Axes de recherche
Cell therapies for severely burned patients
The treatment of burns depends on their degree of severity. While, first and superficial-second degree burns can spontaneously heal and are mostly treated by medical care only, deep-second and third degree burns require surgical interventions to replace the damaged skin. Thus, the gold standard consists of taking healthy skin from uninjured areas and graft it onto the wounds (a technique called split-thickness autograft or Thiersch/Reverdin graft). For patients having severe burns exceeding 40% of their body surface, a cell-based therapy becomes pivotal in order to close the wounds; as cell-based surgical assistance known as cultured epidermal autografts (CEA), consisting of a sheath of keratinocytes from patient's own cells that are grafted. Ongoing studies aim to show the safety and efficacy of CEA use in terms of morbidity, mortality and clinical data. These studies aim to verify the quality of the provided care and allow to continue this life-saving therapy to our patients.
