.P., Scourzic L., Dupuy A., Fataccioli V., Pujals A. et al., 2017/04. Haematologica, 102 (4) pp. e148-e151. Peer-reviewed.
 
The Genetic Basis of Hepatosplenic T-cell Lymphoma.
McKinney M., Moffitt A.B., Gaulard P., Travert M., De Leval L., Nicolae A., Raffeld M., Jaffe E.S., Pittaluga S., Xi L. et al., 2017/04. Cancer discovery, 7 (4) pp. 369-379. Peer-reviewed.
 
How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future.
Schmitz N., de Leval L., 2017/03. British journal of haematology, 176 (6) pp. 851-866. Peer-reviewed.
 
IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis.
Bruls S., Courtois A., Delvenne P., Hustinx R., Moutschen M., De Leval L., Defraigne J.O., Sakalihasan N., 2017/03. The Annals of thoracic surgery, 103 (3) pp. e239-e240. Peer-reviewed.
 
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Ehx G., Fransolet G., de Leval L., D'Hondt S., Lucas S., Hannon M., Delens L., Dubois S., Drion P., Beguin Y. et al., 2017. Oncoimmunology, 6 (5) pp. e1314425. Peer-reviewed.
 
Establishing a formal sarcoma center for children and adults at the Lausanne University Hospital
Bosisio Francesca, Matter Maurice, Fortin Aurélie, CHUV Multidisciplinary Sarcoma Team, 2017. Swiss Knife 3 pp. 16-19. Peer-reviewed.
 
Microfluidics-assisted fluorescence in situ hybridization for advantageous human epidermal growth factor receptor 2 assessment in breast cancer.
Nguyen H.T., Trouillon R., Matsuoka S., Fiche M., de Leval L., Bisig B., Gijs M.A., 2017/01. Laboratory investigation; a journal of technical methods and pathology, 97 (1) pp. 93-103. Peer-reviewed.
 
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
Lemonnier F., Cairns R.A., Inoue S., Li W.Y., Dupuy A., Broutin S., Martin N., Fataccioli V., Pelletier R., Wakeham A. et al., 2016/12/27. Proceedings of the National Academy of Sciences of the United States of America, 113 (52) pp. 15084-15089. Peer-reviewed.
 
Cutaneous presentation of hepatosplenic T-cell lymphoma-a potential mimicker of primary cutaneous gamma-delta T-cell lymphoma.
Karpate A., Barcena C., Hohl D., Bisig B., de Leval L., 2016/11. Virchows Archiv : an international journal of pathology, 469 (5) pp. 591-596. Peer-reviewed.
 
Kontrastverstärkter Ultraschall einer nodulären extramedullären Hämatopoese der Milz bei einem Patienten mit primärer Myelofibrose [Contrast-Enhanced Ultrasound of Nodular Splenic Extramedullary Hematopoiesis in a Patient with Underlying Primary Myelofibrosis]
Hajdu S.D., de Leval L., Meuwly J.Y., 2016/10. Ultraschall in der Medizin, 37 (5) pp. 447-450. Peer-reviewed.
 
PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals.
Banga R., Procopio F.A., Noto A., Pollakis G., Cavassini M., Ohmiti K., Corpataux J.M., de Leval L., Pantaleo G., Perreau M., 2016/07. Nature medicine, 22 (7) pp. 754-761. Peer-reviewed.
Azacytidine Enhances Regulatory T-Cells In Vivo and Prevents Experimental Xenogeneic Graft-Versus-Host Disease
Ehx G., Fransolet G., de Leval L., D'Hondt S., Lucas S., Hannon M., Delens L., Dubois S., Drion P., Beguin Y. et al., 2016/03. pp. S393 dans Biology of Blood and Marrow Transplantation, Biology of Blood and Marrow Transplantation. Peer-reviewed, Elsevier BV.
 
Oropharyngeal NK/T-cell lymphoma presenting with bilateral uveitis.
Grosjean P., Thiry A., De Leval L., Bonnet S., 2016/03. Journal francais d'ophtalmologie, 39 (3) pp. e57-8. Peer-reviewed.
Continuous quantification of HER2 expression by microfluidic precision immunofluorescence estimates HER2 gene amplification in breast cancer.
Dupouy D.G., Ciftlik A.T., Fiche M., Heintze D., Bisig B., de Leval L., Gijs M.A., 2016/02/09. Scientific reports, 6 p. 20277. Peer-reviewed.
 
Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes.
Laurent C., Delas A., Gaulard P., Haioun C., Moreau A., Xerri L., Traverse-Glehen A., Rousset T., Quintin-Roue I., Petrella T. et al., 2016/02. Annals of oncology : official journal of the European Society for Medical Oncology, 27 (2) pp. 306-314. Peer-reviewed.
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
Vallois D., Dobay M.P., Morin R.D., Lemonnier F., Missiaglia E., Juilland M., Iwaszkiewicz J., Fataccioli V., Bisig B., Roberti A. et al., 2016. Blood, 128 (11) pp. 1490-1502. Peer-reviewed.
 
ALK-negative anaplastic large-cell lymphoma.
Gaulard P., de Leval L., 2016. Blood, 127 (2) pp. 175-177. Peer-reviewed.
 
Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.
Vijgen S., Wyss C., Meylan P., Bisig B., Letovanec I., Manuel O., Pascual M., de Leval L., 2016. Transplantation, 100 (1) pp. 134-140. Peer-reviewed.
 
Follicular lymphoma
Harris NL, De Leval L., Louissaint A., Ferry JA, 2016. pp. 321-352 dans Hematopathology chap. 18, Elsevier.
 
Peripheral T-Cell Lymphoma, Not Otherwise Specified
De Leval L., 2016. pp. 641-658 dans Hematopathology chap. 35, Elsevier.
 
Prognostic value of baseline total metabolic tumor volume (TMTV0) measured on FDG-PET/CT in patients with peripheral T-cell lymphoma (PTCL).
Cottereau A.S., Becker S., Broussais F., Casasnovas O., Kanoun S., Roques M., Charrier N., Bertrand S., Delarue R., Bonnet C. et al., 2016. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo, 27 (4) pp. 719-724. Peer-reviewed.
Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.
Roberti A., Dobay M.P., Bisig B., Vallois D., Boéchat C., Lanitis E., Bouchindhomme B., Parrens M.C., Bossard C., Quintanilla-Martinez L. et al., 2016. Nature Communications, 7 p. 12602. Peer-reviewed.
Artérite de Horton: recommandations Lausannoises de prise en charge [Giant cell arteritis: guidelines of the University Hospital of Lausanne].
Tsetsou S., Michel P., Ribi C., Hirt L., Kawasaki A., Hugli O., De Leval L., Bart P.A., Waeber G., Meuli R. et al., 2015/02. Revue Médicale Suisse, 11 (461) pp. 411-417. Peer-reviewed.
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Küçük C., Jiang B., Hu X., Zhang W., Chan J.K., Xiao W., Lack N., Alkan C., Williams J.C., Avery K.N. et al., 2015. Nature Communications, 6 p. 6025. Peer-reviewed.
 
Anaplastic large cell lymphoma and other rare mature T- and NK-cell lymphomas
Lamant L., Gaulard P., Chan JKC, Jaffe ES, Nakamura S., Molina TJ, De Leval L., 2015. pp. - dans WHO classification of tumours of the lung, pleura, thymus and heart, World Health Organization.
Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets.
de Leval L., Parrens M., Le Bras F., Jais J.P., Fataccioli V., Martin A., Lamant L., Delarue R., Berger F., Arbion F. et al., 2015. Haematologica, 100 (9) pp. e361-e364. Peer-reviewed.
 
Cerebriforms cells in cerebrum: an unusual finding
Sarro R., Gaide O., Letourneau A., Missiaglia E., Bisig B., Hottinger A., Cairoli A., de Leval L., 2015. p. 633 dans 81. Jahrestagung der Schweizerischen Gesellschaft für Pathologie, Der Pathologe.
 
IA02: Principles of lymphoma classification
De Leval L., 2015. pp. - dans AACR Special Conference on Hematologic Malignancies - Translating Discoveries to Novel Therapies, Clinical Cancer Research. Peer-reviewed.
 
KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype.
Clipson A., Wang M., de Leval L., Ashton-Key M., Wotherspoon A., Vassiliou G., Bolli N., Grove C., Moody S., Escudero-Ibarz L. et al., 2015. Leukemia, 29 (5) pp. 1177-1185. Peer-reviewed.
 
Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients.
Geyer J.T., Subramaniyam S., Jiang Y., Elemento O., Ferry J.A., de Leval L., Nakashima M.O., Liu Y.C., Martin P., Mathew S. et al., 2015. Human Pathology, 46 (2) pp. 260-271. Peer-reviewed.
 
Lymphocytic variant hypereosinophilic syndrome progressing to angioimmunoblastic T-cell lymphoma.
Roufosse F., de Leval L., van Krieken H., van Deuren M., 2015. Leukemia and Lymphoma, 56 (6) pp. 1891-1894. Peer-reviewed.
 
Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.
Ribera-Cortada I., Martinez D., Amador V., Royo C., Navarro A., Beà S., Gine E., de Leval L., Serrano S., Wotherspoon A. et al., 2015. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc, 28 (11) pp. 1435-1447. Peer-reviewed.
 
Recent advances in intestinal lymphomas.
Foukas P.G., de Leval L., 2015. Histopathology, 66 (1) pp. 112-136.
 
The microenvironment in T-cell lymphomas
De Leval L., Gaulard P., 2015. pp. 112-131 dans Hodgkin And Non-Hodgkin Lymphomas Seen Through Their Microenvironment: Impact on Diagnosis, Prognosis and Innovative Therapy chap. 8, Future Medicine Ltd.
Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels.
Bossard C., Dobay M.P., Parrens M., Lamant L., Missiaglia E., Haioun C., Martin A., Fabiani B., Delarue R., Tournilhac O. et al., 2014/11/06. Blood, 124 (19) pp. 2983-2986. Peer-reviewed.
 
Current Issues in the Diagnosis and Classification of Peripheral T-Cell Lymphomas
Nolan G., de Leval L., Feldman A., Swerdlow SH, Cerroni L., 2014/03. dans Annual Meeting 2014 of Society for Hematopathology.
 
Accuracy of sentinel lymph node dissection for melanoma staging in the presence of a collision tumour with a lymphoproliferative disease.
Gero D., Queiros da Mota V., Boubaker A., Berthod G., de Leval L., Demartines N., Matter M., 2014. Melanoma Research, 24 (4) pp. 371-376.
 
Cellular origin of T-cell lymphomas.
de Leval L., Gaulard P., 2014. Blood, 123 (19) pp. 2909-2910.
Conjunctival MALT lymphoma: utility of FDG PET/CT for diagnosis, staging, and evaluation of treatment response.
Sallak A., Besson F.L., Pomoni A., Christinat A., Adler M., Aegerter J.P., Nguyen C., de Leval L., Frossard V., Prior J.O., 2014. Clinical Nuclear Medicine, 39 (3) pp. 295-297.
 
Cytotoxic T-cell and NK-cell Lymphomas: Current Questions and Controversies.
Swerdlow S.H., Jaffe E.S., Brousset P., Chan J.K., de Leval L., Gaulard P., Harris N.L., Pileri S., Weiss L.M., International Lymphoma Study Group, 2014. American Journal of Surgical Pathology, 38 (10) pp. e60-e71.
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