Laurent Perez

Publications | Mémoires et thèses

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49 publications

En préparation
 
RAIN: a Machine Learning-based identification for HIV-1 bNAbs
Perez Laurent, Foglierini Mathilde.
[DOI][Pmid][serval:BIB_BC17BC4AD414]
2024
 
Un outil d’intelligence artificielle pour la découverte d’anticorps neutralisants à large spectre contre le virus VIH [AI-based discovery of broadly neutralizing antibodies against HIV-1]
Foglierini M., Perez L., 2024/11. Medecine sciences, 40 (11) pp. 819-821. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EEAF6E2AC665]
RAIN: machine learning-based identification for HIV-1 bNAbs.
Foglierini M., Nortier P., Schelling R., Winiger R.R., Jacquet P., O'Dell S., Demurtas D., Mpina M., Lweno O., Muller Y.D. et al., 2024/06/24. Nature communications, 15 (1) p. 5339. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7E0011402784]
Non-uptake of COVID-19 vaccines and reasons for non-uptake among healthcare workers in Uganda: a cross-sectional study.
Kyakuwa N., Abaasa A., Mpooya S., Kalutte H., Atuhairwe C., Perez L., Kikaire B., 2024/05/25. BMC health services research, 24 (1) p. 663. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CB33FBD0677F]
 
Therapeutic antibodies and alternative formats against SARS-CoV-2.
Winiger R.R., Perez L., 2024/03. Antiviral research, 223 p. 105820. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A112961BCF9C]
High uptake of COVID-19 vaccines among healthcare workers in urban Uganda.
Kyakuwa N., Kimbugwe G., Nakanjako F., Kalute H., Mpooya S., Atuhairwe C., Perez L., Kikaire B., 2024. PloS one, 19 (4) pp. e0277072. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_F48C46C29EC1]
2023
 
Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.
Fenwick C., Turelli P., Duhoo Y., Lau K., Herate C., Marlin R., Lamrayah M., Campos J., Esteves-Leuenberger L., Farina A. et al., 2023/12. The Journal of infection, 87 (6) pp. 524-537. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0A69FF2015C1]
Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.
Ols S., Lenart K., Arcoverde Cerveira R., Miranda M.C., Brunette N., Kochmann J., Corcoran M., Skotheim R., Philomin A., Cagigi A. et al., 2023/10/10. Immunity, 56 (10) pp. 2425-2441.e14. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8E02FAD2D2CE]
Intradermal skin test with mRNA vaccines as a surrogate marker of T cell immunity in immunocompromised patients.
Fallet B., Foglierini M., Porret R., Alcaraz-Serna A., Sauvage C., Jenelten R., Caplanusi T., Gilliet M., Perez L., Fenwick C. et al., 2023/08. The Journal of infection, 87 (2) pp. 111-119. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9DA429039D3E]
The Statistical Analysis of the Varying Brain.
Chén Oliver Y., Thanh Vũ Duy, Greub Gilbert, Cao Hengyi, He Xingru, Muller Yannick, Petrovas Constantinos, Shou Haochang, Nguyen Viet-Dung, Zhi Bangdong et al., 2023/07/02. IEEE Statistical Signal Processing (SSP). Peer-reviewed.
[URN][DOI][WoS][serval:BIB_C6B3B6AA1F8B]
2022
Antibodies to combat viral infections: development strategies and progress.
Pantaleo G., Correia B., Fenwick C., Joo V.S., Perez L., 2022/09. Nature reviews. Drug discovery, 21 (9) pp. 676-696. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_09F440C68729]
 
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys.
Fenwick C., Turelli P., Ni D., Perez L., Lau K., Herate C., Marlin R., Lana E., Pellaton C., Raclot C. et al., 2022/09. Nature microbiology, 7 (9) pp. 1376-1389. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_539E1A543541]
Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells.
Munoz O., Banga R., Schelling R., Procopio F.A., Mastrangelo A., Nortier P., Ohmiti K., Daraspe J., Cavassini M., Fenwick C. et al., 2022/07. PLoS pathogens, 18 (7) pp. e1010673. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BEB839579791]
Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Kschonsak M., Johnson M.C., Schelling R., Green E.M., Rougé L., Ho H., Patel N., Kilic C., Kraft E., Arthur C.P. et al., 2022/03/11. Science advances, 8 (10) pp. eabm2536. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9AD2F453F4AF]
 
SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties
Fenwick Craig, Turelli Priscilla, Ni Dongchun, Perez Laurent, Lau Kelvin, Lana Erica, Pellaton Céline, Raclot Charlène, Esteves-Leuenberger Line, Campos Jérémy et al., 2022/03..
[DOI][serval:BIB_938CCD54F9CA]
2021
Characterizing cytomegalovirus infection one cell at a time.
Perez L., 2021/12. Nature microbiology, 6 (12) pp. 1477-1478. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3F64045630BA]
A highly potent antibody effective against SARS-CoV-2 variants of concern.
Fenwick C., Turelli P., Perez L., Pellaton C., Esteves-Leuenberger L., Farina A., Campos J., Lana E., Fiscalini F., Raclot C. et al., 2021/10/12. Cell reports, 37 (2) p. 109814. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6CC56B59453A]
 
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.
Glaros V., Rauschmeier R., Artemov A.V., Reinhardt A., Ols S., Emmanouilidi A., Gustafsson C., You Y., Mirabello C., Björklund Å.K. et al., 2021/09/14. Immunity, 54 (9) pp. 2005-2023.e10. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_35B9E7F5BCE4]
 
Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2
Low Jun Siong, Vaqueirinho Daniela, Mele Federico, Foglierini Mathilde, Jerak Josipa, Perotti Michela, Jarrossay David, Jovic Sandra, Perez Laurent, Cacciatore Rosalia et al., 2021/05/18. Science pp. eabg8985.
[DOI][serval:BIB_1B85AC21AB8E]
 
Chimeric antigen receptor T-cell therapy for HIV cure.
Alfageme-Abello O., Porret R., Perreau M., Perez L., Muller Y.D., 2021/03/01. Current opinion in HIV and AIDS, 16 (2) pp. 88-97. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FD634884AC0E]
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.
Muller Y.D., Nguyen D.P., Ferreira LMR, Ho P., Raffin C., Valencia RVB, Congrave-Wilson Z., Roth T.L., Eyquem J., Van Gool F. et al., 2021. Frontiers in immunology, 12 p. 639818. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_35407AE1906E]
2020
Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity.
Perotti M., Marcandalli J., Demurtas D., Sallusto F., Perez L., 2020/12. PLoS pathogens, 16 (12) pp. e1009169. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_711970C96BE8]
 
AncesTree: An interactive immunoglobulin lineage tree visualizer
Mathilde Foglierini, Leontios Pappas, Antonio Lanzavecchia, Davide Corti, Laurent Perez, 2020/07/10. PLOS Computational Biology.
[DOI][serval:BIB_5BA83EB33C6F]
 
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.
Perez Laurent, 2020/04/22. Frontiers in immunology.
[DOI][Pmid][serval:BIB_1911BBFA3FD3]
2019
 
Virus-Like Particles and Nanoparticles for Vaccine Development against HCMV
Michela Perotti, Laurent Perez, 2019/12/28. Viruses.
[DOI][serval:BIB_79E4121F3240]
 
Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1
Miguel Palomino-Segura, Laurent Perez, Yagmur Farsakoglu, Tommaso Virgilio, Irene Latino, Rocco D'Antuono, Nikolaos Chatziandreou, Diego U Pizzagalli, Guojun Wang, Adolfo García-Sastre et al., 2019/11/29. Nature Microbiology.
[DOI][serval:BIB_06D0C1FBD080]
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.
Marcandalli J., Fiala B., Ols S., Perotti M., de van der Schueren W., Snijder J., Hodge E., Benhaim M., Ravichandran R., Carter L. et al., 2019/03/07. Cell, 176 (6) pp. 1420-1431.e17. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9448E40DDE5A]
 
HCMV Envelope Glycoprotein Diversity Demystified
Foglierini M., Marcandalli J., Perez L., 2019. Front Microbiol, 10 p. 1005.
[DOI][serval:BIB_4104AA3DF94F]
2018
 
Human cytomegalovirus (HCMV)-specific T cell but not neutralizing or IgG binding antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients
Lilleri D., Zelini P., Fornara C., Zavaglio F., Rampino T., Perez L., Gabanti E., Gerna G., 2018/10. J Med Virol, 90 (10) pp. 1620-1628.
[DOI][serval:BIB_D2579A1882F1]
 
False human cytomegalovirus IgG-positivity at prenatal screening
Furione M., Sarasini A., Arossa A., Fornara C., Lilleri D., Perez L., Parea M., Zavattoni M., Spinillo A., Marone P. et al., 2018/07. J Clin Virol, 104 pp. 34-38.
[DOI][serval:BIB_CB60C458FCA5]
 
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli, Sonia Barbieri, Mathilde Foglierini, Chiara Silacci Fregni, Jessica Marcandalli, Said Jongo et al., 2018/03. Nature Medicine.
[DOI][serval:BIB_F0B1E27E240C]
 
An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
Martinez-Martin N., Marcandalli J., Huang C. S., Arthur C. P., Perotti M., Foglierini M., Ho H., Dosey A. M., Shriver S., Payandeh J. et al., 2018. Cell, 174 (5) pp. 1158-1171.e19.
[DOI][serval:BIB_643513D32DF9]
2017
 
Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells
Davide Genini, Lara Brambilla, Erik Laurini, Jessica Merulla, Gianluca Civenni, Shusil Pandit, Rocco D'Antuono, Laurent Perez, David E. Levy, Sabrina Pricl et al., 2017/06/20. Proceedings of the National Academy of Sciences.
[DOI][serval:BIB_B545B3B9BD48]
2016
 
Antibody-guided vaccine design: identification of protective epitopes
Antonio Lanzavecchia, Alexander Frühwirth, Laurent Perez, Davide Corti, 2016/08. Current Opinion in Immunology.
[DOI][serval:BIB_C3374582EFDC]
 
Monoclonal Antibodies to Different Components of the Human Cytomegalovirus (HCMV) Pentamer gH/gL/pUL128L and Trimer gH/gL/gO as well as Antibodies Elicited during Primary HCMV Infection Prevent Epithelial Cell Syncytium Formation
Gerna G., Percivalle E., Perez L., Lanzavecchia A., Lilleri D., 2016. J Virol, 90 (14) pp. 6216-6223.
[DOI][serval:BIB_E87CD315D5F9]
 
Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
Kabanova A., Marcandalli J., Zhou T., Bianchi S., Baxa U., Tsybovsky Y., Lilleri D., Silacci-Fregni C., Foglierini M., Fernandez-Rodriguez B. M. et al., 2016. Nat Microbiol, 1 (8) p. 16082.
[DOI][serval:BIB_859180C7DC5B]
 
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
Corti D., Misasi J., Mulangu S., Stanley D. A., Kanekiyo M., Wollen S., Ploquin A., Doria-Rose N. A., Staupe R. P., Bailey M. et al., 2016. Science, 351 (6279) pp. 1339-42.
[DOI][serval:BIB_52D6B2B6B6ED]
 
The C-terminal domain of TPX2 is made of alpha-helical tandem repeats
Sanchez-Pulido L., Perez L., Kuhn S., Vernos I., Andrade-Navarro M. A., 2016. BMC Struct Biol, 16 (1) p. 17.
[DOI][serval:BIB_30CB6F41AD0C]
2015
 
Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
Brambilla L., Genini D., Laurini E., Merulla J., Perez L., Fermeglia M., Carbone G. M., Pricl S., Catapano C. V., 2015/06. Mol Oncol, 9 (6) pp. 1194-206.
[DOI][serval:BIB_B7D7DF1E241F]
2014
 
Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies
Kabanova A., Perez L., Lilleri D., Marcandalli J., Agatic G., Becattini S., Preite S., Fuschillo D., Percivalle E., Sallusto F. et al., 2014. Proc Natl Acad Sci U S A, 111 (50) pp. 17965-70.
[DOI][serval:BIB_04D7294A51E7]
2013
 
Cross-neutralization of four paramyxoviruses by a human monoclonal antibody
Perez Laurent, 2013. Nature.
[DOI][serval:BIB_A94F689914AE]
2010
 
Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations
Perez L. H., Butler M., Creasey T., Dzink-Fox J., Gounarides J., Petit S., Ropenga A., Ryder N., Smith K., Smith P. et al., 2010. PLoS One, 5 (6) pp. e10915.
[DOI][serval:BIB_EBDC954A1085]
2008
 
The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown
Vos J. W., Pieuchot L., Evrard J. L., Janski N., Bergdoll M., de Ronde D., Perez L. H., Sardon T., Vernos I., Schmit A. C., 2008/10. Plant Cell, 20 (10) pp. 2783-97.
[DOI][serval:BIB_A39D61CF5045]
 
Negative regulation of cell-cycle progression by RINGO/Speedy E
Dinarina A., Ruiz E. J., O'Loghlen A., Mouron S., Perez L., Nebreda A. R., 2008. Biochem J, 410 (3) pp. 535-42.
[DOI][serval:BIB_791D7789F41C]
2005
 
Quantitative SUMO-1 modification of a vaccinia virus protein is required for its specific localization and prevents its self-association
Palacios S., Perez L. H., Welsch S., Schleich S., Chmielarska K., Melchior F., Locker J. K., 2005/06. Mol Biol Cell, 16 (6) pp. 2822-35.
[DOI][serval:BIB_8FF90D3B7DD3]
 
Characterization of a new family of cyclin-dependent kinase activators
Dinarina A., Perez L. H., Davila A., Schwab M., Hunt T., Nebreda A. R., 2005. Biochem J, 386 (Pt 2) pp. 349-55.
[DOI][serval:BIB_96B4310B9117]
2002
 
Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes
Perez L. H., Antonio C., Flament S., Vernos I., Nebreda A. R., 2002/10. Nat Cell Biol, 4 (10) pp. 737-42.
[DOI][serval:BIB_685836A44691]
 
Cadmium induces direct morphological changes in mesangial cell culture
Perez Laurent, 2002. Toxicology.
[DOI][serval:BIB_BA17E72CBE36]
2001
 
Differential Regulation of Cdc2 and Cdk2 by RINGO and Cyclins
Perez Laurent, 2001. Journal of Biological Chemistry.
[DOI][serval:BIB_3EC45D5F2F83]
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