Nicolas Mermod

Publications | Mémoires et thèses

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115 publications

2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 |
2021
 
PiggyBac transposase and transposon derivatives for gene transfer targeting the ribosomal DNA loci of CHO cells.
Bire S., Dusserre Y., Bigot Y., Mermod N., 2021/11/20. Journal of biotechnology, 341 pp. 103-112. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2E20E13CC582]
 
Rheological properties of skeletal muscles in a Duchenne muscular dystrophy murine model before and after autologous cell therapy.
Zemła J., Iyer P.S., Pyka-Fościak G., Mermod N., Lekka M., 2021/11/09. Journal of biomechanics, 128 p. 110770. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_81DE96D7241D]
2020
Genome-wide analysis of single nucleotide variants allows for robust and accurate assessment of clonal derivation in cell lines used to produce biologics.
Kuhn A., Le Fourn V., Fisch I., Mermod N., 2020/12. Biotechnology and bioengineering, 117 (12) pp. 3628-3638. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BE8E8002A0B6]
Transient vitamin B5 starving improves mammalian cell homeostasis and protein production.
Pourcel L., Buron F., Garcia F., Delaloix M.S., Le Fourn V., Girod P.A., Mermod N., 2020/07. Metabolic engineering, 60 pp. 77-86. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A31339F7E913]
Influence of cytoskeleton organization on recombinant protein expression by CHO cells.
Pourcel L., Buron F., Arib G., Le Fourn V., Regamey A., Bodenmann I., Girod P.A., Mermod N., 2020/04. Biotechnology and bioengineering, 117 (4) pp. 1117-1126. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_02A3B3842F19]
Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells.
Berger A., Le Fourn V., Masternak J., Regamey A., Bodenmann I., Girod P.A., Mermod N., 2020/04. Biotechnology and bioengineering, 117 (4) pp. 1101-1116. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D3B3130E78A9]
Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release.
Duroy P.O., Bosshard S., Schmid-Siegert E., Neuenschwander S., Arib G., Lemercier P., Masternak J., Roesch L., Buron F., Girod P.A. et al., 2020/02. Biotechnology and bioengineering, 117 (2) pp. 466-485. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3F6D075DCCE1]
2019
 
Characterization of mesoangioblast cell fate and improved promyogenic potential of a satellite cell-like subpopulation upon transplantation in dystrophic murine muscles.
Mavoungou L.O., Neuenschwander S., Pham U., Iyer P.S., Mermod N., 2019/12. Stem cell research, 41 p. 101619. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2BB88877D39D]
 
A role for alternative end-joining factors in homologous recombination and genome editing in Chinese hamster ovary cells.
Bosshard S., Duroy P.O., Mermod N., 2019/10. DNA repair, 82 p. 102691. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A23C722A208B]
2018
 
Autologous Cell Therapy Approach for Duchenne Muscular Dystrophy using PiggyBac Transposons and Mesoangioblasts.
Iyer P.S., Mavoungou L.O., Ronzoni F., Zemla J., Schmid-Siegert E., Antonini S., Neff L.A., Dorchies O.M., Jaconi M., Lekka M. et al., 2018/04/04. Molecular therapy, 26 (4) pp. 1093-1108. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0BE77D405BD4]
2017
 
Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest
Droz X., Harraghy N., Lançon E., Le Fourn V., Calabrese D., Colombet T., Liechti P., Rida A., Girod P.A., Mermod N., 2017. Biotechnology and Bioengineering, 114 (8) pp. 1791-1802. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_951315D027DD]
MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering.
Kostyrko K., Neuenschwander S., Junier T., Regamey A., Iseli C., Schmid-Siegert E., Bosshard S., Majocchi S., Le Fourn V., Girod P.A. et al., 2017. Biotechnology and Bioengineering, 114 (2) pp. 384-396. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_322831BD76E3]
2016
Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.
Kostyrko K., Mermod N., 2016. Nucleic Acids Research, 44 (6) pp. e56. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_9C7D202B44D3]
Development of a candidate reference material for adventitious virus detection in vaccine and biologicals manufacturing by deep sequencing.
Mee E.T., Preston M.D., Minor P.D., Schepelmann S., CS533 Study Participants, 2016. Vaccine, 34 (17) pp. 2035-2043.
[URN][DOI][WoS][Pmid][serval:BIB_000A07822074]
2015
 
A role for homologous recombination proteins in cell cycle regulation.
Kostyrko K., Bosshard S., Urban Z., Mermod N., 2015. Cell Cycle, 14 (17) pp. 2853-2861.
[DOI][WoS][Pmid][serval:BIB_677D328C43ED]
 
Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.
Harraghy N., Calabrese D., Fisch I., Girod P.A., LeFourn V., Regamey A., Mermod N., 2015. Biotechnology Journal, 10 (7) pp. 967-978.
[DOI][WoS][Pmid][serval:BIB_9CF43F1E2DD1]
 
Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.
Edelmann S., Fahrner R., Malinka T., Song B.H., Stroka D., Mermod N., 2015. Liver International, 35 (4) pp. 1185-1194.
[DOI][WoS][Pmid][serval:BIB_3109692321ED]
2014
 
A PiggyBac-mediated approach for muscle gene transfer or cell therapy.
Ley D., Van Zwieten R., Puttini S., Iyer P., Cochard A., Mermod N., 2014. Stem Cell Research, 13 (3 Pt A) pp. 390-403.
[DOI][WoS][Pmid][serval:BIB_F2194B4273DB]
 
Assessing dystrophies and other muscle diseases at the nanometer scale by atomic force microscopy.
van Zwieten R.W., Puttini S., Lekka M., Witz G., Gicquel-Zouida E., Richard I., Lobrinus J.A., Chevalley F., Brune H., Dietler G. et al., 2014. Nanomedicine, 9 (4) pp. 393-406.
[URN][DOI][WoS][Pmid][serval:BIB_59BA463FB28E]
 
CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion.
Le Fourn V., Girod P.A., Buceta M., Regamey A., Mermod N., 2014. Metabolic Engineering, 21 pp. 91-102.
[DOI][WoS][Pmid][serval:BIB_C2E58E538DD5]
Epigenetic regulatory elements associate with specific histone modifications to prevent silencing of telomeric genes.
Majocchi S., Aritonovska E., Mermod N., 2014. Nucleic Acids Research, 42 (1) pp. 193-204.
[URN][DOI][WoS][Pmid][serval:BIB_F17FEA13EB14]
Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.
Deák F., Mátés L., Korpos E., Zvara A., Szénási T., Kiricsi M., Mendler L., Keller-Pintér A., Ozsvári B., Juhász H. et al., 2014. Journal of Cell Science, 127 (Pt 15) pp. 3240-3256.
[URN][DOI][WoS][Pmid][serval:BIB_DE99756211BD]
 
Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies.
Puttini S., Panaite P.A., Mermod N., Renaud S., Steck A.J., Kuntzer T., 2014. Journal of Neuroimmunology, 270 (1-2) pp. 61-66. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_765A9534E629]
2013
 
IL-17F co-expression improves cell growth characteristics and enhances recombinant protein production during CHO cell line engineering.
Contie M., Leger O., Fouque N., Poitevin Y., Kosco-Vilbois M., Mermod N., Elson G., 2013. Biotechnology and Bioengineering, 110 (4) pp. 1153-1163.
[DOI][WoS][Pmid][serval:BIB_B437F876A1C9]
MAR elements and transposons for improved transgene integration and expression.
Ley D., Harraghy N., Le Fourn V., Bire S., Girod P.A., Regamey A., Rouleux-Bonnin F., Bigot Y., Mermod N., 2013. PLoS One, 8 (4) pp. e62784.
[URN][DOI][WoS][Pmid][serval:BIB_689882DD46E1]
MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation.
Puttini S., van Zwieten R.W., Saugy D., Lekka M., Hogger F., Ley D., Kulik A.J., Mermod N., 2013. BMC Molecular Biology, 14 p. 26.
[URN][DOI][WoS][Pmid][serval:BIB_B81D2BB6080C]
Molecular characterization of a human matrix attachment region epigenetic regulator.
Arope S., Harraghy N., Pjanic M., Mermod N., 2013. PLoS One, 8 (11) pp. e79262.
[URN][DOI][WoS][Pmid][serval:BIB_F39C96561823]
Nuclear Factor I genomic binding associates with chromatin boundaries.
Pjanic M., Schmid C.D., Gaussin A., Ambrosini G., Adamcik J., Pjanic P., Plasari G., Kerschgens J., Dietler G., Bucher P. et al., 2013. BMC Genomics, 14 p. 99.
[URN][DOI][WoS][Pmid][serval:BIB_0E579776B32C]
Optimization of the piggyBac Transposon Using mRNA and Insulators: Toward a More Reliable Gene Delivery System.
Bire S., Ley D., Casteret S., Mermod N., Bigot Y., Rouleux-Bonnin F., 2013. PLoS One, 8 (12) pp. e82559.
[URN][DOI][WoS][Pmid][serval:BIB_29EE4DF18FE8]
2012
 
CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors.
Gaussin A., Modlich U., Bauche C., Niederländer N.J., Schambach A., Duros C., Artus A., Baum C., Cohen-Haguenauer O., Mermod N., 2012. Gene Therapy, 19 (1) pp. 15-24.
[DOI][WoS][Pmid][serval:BIB_CB32741F814E]
 
In situ evaluation of single-cell lysis by cytosol extraction observation through fluorescence decay and dielectrophoretic trapping time
Mernier G., Majocchi S., Mermod N., Renaud P., 2012. Sensors and Actuators B-Chemical, 166 pp. 907-912.
[DOI][WoS][serval:BIB_060EB126E499]
 
Using matrix attachment regions to improve recombinant protein production.
Harraghy N., Buceta M., Regamey A., Girod P.A., Mermod N., 2012. Methods in Molecular Biology, 801 pp. 93-110.
[DOI][WoS][Pmid][serval:BIB_96D3473CAF1E]
2011
High-level transgene expression by homologous recombination-mediated gene transfer.
Grandjean M., Girod P.A., Calabrese D., Kostyrko K., Wicht M., Yerly F., Mazza C., Beckmann J.S., Martinet D., Mermod N., 2011. Nucleic Acids Research, 39 (15) pp. e104.
[URN][DOI][WoS][Pmid][serval:BIB_ADEE6654D99A]
 
Identification of a potent MAR element from the mouse genome and assessment of its activity in stable and transient transfections.
Harraghy N., Regamey A., Girod P.A., Mermod N., 2011. Journal of Biotechnology, 154 (1) pp. 11-20.
[DOI][WoS][Pmid][serval:BIB_AF226AEC1E2D]
Nuclear factor I revealed as family of promoter binding transcription activators.
Pjanic M., Pjanic P., Schmid C., Ambrosini G., Gaussin A., Plasari G., Mazza C., Bucher P., Mermod N., 2011. BMC Genomics, 12 p. 181.
[URN][DOI][WoS][Pmid][serval:BIB_310D201A54E8]
Protein-Binding Microarray Analysis of Tumor Suppressor AP2α Target Gene Specificity.
Kerschgens J., Renaud S., Schütz F., Grasso L., Egener-Kuhn T., Delaloye J.F., Lehr H.A., Vogel H., Mermod N., 2011. Plos One, 6 (8) pp. e22895.
[URN][DOI][WoS][Pmid][serval:BIB_279EFB4814CA]
 
Use of human MAR elements to improve retroviral vector production.
Buceta M., Galbete J.L., Kostic C., Arsenijevic Y., Mermod N., 2011. Gene Therapy, 18 (1) pp. 7-13. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_970D20965719]
2010
 
Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling.
Plasari G., Edelmann S., Högger F., Dusserre Y., Mermod N., Calabrese A., 2010. Journal of Biological Chemistry, 285 (44) pp. 34115-34125. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D17A1AB4E7D7]
2009
 
Avoiding epigenetic variations in transgene expression with genetic insulators
Gaussin A., Duros C., Artus A., Auclair C., Cohen-Haguenauer O., Mermod N., 2009., Abstracts, Combined Meeting 2009, November 20-25, 2009, Hannover, Germany, Convention Center at Hannover Fairground XVIIth Annual Congress of the European Society of Gene and Cell Therapy, 16th Annual Meeting of the German Society of Gene Therapy, 4th Annual Congress of the German Society for Stem Cell Research, Co-organized by the European Branch of the International Society for Cellular Therapy pp. 1506-1506 dans ESGCT, DGGT, GSZ, and ISCT 2009 Poster Presentations, Human Gene Therapy. Peer-reviewed.
[DOI][WoS][serval:BIB_B4B957503854]
 
Characterization of insulators and barrier elements for gene therapy
Mermod N., 2009., Abstracts 8th Annual Meeting French Society of Cell and Gene Therapy, 21-23 June 2009, Faculté de Médecine de la Pitié-Salpêtrière, Paris, France pp. 658-658 dans SFTCG 2009 Invited Presentations, Human Gene Therapy. Peer-reviewed.
[DOI][serval:BIB_86FC6084DC0C]
 
Chromatin insulators and Prospective Application for gene Therapy.
Gaussin A., Mermod N., 2009. Gene Therapy Review pp. on line.
[serval:BIB_9404481E95ED]
 
Diagnosis of muscular dystrophies at the nanometer scale
Puttini S., Lekka M., Kuntzer T., Mermod N., Kulik A., 2009. pp. 544-545 dans 14th International Congress of the World Muscle Society, Neuromuscular Disorders. Peer-reviewed.
[DOI][WoS][serval:BIB_630867330092]
 
Directed integration of new insulated lentiviral vectors to heterochromatin towards safer gene transfer to stem cells
Artus A., Duros C., Botbol Y., Gaussin A., Mermod N., Lavigne M., Cohen-Haguenauer O., 2009., Abstracts, Combined Meeting 2009, November 20-25, 2009, Hannover, Germany, Convention Center at Hannover Fairground XVIIth Annual Congress of the European Society of Gene and Cell Therapy, 16th Annual Meeting of the German Society of Gene Therapy, 4th Annual Congress of the German Society for Stem Cell Research, Co-organized by the European Branch of the International Society for Cellular Therapy pp. 1502-1502 dans ESGCT, DGGT, GSZ, and ISCT 2009 Poster Presentations, Human Gene Therapy. Peer-reviewed.
[DOI][WoS][serval:BIB_0892D6FCDE62]
 
Gene-mediated restoration of normal myofiber elasticity in dystrophic muscles.
Puttini S., Lekka M., Dorchies O.M., Saugy D., Incitti T., Ruegg U.T., Bozzoni I., Kulik A.J., Mermod N., 2009. Molecular Therapy, 17 (1) pp. 19-25.
[DOI][WoS][Pmid][serval:BIB_C5F9F028FED0]
 
Insulated retroviral vectors towards safe and efficient genetic modification of stem cells
Duros C., Artus A., Auclair C., Gaussin A., Mermod N., Arock M., Schmidt M., Von Kalle C., Cohen-Haguenauer O. Y., 2009., Abstracts 8th Annual Meeting French Society of Cell and Gene Therapy, 21-23 June 2009, Faculté de Médecine de la Pitié-Salpêtrière ? Paris, France pp. 666-666 dans SFTCG 2009 Oral Presentations, Human Gene Therapy. Peer-reviewed.
[DOI][WoS][serval:BIB_4B131C9836F6]
 
MAR elements regulate the probability of epigenetic switching between active and inactive gene expression.
Galbete J.L., Buceta M., Mermod N., 2009. Molecular BioSystems, 5 (2) pp. 143-150.
[DOI][WoS][Pmid][serval:BIB_9506ADE3A90F]
Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family.
Escher P., Gouras P., Roduit R., Tiab L., Bolay S., Delarive T., Chen S., Tsai C.C., Hayashi M., Zernant J. et al., 2009. Human Mutation, 30 (3) pp. 342-351. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_07CD9A3E0C0E]
 
Novel insulated gamma and lentis retroviral vectors towards safer genetic modification of stem cells
Duros C., Artus A., Gaussin A., Scholtz S., Mermod N., Schmidt M., von Kalle C., Cohen-Haguenauer O., 2009., Abstracts, Combined Meeting 2009, November 20-25, 2009, Hannover, Germany, Convention Center at Hannover Fairground XVIIth Annual Congress of the European Society of Gene and Cell Therapy, 16th Annual Meeting of the German Society of Gene Therapy, 4th Annual Congress of the German Society for Stem Cell Research, Co-organized by the European Branch of the International Society for Cellular Therapy pp. 1505-1505 dans ESGCT, DGGT, GSZ, and ISCT 2009 Poster Presentations, Human Gene Therapy. Peer-reviewed.
[DOI][WoS][serval:BIB_F9F942D64015]
 
Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression.
Plasari G., Calabrese A., Dusserre Y., Gronostajski R.M., McNair A., Michalik L., Mermod N., 2009. Molecular and Cellular Biology, 29 (22) pp. 6006-6017. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_009622F1FEE9]
 
Protein-binding microarrays: probing disease markers at the interface of proteomics and genomics.
Kerschgens J., Egener-Kuhn T., Mermod N., 2009. Trends in Molecular Medicine, 15 (8) pp. 352-358.
[DOI][WoS][Pmid][serval:BIB_A3424A57C803]
 
Stochastic models and numerical algorithms for a class of regulatory gene networks.
Fournier T., Gabriel J.P., Pasquier J., Mazza C., Galbete J., Mermod N., 2009. Bulletin of Mathematical Biology, 71 (6) pp. 1394-1431.
[DOI][WoS][Pmid][serval:BIB_C2FE6E71EED8]
 
Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing.
Esnault G., Majocchi S., Martinet D., Besuchet-Schmutz N., Beckmann J.S., Mermod N., 2009. Molecular and Cellular Biology, 29 (9) pp. 2409-2418. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8EBBCF62537B]
 
Use of MAR elements to increase the production of recombinant proteins.
Gorman C., Arope S., Grandjean M., Girod P.-A., Mermod N., 2009. pp. 1-32 dans Al-Rubeai M. (eds.) Cell Line Development, Springer.
[DOI][serval:BIB_520610977E01]
2008
 
Sustained transgene expression using MAR elements.
Harraghy N., Gaussin A., Mermod N., 2008. Current Gene Therapy, 8 (5) pp. 353-366.
[DOI][WoS][Pmid][serval:BIB_B7D9B1ABC84D]
2007
Steady-state expression of self-regulated genes.
Fournier T., Gabriel J.P., Mazza C., Pasquier J., Galbete J.L., Mermod N., 2007/10. Bioinformatics, 23 (23) pp. 3185-3192.
[URN][DOI][WoS][Pmid][serval:BIB_32914927AA4F]
 
Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells.
Girod P.A., Nguyen D.Q., Calabrese D., Puttini S., Grandjean M., Martinet D., Regamey A., Saugy D., Beckmann J.S., Bucher P. et al., 2007/09. Nature Methods, 4 (9) pp. 747-753.
[DOI][WoS][Pmid][serval:BIB_FBEEC01204C1]
 
Genetic insulators and epigenetic variations in gene expression and regulation
Gaussin A., Esnault G., Mermod N., 2007. pp. 989-989 dans 15th Annual Congress of the European Society of Gene and Cell Therapy, Human Gene Therapy. Peer-reviewed.
[WoS][serval:BIB_47AEB0A890F8]
Statistical significance of quantitative PCR.
Karlen Y., McNair A., Perseguers S., Mazza C., Mermod N., 2007. Bmc Bioinformatics, 8 p. 131.
[URN][DOI][WoS][Pmid][serval:BIB_E8F1EE8FA614]
2006
 
Identification of peptide ligands to the chemokine receptor CCR5 and their maturation by gene shuffling.
Vyroubalova E.C., Hartley O., Mermod N., Fisch I., 2006/04. Molecular Immunology, 43 (10) pp. 1573-1578.
[DOI][WoS][Pmid][serval:BIB_40146D7DD41B]
Fast generation of high producer cho cell lines by an iterative transfection process
Girod P.A., Grandjean M., Calabrese D., Martinet D., Beckmann J., Mermod N., 2006. pp. S41 dans 4th Recombinant Protein Production Meeting, Microbial Cell Factories. Peer-reviewed.
[URN][DOI][serval:BIB_B2EC90518D2B]
2005
 
Use of the chicken lysozyme 5' matrix attachment region to generate high producer CHO cell lines.
Girod P.A., Zahn-Zabal M., Mermod N., 2005/07. Biotechnology and Bioengineering, 91 (1) pp. 1-11.
[DOI][WoS][Pmid][serval:BIB_358EDB26B6C3]
 
MAR elements as tools to increase protein production by CHO cells
Girod P.A., Zahn-Zabal M.M., Mermod N., 2005., Proceedings of the 18th ESACT Meeting Granada, Spain, May 11-14, 2003 pp. 411-415 dans Gòdia F., Fussenegger M. (eds.) Animal Cell Technology Meets Genomics., ESACT Proceedings, Springer.
[DOI][serval:BIB_4C16B97533D7]
Proof of concept for microarray-based detection of DNA-binding oncogenes in cell extracts.
Egener T., Roulet E., Zehnder M., Bucher P., Mermod N., 2005. Nucleic Acids Research, 33 (8) pp. e79.
[URN][DOI][WoS][Pmid][serval:BIB_B12289BE4F94]
 
Reversal of the silencing of tetracycline-controlled genes requires the coordinate action of distinctly acting transcription factors.
Pankiewicz R., Karlen Y., Imhof M.O., Mermod N., 2005/01. Journal of Gene Medicine, 7 (1) pp. 117-132.
[DOI][WoS][Pmid][serval:BIB_0CF2945FAA97]
 
Structure-function characterization and optimization of a plant-derived antibacterial peptide.
Suarez M., Haenni M., Canarelli S., Fisch F., Chodanowski P., Servis C., Michielin O., Freitag R., Moreillon P., Mermod N., 2005. Antimicrobial Agents and Chemotherapy, 49 (9) pp. 3847-3857.
[DOI][WoS][Pmid][serval:BIB_84A7DD08EC24]
2004
 
Chromatin domain boundaries delimited by a histone-binding protein in yeast.
Ferrari S., Simmen K.C., Dusserre Y., Müller K., Fourel G., Gilson E., Mermod N., 2004/12. Journal of Biological Chemistry, 279 (53) pp. 55520-55530.
[DOI][WoS][Pmid][serval:BIB_5062161CA23C]
 
Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression.
Tan N.S., Michalik L., Di-Poï N., Ng C.Y., Mermod N., Roberts A.B., Desvergne B., Wahli W., 2004. EMBO Journal, 23 (21) pp. 4211-4221. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C76B9D75FB34]
2003
 
Transcriptional activation of the utrophin promoter B by a constitutively active Ets-transcription factor.
Briguet A., Bleckmann D., Bettan M., Mermod N., Meier T., 2003/02. Neuromuscular Disorders, 13 (2) pp. 143-150.
[DOI][WoS][Pmid][serval:BIB_15A0BA693E7A]
 
Expression of a plant-derived peptide harboring water-cleaning and antimicrobial activities.
Suarez M., Entenza J.M., Doerries C., Meyer E., Bourquin L., Sutherland J., Marison I., Moreillon P., Mermod N., 2003. Biotechnology and Bioengineering, 81 (1) pp. 13-20.
[DOI][WoS][Pmid][serval:BIB_1432067B496B]
 
Use of scaffold/matrix-attachment regions for protein production
Girod P. A., Mermod N., 2003. pp. 359-379 dans Makrides S.C. (eds.) Gene transfer and expression in mammalian cells, Elsevier.
[DOI][serval:BIB_8DBA805FDC8A]
2002
 
Comparative study and identification of potent eukaryotic transcriptional repressors in gene switch systems.
Imhof M.O., Chatellard P., Mermod N., 2002. Journal of Biotechnology, 97 (3) pp. 275-285.
[DOI][WoS][Pmid][serval:BIB_2B92BDC0FC80]
 
Gene transfer : The ins, the outs... and the next generation.
Mermod N., Cornetta K.G., 2002. Current Opinion in Biotechnology, 13 (5) pp. 415-417. Peer-reviewed.
[DOI][WoS][serval:BIB_24442]
 
High-throughput SELEX SAGE method for quantitative modeling of transcription-factor binding sites.
Roulet E., Busso S., Camargo A.A., Simpson A.J., Mermod N., Bucher P., 2002. Nature Biotechnology, 20 (8) pp. 831-835.
[DOI][WoS][Pmid][serval:BIB_AD8B977B18DC]
2001
 
Development of stable cell lines for production or regulated expression using matrix attachment regions.
Zahn-Zabal M., Kobr M., Girod P.A., Imhof M., Chatellard P., de Jesus M., Wurm F., Mermod N., 2001/04. Journal of Biotechnology, 87 (1) pp. 29-42.
[DOI][WoS][Pmid][serval:BIB_D9E7557AD0B6]
 
An activation-independent role of transcription factors in insulator function.
Fourel G., Boscheron C., Revardel E., Lebrun E., Hu Y.F., Simmen K.C., Müller K., Li R., Mermod N., Gilson E., 2001/02. EMBO Reports, 2 (2) pp. 124-132.
[DOI][WoS][Pmid][serval:BIB_1A97071D237A]
 
Upregulation of vasopressin V1A receptor mRNA and protein in vascular smooth muscle cells following cyclosporin A treatment.
Cottet-Maire F., Avdonin P.V., Roulet E., Buetler T.M., Mermod N., Ruegg U.T., 2001/02. British Journal of Pharmacology, 132 (4) pp. 909-917.
[DOI][WoS][Pmid][serval:BIB_65329ADDB8A9]
2000
 
A regulatory network for the efficient control of transgene expression.
Imhof M.O., Chatellard P., Mermod N., 2000. The Journal of Gene Medicine, 2 (2) pp. 107-116.
[DOI][WoS][Pmid][serval:BIB_16522]
 
CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display.
Miescher S., Zahn-Zabal M., De Jesus M., Moudry R., Fisch I., Vogel M., Kobr M., Imboden M.A., Kragten E., Bichler J. et al., 2000. British Journal of Haematology, 111 (1) pp. 157-166.
[DOI][WoS][Pmid][serval:BIB_16540]
 
Experimental analysis and computer prediction of CTF/NFI transcription factor DNA binding sites.
Roulet E., Bucher P., Schneider R., Wingender E., Dusserre Y., Werner T., Mermod N., 2000. Journal of Molecular Biology, 297 (4) pp. 833-848.
[DOI][WoS][Pmid][serval:BIB_C0A73F212EB6]
 
The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo.
Müller K., Mermod N., 2000. Journal of Biological Chemistry, 275 (3) pp. 1645-1650.
[DOI][WoS][Pmid][serval:BIB_EA36FD9A7818]
1999
 
An autoregulatory loop controlling CYP1A1 gene expression: role of H(2)O(2) and NFI.
Morel Y., Mermod N., Barouki R., 1999. Molecular and Cellular Biology, 19 (10) pp. 6825-6832.
[WoS][Pmid][serval:BIB_49F672210DC6]
 
Biotechnology in Lausanne: the Rh D project.
Von Stockar U., Kragten E., Marison I.W., Amstutz H., Miescher S., Fisch I., Mermod N., DeJesus M., Freitag R., Wurm F., 1999. Chimia, 53 (11) pp. 554-557. Peer-reviewed.
[WoS][serval:BIB_F58EC427315F]
 
Matrix attachment regions in stable CHO cell line development.
Zahn, M., , Kobr M., Mermod N, 1999. pp. 79-81 dans Bernard A., Griffiths B., Noé W., Wurm F. (eds.) Animal cell technology: products from cells, cells as products, Kluwer.
[DOI][serval:BIB_32B7EC74862B]
 
The SPP Biotech Module 1: Proteins for medical applications. A multidisciplinary effort for the development of a recombinant anti-RHD antibody preparation for the prevention of the hemolytic disease of the newborn.
Amstutz H., Miescher S., Moudry R., Desjardin S., Imboden M., Morgenthaler J.J., Zahn M., Kobr M., Fisch I., Corthésy B. et al., 1999., Proceedings of the 16th ESACT Meeting, April 25-29, 1999, Lugano, Switzerland pp. 455-458 dans Bernard A., Griffiths B., Noé W., Wurm F. (eds.) Animal cell technology: products from cells, cells as products, Kluwer Academic Publishing.
[serval:BIB_12395]
1998
 
Evaluation of computer tools for the prediction of transcription factor binding sites on genomic DNA.
Roulet E., Fisch I., Junier T., Bucher P., Mermod N., 1998. In Silico Biology, 1 (1) pp. 21-28.
[Pmid][serval:BIB_5CD24CAB3E09]
 
Micro-patterning of biomolecules on polymer substrates.
Schwarz A., Rossier J.S., Roulet E., Mermod N., Roberts M.A., Girault H.H., 1998. Langmuir, 14 (19) pp. 5526-5531.
[DOI][WoS][serval:BIB_76E6DB210730]
1997
 
Transforming growth factor-beta: the breaking open of a black box.
Alevizopoulos A., Mermod N., 1997/07. Bioessays, 19 (7) pp. 581-591.
[DOI][WoS][Pmid][serval:BIB_5B8C3494D769]
 
Regulation of the transforming growth factor beta-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV.
Alevizopoulos A., Dusserre Y., Rüegg U., Mermod N., 1997. Journal of Biological Chemistry, 272 (38) pp. 23597-23605.
[DOI][WoS][Pmid][serval:BIB_E7C9944DB328]
1996
 
Antagonistic regulation of a proline-rich transcription factor by transforming growth factor beta and tumor necrosis factor alpha.
Alevizopoulos A., Mermod N., 1996. Journal of Biological Chemistry, 271 (47) pp. 29672-29681.
[DOI][WoS][Pmid][serval:BIB_E2798EDB2860]
1995
 
A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.
Alevizopoulos A., Dusserre Y., Tsai-Pflugfelder M., von der Weid T., Wahli W., Mermod N., 1995/12. Genes and Development, 9 (24) pp. 3051-3066.
[DOI][WoS][Pmid][serval:BIB_2CB9DB552536]
 
Regulation of the DNA-binding and transcriptional activities of Xenopus laevis NFI-X by a novel C-terminal domain.
Roulet E., Armentero M.T., Krey G., Corthésy B., Dreyer C., Mermod N., Wahli W., 1995/10. Molecular and Cellular Biology, 15 (10) pp. 5552-5562.
[WoS][Pmid][serval:BIB_2645C08A982D]
1994
 
Targeting of DNA polymerase to the adenovirus origin of DNA replication by interaction with nuclear factor I.
Armentero M.T., Horwitz M., Mermod N., 1994/11. Proceedings of the National Academy of Sciences of the United States of America, 91 (24) pp. 11537-11541.
[DOI][WoS][Pmid][serval:BIB_6DFE18C8C6DE]
 
Post-transcriptional down-regulation of expression of transcription factor NF1 by Ha-ras oncogene.
Nebl G., Mermod N., Cato A.C., 1994/03. Journal of Biological Chemistry, 269 (10) pp. 7371-7378.
[WoS][Pmid][serval:BIB_9BC9FD2E9F86]
1993
 
Purified cofactors and histone H1 mediate transcription regulation by CTF/NF-I.
Dusserre Y., Mermod N., 1993/06. Annals of the New York Academy of Sciences, 684 pp. 230-232.
[DOI][Pmid][serval:BIB_4D361EA7489A]
1992
 
Purified cofactors and histone H1 mediate transcriptional regulation by CTF/NF-I.
Dusserre Y., Mermod N., 1992/11. Molecular and Cellular Biology, 12 (11) pp. 5228-5237.
[WoS][Pmid][serval:BIB_08E98598BD75]
1991
 
A pancreatic exocrine cell factor and AP4 bind overlapping sites in the amylase 2A enhancer.
Fodor E., Weinrich S.L., Meister A., Mermod N., Rutter W.J., 1991/08. Biochemistry, 30 (33) pp. 8102-8108.
[DOI][WoS][Pmid][serval:BIB_785D226CE52F]
 
Synergistic transcriptional activation by CTF/NF-I and the estrogen receptor involves stabilized interactions with a limiting target factor.
Martinez E., Dusserre Y., Wahli W., Mermod N., 1991/06. Molecular and Cellular Biology, 11 (6) pp. 2937-2945.
[WoS][Pmid][serval:BIB_BD22DD3F60F6]
1990
 
Protein-protein interactions between adenovirus DNA polymerase and nuclear factor I mediate formation of the DNA replication preinitiation complex.
Chen M., Mermod N., Horwitz M.S., 1990/10. Journal of Biological Chemistry, 265 (30) pp. 18634-18642.
[WoS][Pmid][serval:BIB_A978D0D0A91A]
 
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.
Hu Y.F., Lüscher B., Admon A., Mermod N., Tjian R., 1990/10. Genes and Development, 4 (10) pp. 1741-1752.
[DOI][WoS][Pmid][serval:BIB_52019A23F870]
 
Commentary
Mermod N., 1990. The Scientist, 4 p. 17.
[serval:BIB_0A08872CA29E]
1989
 
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.
Mermod N., O'Neill E.A., Kelly T.J., Tjian R., 1989/08. Cell, 58 (4) pp. 741-753.
[DOI][WoS][Pmid][serval:BIB_BBED813F1F73]
1988
 
Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.
Comb M., Mermod N., Hyman S.E., Pearlberg J., Ross M.E., Goodman H.M., 1988/12. EMBO Journal, 7 (12) pp. 3793-3805.
[WoS][Pmid][serval:BIB_B82BB713892E]
 
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
Santoro C., Mermod N., Andrews P.C., Tjian R., 1988/07. Nature, 334 (6179) pp. 218-224.
[DOI][WoS][Pmid][serval:BIB_E8124AD8E29E]
 
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro.
Mermod N., Williams T.J., Tjian R., 1988/04. Nature, 332 (6164) pp. 557-561.
[DOI][WoS][Pmid][serval:BIB_7655E361D7D5]
 
Regulation of gene expression by interferons: control of H-2 promoter responses.
Korber B., Mermod N., Hood L., Stroynowski I., 1988/03. Science, 239 (4845) pp. 1302-1306.
[DOI][WoS][Pmid][serval:BIB_3662EA5CBC21]
1987
 
Regulatory circuits controlling transcription of TOL plasmid operon encoding meta-cleavage pathway for degradation of alkylbenzoates by Pseudomonas.
Ramos J.L., Mermod N., Timmis K.N., 1987/11. Molecular Microbiology, 1 (1) pp. 293-300.
[DOI][WoS][Pmid][serval:BIB_AF58F444A992]
 
The xylS gene positive regulator of TOL plasmid pWWO: identification, sequence analysis and overproduction leading to constitutive expression of meta cleavage operon.
Mermod N., Ramos J.L., Bairoch A., Timmis K.N., 1987/05. Molecular and General Genetics, 207 (2-3) pp. 349-354.
[DOI][WoS][Pmid][serval:BIB_0933BCDF3B43]
 
Roles of the divergent branches of the meta-cleavage pathway in the degradation of benzoate and substituted benzoates.
Harayama S., Mermod N., Rekik M., Lehrbach P.R., Timmis K.N., 1987/02. Journal of Bacteriology, 169 (2) pp. 558-564.
[WoS][Pmid][serval:BIB_5378A80C60A1]
 
Genetic manipulation of catabolic pathways of Pseudomonas.
Mermod N., Ramos R.L., Harayama S., Engesser K.H., Knackmuss H.-J., Timmis K.N., 1987. Dechema-Monographien, 105 pp. 163-178.
[serval:BIB_95891E2A952C]
1986
 
Gene order of the TOL catabolic plasmid upper pathway operon and oxidation of both toluene and benzyl alcohol by the xylA product.
Harayama S., Leppik R.A., Rekik M., Mermod N., Lehrbach P.R., Reineke W., Timmis K.N., 1986/08. Journal of Bacteriology, 167 (2) pp. 455-461.
[WoS][Pmid][serval:BIB_15B663716FD8]
 
Vector for regulated expression of cloned genes in a wide range of gram-negative bacteria.
Mermod N., Ramos J.L., Lehrbach P.R., Timmis K.N., 1986/08. Journal of Bacteriology, 167 (2) pp. 447-454.
[WoS][Pmid][serval:BIB_907749AD608E]
 
Gene cloning and manipulation in Pseudomonas.
Mermod N., Lehrbach P.R., Don R.H., Timmis K.N., 1986. pp. 325-355 dans Sokatch J.R. (eds.) The biology of Pseudomonas, Academic Press.
[serval:BIB_F03720B5E7A8]
 
New route to bacterial production of indigo.
Mermod N., Harayama S., Timmis K.N., 1986. Nature Biotechnology, 4 pp. 321-324. Peer-reviewed.
[DOI][WoS][serval:BIB_06843D3B1A03]
1985
 
Analysis and manipulation of plasmid encoded pathways for the catabolism of aromatic compounds by soil bacteria.
Timmis K.N., Lehrbach P.R., Harayama S., Don R.H., Mermod N., Bas S., Leppik R., Weightman A.J., Reineke W., Knackmuss H.-J., 1985. pp. 719-739 dans Helinski D.R., Cohen S.N., Clewell D B., Jackson D.A., Hollaender A. (eds.) Plasmids in bacteria, Plenum Press.
[serval:BIB_1481B5C4CB4A]
1984
 
Transcription of the TOL plasmid toluate catabolic pathway operon of Pseudomonas putida is determined by a pair of co-ordinately and positively regulated overlapping promoters.
Mermod N., Lehrbach P.R., Reineke W., Timmis K.N., 1984/11. EMBO Journal, 3 (11) pp. 2461-2466.
[WoS][Pmid][serval:BIB_18B4634A4ABE]
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