Axes de recherche
Bioengineering 3D tissue and disease models
Research in our group focuses on developing biomaterials to modulate the physical and biological properties of the 3D cell nice, which we use for organoid-based disease modelling and tissue engineering applications. Tissue models in our lab are particularly focussed on diseases associated with pathological matrix remodelling, such as intestinal fibrosis, aortic aneurysm, and osteoarthritis. We are an interdisciplinary group that brings together chemists, biologists, physicists, mathematicians and clinicians. Check out some of our recent work below :
Yan Z… Gentleman E (2024) “FRET sensor-modified synthetic hydrogels for real-time monitoring of cell-derived matrix metalloproteinase activity using fluorescence lifetime imaging.” Advanced Functional Materials. 2309711 doi.org/10.1002/adfm.202309711
Cameron O… Gentleman E (2023) “Listen to your gut: Key concepts for bioengineering advanced models of the intestine.” Advanced Science. 2302156. doi: 10.1002/advs.202302165
Blackford S… Gentleman E*, Rashid T* (2023) “RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling.” Biomaterials. 293:121982 doi.org/10.1016/j.biomaterials.2022.121982
Blache U… Gentleman E (2022) “Engineered hydrogels for mechanobiology.” Nature Reviews Methods Primers. 2:98. doi: 10.1038/s43586-022-00179-7.
Norman MDA… Bozec L†, Gentleman E† (2021) “Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy.” Nature Protocols. 16: 2418-49. doi: 10.1038/s41596-021-00495-4
Jowett GM… Neves JF†, Gentleman E† (2021) “ILC1 drive intestinal epithelial and matrix remodelling.” Nature Materials 20: 251-9. doi: 10.1038/s41563-020-0783-8
