Genrich Tolstonog

Publications | Phd and Masters theses

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48 publications

2024 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003 | 2002 | 2001 | 2000 | 1998 | 1996 |
2024
A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation.
Josi R., Speiser D.E., de Brot S., Vogt A.C., Sevick-Muraca E.M., Tolstonog G.V., Bachmann M.F., Mohsen M.O., 2024/04/19. iScience, 27 (4) p. 109439. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_958F1E78AC86]
2021
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Fukuda S., Narendran S., Varshney A., Nagasaka Y., Wang S.B., Ambati K., Apicella I., Pereira F., Fowler B.J., Yasuma T. et al., 2021/10. Science advances, 7 (40) pp. eabj3658. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_19971A01C1BC]
 
CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors.
Labiano S., Roh V., Godfroid C., Hiou-Feige A., Romero J., Sum E., Rapp M., Boivin G., Wyss T., Simon C. et al., 2021/07/15. Clinical cancer research, 27 (14) pp. 4054-4065. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_01B309C22867]
 
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Fukuda S., Varshney A., Fowler B.J., Wang S.B., Narendran S., Ambati K., Yasuma T., Magagnoli J., Leung H., Hirahara S. et al., 2021/02/09. Proceedings of the National Academy of Sciences of the United States of America, 118 (6) pp. e2022751118. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EC89440D2AA6]
Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model
Domingos-Pereira Sonia, Roh Vincent, Hiou-Feige Agnès, Galliverti Gabriele, Simon Christian, Tolstonog Genrich V., Nardelli-Haefliger Denise, 2021/01/01. OncoImmunology, 10 (1) p. 1912473.
[URN][DOI][WoS][serval:BIB_41FC84C2290A]
2020
 
Development and validation of a multivariable prediction model for the identification of occult lymph node metastasis in oral squamous cell carcinoma.
Mermod M., Jourdan E.F., Gupta R., Bongiovanni M., Tolstonog G., Simon C., Clark J., Monnier Y., 2020/08. Head & neck, 42 (8) pp. 1811-1820. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F50D846E2457]
 
The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma.
Roh V., Hiou-Feige A., Misetic V., Rivals J.P., Sponarova J., Teh M.T., Ferreira Lopes S., Truan Z., Mermod M., Monnier Y. et al., 2020/01. The Journal of pathology, 250 (1) pp. 107-119. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0EE0AF2ED71C]
2019
 
Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification.
Mermod M., Bongiovanni M., Petrova T., Goun E., Simon C., Tolstonog G., Monnier Y., 2019/02. Otolaryngology: head and neck surgery, 160 (2) pp. 277-283. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9BFA9A270953]
2018
Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma.
Roh V., Abramowski P., Hiou-Feige A., Cornils K., Rivals J.P., Zougman A., Aranyossy T., Thielecke L., Truan Z., Mermod M. et al., 2018/11/20. Cell reports, 25 (8) pp. 2208-2222.e7. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B1CDCE626F72]
 
Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer.
Mermod M., Hiou-Feige A., Bovay E., Roh V., Sponarova J., Bongiovanni M., Vermeer D.W., Lee J.H., Petrova T.V., Rivals J.P. et al., 2018/06/15. International journal of cancer, 142 (12) pp. 2518-2528. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F05A2D65979F]
2017
 
Trends in Surgical Research in Head and Neck Cancer.
Tolstonog G., Simon C., 2017/06. Current treatment options in oncology, 18 (6) p. 38. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E43E00A6466F]
 
Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis.
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y., 2017/01. Head & neck, 39 (1) pp. 98-108. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8A5414AD1E48]
2016
 
Extracapsular spread in head and neck squamous cell carcinoma: A systematic review and meta-analysis.
Mermod M., Tolstonog G., Simon C., Monnier Y., 2016/11. Oral oncology, 62 pp. 60-71. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D5E679056093]
 
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification.
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y., 2016/09. Head & neck, 38 (9) pp. 1407-1415. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AC7C98A91446]
2015
 
Mutant p53 promotes epithelial-mesenchymal plasticity and enhances metastasis in mammary carcinomas of WAP-T mice.
Lenfert E., Maenz C., Heinlein C., Jannasch K., Schumacher U., Pantel K., Tolstonog G.V., Deppert W., Wegwitz F., 2015. International Journal of Cancer. Journal International du Cancer, 136 (6) pp. E521-E533. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_373D268BE26D]
2014
Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients
Otto B., Koenig A.M., Tolstonog G.V., Jeschke A., Klaetschke K., Vashist Y.K., Wicklein D., Wagener C., Izbicki J.R., Streichert T., 2014. Plos One, 9 (7) pp. e102552. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_391E280A3DF2]
2013
 
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression.
Otto B., Gruner K., Heinlein C., Wegwitz F., Nollau P., Ylstra B., Pantel K., Schumacher U., Baumbusch L.O., Martin-Subero J.I. et al., 2013. International Journal of Cancer. Journal International du Cancer, 132 (6) pp. 1300-1310.
[DOI][WoS][Pmid][serval:BIB_169C9D973A2D]
 
Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp--/rag2-- mice.
Gebauer F., Wicklein D., Stübke K., Nehmann N., Schmidt A., Salamon J., Peldschus K., Nentwich M.F., Adam G., Tolstonog G. et al., 2013. Gut, 62 (5) pp. 741-750.
[DOI][WoS][Pmid][serval:BIB_455C514E5EFA]
 
Transcription factors link mouse WAP-T mammary tumors with human breast cancer.
Otto B., Streichert T., Wegwitz F., Gevensleben H., Klätschke K., Wagener C., Deppert W., Tolstonog G.V., 2013. International Journal of Cancer. Journal International du Cancer, 132 (6) pp. 1311-1322.
[DOI][WoS][Pmid][serval:BIB_7B9911011493]
2012
 
Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity.
Quante T., Otto B., Brázdová M., Kejnovská I., Deppert W., Tolstonog G.V., 2012/09/01. Cell cycle, 11 (17) pp. 3290-3303. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4980B6B11F42]
 
Recombinant p53 displays heterogeneity during isoelectric focusing.
Heukeshoven J., März A., Warnecke G., Deppert W., Tolstonog G.V., 2012/09. Electrophoresis, 33 (18) pp. 2818-2827. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3DBC791FCD19]
2010
 
Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system.
Wegwitz F., Kluth M.A., Mänz C., Otto B., Gruner K., Heinlein C., Kühl M., Warnecke G., Schumacher U., Deppert W. et al., 2010/08/11. PloS one, 5 (8) pp. e12103. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1AB1B4204867]
 
Metabolic sensing by p53: keeping the balance between life and death.
Tolstonog G.V., Deppert W., 2010/07/27. Proceedings of the National Academy of Sciences of the United States of America, 107 (30) pp. 13193-13194. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_60A0C3B561FC]
2009
 
Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.
Hermannstädter A., Ziegler C., Kühl M., Deppert W., Tolstonog G.V., 2009/10. Journal of virology, 83 (19) pp. 10106-10118. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_43B7C0F6AA55]
 
The caspase-9 derived C-terminal fragment of cytokeratin 18 modulates topoisomerase action.
Schutte B., Henfling M.E., Verheyen F.K., Li G., Tolstonog G.V., Ramaekers F.C., 2009/09. International journal of oncology, 35 (3) pp. 625-630. Peer-reviewed.
[WoS][Pmid][serval:BIB_0D2C684687EC]
 
The p53 transcriptional synapse: activation on demand.
Tolstonog G.V., Deppert W., 2009/09. Nature structural & molecular biology, 16 (9) pp. 900-901. Peer-reviewed.
[WoS][Pmid][serval:BIB_562FCDEB5418]
 
Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences.
Brázdová M., Quante T., Tögel L., Walter K., Loscher C., Tichý V., Cincárová L., Deppert W., Tolstonog G.V., 2009/04. Nucleic acids research, 37 (5) pp. 1486-1500. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0DAFE0C77432]
 
Keratinocytes as depository of ammonium-inducible glutamine synthetase: age- and anatomy-dependent distribution in human and rat skin.
Danielyan L., Zellmer S., Sickinger S., Tolstonog G.V., Salvetter J., Lourhmati A., Reissig D.D., Gleiter C.H., Gebhardt R., Buniatian G.H., 2009. PloS one, 4 (2) pp. e4416. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DF4140BBDC00]
2008
 
Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis.
Heinlein C., Krepulat F., Löhler J., Speidel D., Deppert W., Tolstonog G.V., 2008/04/15. International journal of cancer, 122 (8) pp. 1701-1709. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_96B61AD2C07A]
 
Functional endogenous LINE-1 retrotransposons are expressed and mobilized in rat chloroleukemia cells.
Kirilyuk A., Tolstonog G.V., Damert A., Held U., Hahn S., Löwer R., Buschmann C., Horn A.V., Traub P., Schumann G.G., 2008/02. Nucleic acids research, 36 (2) pp. 648-665. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7CEC1771FCA5]
2007
 
Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression.
Oricchio E., Sciamanna I., Beraldi R., Tolstonog G.V., Schumann G.G., Spadafora C., 2007/06/21. Oncogene, 26 (29) pp. 4226-4233. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D64A8F36DE19]
 
Colocalization of glial fibrillary acidic protein, metallothionein, and MHC II in human, rat, NOD/SCID, and nude mouse skin keratinocytes and fibroblasts.
Danielyan L., Tolstonog G., Traub P., Salvetter J., Gleiter C.H., Reisig D., Gebhardt R., Buniatian G.H., 2007/03. The Journal of investigative dermatology, 127 (3) pp. 555-563. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_503D5491B156]
2006
 
Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling.
Lucchinetti E., Feng J., Silva Rd, Tolstonog G.V., Schaub M.C., Schumann G.G., Zaugg M., 2006/04/13. Physiological genomics, 25 (2) pp. 314-324. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_11CD0E4F7666]
2005
 
Spontaneously immortalized mouse embryo fibroblasts: growth behavior of wild-type and vimentin-deficient cells in relation to mitochondrial structure and activity.
Tolstonog G.V., Belichenko-Weitzmann I.V., Lu J.P., Hartig R., Shoeman R.L., Traub U., Traub P., 2005/11. DNA and cell biology, 24 (11) pp. 680-709. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_056BBC2A7D52]
 
Stability and association with the cytomatrix of mitochondrial DNA in spontaneously immortalized mouse embryo fibroblasts containing or lacking the intermediate filament protein vimentin.
Bannikova S., Zorov D.B., Shoeman R.L., Tolstonog G.V., Traub P., 2005/11. DNA and cell biology, 24 (11) pp. 710-735. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AC10E9010E6E]
 
Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.
Krepulat F., Löhler J., Heinlein C., Hermannstädter A., Tolstonog G.V., Deppert W., 2005/07/07. Oncogene, 24 (29) pp. 4645-4659. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B436C23881B1]
 
Interaction in vitro of type III intermediate filament proteins with higher order structures of single-stranded DNA, particularly with G-quadruplex DNA.
Tolstonog G.V., Li G., Shoeman R.L., Traub P., 2005/02. DNA and cell biology, 24 (2) pp. 85-110. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EDF73CD3B978]
2003
 
Type III intermediate filament proteins interact with four-way junction DNA and facilitate its cleavage by the junction-resolving enzyme T7 endonuclease I.
Li G., Tolstonog G.V., Sabasch M., Traub P., 2003/04. DNA and cell biology, 22 (4) pp. 261-291. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B98D8C5E414A]
 
Interaction in vitro of type III intermediate filament proteins with Z-DNA and B-Z-DNA junctions.
Li G., Tolstonog G.V., Traub P., 2003/03. DNA and cell biology, 22 (3) pp. 141-169. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7FB9525C35D7]
2002
 
Interaction in vitro of type III intermediate filament proteins with supercoiled plasmid DNA and modulation of eukaryotic DNA topoisomerase I and II activities.
Li G., Tolstonog G.V., Sabasch M., Traub P., 2002/10. DNA and cell biology, 21 (10) pp. 743-769. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_922BCCD6DDD3]
 
Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function.
Tolstonog G.V., Sabasch M., Traub P., 2002/03. DNA and cell biology, 21 (3) pp. 213-239. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_99D06B08FBD4]
 
Interaction in vitro of type III intermediate filament proteins with triplex DNA.
Li G., Tolstonog G.V., Traub P., 2002/03. DNA and cell biology, 21 (3) pp. 163-188. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_89272C865320]
2001
 
Isolation of SDS-stable complexes of the intermediate filament protein vimentin with repetitive, mobile, nuclear matrix attachment region, and mitochondrial DNA sequence elements from cultured mouse and human fibroblasts.
Tolstonog G.V., Mothes E., Shoeman R.L., Traub P., 2001/09. DNA and cell biology, 20 (9) pp. 531-554. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B84FD1D5443E]
 
Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts.
Tolstonog G.V., Shoeman R.L., Traub U., Traub P., 2001/09. DNA and cell biology, 20 (9) pp. 509-529. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B1CEA4767DA1]
 
Sites of nucleic acid binding in type I-IV intermediate filament subunit proteins.
Wang Q., Tolstonog G.V., Shoeman R., Traub P., 2001/08/28. Biochemistry, 40 (34) pp. 10342-10349. Peer-reviewed.
[WoS][Pmid][serval:BIB_213239066C16]
2000
 
Intermediate filaments reconstituted from vimentin, desmin, and glial fibrillary acidic protein selectively bind repetitive and mobile DNA sequences from a mixture of mouse genomic DNA fragments.
Tolstonog G.V., Wang X., Shoeman R., Traub P., 2000/11. DNA and cell biology, 19 (11) pp. 647-677. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8E82B0FCDBE6]
1998
 
DNA-mediated transport of the intermediate filament protein vimentin into the nucleus of cultured cells.
Hartig R., Shoeman R.L., Janetzko A., Tolstonog G., Traub P., 1998/12/18. Journal of cell science, 111 ( Pt 24) pp. 3573-3584. Peer-reviewed.
[WoS][Pmid][serval:BIB_F42C3D5E14F3]
1996
 
Selective binding of specific mouse genomic DNA fragments by mouse vimentin filaments in vitro.
Wang X., Tolstonog G., Shoeman R.L., Traub P., 1996/03. DNA and cell biology, 15 (3) pp. 209-225. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_44C2513558A0]
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