Manuele Rebsamen

Publications | Mémoires et thèses

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32 publications

2025 | 2023 | 2022 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 |
2025
CCDC134 controls TLR biogenesis through the ER chaperone Gp96
Bernaleau Léa, Drobek Michaela, Blank Fenja, Walch Philipp, Delacrétaz Maeva, Drobek Ales, Monguió-Tortajada Marta, Broz Petr, Majer Olivia, Rebsamen Manuele, 2025/03/03. Journal of Experimental Medicine, 222 (3). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_02463DF581EB]
The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse.
Drobek A., Bernaleau L., Delacrétaz M., Calderon Copete S., Royer-Chardon C., Longepierre M., Monguió-Tortajada M., Korzeniowski J., Rotman S., Marquis J. et al., 2025/01/24. Nature communications, 16 (1) p. 967. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_5CCF71D82E31]
2023
A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
Boeszoermenyi Andras, Bernaleau Léa, Chen Xudong, Kartnig Felix, Xie Min, Zhang Haobo, Zhang Sensen, Delacrétaz Maeva, Koren Anna, Hopp Ann-Katrin et al., 2023/10/20. Nature Communications, 14 (1). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_829247FD8455]
Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
Chen Xudong, Xie Min, Zhang Sensen, Monguió-Tortajada Marta, Yin Jian, Liu Chang, Zhang Youqi, Delacrétaz Maeva, Song Mingyue, Wang Yixue et al., 2023/10/20. Nature Communications, 14 (1). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_DEFB75963887]
SLC15A4 controls endolysosomal TLR7–9 responses by recruiting the innate immune adaptor TASL
Zhang Haobo, Bernaleau Léa, Delacrétaz Maeva, Hasanovic Ed, Drobek Ales, Eibel Hermann, Rebsamen Manuele, 2023/08. Cell Reports, 42 (8) p. 112916. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D9B6F053E4A5]
SLC15A4 controls endolysosomal TLR7-9 responses by recruiting the innate immune adaptor TASL
Haobo Zhang, Léa Bernaleau, Maeva Delacrétaz, Ed Hasanovic, Hermann Eibel, Manuele Rebsamen, 2023/03/27..
[URN][DOI][serval:BIB_DE91D1D2BC15]
2022
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions.
Rebsamen M., Girardi E., Sedlyarov V., Scorzoni S., Papakostas K., Vollert M., Konecka J., Guertl B., Klavins K., Wiedmer T. et al., 2022/11. Life science alliance, 5 (11) pp. e202201404. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_ECC63CD3FA4B]
2020
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import.
Girardi E., Agrimi G., Goldmann U., Fiume G., Lindinger S., Sedlyarov V., Srndic I., Gürtl B., Agerer B., Kartnig F. et al., 2020/12/01. Nature communications, 11 (1) p. 6145. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_75C6C477E13D]
A substrate-based ontology for human solute carriers.
Meixner E., Goldmann U., Sedlyarov V., Scorzoni S., Rebsamen M., Girardi E., Superti-Furga G., 2020/07. Molecular systems biology, 16 (7) pp. e9652. Peer-reviewed.
[DOI][Pmid][serval:BIB_A5649B056C99]
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
Heinz L.X., Lee J., Kapoor U., Kartnig F., Sedlyarov V., Papakostas K., César-Razquin A., Essletzbichler P., Goldmann U., Stefanovic A. et al., 2020/05. Nature, 581 (7808) pp. 316-322. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E5CFC01382DB]
2019
 
Insights into the transport side of the human SLC38A9 transceptor.
Scalise M., Galluccio M., Pochini L., Cosco J., Trotta M., Rebsamen M., Superti-Furga G., Indiveri C., 2019/09/01. Biochimica et biophysica acta. Biomembranes, 1861 (9) pp. 1558-1567. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5CE1146D9723]
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.
Fauster A., Rebsamen M., Willmann K.L., César-Razquin A., Girardi E., Bigenzahn J.W., Schischlik F., Scorzoni S., Bruckner M., Konecka J. et al., 2019/06. Cell Death and Differentiation.
[DOI][WoS][Pmid][serval:BIB_739507C7DF9E]
2018
LZTR1 is a regulator of RAS ubiquitination and signaling
Bigenzahn Johannes W., Collu Giovanna M., Kartnig Felix, Pieraks Melanie, Vladimer Gregory I., Heinz Leonhard X., Sedlyarov Vitaly, Schischlik Fiorella, Fauster Astrid, Rebsamen Manuele et al., 2018/12/07. Science, 362 (6419) pp. 1171-1177.
[DOI][WoS][Pmid][serval:BIB_58BEABE1C7DC]
 
The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.
Sedlyarov V., Eichner R., Girardi E., Essletzbichler P., Goldmann U., Nunes-Hasler P., Srndic I., Moskovskich A., Heinz L.X., Kartnig F. et al., 2018/06/13. Cell host & microbe, 23 (6) pp. 766-774.e5. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2F9360B2E685]
2017
 
LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
Filipek Przemyslaw A., de Araujo Mariana E.G., Vogel Georg F., De Smet Cedric H., Eberharter Daniela, Rebsamen Manuele, Rudashevskaya Elena L., Kremser Leopold, Yordanov Teodor, Tschaikner Philipp et al., 2017/12/04. Journal of Cell Biology, 216 (12) pp. 4199-4215.
[DOI][WoS][Pmid][serval:BIB_61EFA5CA28A1]
2016
 
SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1
Rebsamen Manuele, Superti-Furga Giulio, 2016/06/02. Autophagy, 12 (6) pp. 1061-1062.
[DOI][WoS][Pmid][serval:BIB_65B391F2384C]
 
An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.
Bigenzahn J.W., Fauster A., Rebsamen M., Kandasamy R.K., Scorzoni S., Vladimer G.I., Müller A.C., Gstaiger M., Zuber J., Bennett K.L. et al., 2016/03. Molecular & cellular proteomics, 15 (3) pp. 1139-1150. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5EACE3AC18B6]
 
A time-resolved molecular map of the macrophage response to VSV infection.
Kandasamy R.K., Vladimer G.I., Snijder B., Müller A.C., Rebsamen M., Bigenzahn J.W., Moskovskich A., Sabler M., Stefanovic A., Scorzoni S. et al., 2016. NPJ systems biology and applications, 2 p. 16027. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D844CBF75620]
2015
 
Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
Dixon Scott J., Winter Georg E., Musavi Leila S., Lee Eric D., Snijder Berend, Rebsamen Manuele, Superti-Furga Giulio, Stockwell Brent R., 2015/07/17. ACS Chemical Biology, 10 (7) pp. 1604-1609.
[DOI][WoS][Pmid][serval:BIB_1112E7122FDB]
 
The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
Heinz Leonhard X., Baumann Christoph L., Köberlin Marielle S., Snijder Berend, Gawish Riem, Shui Guanghou, Sharif Omar, Aspalter Irene M., Müller André C., Kandasamy Richard K. et al., 2015/06. Cell Reports, 11 (12) pp. 1919-1928.
[DOI][WoS][Pmid][serval:BIB_B82126216D8E]
 
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
Fauster A, Rebsamen M, Huber K V M, Bigenzahn J W, Stukalov A, Lardeau C-H, Scorzoni S, Bruckner M, Gridling M, Parapatics K et al., 2015/05. Cell Death & Disease, 6 (5) pp. e1767-e1767.
[DOI][WoS][Pmid][serval:BIB_2468215DE9E7]
 
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
Rebsamen Manuele, Pochini Lorena, Stasyk Taras, de Araújo Mariana E. G., Galluccio Michele, Kandasamy Richard K., Snijder Berend, Fauster Astrid, Rudashevskaya Elena L., Bruckner Manuela et al., 2015/03. Nature, 519 (7544) pp. 477-481.
[DOI][WoS][Pmid][serval:BIB_049EFC893637]
2013
 
Protein interaction networks in innate immunity.
Rebsamen M., Kandasamy R.K., Superti-Furga G., 2013/12. Trends in immunology, 34 (12) pp. 610-619. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2775A69447A8]
 
A reversible gene trap collection empowers haploid genetics in human cells.
Bürckstümmer T., Banning C., Hainzl P., Schobesberger R., Kerzendorfer C., Pauler F.M., Chen D., Them N., Schischlik F., Rebsamen M. et al., 2013/10. Nature methods, 10 (10) pp. 965-971. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A2D837180513]
2012
 
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.
Staehli F., Ludigs K., Heinz L.X., Seguín-Estévez Q., Ferrero I., Braun M., Schroder K., Rebsamen M., Tardivel A., Mattmann C. et al., 2012. Journal of Immunology, 188 (8) pp. 3820-3828.
[DOI][WoS][Pmid][serval:BIB_98F298ABDC3E]
 
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
Heinz L.X., Rebsamen M., Rossi D.C., Staehli F., Schroder K., Quadroni M., Gross O., Schneider P., Tschopp J., 2012. Cell Death and Differentiation, 19 (4) pp. 722-731.
[DOI][WoS][Pmid][serval:BIB_7138FF5142AF]
2011
 
NLRX1/NOD5 deficiency does not affect MAVS signalling.
Rebsamen M., Vazquez J., Tardivel A., Guarda G., Curran J., Tschopp J., 2011. Cell Death and Differentiation, 18 (8) p. 1387.
[DOI][WoS][Pmid][serval:BIB_759AC6AE4779]
2010
 
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Poeck H., Bscheider M., Gross O., Finger K., Roth S., Rebsamen M., Hannesschläger N., Schlee M., Rothenfusser S., Barchet W. et al., 2010. Nature Immunology, 11 (1) pp. 63-69. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0B371CFE3C3D]
 
Viruses under the control of RIP kinases.
Rebsamen M., Tschopp J., 2010. Cell Cycle, 9 (3) pp. 438-439. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3D7EB56B6A3F]
2009
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Rebsamen M., Heinz L.X., Meylan E., Michallet M.C., Schroder K., Hofmann K., Vazquez J., Benedict C.A., Tschopp J., 2009. EMBO reports, 10 (8) pp. 916-922. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_98489985CB9E]
2008
 
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Rebsamen M., Meylan E., Curran J., Tschopp J., 2008/11. Cell death and differentiation, 15 (11) pp. 1804-1811. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_65E4DCA6F4DB]
 
TRADD protein is an essential component of the RIG-like helicase antiviral pathway
Michallet M. C., Meylan E., Ermolaeva M. A., Vazquez J., Rebsamen M., Curran J., Poeck H., Bscheider M., Hartmann G., Konig M. et al., 2008. Immunity, 28 (5) pp. 651-661. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_349C12B082E1]
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