Bernhard Gentner

Publications | Mémoires et thèses

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68 publications

En préparation
 
DNA-Dependent Protein Kinase Inhibitors PI-103 and Samotolisib Augment CRISPR/Cas9 Knockin Efficiency in Human T Cells
Džafo Emina, Hafezi Morteza, Giordano Attianese Greta Maria Paola, Reichenbach Patrick, Grillet Stephane, Scholten Kirsten, Coukos George, Irving Melita, Gentner Bernhard.
[DOI][serval:BIB_7318185C7D2B]
2024
 
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells.
Della Volpe L., Midena F., Vacca R., Tavella T., Alessandrini L., Farina G., Brandas C., Lo Furno E., Giannetti K., Carsana E. et al., 2024/11/19. Cell reports. Medicine, 5 (11) p. 101823. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4C0238456CA7]
 
Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome.
Consiglieri G., Tucci F., De Pellegrin M., Guerrini B., Cattoni A., Risca G., Scarparo S., Sarzana M., Pontesilli S., Mellone R. et al., 2024/05. Science translational medicine, 16 (745) pp. eadi8214. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_347F51481FD7]
2023
 
miR-126 identifies a quiescent and chemo-resistant human B-ALL cell subset that correlates with minimal residual disease.
Caserta C., Nucera S., Barcella M., Fazio G., Naldini M.M., Pagani R., Pavesi F., Desantis G., Zonari E., D'Angiò M. et al., 2023/10. Leukemia, 37 (10) pp. 1994-2005. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_27B8A2CE71A6]
Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation-Immune signature correlates with response.
Apostolova P., Kreutmair S., Toffalori C., Punta M., Unger S., Burk A.C., Wehr C., Maas-Bauer K., Melchinger W., Haring E. et al., 2023/10. British journal of haematology, 203 (2) pp. 264-281. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_34E444E517E5]
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia.
Naldini M.M., Casirati G., Barcella M., Rancoita PMV, Cosentino A., Caserta C., Pavesi F., Zonari E., Desantis G., Gilioli D. et al., 2023/03/08. Nature communications, 14 (1) p. 1285. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4340DDF44BFE]
2022
 
CD14 positive cells accelerate hematopoietic stem cell engraftment
Pievani Alice, Granata Valentina, Desantis Giacomo, Antolini Laura, Ornaghi Sara, Galleu Antonio, Biondi Andrea, Gentner Bernhard, Dazzi Francesco, Serafini Marta, 2022/06. Bone Marrow Transplantation, 57 (6) pp. 942-948.
[DOI][WoS][Pmid][serval:BIB_5B2763BE2376]
 
Allogeneic hematopoietic stem cell transplantation in patients older than 65 years with acute myeloid leukemia and myelodysplastic syndrome: a 15-year experience
Piemontese Simona, Lazzari Lorenzo, Ruggeri Annalisa, Marcatti Magda, Lupo Stanghellini Maria Teresa, Giglio Fabio, Greco Raffaella, Lorentino Francesca, Clerici Daniela, Assanelli Andrea et al., 2022/04. Bone Marrow Transplantation, 57 (4) pp. 678-680.
[DOI][WoS][Pmid][serval:BIB_B1E3B60B58D6]
 
The EHA Research Roadmap: Hematopoietic Stem Cell Gene Therapy
Naldini Luigi, Cicalese Maria Pia, Bernardo Maria Ester, Gentner Bernhard, Gabaldo Michela, Ferrari Giuliana, Aiuti Alessandro, 2022/02. HemaSphere, 6 (2) pp. e671.
[DOI][WoS][Pmid][serval:BIB_210E57E473AC]
 
Evidence of Treatment Benefits in Patients with Mucopolysaccharidosis Type I-Hurler in Long-term Follow-up Using a New Magnetic Resonance Imaging Scoring System
Pontesilli Silvia, Baldoli Cristina, Rosa Pasquale Anthony Della, Cattoni Alessandro, Bernardo Maria Ester, Meregalli Pamela, Gasperini Serena, Motta Serena, Fumagalli Francesca, Tucci Francesca et al., 2022/01. The Journal of Pediatrics, 240 pp. 297-301.e5.
[DOI][Pmid][serval:BIB_94F6117688E3]
2021
 
Hematopoietic Stem- and Progenitor-Cell Gene Therapy for Hurler Syndrome
Gentner Bernhard, Tucci Francesca, Galimberti Stefania, Fumagalli Francesca, De Pellegrin Maurizio, Silvani Paolo, Camesasca Chiara, Pontesilli Silvia, Darin Silvia, Ciotti Francesca et al., 2021/11/18. New England Journal of Medicine, 385 (21) pp. 1929-1940.
[DOI][WoS][Pmid][serval:BIB_4BB789839CEB]
 
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses
Mucci Adele, Antonarelli Gabriele, Caserta Carolina, Vittoria Francesco Maria, Desantis Giacomo, Pagani Riccardo, Greco Beatrice, Casucci Monica, Escobar Giulia, Passerini Laura et al., 2021/10/07. EMBO Molecular Medicine, 13 (10).
[DOI][WoS][Pmid][serval:BIB_ED98305AEA26]
 
Peripheral blood stem and progenitor cell collection in pediatric candidates for ex vivo gene therapy: a 10-year series
Canarutto Daniele, Tucci Francesca, Gattillo Salvatore, Zambelli Matilde, Calbi Valeria, Gentner Bernhard, Ferrua Francesca, Marktel Sarah, Migliavacca Maddalena, Barzaghi Federica et al., 2021/09. Molecular Therapy - Methods & Clinical Development, 22 pp. 76-83.
[DOI][WoS][Pmid][serval:BIB_A41286C26FBD]
 
Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
Jofra Hernández Raisa, Calabria Andrea, Sanvito Francesca, De Mattia Fabiola, Farinelli Giada, Scala Serena, Visigalli Ilaria, Carriglio Nicola, De Simone Maura, Vezzoli Michela et al., 2021/01. Molecular Therapy, 29 (1) pp. 86-102.
[DOI][WoS][Pmid][serval:BIB_103CBDFDB944]
2020
 
Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche
Beneforti Linda, Dander Erica, Bresolin Silvia, Bueno Clara, Acunzo Denise, Bertagna Mayla, Ford Anthony, Gentner Bernhard, Kronnie Geertruy te, Vergani Patrizia et al., 2020/07. British Journal of Haematology, 190 (2) pp. 262-273.
[DOI][WoS][Pmid][serval:BIB_35640A807862]
 
Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis
Capo Valentina, Penna Sara, Merelli Ivan, Barcella Matteo, Scala Serena, Basso-Ricci Luca, Draghici Elena, Palagano Eleonora, Zonari Erika, Desantis Giacomo et al., 2020/01/16. Haematologica, 106 (1) pp. 74-86.
[DOI][WoS][Pmid][serval:BIB_5F9FD4A72ADF]
2019
 
In Vivo Selection for Gene-Corrected HSPCs Advances Gene Therapy for a Rare Stem Cell Disease
Gentner Bernhard, Naldini Luigi, 2019/11. Cell Stem Cell, 25 (5) pp. 592-593.
[DOI][WoS][Pmid][serval:BIB_E29F05892D82]
 
Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant<i>Ex Vivo</i>Gene Therapy Settings
Petrillo Carolina, Calabria Andrea, Piras Francesco, Capotondo Alessia, Spinozzi Giulio, Cuccovillo Ivan, Benedicenti Fabrizio, Naldini Luigi, Montini Eugenio, Biffi Alessandra et al., 2019/09/01. Human Gene Therapy, 30 (9) pp. 1133-1146.
[DOI][WoS][Pmid][serval:BIB_88892BF70243]
 
MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation
Crisafulli Laura, Muggeo Sharon, Uva Paolo, Wang Yulei, Iwasaki Masayuki, Locatelli Silvia, Anselmo Achille, Colombo Federico S., Carlo-Stella Carmelo, Cleary Michael L. et al., 2019/09. Haematologica, 104 (9) pp. 1744-1755.
[DOI][WoS][Pmid][serval:BIB_682D09E3D841]
 
Acute myeloid leukaemia niche regulates response to L‐asparaginase
Michelozzi Ilaria M., Granata Valentina, De Ponti Giada, Alberti Gaia, Tomasoni Chiara, Antolini Laura, Gambacorti-Passerini Carlo, Gentner Bernhard, Dazzi Francesco, Biondi Andrea et al., 2019/08. British Journal of Haematology, 186 (3) pp. 420-430.
[DOI][WoS][Pmid][serval:BIB_F7CAE14C4E88]
 
Targeting a Pre-existing Anti-transgene T Cell Response for Effective Gene Therapy of MPS-I in the Mouse Model of the Disease
Squeri Giorgia, Passerini Laura, Ferro Francesca, Laudisa Cecilia, Tomasoni Daniela, Deodato Federica, Donati Maria Alice, Gasperini Serena, Aiuti Alessandro, Bernardo Maria Ester et al., 2019/07. Molecular Therapy, 27 (7) pp. 1215-1227.
[DOI][WoS][Pmid][serval:BIB_53A6BF9FCFB8]
 
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation
Toffalori Cristina, Zito Laura, Gambacorta Valentina, Riba Michela, Oliveira Giacomo, Bucci Gabriele, Barcella Matteo, Spinelli Orietta, Greco Raffaella, Crucitti Lara et al., 2019/04. Nature Medicine, 25 (4) pp. 603-611.
[DOI][WoS][Pmid][serval:BIB_95ABA3731ED9]
2018
 
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells
Petrillo Carolina, Thorne Lucy G., Unali Giulia, Schiroli Giulia, Giordano Anna M.S., Piras Francesco, Cuccovillo Ivan, Petit Sarah J., Ahsan Fatima, Noursadeghi Mahdad et al., 2018/12. Cell Stem Cell, 23 (6) pp. 820-832.e9.
[DOI][WoS][Pmid][serval:BIB_676718992F5E]
 
Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
Escobar Giulia, Barbarossa Luigi, Barbiera Giulia, Norelli Margherita, Genua Marco, Ranghetti Anna, Plati Tiziana, Camisa Barbara, Brombin Chiara, Cittaro Davide et al., 2018/12. Nature Communications, 9 (1).
[DOI][WoS][Pmid][serval:BIB_F72164792A71]
 
Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches
Fraldi Alessandro, Serafini Marta, Sorrentino Nicolina Cristina, Gentner Bernhard, Aiuti Alessandro, Bernardo Maria Ester, 2018/11. Italian Journal of Pediatrics, 44 (S2).
[DOI][WoS][Pmid][serval:BIB_EB670FF6C900]
 
Impaired X-CGD T cell compartment is gp91phox-NADPH oxidase independent
Chiriaco Maria, Casciano Fabio, Di Matteo Gigliola, Gentner Berhard, Claps Alessia, Di Cesare Silvia, Cotugno Nicola, D'Argenio Patrizia, Rossi Paolo, Aiuti Alessandro et al., 2018/08. Clinical Immunology, 193 pp. 52-59.
[DOI][WoS][Pmid][serval:BIB_DAF9FD0BB5FD]
 
Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections
Hetzel Miriam, Mucci Adele, Blank Patrick, Nguyen Ariane Hai Ha, Schiller Jan, Halle Olga, Kühnel Mark-Philipp, Billig Sandra, Meineke Robert, Brand Daniel et al., 2018/02/01. Blood, 131 (5) pp. 533-545.
[DOI][WoS][Pmid][serval:BIB_884BDC10CD27]
2017
 
Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I
Azario Isabella, Pievani Alice, Del Priore Federica, Antolini Laura, Santi Ludovica, Corsi Alessandro, Cardinale Lucia, Sawamoto Kazuki, Kubaski Francyne, Gentner Bernhard et al., 2017/12. Scientific Reports, 7 (1).
[DOI][WoS][Pmid][serval:BIB_F2EC9B68CFFB]
 
Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells
Piras Francesco, Riba Michela, Petrillo Carolina, Lazarevic Dejan, Cuccovillo Ivan, Bartolaccini Sara, Stupka Elia, Gentner Bernhard, Cittaro Davide, Naldini Luigi et al., 2017/09. EMBO Molecular Medicine, 9 (9) pp. 1198-1211.
[DOI][WoS][Pmid][serval:BIB_B0573BA5C6D6]
 
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease
Mastaglio Sara, Genovese Pietro, Magnani Zulma, Ruggiero Eliana, Landoni Elisa, Camisa Barbara, Schiroli Giulia, Provasi Elena, Lombardo Angelo, Reik Andreas et al., 2017/08/03. Blood, 130 (5) pp. 606-618.
[DOI][WoS][Pmid][serval:BIB_B368D5519CBC]
 
Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy
Zonari Erika, Desantis Giacomo, Petrillo Carolina, Boccalatte Francesco E., Lidonnici Maria Rosa, Kajaste-Rudnitski Anna, Aiuti Alessandro, Ferrari Giuliana, Naldini Luigi, Gentner Bernhard, 2017/04. Stem Cell Reports, 8 (4) pp. 977-990.
[DOI][WoS][Pmid][serval:BIB_B26E0E00D9B8]
 
Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced <i>in vivo</i> homing capacity compared to plerixafor alone
Lidonnici Maria Rosa, Aprile Annamaria, Frittoli Marta Claudia, Mandelli Giacomo, Paleari Ylenia, Spinelli Antonello, Gentner Bernhard, Zambelli Matilde, Parisi Cristina, Bellio Laura et al., 2017/04. Haematologica, 102 (4) pp. e120-e124.
[DOI][WoS][Pmid][serval:BIB_663DB8CBB5C9]
2016
 
Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response
Farinelli Giada, Jofra Hernandez Raisa, Rossi Alice, Ranucci Serena, Sanvito Francesca, Migliavacca Maddalena, Brombin Chiara, Pramov Aleksandar, Di Serio Clelia, Bovolenta Chiara et al., 2016/10. Molecular Therapy, 24 (10) pp. 1873-1880.
[DOI][WoS][Pmid][serval:BIB_2FEB2722CCAD]
 
Elderly patients &gt; 65 years of age with acute myeloid leukemia and normal karyotype benefit from intensive therapeutic programs
Bernardi Massimo, Carrabba Matteo, Messina Carlo, Milani Raffaella, Sala Elisa, Pavesi Francesca, Gentner Bernhard, Peccatori Jacopo, Assanelli Andrea, Marktel Sarah et al., 2016/06. American Journal of Hematology, 91 (6) pp. E302-E303.
[DOI][WoS][Pmid][serval:BIB_2ED6D7927735]
 
miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia
Nucera Silvia, Giustacchini Alice, Boccalatte Francesco, Calabria Andrea, Fanciullo Cristiana, Plati Tiziana, Ranghetti Anna, Garcia-Manteiga Jose, Cittaro Davide, Benedicenti Fabrizio et al., 2016/06. Cancer Cell, 29 (6) pp. 905-921.
[DOI][WoS][Pmid][serval:BIB_9EE96D56E8AB]
 
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Lechman Eric R., Gentner Bernhard, Ng Stanley W.K., Schoof Erwin M., van Galen Peter, Kennedy James A., Nucera Silvia, Ciceri Fabio, Kaufmann Kerstin B., Takayama Naoya et al., 2016/04. Cancer Cell, 29 (4) pp. 602-606.
[DOI][WoS][Pmid][serval:BIB_FC0DD2EE0F25]
2015
 
MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia
Gentner Bernhard, Pochert Nicole, Rouhi Arefeh, Boccalatte Francesco, Plati Tiziana, Berg Tobias, Sun Su Ming, Mah Sarah M., Mirkovic-Hösle Milijana, Ruschmann Jens et al., 2015/10. Experimental Hematology, 43 (10) pp. 858-868.e7.
[DOI][WoS][Pmid][serval:BIB_377D2CD47594]
 
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy
Ungari Silvia, Montepeloso Annita, Morena Francesco, Cocchiarella Fabienne, Recchia Alessandra, Martino Sabata, Gentner Bernhard, Naldini Luigi, Biffi Alessandra, 2015. Molecular Therapy - Methods &amp; Clinical Development, 2 p. 15038.
[DOI][WoS][Pmid][serval:BIB_DE72FA4EF68D]
2014
 
Dual-regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatosis
Chiriaco Maria, Farinelli Giada, Capo Valentina, Zonari Erika, Scaramuzza Samantha, Di Matteo Gigliola, Sergi Lucia Sergi, Migliavacca Maddalena, Hernandez Raisa Jofra, Bombelli Ferdinando et al., 2014/08. Molecular Therapy, 22 (8) pp. 1472-1483.
[DOI][WoS][Pmid][serval:BIB_942FFB136434]
 
Targeted genome editing in human repopulating haematopoietic stem cells
Genovese Pietro, Schiroli Giulia, Escobar Giulia, Di Tomaso Tiziano, Firrito Claudia, Calabria Andrea, Moi Davide, Mazzieri Roberta, Bonini Chiara, Holmes Michael C. et al., 2014/06. Nature, 510 (7504) pp. 235-240.
[DOI][WoS][Pmid][serval:BIB_97D6650B246D]
 
Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
Escobar Giulia, Gentner Bernhard, Naldini Luigi, Mazzieri Roberta, 2014/05. OncoImmunology, 3 (5) pp. e28696.
[DOI][WoS][Pmid][serval:BIB_5B94FACAF56F]
 
microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons
Åkerblom Malin, Petri Rebecca, Sachdeva Rohit, Klussendorf Thies, Mattsson Bengt, Gentner Bernhard, Jakobsson Johan, 2014/04/01. Development, 141 (7) pp. 1580-1588.
[DOI][WoS][Pmid][serval:BIB_ADC0A5A738E0]
 
Genetic Engineering of Hematopoiesis for Targeted IFN-α Delivery Inhibits Breast Cancer Progression
Escobar Giulia, Moi Davide, Ranghetti Anna, Ozkal-Baydin Pinar, Squadrito Mario Leonardo, Kajaste-Rudnitski Anna, Bondanza Attilio, Gentner Bernhard, De Palma Michele, Mazzieri Roberta et al., 2014/01. Science Translational Medicine, 6 (217).
[DOI][WoS][Pmid][serval:BIB_45AB09C150EC]
2013
 
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
Casucci Monica, Nicolis di Robilant Benedetta, Falcone Laura, Camisa Barbara, Norelli Margherita, Genovese Pietro, Gentner Bernhard, Gullotta Fabiana, Ponzoni Maurilio, Bernardi Massimo et al., 2013/11/14. Blood, 122 (20) pp. 3461-3472.
[DOI][WoS][Pmid][serval:BIB_644298D8DBF9]
 
MicroRNA-126–mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors
Okuyama Kazuki, Ikawa Tomokatsu, Gentner Bernhard, Hozumi Katsuto, Harnprasopwat Ratanakanit, Lu Jun, Yamashita Riu, Ha Daon, Toyoshima Takae, Chanda Bidisha et al., 2013/08/13. Proceedings of the National Academy of Sciences, 110 (33) pp. 13410-13415.
[DOI][WoS][Pmid][serval:BIB_E47AFA1898EE]
 
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
Zonari Erika, Pucci Ferdinando, Saini Massimo, Mazzieri Roberta, Politi Letterio S., Gentner Bernhard, Naldini Luigi, 2013/07/11. Blood, 122 (2) pp. 243-252.
[DOI][WoS][Pmid][serval:BIB_D4FB429599BF]
 
Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche
Lattanzi Annalisa, Gentner Bernhard, Corno Daniela, Di Tomaso Tiziano, Mestdagh Pieter, Speleman Frank, Naldini Luigi, Gritti Angela, 2013/06/27. PLoS ONE, 8 (6) pp. e67411.
[DOI][WoS][Pmid][serval:BIB_7A91C75FED1B]
 
miR-142-3p Prevents Macrophage Differentiation during Cancer-Induced Myelopoiesis
Sonda Nada, Simonato Francesca, Peranzoni Elisa, Calì Bianca, Bortoluzzi Stefania, Bisognin Andrea, Wang Ena, Marincola Francesco M., Naldini Luigi, Gentner Bernhard et al., 2013/06. Immunity, 38 (6) pp. 1236-1249.
[DOI][WoS][Pmid][serval:BIB_31FF9474E572]
 
A Double-Switch Vector System Positively Regulates Transgene Expression by Endogenous microRNA Expression (miR-ON Vector)
Amendola Mario, Giustacchini Alice, Gentner Bernhard, Naldini Luigi, 2013/05. Molecular Therapy, 21 (5) pp. 934-946.
[DOI][WoS][Pmid][serval:BIB_EDDF46F92F7C]
2012
 
Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion
Lechman Eric R., Gentner Bernhard, van Galen Peter, Giustacchini Alice, Saini Massimo, Boccalatte Francesco E., Hiramatsu Hidefumi, Restuccia Umberto, Bachi Angela, Voisin Veronique et al., 2012/12. Cell Stem Cell, 11 (6) pp. 799-811.
[DOI][WoS][Pmid][serval:BIB_A73AD9AC1071]
 
Exploiting microRNA regulation for genetic engineering : Exploiting microRNA regulation
Gentner B., Naldini L., 2012/11. Tissue Antigens, 80 (5) pp. 393-403.
[DOI][WoS][Pmid][serval:BIB_B3556D3310A4]
 
MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy
Lachmann N, Jagielska J, Heckl D, Brennig S, Pfaff N, Maetzig T, Modlich U, Cantz T, Gentner B, Schambach A et al., 2012/09. Gene Therapy, 19 (9) pp. 915-924.
[DOI][WoS][Pmid][serval:BIB_910B24F12AA9]
 
MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant
Akerblom M., Sachdeva R., Barde I., Verp S., Gentner B., Trono D., Jakobsson J., 2012/06/27. Journal of Neuroscience, 32 (26) pp. 8879-8889.
[DOI][WoS][Pmid][serval:BIB_7C07A68E7806]
2011
 
A microRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells
Di Stefano Bruno, Maffioletti Sara Martina, Gentner Bernhard, Ungaro Federica, Schira Giulia, Naldini Luigi, Broccoli Vania, 2011/11/01. Stem Cells, 29 (11) pp. 1684-1695.
[DOI][WoS][Pmid][serval:BIB_717E880AC2E7]
 
Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
Mazzieri Roberta, Pucci Ferdinando, Moi Davide, Zonari Erika, Ranghetti Anna, Berti Alvise, Politi Letterio S., Gentner Bernhard, Brown Jeffrey L., Naldini Luigi et al., 2011/04. Cancer Cell, 19 (4) pp. 512-526.
[DOI][WoS][Pmid][serval:BIB_2B9536A227BC]
2010
 
Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy.
Gentner B., Visigalli I., Hiramatsu H., Lechman E., Ungari S., Giustacchini A., Schira G., Amendola M., Quattrini A., Martino S. et al., 2010/11/17. Science translational medicine, 2 (58) pp. 58ra84.
[DOI][WoS][Pmid][serval:BIB_71E52BBA9EDE]
 
The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche
Visigalli Ilaria, Ungari Silvia, Martino Sabata, Park Hyejung, Cesani Martina, Gentner Bernhard, Sergi Sergi Lucia, Orlacchio Aldo, Naldini Luigi, Biffi Alessandra, 2010/09/16. Blood, 116 (11) pp. 1857-1866.
[DOI][WoS][Pmid][serval:BIB_F4AE2471EAF5]
 
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors
Sachdeva Rohit, Jönsson Marie E., Nelander Jenny, Kirkeby Agnete, Guibentif Carolina, Gentner Bernhard, Naldini Luigi, Björklund Anders, Parmar Malin, Jakobsson Johan, 2010/06/22. Proceedings of the National Academy of Sciences, 107 (25) pp. 11602-11607.
[DOI][WoS][Pmid][serval:BIB_0A51CAC5AC22]
2009
 
Regulated and Multiple miRNA and siRNA Delivery Into Primary Cells by a Lentiviral Platform
Amendola Mario, Passerini Laura, Pucci Ferdinando, Gentner Bernhard, Bacchetta Rosa, Naldini Luigi, 2009/06. Molecular Therapy, 17 (6) pp. 1039-1052.
[DOI][WoS][Pmid][serval:BIB_62126B098DE8]
 
Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases.
Gentner B., Wein A., Croner R.S., Zeittraeger I., Wirtz R.M., Roedel F., Dimmler A., Dorlaque L., Hohenberger W., Hahn E.G. et al., 2009/01. Anticancer research, 29 (1) pp. 67-74. Peer-reviewed.
[WoS][Pmid][serval:BIB_E49FB20975C1]
 
Stable knockdown of microRNA in vivo by lentiviral vectors
Gentner Bernhard, Schira Giulia, Giustacchini Alice, Amendola Mario, Brown Brian D, Ponzoni Maurilio, Naldini Luigi, 2009/01. Nature Methods, 6 (1) pp. 63-66.
[DOI][WoS][Pmid][serval:BIB_6FB6FF7EA998]
2007
 
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
Brown Brian D, Gentner Bernhard, Cantore Alessio, Colleoni Silvia, Amendola Mario, Zingale Anna, Baccarini Alessia, Lazzari Giovanna, Galli Cesare, Naldini Luigi, 2007/12. Nature Biotechnology, 25 (12) pp. 1457-1467.
[DOI][WoS][Pmid][serval:BIB_F6C0E0326DD0]
2005
 
Genetic Testing for Germline Mutations of the APC Gene in Patients With Apparently Sporadic Desmoid Tumors but a Family History of Colorectal Carcinoma
Brueckl Wolfgang M., Ballhausen Wolfgang G., Förtsch Thomas, Günther Klaus, Fiedler Wolfgang, Gentner Bernhard, Croner Roland, Boxberger Frank, Kirchner Thomas, Hahn Eckhart G. et al., 2005/06. Diseases of the Colon &amp; Rectum, 48 (6) pp. 1275-1281.
[DOI][WoS][Pmid][serval:BIB_B580623363C1]
 
Zufallsbefund einer attenuierten familiären adenomatösen Polyposis (AFAP)
Gentner B, Kraus C, Schwab D, Benninger J, Wein A, Hahn E G, Brueckl W M, 2005/06. Zeitschrift für Gastroenterologie, 43 (06) pp. 591-595.
[DOI][WoS][Pmid][serval:BIB_275EF2BE95F4]
2004
 
Clonal Analysis of Individual Marrow‐Repopulating Cells after Experimental Peripheral Blood Progenitor Cell Transplantation
Nagy K. Zsuzsanna, Laufs Stephanie, Gentner Bernhard, Naundorf Sonja, Kuehlcke Klaus, Topaly Julian, Buss Eike C., Zeller W. Jens, Fruehauf Stefan, 2004/07. STEM CELLS, 22 (4) pp. 570-579.
[DOI][WoS][Pmid][serval:BIB_EDBF734DCC18]
2003
 
Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy
Parikh A, 2003/12/01. Journal of Gastrointestinal Surgery, 7 (8) pp. 1082-1088.
[DOI][WoS][Pmid][serval:BIB_FB98F7A744C5]
 
Rapid detection of retroviral vector integration sites in colony-forming human peripheral blood progenitor cells using PCR with arbitrary primers
Gentner B, Laufs S, Nagy K Z, Zeller W J, Fruehauf S, 2003/05/01. Gene Therapy, 10 (9) pp. 789-794.
[DOI][WoS][Pmid][serval:BIB_319CD7DFF8C6]
 
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
Laufs S., 2003/03/15. Blood, 101 (6) pp. 2191-2198.
[DOI][WoS][Pmid][serval:BIB_7BE7E1CB25FA]
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