Lukas Flatz

Publications | Mémoires et thèses

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17 publications

2018 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 |
Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation.
Hartwig T., Zwicky P., Schreiner B., Yawalkar N., Cheng P., Navarini A., Dummer R., Flatz L., Conrad C., Schlapbach C. et al., 2018/12/26. Cell reports, 25 (13) pp. 3564-3572.e4. Peer-reviewed.
Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection.
Johnson S., Bergthaler A., Graw F., Flatz L., Bonilla W.V., Siegrist C.A., Lambert P.H., Regoes R.R., Pinschewer D.D., 2015. Journal of Immunology, 194 (4) pp. 1755-1762. Peer-reviewed.
 
Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation.
Roychoudhuri R., Lefebvre F., Honda M., Pan L., Ji Y., Klebanoff C.A., Nichols C.N., Fourati S., Hegazy A.N., Goulet J.P. et al., 2015. Vaccine, 33 (7) pp. 914-923. Peer-reviewed.
 
Cancer immunotherapy drives implementation science in oncology.
Speiser D.E., Flatz L., 2014. Human Vaccines and Immunotherapeutics, 10 (11) pp. 3107-3110.
 
Evolution of Recombinant Lymphocytic Choriomeningitis Virus/Lassa Virus In Vivo Highlights the Importance of the GPC Cytosolic Tail in Viral Fitness
Sommerstein R., Ramos da Palma J., Ölschläger S., Bergthaler A., Barba L., Lee B.P.L., Pasquato A., Flatz L., 2014. Journal of Virology, 88 (15) pp. 8340-8348. Peer-reviewed.
 
Anti-TNF Therapy in the Treatment of Psoriasis in a Patient with Acute-on-Chronic Pancreatitis.
Clayton H., Flatz L., Vollenweider-Roten S., Schoepfer A., Gilliet M., Conrad C., 2013. Dermatology, 227 (3) pp. 193-196.
Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
Flatz L., Conrad C., 2013. Psoriasis: Targets and Therapy, 3 pp. 1-10.
Vaccination Strategies against Highly Pathogenic Arenaviruses: The Next Steps toward Clinical Trials.
Olschläger S., Flatz L., 2013. Plos Pathogens, 9 (4) pp. e1003212.
 
Sensitive and rapid detection of ganciclovir resistance by PCR based MALDI-TOF analysis.
Zürcher S., Mooser C., Lüthi A.U., Mühlemann K., Barbani M.T., Mohacsi P., Garzoni C., Gorgievski-Hrisoho M., Schaller A., Flatz L., 2012. Journal of Clinical Virology, 54 (4) pp. 359-363.
 
Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function.
Kerber R., Rieger T., Busch C., Flatz L., Pinschewer D.D., Kümmerer B.M., Günther S., 2011. Journal of Virology, 85 (23) pp. 12518-12528.
 
Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines.
Flatz L., Roychoudhuri R., Honda M., Filali-Mouhim A., Goulet J.P., Kettaf N., Lin M., Roederer M., Haddad E.K., Sékaly R.P. et al., 2011. Proceedings of the National Academy of Sciences of the United States of America, 108 (14) pp. 5724-5729.
 
Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity.
Flatz L., Hegazy A.N., Bergthaler A., Verschoor A., Claus C., Fernandez M., Gattinoni L., Johnson S., Kreppel F., Kochanek S. et al., 2010. Nature Medicine, 16 (3) pp. 339-345.
 
Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes.
Pinschewer D.D., Flatz L., Steinborn R., Horvath E., Fernandez M., Lutz H., Suter M., Bergthaler A., 2010. International Immunology, 22 (9) pp. 749-756.
 
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.
Hegazy A.N., Peine M., Helmstetter C., Panse I., Fröhlich A., Bergthaler A., Flatz L., Pinschewer D.D., Radbruch A., Löhning M., 2010. Immunity, 32 (1) pp. 116-128.
 
T cell-dependence of Lassa fever pathogenesis.
Flatz L., Rieger T., Merkler D., Bergthaler A., Regen T., Schedensack M., Bestmann L., Verschoor A., Kreutzfeldt M., Brück W. et al., 2010. Plos Pathogens, 6 (3) pp. e1000836.
 
Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression.
Bergthaler A., Flatz L., Hegazy A.N., Johnson S., Horvath E., Löhning M., Pinschewer D.D., 2010. Proceedings of the National Academy of Sciences of the United States of America, 107 (50) pp. 21641-21646.
 
Impaired antibody response causes persistence of prototypic T cell-contained virus.
Bergthaler A., Flatz L., Verschoor A., Hegazy A.N., Holdener M., Fink K., Eschli B., Merkler D., Sommerstein R., Horvath E. et al., 2009. Plos Biology, 7 (4) pp. e1000080.
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