Isabel Lopez Mejia

Publications | Phd and Masters theses

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33 publications

En préparation
 
CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen-related receptor (ERR)-driven oxidative metabolism in skeletal muscle
Barquissau Valentin, Zanou Nadège, Geller Sarah, Castillo-Armengol Judit, Marzetta Flavia, Huber Katharina, Ziegler Dorian, Lopez-Mejia Isabel, Fernandez Joan Blanco, Roger Catherine et al..
[DOI][serval:BIB_2CA3F1A4A423]
2023
Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies.
Vidal J., Fernandez E.A., Wohlwend M., Laurila P.P., Lopez-Mejia A., Ochala J., Lobrinus A.J., Kayser B., Lopez-Mejia I.C., Place N. et al., 2023/12. Journal of cachexia, sarcopenia and muscle, 14 (6) pp. 2882-2897. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5FA8F26A1D9D]
Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness.
Lopez-Mejia I.C., Pijuan J., Navaridas R., Santacana M., Gatius S., Velasco A., Castellà G., Panosa A., Cabiscol E., Pinyol M. et al., 2023/01. Molecular oncology, 17 (1) pp. 98-118. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_549BE66DECEF]
2022
Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Chen Y., Fernandez E.A., Roger C., Lopez-Mejia I.C., Fajas Coll L., Ji H., 2022/06. FEBS letters, 596 (11) pp. 1434-1444. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C1D722D17E1D]
Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation.
Khan AUH, Salehi H., Alexia C., Valdivielso J.M., Bozic M., Lopez-Mejia I.C., Fajas L., Gerbal-Chaloin S., Daujat-Chavanieu M., Gitenay D. et al., 2022/04/20. Cells, 11 (9) p. 1392. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0CB7B6A1E909]
Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor.
Snäkä T., Bekkar A., Desponds C., Prével F., Claudinot S., Isorce N., Teixeira F., Grasset C., Xenarios I., Lopez-Mejia I.C. et al., 2022. Frontiers in immunology, 13 p. 882867. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6C22CA5A408C]
2021
Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity.
Zanou N., Dridi H., Reiken S., Imamura de Lima T., Donnelly C., De Marchi U., Ferrini M., Vidal J., Sittenfeld L., Feige J.N. et al., 2021/12/10. Nature communications, 12 (1) p. 7219. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4B4985CA147A]
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity.
Dumauthioz N., Tschumi B., Wenes M., Marti B., Wang H., Franco F., Li W., Lopez-Mejia I.C., Fajas L., Ho P.C. et al., 2021/07. Cellular & molecular immunology, 18 (7) pp. 1761-1771. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D554C59D6F3C]
2020
 
PamgeneAnalyzeR: open and reproducible pipeline for kinase profiling.
Bekkar A., Nasrallah A., Guex N., Fajas L., Xenarios I., Lopez-Mejia I.C., 2020/12/22. Bioinformatics, 36 (20) pp. 5117-5119. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F6B4F7EFAFFB]
 
Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues.
Castillo-Armengol J., Barquissau V., Geller S., Ji H., Severi I., Venema W., Fenandez E.A., Moret C., Huber K., Leal-Esteban L.C. et al., 2020/09/03. EMBO reports, 21 (9) pp. e49807. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BA842E7BA291]
 
A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion.
Berdous D., Berney X., Sanchez-Archidona A.R., Jan M., Roujeau C., Lopez-Mejia I.C., Mynatt R., Thorens B., 2020/07. Molecular metabolism, 37 p. 100993. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E7C44B7C6874]
 
CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.
Ji H., Chen Y., Castillo-Armengol J., Dreos R., Moret C., Niederhäuser G., Delacuisine B., Lopez-Mejia I.C., Denechaud P.D., Fajas L., 2020/06/26. iScience, 23 (6) p. 101163. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EBF3BB5349A2]
 
Lamin C Counteracts Glucose Intolerance in Aging, Obesity, and Diabetes Through β-Cell Adaptation.
de Toledo M., Lopez-Mejia I.C., Cavelier P., Pratlong M., Barrachina C., Gromada X., Annicotte J.S., Tazi J., Chavey C., 2020/04. Diabetes, 69 (4) pp. 647-660. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_886EB4D40055]
2019
 
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival.
Martínez-Carreres L., Puyal J., Leal-Esteban L.C., Orpinell M., Castillo-Armengol J., Giralt A., Dergai O., Moret C., Barquissau V., Nasrallah A. et al., 2019/10/15. Cancer research, 79 (20) pp. 5245-5259. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A55F9416C381]
Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion.
Geller S., Arribat Y., Netzahualcoyotzi C., Lagarrigue S., Carneiro L., Zhang L., Amati F., Lopez-Mejia I.C., Pellerin L., 2019/10/01. Cell metabolism, 30 (4) pp. 833-844.e7. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0795ED63E452]
 
Inter-organ communication: a gatekeeper for metabolic health.
Castillo-Armengol J., Fajas L., Lopez-Mejia I.C., 2019/09. EMBO reports, 20 (9) pp. e47903. Peer-reviewed.
[DOI][Pmid][serval:BIB_3D85056E88C8]
2018
 
Dietary Fiber Confers Protection against Flu by Shaping Ly6c<sup>-</sup> Patrolling Monocyte Hematopoiesis and CD8<sup>+</sup> T Cell Metabolism.
Trompette A., Gollwitzer E.S., Pattaroni C., Lopez-Mejia I.C., Riva E., Pernot J., Ubags N., Fajas L., Nicod L.P., Marsland B.J., 2018/05/15. Immunity, 48 (5) pp. 992-1005.e8. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0721FE87A408]
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.
Giralt A., Denechaud P.D., Lopez-Mejia I.C., Delacuisine B., Blanchet E., Bonner C., Pattou F., Annicotte J.S., Fajas L., 2018/05. Molecular metabolism, 11 pp. 104-112. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_ED95377F8A23]
 
Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.
Lopez-Mejia I.C., Castillo-Armengol J., Lagarrigue S., Fajas L., 2018/03. Cellular and molecular life sciences, 75 (6) pp. 975-987. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D70173D2EEC9]
Cdkn2a deficiency promotes adipose tissue browning.
Rabhi N., Hannou S.A., Gromada X., Salas E., Yao X., Oger F., Carney C., Lopez-Mejia I.C., Durand E., Rabearivelo I. et al., 2018/02. Molecular metabolism, 8 pp. 65-76. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2CA9563F93C5]
CDK4, a new metabolic sensor that antagonizes AMPK.
Fajas L., Lopez-Mejia I.C., 2018. Molecular & cellular oncology, 5 (5) pp. e1409862. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_31B3469F93CE]
2017
The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway.
Khan AUH, Allende-Vega N., Gitenay D., Gerbal-Chaloin S., Gondeau C., Vo D.N., Belkahla S., Orecchioni S., Talarico G., Bertolini F. et al., 2017/09/06. Scientific reports, 7 (1) p. 10654. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_067DA1C10A2D]
 
Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo J., Lopez-Herrera C., Apolit C., Bareche Y., Lapasset L., Chavey C., Capozi S., Mahuteau-Betzer F., Najman R., Fornarelli P. et al., 2017/03. International journal of obesity, 41 (3) pp. 390-401. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_886E90B08DC1]
 
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Lopez-Mejia I.C., Lagarrigue S., Giralt A., Martinez-Carreres L., Zanou N., Denechaud P.D., Castillo-Armengol J., Chavey C., Orpinell M., Delacuisine B. et al., 2017. Molecular Cell, 68 (2) pp. 336-349.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F02666506F7E]
2016
 
Contrôle de l’homéostasie glucido-lipidique par les facteurs du cycle cellulaire CDK4 et E2F1 [Cell cycle regulators CDK4 and E2F1 control glucose and lipid homeostasis]
Denechaud P.D., Lopez-Mejia I.C., Fajas L., 2016/10. Medecine sciences : M/S, 32 (10) pp. 815-818.
[DOI][WoS][Pmid][serval:BIB_C6B5E0F7A130]
 
CDK4 is an essential insulin effector in adipocytes.
Lagarrigue S., Lopez-Mejia I.C., Denechaud P.D., Escoté X., Castillo-Armengol J., Jimenez V., Chavey C., Giralt A., Lai Q., Zhang L. et al., 2016. Journal of Clinical Investigation, 126 (1) pp. 335-348. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E56CC40E7CB9]
 
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.
Denechaud P.D., Lopez-Mejia I.C., Giralt A., Lai Q., Blanchet E., Delacuisine B., Nicolay B.N., Dyson N.J., Bonner C., Pattou F. et al., 2016. Journal of Clinical Investigation, 126 (1) pp. 137-150.
[DOI][WoS][Pmid][serval:BIB_D4C8969D5304]
Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.
Zhang L., Tschumi B.O., Lopez-Mejia I.C., Oberle S.G., Meyer M., Samson G., Rüegg M.A., Hall M.N., Fajas L., Zehn D. et al., 2016. Cell Reports, 14 (5) pp. 1206-1217. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CB0706D22A19]
Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.
Scholz G., Jandus C., Zhang L., Grandclément C., Lopez-Mejia I.C., Soneson C., Delorenzi M., Fajas L., Held W., Dormond O. et al., 2016. Ebiomedicine, 4 pp. 50-61. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_5D18A226530B]
 
Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells.
Petrov P.D., Ribot J., López-Mejía I.C., Fajas L., Palou A., Bonet M.L., 2016. Journal of Cellular Physiology, 231 (3) pp. 708-718. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8B67B071031B]
2015
 
Cell cycle regulation of mitochondrial function.
Lopez-Mejia I.C., Fajas L., 2015. Current Opinion in Cell Biology, 33 pp. 19-25. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D9F84F046F43]
2014
 
Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia I.C., de Toledo M., Chavey C., Lapasset L., Cavelier P., Lopez-Herrera C., Chebli K., Fort P., Beranger G., Fajas L. et al., 2014. Embo Reports, 15 (5) pp. 529-539. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F93AC620BB91]
2013
Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion.
Lopez-Mejia I.C., De Toledo M., Della Seta F., Fafet P., Rebouissou C., Deleuze V., Blanchard J.M., Jorgensen C., Tazi J., Vignais M.L., 2013. Molecular Biology of the Cell, 24 (20) pp. 3164-3176. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2AD6B0F09199]
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