Jean-Yves Chatton

Publications | Mémoires et thèses

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82 publications

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The lactate receptor HCAR1: A key modulator of epileptic seizure activity
Alessandri Maxime, Osorio-Forero Alejandro, Lüthi Anita, Chatton Jean-Yves, 2024/05. iScience, 27 (5) p. 109679.
Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer's disease.
Crivelli S.M., Gaifullina A., Chatton J.Y., 2024. Frontiers in neuroscience, 18 p. 1483708. Peer-reviewed.
Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
Rosenberg N., Reva M., Binda F., Restivo L., Depierre P., Puyal J., Briquet M., Bernardinelli Y., Rocher A.B., Markram H. et al., 2023/04. Glia, 71 (4) pp. 957-973. Peer-reviewed.
Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach.
Strefeler A., Jan M., Quadroni M., Teav T., Rosenberg N., Chatton J.Y., Guex N., Gallart-Ayala H., Ivanisevic J., 2023/01/09. Alzheimer's research & therapy, 15 (1) p. 8. Peer-reviewed.
 
Mitochondria morphometry in 3D datasets obtained from mouse brains with serial block-face scanning electron microscopy
Jiao Wei, Chatton Jean-Yves, Genoud Christel, 2023. pp. 197-211 dans Volume Electron Microscopy, Elsevier.
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.
Briquet M., Rocher A.B., Alessandri M., Rosenberg N., de Castro Abrantes H., Wellbourne-Wood J., Schmuziger C., Ginet V., Puyal J., Pralong E. et al., 2022/09. Journal of cerebral blood flow and metabolism, 42 (9) pp. 1650-1665. Peer-reviewed.
Lactate Neuroprotection against Transient Ischemic Brain Injury in Mice Appears Independent of HCAR1 Activation.
Buscemi L., Price M., Castillo-González J., Chatton J.Y., Hirt L., 2022/05/21. Metabolites, 12 (5) p. 465. Peer-reviewed.
Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors.
Wellbourne-Wood J., Briquet M., Alessandri M., Binda F., Touya M., Chatton J.Y., 2022/02/25. Biosensors, 12 (3) p. 142. Peer-reviewed.
Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS.
van der Velpen V., Rosenberg N., Maillard V., Teav T., Chatton J.Y., Gallart-Ayala H., Ivanisevic J., 2021/10. Journal of neurochemistry, 159 (2) pp. 378-388. Peer-reviewed.
 
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
Wahis J., Baudon A., Althammer F., Kerspern D., Goyon S., Hagiwara D., Lefevre A., Barteczko L., Boury-Jamot B., Bellanger B. et al., 2021/04. Nature Neuroscience, 24 (4) pp. 529-541. Peer-reviewed.
 
Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster.
Paglione M., Rosell A.L., Chatton J.Y., Neukomm L.J., 2020/03/16. Journal of visualized experiments 157. Peer-reviewed.
The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G<sub>α</sub> and G<sub>βγ</sub> Subunits.
de Castro Abrantes H., Briquet M., Schmuziger C., Restivo L., Puyal J., Rosenberg N., Rocher A.B., Offermanns S., Chatton J.Y., 2019/06/05. The Journal of neuroscience, 39 (23) pp. 4422-4433. Peer-reviewed.
Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures.
Merienne N., Meunier C., Schneider A., Seguin J., Nair S.S., Rocher A.B., Le Gras S., Keime C., Faull R., Pellerin L. et al., 2019/02/26. Cell reports, 26 (9) pp. 2477-2493.e9. Peer-reviewed.
Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes.
Rimmele T.S., de Castro Abrantes H., Wellbourne-Wood J., Lengacher S., Chatton J.Y., 2018/08/15. ACS chemical neuroscience, 9 (8) pp. 2009-2015. Peer-reviewed.
From Cultured Rodent Neurons to Human Brain Tissue: Model Systems for Pharmacological and Translational Neuroscience.
Wellbourne-Wood J., Chatton J.Y., 2018/08/15. ACS chemical neuroscience, 9 (8) pp. 1975-1985. Peer-reviewed.
Control of Glutamate Transport by Extracellular Potassium: Basis for a Negative Feedback on Synaptic Transmission.
Rimmele T.S., Rocher A.B., Wellbourne-Wood J., Chatton J.Y., 2017/06/01. Cerebral cortex, 27 (6) pp. 3272-3283. Peer-reviewed.
Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep.
Lecci S., Fernandez L.M., Weber F.D., Cardis R., Chatton J.Y., Born J., Lüthi A., 2017/02. Science advances, 3 (2) pp. e1602026. Peer-reviewed.
Imaging extracellular potassium dynamics in brain tissue using a potassium-sensitive nanosensor.
Wellbourne-Wood J., Rimmele T.S., Chatton J.Y., 2017. Neurophotonics, 4 (1) p. 015002. Peer-reviewed.
Sodium signaling and astrocyte energy metabolism.
Chatton J.Y., Magistretti P.J., Barros L.F., 2016/10. Glia, 64 (10) pp. 1667-1676. Peer-reviewed.
Astrocyte sodium signaling and neuro-metabolic coupling in the brain.
Rose C.R., Chatton J.Y., 2016. Neuroscience, 323 pp. 121-134. Peer-reviewed.
Ionic Homeostasis in Glia: A Fluorescence Microscopy Approach☆
Chatton J.Y., 2015. dans Reference Module in Biomedical Sciences, Elsevier.
A novel optical intracellular imaging approach for potassium dynamics in astrocytes.
Rimmele T.S., Chatton J.Y., 2014. Plos One, 9 (10) pp. e109243. Peer-reviewed.
Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival.
Perreten Lambert H., Zenger M., Azarias G., Chatton J.Y., Magistretti P.J., Lengacher S., 2014. Journal of Biological Chemistry, 289 (45) pp. 31014-31028. Peer-reviewed.
Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression.
Vallois D., Niederhäuser G., Ibberson M., Nagaray V., Marselli L., Marchetti P., Chatton J.Y., Thorens B., 2014. PLoS One, 9 (7) pp. e103277.
Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion.
Lamy C.M., Sanno H., Labouèbe G., Picard A., Magnan C., Chatton J.Y., Thorens B., 2014. Cell Metabolism, 19 (3) pp. 527-538. Peer-reviewed.
Lactate modulates the activity of primary cortical neurons through a receptor-mediated pathway.
Bozzo L., Puyal J., Chatton J.Y., 2013. PLoS One, 8 (8) pp. e71721. Peer-reviewed.
 
HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking.
Pétremand J., Puyal J., Chatton J.Y., Duprez J., Allagnat F., Frias M., James R.W., Waeber G., Jonas J.C., Widmann C., 2012. Diabetes, 61 (5) pp. 1100-1111.
Sodium sensing in neurons with a dendrimer-based nanoprobe.
Lamy C.M., Sallin O., Loussert C., Chatton J.Y., 2012. ACS Nano, 6 (2) pp. 1176-1187. Peer-reviewed.
Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold.
Wimmer R.D., Astori S., Bond C.T., Rovó Z., Chatton J.Y., Adelman J.P., Franken P., Lüthi A., 2012. Journal of Neuroscience, 32 (40) pp. 13917-13928. Peer-reviewed.
Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes.
Azarias G., Perreten H., Lengacher S., Poburko D., Demaurex N., Magistretti P.J., Chatton J.Y., 2011. Journal of Neuroscience, 31 (10) pp. 3550-3559. Peer-reviewed.
Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.
Pasqual G., Rojek J.M., Masin M., Chatton J.Y., Kunz S., 2011. Plos Pathogens, 7 (9) pp. e1002232.
Optical probing of sodium dynamics in neurons and astrocytes.
Lamy C.M., Chatton J.Y., 2011. Neuroimage, 58 (2) pp. 572-578. Peer-reviewed.
Selective ion changes during spontaneous mitochondrial transients in intact astrocytes.
Azarias G., Chatton J.Y., 2011. PLoS One, 6 (12) pp. e28505.
Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate.
Bozzo L., Chatton J.-Y., 2010. Brain Research 1316 pp. 27-34. Peer-reviewed.
 
Mécanisme moléculaire de protection des HDLs contre le stress du réticulum endoplasmique dans la cellule beta pancréatique. [Molecular mechanisms of HDLs to protect against the endoplasmic reticulum stress in pancreatic beta cell.]
Petremand J., Chatton J. Y., Waeber G., Widmann C., 2010. p. 4 dans Congrès Francophone Annuel de Diabétologie SFD 201, Diabete and Metabolism. Peer-reviewed.
 
Glial Ion Homeostasis: A Fluorescence Microscopy Approach
Chatton J.-Y., 2009. pp. 835-843 dans Squire L.R. (eds.) Encyclopedia of Neuroscience, Academic Press.
 
Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process.
Pierre K., Chatton J.Y., Parent A., Repond C., Gardoni F., Di Luca M., Pellerin L., 2009. European Journal of Neuroscience, 29 (10) pp. 1951-1963. Peer-reviewed.
Differential effects of glutamate transporter inhibitors on the global electrophysiological response of astrocytes to neuronal stimulation
Bernardinelli Y., Chatton J. Y., 2008/11. Brain Research, 1240 pp. 47-53. Peer-reviewed.
Spontaneous NA+ transients in individual mitochondria of intact astrocytes.
Azarias G., Van de Ville D., Unser M., Chatton J.Y., 2008. Glia, 56 (3) pp. 342-53. Peer-reviewed.
 
Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons.
Centeno C., Repici M., Chatton J.Y., Riederer B.M., Bonny C., Nicod P., Price M., Clarke P.G., Papa S., Franzoso G. et al., 2007. Cell Death and Differentiation, 14 (2) pp. 240-253. Peer-reviewed.
 
Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons.
Morgenthaler F.D., Kraftsik R., Catsicas S., Magistretti P.J., Chatton J.Y., 2006. Neuroscience, 141 (1) pp. 157-65. Peer-reviewed.
 
In situ fluorescence imaging of glutamate-evoked mitochondrial Na+ responses in astrocytes.
Bernardinelli Y., Azarias G., Chatton J.Y., 2006. Glia, 54 (5) pp. 460-70. Peer-reviewed.
 
Flash photolysis using a light emitting diode: an efficient, compact, and affordable solution
Bernardinelli Y., Haeberli C., Chatton J. Y., 2005/06. Cell Calcium, 37 (6) pp. 565-72.
 
Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes.
Magistretti P.J., Chatton J.Y., 2005. Journal of Neural Transmission, 112 (1) pp. 77-85. Peer-reviewed.
 
Involvement of inositol 1,4,5-trisphosphate in nicotinic calcium responses in dystrophic myotubes assessed by near-plasma membrane calcium measurement.
Basset O., Boittin F.X., Dorchies O.M., Chatton J.Y., van Breemen C., Ruegg U.T., 2004/11. Journal of Biological Chemistry, 279 (45) pp. 47092-47100. Peer-reviewed.
 
Astrocytes generate Na+-mediated metabolic waves
Bernardinelli Y., Magistretti P. J., Chatton J. Y., 2004/10. Proceedings of the National Academy of Sciences of the United States of America, 101 (41) pp. 14937-42.
 
Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes
Brunet J. F., Grollimund L., Chatton J. Y., Lengacher S., Magistretti P. J., Villemure J. G., Pellerin L., 2004/04. Glia, 46 (1) pp. 8-17. Peer-reviewed.
 
A mechanism for astrocyte-neuron metabolic coupling: relevance for functional imaging
Magistretti Pierre J., Chatton Jean-Yves, Pellerin Luc, 2004. pp. 10-11 dans , International Journal of Neuropsychopharmacology. Peer-reviewed.
 
GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission
Chatton J. Y., Pellerin L., Magistretti P. J., 2003/10. Proceedings of the National Academy of Sciences of the United States of America, 100 (21) pp. 12456-61.
Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons.
Burkhalter J., Fiumelli H., Allaman I., Chatton J.Y., Martin J.L., 2003/09. Journal of Neuroscience, 23 (23) pp. 8212-8220. Peer-reviewed.
 
Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex
Voutsinos-Porche B., Bonvento G., Tanaka K., Steiner P., Welker E., Chatton J. Y., Magistretti P. J., Pellerin L., 2003/01. Neuron, 37 (2) pp. 275-86.
 
Role of neuron-glia interaction in the regulation of brain glucose utilization.
Pellerin L., Bonvento G., Chatton J.Y., Pierre K., Magistretti P.J., 2002/10. Diabetes, nutrition &amp; metabolism, 15 (5) pp. 268-273. Peer-reviewed.
 
Detection of nitric oxide production by fluorescent indicators
Chatton J. Y., Broillet M. C., 2002. Methods in Enzymology, 359 pp. 134-48.
 
The role of astrocytes in coupling synaptic activity to glucose utilization
Magistretti Pierre, Chatton Jean-Yves, Pellerin Luc, 2002. pp. 75-83 dans Volterra Andrea, Magistretti Pierre J., Haydon Philip G. (eds.) The tripartite synapse : glia in synaptic transmission chap. 6, Oxford University Press.
 
Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons
Chatton J. Y., Idle J. R., Vagbo C. B., Magistretti P. J., 2001/12. Journal of Pharmacology and Experimental Therapeutics, 299 (3) pp. 1161-8.
 
Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain.
Uldry M., Ibberson M., Horisberger J.D., Chatton J.Y., Riederer B.M., Thorens B., 2001/08. EMBO journal, 20 (16) pp. 4467-4477. Peer-reviewed.
 
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes
Chatton J. Y., Shimamoto K., Magistretti P. J., 2001/03. Brain Research, 893 (1-2) pp. 46-52.
 
Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging.
Broillet M., Randin O., Chatton J., 2001/03. FEBS Letters, 491 (3) pp. 227-232. Peer-reviewed.
 
A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics.
Chatton J.Y., Marquet P., Magistretti P.J., 2000. European Journal of Neuroscience, 12 (11) pp. 3843-3853. Peer-reviewed.
 
Acute application of the tricyclic antidepressant desipramine presynaptically stimulates the exocytosis of glutamate in the hippocampus
Bouron A., Chatton J. Y., 1999/03. Neuroscience, 90 (3) pp. 729-36.
 
Roles of Na(+)-Ca2+ exchange and of mitochondria in the regulation of presynaptic Ca2+ and spontaneous glutamate release
Scotti A. L., Chatton J. Y., Reuter H., 1999/02. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 354 (1381) pp. 357-64.
 
Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes
Cao Y., Chatton J. Y., 1998/03. FEBS Letters, 424 (1-2) pp. 33-6.
 
Permissive role of cAMP in the oscillatory Ca2+ response to inositol 1,4,5-trisphosphate in rat hepatocytes
Chatton J. Y., Cao Y., Liu H., Stucki J. W., 1998/03. Biochemical Journal, 330 (3) pp. 1411-1416.
 
Perturbation of myo-inositol-1,4,5-trisphosphate levels during agonist-induced Ca2+ oscillations
Chatton J. Y., Cao Y., Stucki J. W., 1998/01. Biophysical Journal, 74 (1) pp. 523-31.
 
Agonist-specific behaviour of the intracellular Ca2+ response in rat hepatocytes
Chatton J. Y., Cao Y., Stucki J. W., 1997/12. Biochemical Journal, 328 (2) pp. 573-579.
 
Modulation of hormone-induced calcium oscillations by intracellular pH in rat hepatocytes
Chatton J. Y., Liu H., Stucki J. W., 1997/05. American Journal of Physiology, 272 (5 Pt 1) pp. G954-61.
 
A critical evaluation of in situ measurement of mitochondrial electrical potentials in single hepatocytes
Ubl J. J., Chatton J. Y., Chen S., Stucki J. W., 1996/09. Biochimica et Biophysica Acta-Bioenergetics, 1276 (2) pp. 124-32. Peer-reviewed.
 
Determination of the Na permeability of the tight junctions of MDCK cells by fluorescence microscopy
Kovbasnjuk O., Chatton J. Y., Friauf W. S., Spring K. R., 1995/12. Journal of Membrane Biology, 148 (3) pp. 223-32.
 
Simultaneous measurements of Ca2+ in the intracellular stores and the cytosol of hepatocytes during hormone-induced Ca2+ oscillations
Chatton J. Y., Liu H., Stucki J. W., 1995/07. FEBS Letters, 368 (1) pp. 165-8.
 
The sodium concentration of the lateral intercellular spaces of MDCK cells: a microspectrofluorimetric study
Chatton J. Y., Spring K. R., 1995/03. Journal of Membrane Biology, 144 (1) pp. 11-9.
 
Acidic pH of the lateral intercellular spaces of MDCK cells cultured on permeable supports
Chatton J. Y., Spring K. R., 1994/06. Journal of Membrane Biology, 140 (2) pp. 89-99.
 
pH, morphology, and diffusion in lateral intercellular spaces of epithelial cell monolayers
Harris P. J., Chatton J. Y., Tran P. H., Bungay P. M., Spring K. R., 1994/01. American Journal of Physiology, 266 (1 Pt 1) pp. C73-80.
 
Light sources and wavelength selection for widefield fluorescence microscopy
Chatton Jean-Yves, Spring Kenneth R., 1993. Microsc. Soc. Am. Bull., 23 (4) pp. 324-333. Peer-reviewed.
 
Properties of the lateral intercellular spaces of cultured renal epithelial cells
Chatton Jean-Yves, Harris Peter J., Spring Kenneth R., 1993. pp. 259-268 dans Ussing HH, Fischbarg J, Sten-Knudsen O, Larsen EH, Willumsen NJ (eds.) Isotonic Transport in Leaky Epithelia, Munksgaard.
 
Nonionic diffusion of salicylic acid through MDCK cell monolayers
Chatton J. Y., Roch-Ramel F., 1992/06. Journal of Pharmacology and Experimental Therapeutics, 261 (3) pp. 1071-9.
 
Transport of salicylic acid through monolayers of a kidney epithelial cell line (LLC-PK1)
Chatton J. Y., Roch-Ramel F., 1992/05. Journal of Pharmacology and Experimental Therapeutics, 261 (2) pp. 518-24.
 
Once-a-week azithromycin in AIDS patients: tolerability, kinetics, and effects on zidovudine disposition.
Chave J.P., Munafo A., Chatton J.Y., Dayer P., Glauser M.P., Biollaz J., 1992. Antimicrobial Agents and Chemotherapy, 36 (5) pp. 1013-1018.
 
Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide.
Chatton J.Y., Munafo A., Chave J.P., Steinhäuslin F., Roch-Ramel F., Glauser M.P., Biollaz J., 1992. British Journal of Clinical Pharmacology, 34 (6) pp. 551-554.
 
Passive permeability of salicylic acid in renal proximal S2 and S3 tubules
Chatton J. Y., Roch-Ramel F., 1991/03. Journal of Pharmacology and Experimental Therapeutics, 256 (3) pp. 1112-8.
 
Renal secretion of 3'-azido-3'-deoxythymidine by the rat
Chatton J. Y., Odone M., Besseghir K., Roch-Ramel F., 1990/10. Journal of Pharmacology and Experimental Therapeutics, 255 (1) pp. 140-5.
 
Salicylic acid permeability properties of the rabbit cortical collecting duct
Chatton J. Y., Besseghir K., Roch-Ramel F., 1990/10. American Journal of Physiology, 259 (4 Pt 2) pp. F613-8.
 
Transport of the organic cation N1-methylnicotinamide by the rabbit proximal tubule. II. Reabsorption and secretion in the isolated perfused tubule
Besseghir K., Chatton J. Y., Roch-Ramel F., 1990/05. Journal of Pharmacology and Experimental Therapeutics, 253 (2) pp. 452-60.
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