Werner Held

Publications | Mémoires et thèses

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128 publications

En préparation | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1990 | 1989 |
En préparation
 
The human CD8 T stem cell-like memory phenotype appears in the acute phase in Yellow Fever virus vaccination
Marraco Silvia A. Fuertes, Bovay Amandine, Nassiri Sina, Maby-El Hajjami Hélène, Ouertatani-Sakouhi Hajer, Held Werner, Speiser Daniel E..
[DOI][serval:BIB_D644B7DF7CE4]
 
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
Tillé Laure, Cropp Daniela, Bodley Gabrielle, Andreatta Massimo, Charmoy Mélanie, Crespo Isaac, Nassiri Sina, Lourenco Joao, Leblond Marine, Lopez-Rodriguez Cristina et al..
[DOI][serval:BIB_3D15B154D604]
2024
 
The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8<sup>+</sup> T cells against cancer.
Feng B., Bai Z., Zhou X., Zhao Y., Xie Y.Q., Huang X., Liu Y., Enbar T., Li R., Wang Y. et al., 2024/10. Nature, 634 (8034) pp. 712-720. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8B9B2D07B620]
Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis.
Massara M., Dolfi B., Wischnewski V., Nolan E., Held W., Malanchi I., Joyce J.A., 2024/07/19. iScience, 27 (7) p. 110284. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_9FCB37CBD16B]
2023
Emergence and fate of stem cell-like Tcf7<sup>+</sup> CD8<sup>+</sup> T cells during a primary immune response to viral infection.
Silva J.G., Pais Ferreira D., Dumez A., Wyss T., Veber R., Danilo M., Pinschewer D.D., Charmoy M., Held W., 2023/11/17. Science immunology, 8 (89) pp. eadh3113. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_0FB9CCAB8627]
Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion.
Tillé L., Cropp D., Charmoy M., Reichenbach P., Andreatta M., Wyss T., Bodley G., Crespo I., Nassiri S., Lourenco J. et al., 2023/10. Nature immunology, 24 (10) pp. 1645-1653. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9B944FAF7B77]
Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems.
Girotra M., Chiang Y.H., Charmoy M., Ginefra P., Hope H.C., Bataclan C., Yu Y.R., Schyrr F., Franco F., Geiger H. et al., 2023/09. Nature aging, 3 (9) pp. 1057-1066. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E2F47D89B9B9]
 
Hugh Robson MacDonald (1946-2023).
Wilson A., Ferrero I., Speiser D.E., Held W., Romero P., 2023/05/09. Immunity, 56 (5) pp. 893-894. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BE6A0AFFEA73]
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.
Marx A.F., Kallert S.M., Brunner T.M., Villegas J.A., Geier F., Fixemer J., Abreu-Mota T., Reuther P., Bonilla W.V., Fadejeva J. et al., 2023/04/11. Immunity, 56 (4) pp. 813-828.e10. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_796365D38E1A]
 
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.
Sacirbegovic F., Günther M., Greco A., Zhao D., Wang X., Zhou M., Rosenberger S., Oberbarnscheidt M.H., Held W., McNiff J. et al., 2023/02/14. Immunity, 56 (2) pp. 369-385.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_84CE58F053D5]
2022
Stem-cell-like T cells have a specific entry gate to the tumor.
Held W., Luther S.A., Petrova T.V., 2022/03/14. Cancer cell, 40 (3) pp. 243-245. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_51451730613C]
2021
PD-1<sup>+</sup> Tcf1<sup>+</sup> CD8<sup>+</sup> T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure.
Charmoy M., Wyss T., Delorenzi M., Held W., 2021/09/07. Cell reports, 36 (10) p. 109672. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2783DEBAC783]
Not All Tumor-Infiltrating CD8+ T Cells Are Created Equal.
Held W., Speiser D.E., 2021/02/08. Cancer cell, 39 (2) pp. 145-147. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_E8253423DFBD]
2020
Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation.
Pais Ferreira D., Silva J.G., Wyss T., Fuertes Marraco S.A., Scarpellino L., Charmoy M., Maas R., Siddiqui I., Tang L., Joyce J.A. et al., 2020/11/17. Immunity, 53 (5) pp. 985-1000.e11. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A0FD9237651F]
Stemming the Tide of Cancer
Speiser DE, Held W, 2020/07/31..
[URN][serval:BIB_A4F7C29DB6C8]
Tcf1<sup>+</sup> cells are required to maintain the inflationary T cell pool upon MCMV infection.
Welten SPM, Yermanos A., Baumann N.S., Wagen F., Oetiker N., Sandu I., Pedrioli A., Oduro J.D., Reddy S.T., Cicin-Sain L. et al., 2020/05/08. Nature communications, 11 (1) p. 2295. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4C6B9A0F8CD8]
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq
Carmona Santiago J., Siddiqui Imran, Bilous Mariia, Held Werner, Gfeller David, 2020/01/01. OncoImmunology, 9 (1) p. 1737369. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EDA6E7092CF7]
2019
Defining 'T cell exhaustion'.
Blank C.U., Haining W.N., Held W., Hogan P.G., Kallies A., Lugli E., Lynn R.C., Philip M., Rao A., Restifo N.P. et al., 2019/11. Nature reviews. Immunology, 19 (11) pp. 665-674. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_46B67C7C36BE]
Intratumoral CD8<sup>+</sup> T cells with stem cell-like properties: Implications for cancer immunotherapy.
Held W., Siddiqui I., Schaeuble K., Speiser D.E., 2019/10/23. Science translational medicine, 11 (515) pp. eaay6863. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_2890415E8A72]
γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia.
Luong-Gardiol N., Siddiqui I., Pizzitola I., Jeevan-Raj B., Charmoy M., Huang Y., Irmisch A., Curtet S., Angelov G.S., Danilo M. et al., 2019/04/15. Cancer cell, 35 (4) pp. 649-663.e10. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B56A0F7637FF]
Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.
Lan Q., Peyvandi S., Duffey N., Huang Y.T., Barras D., Held W., Richard F., Delorenzi M., Sotiriou C., Desmedt C. et al., 2019/04. Oncogene, 38 (15) pp. 2814-2829. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_94A8CCA9EF90]
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Niogret C., Miah SMS, Rota G., Fonta N.P., Wang H., Held W., Birchmeier W., Sexl V., Yang W., Vivier E. et al., 2019/03/29. Nature communications, 10 (1) p. 1444. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1D70F1981844]
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Siddiqui I., Schaeuble K., Chennupati V., Fuertes Marraco S.A., Calderon-Copete S., Pais Ferreira D., Carmona S.J., Scarpellino L., Gfeller D., Pradervand S. et al., 2019/01/15. Immunity, 50 (1) pp. 195-211.e10. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8DBCBF3E53B5]
2018
Transcriptional regulation of murine natural killer cell development, differentiation and maturation.
Held W., Jeevan-Raj B., Charmoy M., 2018/09. Cellular and molecular life sciences, 75 (18) pp. 3371-3379. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1E93DC8609A6]
Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation.
Danilo M., Chennupati V., Silva J.G., Siegert S., Held W., 2018/02/20. Cell reports, 22 (8) pp. 2107-2117. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C287A133B463]
2017
Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.
Chennupati V., Held W., 2017/12/19. Immunity, 47 (6) pp. 1009-1011. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F6047C7A6B9F]
Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation.
Abbuehl J.P., Tatarova Z., Held W., Huelsken J., 2017/08/03. Cell stem cell, 21 (2) pp. 241-255.e6. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_22612957789F]
The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes.
Jeevan-Raj B., Gehrig J., Charmoy M., Chennupati V., Grandclément C., Angelino P., Delorenzi M., Held W., 2017/07/18. Cell reports, 20 (3) pp. 613-626. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_87F6877665CF]
TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation.
Wieland D., Kemming J., Schuch A., Emmerich F., Knolle P., Neumann-Haefelin C., Held W., Zehn D., Hofmann M., Thimme R., 2017/05/03. Nature communications, 8 p. 15050. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BC4DAD6A8908]
2016
T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.
Utzschneider D.T., Charmoy M., Chennupati V., Pousse L., Ferreira D.P., Calderon-Copete S., Danilo M., Alfei F., Hofmann M., Wieland D. et al., 2016/08/16. Immunity, 45 (2) pp. 415-427. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_26E58D22D474]
Phage Selection of Chemically Stabilized α-Helical Peptide Ligands.
Diderich P., Bertoldo D., Dessen P., Khan M.M., Pizzitola I., Held W., Huelsken J., Heinis C., 2016/03/20. ACS chemical biology, 11 (5) pp. 1422-1427. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_0A65DEA92978]
Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.
Alari-Pahissa E., Grandclément C., Jeevan-Raj B., Leclercq G., Veillette A., Held W., 2016. PLoS One, 11 (4) pp. e0153236. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6562347F8E45]
Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.
Scholz G., Jandus C., Zhang L., Grandclément C., Lopez-Mejia I.C., Soneson C., Delorenzi M., Fajas L., Held W., Dormond O. et al., 2016. Ebiomedicine, 4 pp. 50-61. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_5D18A226530B]
NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels.
Grandclément C., Pick H., Vogel H., Held W., 2016. Plos One, 11 (3) pp. e0151031. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A63D15EF48B9]
NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions.
Ludigs K., Jandus C., Utzschneider D.T., Staehli F., Bessoles S., Dang A.T., Rota G., Castro W., Zehn D., Vivier E. et al., 2016. Nature Communications, 7 p. 10554. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8FDEF0BFED69]
Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling.
Bertoldo D., Khan M.M., Dessen P., Held W., Huelsken J., Heinis C., 2016. Chemmedchem, 11 (8) pp. 834-839. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A9DB2F23A326]
2015
Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.
Hurrell B.P., Schuster S., Grün E., Coutaz M., Williams R.A., Held W., Malissen B., Malissen M., Yousefi S., Simon H.U. et al., 2015. PLoS Pathogens, 11 (5) pp. e1004929.
[URN][DOI][WoS][Pmid][serval:BIB_74421C6C7D5B]
2014
Adaptations of Natural Killer Cells to Self-MHC Class I.
Bessoles S., Grandclément C., Alari-Pahissa E., Gehrig J., Jeevan-Raj B., Held W., 2014. Frontiers in Immunology, 5 p. 349. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BB450D1901CE]
Differences in the transduction of canonical wnt signals demarcate effector and memory CD8 T cells with distinct recall proliferation capacity.
Boudousquié C., Danilo M., Pousse L., Jeevan-Raj B., Angelov G.S., Chennupati V., Zehn D., Held W., 2014. Journal of Immunology, 193 (6) pp. 2784-2791. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1CEC9FA289EB]
Inhibitory receptor-mediated regulation of natural killer cells.
Alari-Pahissa E., Grandclement C., Jeevan-Raj B., Held W., 2014. Critical Reviews in Immunology, 34 (6) pp. 455-465. Peer-reviewed.
[URN][WoS][Pmid][serval:BIB_4698362D418E]
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
Jaworski M., Marsland B.J., Gehrig J., Held W., Favre S., Luther S.A., Perroud M., Golshayan D., Gaide O., Thome M., 2014. EMBO Journal, 33 (23) pp. 2765-2781.
[URN][DOI][WoS][Pmid][serval:BIB_9401281135B4]
2013
Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules.
Bessoles S., Angelov G.S., Back J., Leclercq G., Vivier E., Held W., 2013. Journal of Immunology, 191 (10) pp. 5044-5051.
[URN][DOI][WoS][Pmid][serval:BIB_2B1B56B9E4B6]
Inhibitory receptors and their mode of action: key insights from NK cells.
Held W., 2013. Journal of Immunology, 191 (7) pp. 3489-3490.
[URN][DOI][WoS][Pmid][serval:BIB_DEE53BE7C289]
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
Dudda J.C., Salaun B., Ji Y., Palmer D.C., Monnot G.C., Merck E., Boudousquie C., Utzschneider D.T., Escobar T.M., Perret R. et al., 2013. Immunity, 38 (4) pp. 742-753. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C465F0F1D8F8]
2012
Caspase-3 Protects Stressed Organs against Cell Death.
Khalil H., Peltzer N., Walicki J., Yang J.Y., Dubuis G., Gardiol N., Held W., Bigliardi P., Marsland B., Liaudet L. et al., 2012. Molecular and Cellular Biology, 32 (22) pp. 4523-4533. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3A213E3293BE]
 
Nonclassical NK cell education.
Held W., 2012. Nature Immunology, 13 (12) pp. 1135-1137. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F95CDA3AE044]
2011
Cis-trans interactions of cell surface receptors: biological roles and structural basis.
Held W., Mariuzza R.A., 2011. Cellular and Molecular Life Sciences, 68 (21) pp. 3469-3478.
[URN][DOI][WoS][Pmid][serval:BIB_7D095BF6B21B]
 
Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.
Taveirne S., Filtjens J., Van Ammel E., De Colvenaer V., Kerre T., Taghon T., Vandekerckhove B., Plum J., Held W., Leclercq G., 2011. Blood, 118 (2) pp. 339-347.
[DOI][WoS][Pmid][serval:BIB_407E381A84DB]
 
Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
Merck E., Lees R.K., Voyle R.B., Held W., MacDonald H.R., 2011. Journal of Immunology, 187 (1) pp. 110-117.
[DOI][WoS][Pmid][serval:BIB_9F7C9B8E967C]
Natural killer cell mediated missing-self recognition can protect mice from primary chronic myeloid leukemia in vivo.
Kijima M., Gardiol N., Held W., 2011. PLoS One, 6 (11) pp. e27639.
[URN][DOI][WoS][Pmid][serval:BIB_161236155940]
 
The function of natural killer cells: education, reminders and some good memories.
Held W., Kijima M., Angelov G., Bessoles S., 2011. Current Opinion in Immunology, 23 (2) pp. 228-233.
[DOI][WoS][Pmid][serval:BIB_4D83C8221835]
The Interaction with H-2Dd in cis is Associated with a Conformational Change in the Ly49A NK Cell Receptor
Back Jonathan, Angelov Georgi S., Mariuzza Roy A., Held Werner, 2011. Frontiers in Immunology, 2. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_15E76EFD524B]
2010
 
A KIR-TLR connection
Held Werner, 2010/09/09. Blood, 116 (10) pp. 1629-1630.
[DOI][WoS][Pmid][serval:BIB_2261BF909086]
Constitutive activation of Wnt signaling favors generation of memory CD8 T cells.
Zhao D.M., Yu S., Zhou X., Haring J.S., Held W., Badovinac V.P., Harty J.T., Xue H.H., 2010/02/01. Journal of immunology, 184 (3) pp. 1191-1199. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0080BC0E87C5]
 
Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory.
Jeannet G., Boudousquié C., Gardiol N., Kang J., Huelsken J., Held W., 2010. Proceedings of the National Academy of Sciences of the United States of America, 107 (21) pp. 9777-9782.
[DOI][WoS][Pmid][serval:BIB_48699C0B0836]
 
Probing the interactions of NK cell receptors with ligand expressed in trans and cis.
Back J., Scarpellino L., Held W., 2010. Methods in Molecular Biology, 612 pp. 313-323.
[DOI][WoS][Pmid][serval:BIB_4031ECF390EE]
2009
 
A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.
Chalifour A., Scarpellino L., Back J., Brodin P., Devèvre E., Gros F., Lévy F., Leclercq G., Höglund P., Beermann F. et al., 2009. Immunity, 30 (3) pp. 337-347. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_891F521C981B]
Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.
Back J., Malchiodi E.L., Cho S., Scarpellino L., Schneider P., Kerzic M.C., Mariuzza R.A., Held W., 2009. Immunity, 31 (4) pp. 598-608. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4B901DC34A80]
2008
Cis interactions of immunoreceptors with MHC and non-MHC ligands
Held W., Mariuzza R.A., 2008. Nature Reviews. Immunology, 8 (4) pp. 269-278. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B99E33F9BDD8]
 
Inhibitions in NK-cell maturation.
Held W., 2008. Blood, 112 (1) pp. 8-9.
[DOI][WoS][Pmid][serval:BIB_AA9EF8909DD3]
 
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Jeannet G., Scheller M., Scarpellino L., Duboux S., Gardiol N., Back J., Kuttler F., Malanchi I., Birchmeier W., Leutz A. et al., 2008. Blood, 111 (1) pp. 142-149. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6996BFD53E08]
 
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
Van Den Broeck T., Stevenaert F., Taveirne S., Debacker V., Vangestel C., Vandekerckhove B., Taghon T., Matthys P., Plum J., Held W. et al., 2008. Blood, 112 (13) pp. 5046-5051. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8F39325DFF7E]
 
Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways
Coudert J. D., Scarpellino L., Gros F., Vivier E., Held W., 2008. Blood, 111 (7) pp. 3571-3578. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E3AF42B65712]
 
Tolerance and reactivity of NK cells: two sides of the same coin?
Held W., 2008. European Journal of Immunology, 38 (11) pp. 2930-2933. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7F187459146D]
2007
 
Interactions of Ly49 family receptors with MHC class I ligands in trans and cis.
Scarpellino L., Oeschger F., Guillaume P., Coudert J.D., Lévy F., Leclercq G., Held W., 2007. Journal of immunology, 178 (3) pp. 1277-1284. Peer-reviewed.
[WoS][Pmid][serval:BIB_B4CA2A35F031]
 
Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.
Melichar H.J., Narayan K., Der S.D., Hiraoka Y., Gardiol N., Jeannet G., Held W., Chambers C.A., Kang J., 2007. Science, 315 (5809) pp. 230-233. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_386D8BD56505]
 
Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.
Back J., Chalifour A., Scarpellino L., Held W., 2007. Proceedings of the National Academy of Sciences of the United States of America, 104 (10) pp. 3978-3983. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E7C8E1827B15]
2006
 
T and B lymphocytes exert distinct effects on the homeostasis of NK cells.
Jeannet G., Coudert J.D., Held W., 2006. European journal of immunology, 36 (10) pp. 2725-2734. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CF85EE48500A]
 
The role of the NKG2D receptor for tumor immunity.
Coudert J.D., Held W., 2006. Seminars in cancer biology, 16 (5) pp. 333-343. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C8E15B95143F]
 
Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.
Huang Z., Xie H., Ioannidis V., Held W., Clevers H., Sadim M.S., Sun Z., 2006. Journal of immunology, 176 (8) pp. 4880-4887. Peer-reviewed.
[WoS][Pmid][serval:BIB_10A45330CA05]
2005
Regulation of natural killer cell function: a role for the NK cell's own MHC class I molecules.
Held W., Chalifour A., Coudert J.D., 2005/08. Medical microbiology and immunology, 194 (4) pp. 169-174. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2758AB51F8FD]
 
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells.
Coudert J.D., Zimmer J., Tomasello E., Cebecauer M., Colonna M., Vivier E., Held W., 2005. Blood, 106 (5) pp. 1711-1717. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_025488CD9396]
 
Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival.
Goux D., Coudert J.D., Maurice D., Scarpellino L., Jeannet G., Piccolo S., Weston K., Huelsken J., Held W., 2005. Blood, 106 (5) pp. 1726-1733. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D7D4A7A31084]
 
MHC class I-related chain A conjugated to antitumor antibodies can sensitize tumor cells to specific lysis by natural killer cells.
Germain C., Larbouret C., Cesson V., Donda A., Held W., Mach J.P., Pèlegrin A., Robert B., 2005. Clinical Cancer Research, 11 (20) pp. 7516-7522. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B09733879372]
2004
 
Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.
Doucey M.A., Scarpellino L., Zimmer J., Guillaume P., Luescher I.F., Bron C., Held W., 2004. Nature Immunology, 5 (3) pp. 328-336. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_84274940A2AD]
2003
 
The NK cell receptor repertoire: formation, adaptation and exploitation.
Held W., Coudert J.D., Zimmer J., 2003/04. Current opinion in immunology, 15 (2) pp. 233-237. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3E9AC8FF8D8B]
 
Cutting edge: stimulation with the cognate self-antigen induces expression of the Ly49A receptor on self-reactive T cells which modulates their responsiveness.
Saurer L., Seibold I., Vallan C., Held W., Mueller C., 2003. Journal of immunology, 171 (12) pp. 6334-6338. Peer-reviewed.
[WoS][Pmid][serval:BIB_F5605138A534]
 
Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1.
Ioannidis V., Kunz B., Tanamachi D.M., Scarpellino L., Held W., 2003. Journal of immunology, 171 (2) pp. 769-775. Peer-reviewed.
[WoS][Pmid][serval:BIB_DF924B269DD1]
Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D.
Voyle R.B., Beermann F., Lees R.K., Schümann J., Zimmer J., Held W., MacDonald H.R., 2003. Journal of Experimental Medicine, 197 (7) pp. 919-925. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A09A6B9B87FD]
 
Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition.
Held W., Clevers H., Grosschedl R., 2003. European journal of immunology, 33 (5) pp. 1393-1398. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FB20A05E1494]
2002
 
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
Lowin-Kropf B., Kunz B., Schneider P., Held W., 2002. European Journal of Immunology, 32 (3) pp. 773-782. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_16995758AE8B]
 
Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage.
Ferrero I., Held W., Wilson A., Tacchini-Cottier F., Radtke F., MacDonald H.R., 2002. Blood, 100 (8) pp. 2852-2857. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4AE452F6077F]
 
The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor.
Chambers C.A., Kang J., Wu Y., Held W., Raulet D.H., Allison J.P., 2002. Blood, 99 (12) pp. 4509-4516. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B53A36E7503C]
2001
 
CD8+ T cell development: CD4 to the rescue.
MacDonald H.R., Held W., 2001. Nature Immunology, 2 (12) pp. 1091-1092. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D6E291A0A03B]
 
Cre recombinase-mediated inactivation of H-2Dd transgene expression: evidence for partial missing self-recognition by Ly49A NK cells.
Ioannidis V., Zimmer J., Beermann F., Held W., 2001. Journal of immunology, 167 (11) pp. 6256-6262. Peer-reviewed.
[WoS][Pmid][serval:BIB_2ADFEA5E7278]
H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function.
Zimmer J., Ioannidis V., Held W., 2001. The Journal of Experimental Medicine, 194 (10) pp. 1531-1539. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_18299]
 
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.
Wolfer A., Bakker T., Wilson A., Nicolas M., Ioannidis V., Littman D.R., Lee P.P., Wilson C.B., Held W., MacDonald H.R. et al., 2001. Nature immunology, 2 (3) pp. 235-241. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7B6F739C3164]
 
Positive and negative roles of the trans-acting T cell factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells.
Kunz B., Held W., 2001. Journal of immunology, 166 (10) pp. 6181-6187. Peer-reviewed.
[WoS][Pmid][serval:BIB_2D1254BE1574]
T cell receptor specificity is critical for the development of epidermal gammadelta T cells.
Ferrero I., Wilson A., Beermann F., Held W., MacDonald H.R., 2001. The Journal of Experimental Medicine, 194 (10) pp. 1473-1483. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_20717]
 
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
Ioannidis V., Beermann F., Clevers H., Held W., 2001. Nature Immunology, 2 (8) pp. 691-697. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_20718]
2000
 
Generation of short-term murine natural killer cell clones to analyze Ly49 gene expression.
Held W., Lowin-Kropf B., Raulet D.H., 2000. Methods in molecular biology, 121 pp. 5-12.
[DOI][Pmid][serval:BIB_8B8C1F6B8578]
 
Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1.
Lowin-Kropf B., Kunz B., Beermann F., Held W., 2000. Journal of immunology, 165 (3) pp. 1314-1321. Peer-reviewed.
[WoS][Pmid][serval:BIB_94AB6083656A]
 
Positive impact of inhibitory Ly49 receptor-MHC class I interaction on NK cell development.
Lowin-Kropf B., Held W., 2000. Journal of immunology, 165 (1) pp. 91-95. Peer-reviewed.
[WoS][Pmid][serval:BIB_A392E0C1806B]
 
Transgenic expression of Ly49A on T cells impairs a specific antitumor response.
Brawand P., Lemonnier F.A., MacDonald H.R., Cerottini J.C., Held W., 2000. Journal of immunology, 165 (4) pp. 1871-1876. Peer-reviewed.
[WoS][Pmid][serval:BIB_8D644545DCE9]
1999
 
Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells.
Zerrahn J., Volkmann A., Coles M.C., Held W., Lemonnier F.A., Raulet D.H., 1999. Proceedings of the National Academy of Sciences of the United States of America, 96 (20) pp. 11470-11475. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F60D2BE4EC75]
 
Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.
Held W., Kunz B., Lowin-Kropf B., van de Wetering M., Clevers H., 1999. Immunity, 11 (4) pp. 433-442. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D4E7A0FD1B80]
 
Impaired anti-viral T cell responses due to expression of the Ly49A inhibitory receptor.
Zajac A.J., Vance R.E., Held W., Sourdive D.J., Altman J.D., Raulet D.H., Ahmed R., 1999. Journal of immunology, 163 (10) pp. 5526-5534. Peer-reviewed.
[WoS][Pmid][serval:BIB_BCCFF3B4A338]
 
Mono-allelic Ly49 NK cell receptor expression.
Held W., Kunz B., Ioannidis V., Lowin-Kropf B., 1999. Seminars in immunology, 11 (5) pp. 349-355. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_14E18700A053]
1998
 
An allele-specific, stochastic gene expression process controls the expression of multiple Ly49 family genes and generates a diverse, MHC-specific NK cell receptor repertoire.
Held W., Kunz B., 1998. European journal of immunology, 28 (8) pp. 2407-2416. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D956B88AD93C]
Developmentally regulated extinction of Ly-49 receptor expression permits maturation and selection of NK1.1+ T cells.
MacDonald R.H., Lees R.K., Held W., 1998. The Journal of experimental medicine, 187 (12) pp. 2109-2114. Peer-reviewed.
[URN][WoS][Pmid][serval:BIB_A5CBEA7ABDAD]
1997
 
Expression of the Ly49A gene in murine natural killer cell clones is predominantly but not exclusively mono-allelic.
Held W., Raulet D.H., 1997. European journal of immunology, 27 (11) pp. 2876-2884. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3CBFD06883EC]
 
Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in natural killer cell development.
Held W., Raulet D.H., 1997. The Journal of experimental medicine, 185 (12) pp. 2079-2088. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_116F282230E3]
 
Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors.
Raulet D.H., Held W., Correa I., Dorfman J.R., Wu M.F., Corral L., 1997. Immunological reviews, 155 pp. 41-52. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F4E5920365AC]
 
The MHC reactivity of the T cell repertoire prior to positive and negative selection.
Zerrahn J., Held W., Raulet D.H., 1997. Cell, 88 (5) pp. 627-636. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7BE62904395A]
1996
 
Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor repertoire.
Held W., Dorfman J.R., Wu M.F., Raulet D.H., 1996. European journal of immunology, 26 (10) pp. 2286-2210.1002/eji.183026100392. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6DBBBA94935C]
 
Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection.
Held W., Cado D., Raulet D.H., 1996. The Journal of experimental medicine, 184 (5) pp. 2037-2041. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_83F2853A32BD]
1995
 
Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells
Held Werner, Roland Jacques, Raulet David H., 1995/07. Nature, 376 (6538) pp. 355-358.
[DOI][WoS][Pmid][serval:BIB_E357D3A26FFB]
 
Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates.
Mueller C., Held W., Imboden M.A., Carnaud C., 1995. Diabetes, 44 (1) pp. 112-117. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_39FCE4DC6B3C]
 
Natural killer cell receptors: the offs and ons of NK cell recognition.
Raulet D.H., Held W., 1995. Cell, 82 (5) pp. 697-700. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D2D9596D3930]
 
Quantitation of endogenous mouse mammary tumor virus superantigen expression by lymphocyte subsets.
Waanders G.A., Lees R.K., Held W., MacDonald H.R., 1995. European journal of immunology, 25 (9) pp. 2632-2637. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3BEA38503236]
1994
 
MHC class II hierarchy of superantigen presentation predicts efficiency of infection with mouse mammary tumor virus.
Held W., Waanders G.A., MacDonald H.R., Acha-Orbea H., 1994. International Immunology, 6 (9) pp. 1403-1407. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C9C8FBD9AFE2]
Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: implications for superantigen function.
Held W., Waanders G.A., Acha-Orbea H., MacDonald H.R., 1994. Journal of Experimental Medicine, 180 (6) pp. 2347-2351. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_624FE703C8B8]
 
Superantigens and retroviral infection: insights from mouse mammary tumor virus.
Held W., Acha-Orbea H., MacDonald H.R., Waanders G.A., 1994. Immunology Today, 15 (4) pp. 184-190. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B54116E7972E]
Two waves of recombinase gene expression in developing thymocytes.
Wilson A., Held W., MacDonald H.R., 1994. The Journal of experimental medicine, 179 (4) pp. 1355-1360. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4B7BC91A7C1B]
1993
 
Exogenous and endogenous mouse mammary tumor virus superantigens.
Acha-Orbea H., Held W., Waanders G.A., Shakhov A.N., Scarpellino L., Lees R.K., MacDonald H.R., 1993. Immunological Reviews, 131 (1) pp. 5-25.
[DOI][WoS][Pmid][serval:BIB_8C4921C5AC29]
 
Perforin and tumor necrosis factor alpha in the pathogenesis of experimental allergic encephalomyelitis: comparison of autoantigen induced and transferred disease in Lewis rats.
Held W., Meyermann R., Qin Y., Mueller C., 1993. Journal of autoimmunity, 6 (3) pp. 311-322. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5110F0E48458]
Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus.
Waanders G.A., Shakhov A.N., Held W., Karapetian O., Acha-Orbea H., MacDonald H.R., 1993. Journal of Experimental Medicine, 177 (5) pp. 1359-1366. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B02AB919714B]
 
Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission.
Held W., Waanders G.A., Shakhov A.N., Scarpellino L., Acha-Orbea H., MacDonald H.R., 1993. Cell, 74 (3) pp. 529-540. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_958C4C50E223]
Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus.
Held W., Shakhov A.N., Izui S., Waanders G.A., Scarpellino L., MacDonald H.R., Acha-Orbea H., 1993. Journal of Experimental Medicine, 177 (2) pp. 359-366. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_80C31902CC51]
1992
An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7).
Held W., Shakhov A.N., Waanders G., Scarpellino L., Luethy R., Kraehenbuhl J.P., MacDonald H.R., Acha-Orbea H., 1992. Journal of Experimental Medicine, 175 (6) pp. 1623-1633.
[URN][DOI][WoS][Pmid][serval:BIB_34B1C10DA8A9]
 
Infectious minor lymphocyte stimulating (Mls) antigens.
Acha-Orbea H., Waanders G.A., Shakhov A.N., Held W., 1992. Seminars in Immunology, 4 (5) pp. 297-303.
[Pmid][serval:BIB_2A28C43D697E]
Inhibition of mouse mammary tumor virus-induced T cell responses in vivo by antibodies to an open reading frame protein.
Acha-Orbea H., Scarpellino L., Shakhov A.N., Held W., MacDonald H.R., 1992. Journal of Experimental Medicine, 176 (6) pp. 1769-1772.
[URN][DOI][WoS][Pmid][serval:BIB_35F3DCDA65DB]
 
Mls: a link between immunology and retrovirology.
Acha-Orbea H., Held W., Scarpellino L., Shakhov A.N., 1992. International Reviews of Immunology, 8 (4) pp. 327-336.
[Pmid][serval:BIB_52CCC12C0007]
1990
 
Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes.
Held W., MacDonald H.R., Mueller C., 1990. International immunology, 2 (1) pp. 57-62. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BA46E62A32A0]
 
Expression of T cell receptor genes in the thymus: localization of transcripts in situ and comparison of mature and immature subsets.
Held W., Mueller C., MacDonald H.R., 1990. European journal of immunology, 20 (9) pp. 2133-2136. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_726E8EEBC7BA]
 
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Held W., MacDonald H.R., Weissman I.L., Hess M.W., Mueller C., 1990. Proceedings of the National Academy of Sciences of the United States of America, 87 (6) pp. 2239-2243. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8DD3834DC024]
1989
 
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
Müller C., Kägi D., Aebischer T., Odermatt B., Held W., Podack E.R., Zinkernagel R.M., Hengartner H., 1989. European journal of immunology, 19 (7) pp. 1253-1259. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E24B1B9F9BA1]
 
Production of human antibodies to bee venom phospholipase A2 in vitro.
Held W., Stucki M., Heusser C., Blaser K., 1989. Scandinavian journal of immunology, 29 (2) pp. 203-209. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_066906621E31]
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