Gregoire Courtine

Publications | Mémoires et thèses

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60 publications

Sous presse
 
A digital bridge between brain and spinal cord restores walking after paralysis.
Courtine Grégoire, Bloch Jocelyne Nature. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_73634AC53A9E]
2024
 
Hypothalamic deep brain stimulation augments walking after spinal cord injury.
Cho N., Squair J.W., Aureli V., James N.D., Bole-Feysot L., Dewany I., Hankov N., Baud L., Leonhartsberger A., Sveistyte K. et al., 2024/12. Nature medicine, 30 (12) pp. 3676-3686. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_31B291A5A388]
 
Best practices for differential accessibility analysis in single-cell epigenomics.
Teo AYY, Squair J.W., Courtine G., Skinnider M.A., 2024/10/11. Nature communications, 15 (1) p. 8805. Peer-reviewed.
[DOI][Pmid][serval:BIB_3E68ADF34DBA]
 
Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy.
Sanches E., Ho D., van de Looij Y., Aebi Toulotte A., Baud L., Bouteldja F., Barraud Q., Araneda R., Bleyenheuft Y., Brochard S. et al., 2024/10. Brain, behavior, and immunity, 121 pp. 303-316. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2414AFC1B25C]
Magnesium Test: Universal and Ultra‐Sensitive Method for Measuring Reliability of Thin‐Film‐Encapsulated Bioelectronic Implants in Physiological Environment
Mariello Massimo, Ayama Kosuke, Wu Kangling, Baudino Costanza, Wang Lei, Mutschler Léo, Jourdan Lucas Aurélien, Cleusix Marion Bianca, Furfaro Ivan, Kathe Claudia et al., 2024/08. Advanced Functional Materials, 34 (32).
[URN][DOI][WoS][serval:BIB_7B9E2A2F36A4]
 
Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica.
Skinnider M.A., Gautier M., Teo AYY, Kathe C., Hutson T.H., Laskaratos A., de Coucy A., Regazzi N., Aureli V., James N.D. et al., 2024/07. Nature, 631 (8019) pp. 150-163. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1C539D189A0B]
 
Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.
Moritz C., Field-Fote E.C., Tefertiller C., van Nes I., Trumbower R., Kalsi-Ryan S., Purcell M., Janssen TWJ, Krassioukov A., Morse L.R. et al., 2024/05. Nature medicine, 30 (5) pp. 1276-1283. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4062FEE24797]
 
Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada.
Dionne A., Al-Zakri M., Labelle H., Joncas J., Parent S., Mac-Thiong J.M., Miyanji F., Lonner B., Eren A., Cahill P. et al., 2024. Canadian journal of surgery. Journal canadien de chirurgie, 67 (6suppl1) pp. S17-S76. Peer-reviewed.
[DOI][Pmid][serval:BIB_9201D4B2113D]
Une neuroprothèse spinale contre les déficits locomoteurs de la maladie de Parkinson [A spinal neuroprosthesis against locomotor deficits in Parkinson's disease]
Bezard E., Bloch J., Courtine G., 2024/01. Medecine sciences, 40 (1) pp. 104-106. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_50742CB7CF58]
2023
 
Recovery of walking after paralysis by regenerating characterized neurons to their natural target region.
Squair J.W., Milano M., de Coucy A., Gautier M., Skinnider M.A., James N.D., Cho N., Lasne A., Kathe C., Hutson T.H. et al., 2023/09/22. Science, 381 (6664) pp. 1338-1345. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1B6DFE8A84E2]
 
Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates.
Darricau M., Katsinelos T., Raschella F., Milekovic T., Crochemore L., Li Q., Courtine G., McEwan W.A., Dehay B., Bezard E. et al., 2023/06/01. Brain, 146 (6) pp. 2524-2534. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_50358A4FD2FF]
 
Walking naturally after spinal cord injury using a brain-spine interface.
Lorach H., Galvez A., Spagnolo V., Martel F., Karakas S., Intering N., Vat M., Faivre O., Harte C., Komi S. et al., 2023/06. Nature, 618 (7963) pp. 126-133. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_029278333489]
 
Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models.
Soriano J.E., Hudelle R., Squair J.W., Mahe L., Amir S., Gautier M., Puchalt V.P., Barraud Q., Phillips A.A., Courtine G., 2023/02. Nature protocols, 18 (2) pp. 340-373. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D7C74A0122C3]
Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?
Yuksel M.M., Sun S., Latchoumane C., Bloch J., Courtine G., Raffin E.E., Hummel F.C., 2023. IEEE open journal of engineering in medicine and biology, 4 pp. 300-318. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9A574F21D6B5]
2022
 
Targeted dorsal root entry zone stimulation alleviates pain due to meralgia paresthetica.
Aureli V., Vat M., Hankov N., Théaudin M., Ravier J., Becce F., Demesmaeker R., Asboth L., Courtine G., Bloch J., 2022/12/07. Journal of neural engineering, 19 (6). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_875AD51CA7AB]
 
Natural and targeted circuit reorganization after spinal cord injury.
Anderson M.A., Squair J.W., Gautier M., Hutson T.H., Kathe C., Barraud Q., Bloch J., Courtine G., 2022/12. Nature neuroscience, 25 (12) pp. 1584-1596. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DF82061E8D35]
 
The neurons that restore walking after paralysis.
Kathe C., Skinnider M.A., Hutson T.H., Regazzi N., Gautier M., Demesmaeker R., Komi S., Ceto S., James N.D., Cho N. et al., 2022/11. Nature, 611 (7936) pp. 540-547. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6672FE6DE4F2]
Brain-spine interfaces to reverse paralysis.
Lorach H., Charvet G., Bloch J., Courtine G., 2022/10. National science review, 9 (10) pp. nwac009. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_37E84FC5043A]
Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.
Matson KJE, Russ D.E., Kathe C., Hua I., Maric D., Ding Y., Krynitsky J., Pursley R., Sathyamurthy A., Squair J.W. et al., 2022/09/26. Nature communications, 13 (1) p. 5628. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BE3C58D9C85B]
 
Principles of gait encoding in the subthalamic nucleus of people with Parkinson's disease.
Thenaisie Y., Lee K., Moerman C., Scafa S., Gálvez A., Pirondini E., Burri M., Ravier J., Puiatti A., Accolla E. et al., 2022/09/07. Science translational medicine, 14 (661) pp. eabo1800. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_106DBAF231BC]
 
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys.
Barra B., Conti S., Perich M.G., Zhuang K., Schiavone G., Fallegger F., Galan K., James N.D., Barraud Q., Delacombaz M. et al., 2022/07. Nature neuroscience, 25 (7) pp. 924-934. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_55C465CF903D]
 
Implanted System for Orthostatic Hypotension in Multiple-System Atrophy.
Squair J.W., Berney M., Castro Jimenez M., Hankov N., Demesmaeker R., Amir S., Paley A., Hernandez-Charpak S., Dumont G., Asboth L. et al., 2022/04/07. The New England journal of medicine, 386 (14) pp. 1339-1344. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CDFEFD334F15]
 
Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies.
Pasquini M., James N.D., Dewany I., Coen F.V., Cho N., Lai S., Anil S., Carpaneto J., Barraud Q., Lacour S.P. et al., 2022/03/30. Science robotics, 7 (64) pp. eabk2378. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_384E54C8E47A]
 
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.
Rowald A., Komi S., Demesmaeker R., Baaklini E., Hernandez-Charpak S.D., Paoles E., Montanaro H., Cassara A., Becce F., Lloyd B. et al., 2022/02. Nature medicine, 28 (2) pp. 260-271. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8A46380C5B7D]
 
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice.
Kathe C., Michoud F., Schönle P., Rowald A., Brun N., Ravier J., Furfaro I., Paggi V., Kim K., Soloukey S. et al., 2022/02. Nature biotechnology, 40 (2) pp. 198-208. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_86DCC5FD06F3]
2021
 
Bayesian optimization of peripheral intraneural stimulation protocols to evoke distal limb movements.
Losanno E., Badi M., Wurth S., Borgognon S., Courtine G., Capogrosso M., Rouiller E.M., Micera S., 2021/12/29. Journal of neural engineering, 18 (6) p. 066046. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8E1236B37A8E]
 
Engineering spinal cord repair.
Squair J.W., Gautier M., Sofroniew M.V., Courtine G., Anderson M.A., 2021/12. Current opinion in biotechnology, 72 pp. 48-53. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9515D6405D33]
 
Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates.
Badi M., Wurth S., Scarpato I., Roussinova E., Losanno E., Bogaard A., Delacombaz M., Borgognon S., C Vanc Ara P., Fallegger F. et al., 2021/10/27. Science translational medicine, 13 (617) pp. eabg6463. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2157807CF798]
Confronting false discoveries in single-cell differential expression.
Squair J.W., Gautier M., Kathe C., Anderson M.A., James N.D., Hutson T.H., Hudelle R., Qaiser T., Matson KJE, Barraud Q. et al., 2021/09/28. Nature communications, 12 (1) p. 5692. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4CB73B03B101]
 
Neglected physical human-robot interaction may explain variable outcomes in gait neurorehabilitation research.
Plooij M., Apte S., Keller U., Baines P., Sterke B., Asboth L., Courtine G., von Zitzewitz J., Vallery H., 2021/09/22. Science robotics, 6 (58) pp. eabf1888. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0CBE5AA81E75]
 
Towards adaptive deep brain stimulation: clinical and technical notes on a novel commercial device for chronic brain sensing.
Thenaisie Y., Palmisano C., Canessa A., Keulen B.J., Capetian P., Jiménez M.C., Bally J.F., Manferlotti E., Beccaria L., Zutt R. et al., 2021/08/31. Journal of neural engineering, 18 (4). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E38B62555C78]
 
Prioritization of cell types responsive to biological perturbations in single-cell data with Augur.
Squair J.W., Skinnider M.A., Gautier M., Foster L.J., Courtine G., 2021/08. Nature protocols, 16 (8) pp. 3836-3873. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_508780C61B69]
Enabling reproducible re-analysis of single-cell data.
Skinnider M.A., Squair J.W., Courtine G., 2021/07/26. Genome biology, 22 (1) p. 215. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_61DC9E773215]
 
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Jacobson P.B., Goody R., Lawrence M., Mueller B.K., Zhang X., Hooker B.A., Pfleeger K., Ziemann A., Locke C., Barraud Q. et al., 2021/07. Neurobiology of disease, 155 p. 105385. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3DC276B01807]
MRI-Compatible and Conformal Electrocorticography Grids for Translational Research.
Fallegger F., Schiavone G., Pirondini E., Wagner F.B., Vachicouras N., Serex L., Zegarek G., May A., Constanthin P., Palma M. et al., 2021/05. Advanced science, 8 (9) p. 2003761. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_53CDCE390C81]
Wearable Sensor-Based Real-Time Gait Detection: A Systematic Review.
Prasanth H., Caban M., Keller U., Courtine G., Ijspeert A., Vallery H., von Zitzewitz J., 2021/04/13. Sensors, 21 (8) p. 2727. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F9ADCCB7F350]
Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury.
Bonizzato M., James N.D., Pidpruzhnykova G., Pavlova N., Shkorbatova P., Baud L., Martinez-Gonzalez C., Squair J.W., DiGiovanna J., Barraud Q. et al., 2021/03/26. Nature communications, 12 (1) p. 1925. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4258AB1CF4BF]
 
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury.
Squair J.W., Gautier M., Mahe L., Soriano J.E., Rowald A., Bichat A., Cho N., Anderson M.A., James N.D., Gandar J. et al., 2021/02. Nature, 590 (7845) pp. 308-314. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7E16A50CBFB9]
Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord.
Greiner N., Barra B., Schiavone G., Lorach H., James N., Conti S., Kaeser M., Fallegger F., Borgognon S., Lacour S. et al., 2021/01/19. Nature communications, 12 (1) p. 435. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2000F9859DAE]
 
Cell type prioritization in single-cell data.
Skinnider M.A., Squair J.W., Kathe C., Anderson M.A., Gautier M., Matson KJE, Milano M., Hutson T.H., Barraud Q., Phillips A.A. et al., 2021/01. Nature biotechnology, 39 (1) pp. 30-34. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6B2FE5BC2C8B]
Optogenetic Interrogation of Circuits Following Neurotrauma.
Ceto S., Courtine G., 2021. Frontiers in molecular neuroscience, 14 p. 803856. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_34B7A51F7748]
2020
 
Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation
Schiavone Giuseppe, Kang Xiaoyang, Fallegger Florian, Gandar Jérôme, Courtine Grégoire, Lacour Stéphanie P., 2020/10. Neuron, 108 (2) pp. 238-258. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_99AF3CA917E1]
 
Structured nanoscale metallic glass fibres with extreme aspect ratios.
Yan W., Richard I., Kurtuldu G., James N.D., Schiavone G., Squair J.W., Nguyen-Dang T., Das Gupta T., Qu Y., Cao J.D. et al., 2020/10. Nature nanotechnology, 15 (10) pp. 875-882. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DB9FCDDC7698]
 
Soft Printable Electrode Coating for Neural Interfaces.
Shur M., Fallegger F., Pirondini E., Roux A., Bichat A., Barraud Q., Courtine G., Lacour S.P., 2020/07/20. ACS applied bio materials, 3 (7) pp. 4388-4397. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E00F683D5634]
 
Soft, Implantable Bioelectronic Interfaces for Translational Research.
Schiavone G., Fallegger F., Kang X., Barra B., Vachicouras N., Roussinova E., Furfaro I., Jiguet S., Seáñez I., Borgognon S. et al., 2020/04. Advanced materials, 32 (17) pp. e1906512. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_ACD7C27CDCC6]
Corrigendum: Low-Dimensional Motor Cortex Dynamics Preserve Kinematics Information During Unconstrained Locomotion in Nonhuman Primates.
Xing D., Aghagolzadeh M., Truccolo W., Bezard E., Courtine G., Borton D., 2020. Frontiers in neuroscience, 14 p. 604517. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_8FEB79D0CCA6]
2019
 
Spinal cord repair: advances in biology and technology.
Courtine G., Sofroniew M.V., 2019/06. Nature medicine, 25 (6) pp. 898-908. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A6F73B5DA711]
Neurorestorative interventions involving bioelectronic implants after spinal cord injury.
Cho N., Squair J.W., Bloch J., Courtine G., 2019. Bioelectronic medicine, 5 p. 10. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_64607AEEAA4A]
2018
Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury.
Formento E., Minassian K., Wagner F., Mignardot J.B., Le Goff-Mignardot C.G., Rowald A., Bloch J., Micera S., Capogrosso M., Courtine G., 2018/12. Nature neuroscience, 21 (12) pp. 1728-1741. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F80544F3A538]
 
Targeted neurotechnology restores walking in humans with spinal cord injury.
Wagner F.B., Mignardot J.B., Le Goff-Mignardot C.G., Demesmaeker R., Komi S., Capogrosso M., Rowald A., Seáñez I., Caban M., Pirondini E. et al., 2018/11. Nature, 563 (7729) pp. 65-71. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E3C65AD949FE]
 
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.
Capogrosso M., Wagner F.B., Gandar J., Moraud E.M., Wenger N., Milekovic T., Shkorbatova P., Pavlova N., Musienko P., Bezard E. et al., 2018/09. Nature protocols, 13 (9) pp. 2031-2061. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_94B9EA9825A4]
 
Reducing neuronal inhibition restores locomotion in paralysed mice.
Courtine G., 2018/09. Nature, 561 (7723) pp. 317-318. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3CE22AE084B8]
Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury.
Bonizzato M., Pidpruzhnykova G., DiGiovanna J., Shkorbatova P., Pavlova N., Micera S., Courtine G., 2018/08/01. Nature communications, 9 (1) p. 3015. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_31D14207E066]
 
Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion.
Asboth L., Friedli L., Beauparlant J., Martinez-Gonzalez C., Anil S., Rey E., Baud L., Pidpruzhnykova G., Anderson M.A., Shkorbatova P. et al., 2018/04. Nature neuroscience, 21 (4) pp. 576-588. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8937FE6DA927]
2017
 
A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury.
Mignardot J.B., Le Goff C.G., van den Brand R., Capogrosso M., Fumeaux N., Vallery H., Anil S., Lanini J., Fodor I., Eberle G. et al., 2017/07/19. Science translational medicine, 9 (399) pp. eaah3621. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_19CDDE82B1B7]
 
Electronic Dura Mater Meddling in the Central Nervous System.
Bloch J., Lacour S.P., Courtine G., 2017/04/01. JAMA neurology, 74 (4) pp. 470-475. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_ADA7A5E4E941]
2016
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Capogrosso M., Milekovic T., Borton D., Wagner F., Moraud E.M., Mignardot J.B., Buse N., Gandar J., Barraud Q., Xing D. et al., 2016/11/09. Nature, 539 (7628) pp. 284-288. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_C387724F3B01]
Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury.
Wenger N., Moraud E.M., Gandar J., Musienko P., Capogrosso M., Baud L., Le Goff C.G., Barraud Q., Pavlova N., Dominici N. et al., 2016. Nature Medicine, 22 (2) pp. 138-145. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_06D7E96E24FC]
2015
 
Defining ecological strategies in neuroprosthetics.
Courtine G., Bloch J., 2015. Neuron, 86 (1) pp. 29-33. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E6229DC227F8]
 
Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates.
Friedli L., Rosenzweig E.S., Barraud Q., Schubert M., Dominici N., Awai L., Nielson J.L., Musienko P., Nout-Lomas Y., Zhong H. et al., 2015. Science Translational Medicine, 7 (302) pp. 302ra134. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B5E8991CC41F]
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