Claudia Bagni

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134 publications

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Early dysregulation of GSK3β impairs mitochondrial activity in Fragile X Syndrome.
Cencelli G., Pedini G., Ricci C., Rosina E., Cecchetti G., Gentile A., Aiello G., Pacini L., Garrone B., Ombrato R. et al. Neurobiology of disease. Peer-reviewed.
 
ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome.
D'Addario S.L., Rosina E., Massaro Cenere M., Bagni C., Mercuri N.B., Ledonne A. Molecular psychiatry. Peer-reviewed.
 
Dysregulation of the mTOR-FMRP pathway and synaptic plasticity in an environmental model of ASD.
Hilal M.L., Rosina E., Pedini G., Restivo L., Bagni C. Molecular psychiatry. Peer-reviewed.
 
Activation of the 5-HT1A Receptor by Eltoprazine Restores Mitochondrial and Motor Deficits in a Drosophila Model of Fragile X Syndrome.
Vannelli A., Mariano V., Bagni C., Kanellopoulos A.K., 2024/08/13. International journal of molecular sciences, 25 (16). Peer-reviewed.
 
Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization.
Mariano V., Kanellopoulos A.K., Ricci C., Di Marino D., Borrie S.C., Dupraz S., Bradke F., Achsel T., Legius E., Odent S. et al., 2024/01/15. Biological psychiatry, 95 (2) pp. 161-174. Peer-reviewed.
 
Cancer drug repurposing in autism spectrum disorder.
Pedini G., Chen C.L., Achsel T., Bagni C., 2023/12. Trends in pharmacological sciences, 44 (12) pp. 963-977. Peer-reviewed.
 
Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome.
Mercaldo V., Vidimova B., Gastaldo D., Fernández E., Lo A.C., Cencelli G., Pedini G., De Rubeis S., Longo F., Klann E. et al., 2023/06/07. Neuron, 111 (11) pp. 1760-1775.e8. Peer-reviewed.
FMRP expression in primary breast tumor cells correlates with recurrence and specific site of metastasis.
Caredda E., Pedini G., D'Amico F., Scioli M.G., Pacini L., Orsaria P., Vanni G., Buonomo O.C., Orlandi A., Bagni C. et al., 2023/06. PloS one, 18 (6) pp. e0287062. Peer-reviewed.
Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals.
Cencelli G., Pacini L., De Luca A., Messia I., Gentile A., Kang Y., Nobile V., Tabolacci E., Jin P., Farace M.G. et al., 2023/02/27. Cells, 12 (5) p. 758. Peer-reviewed.
SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila.
Mariano V., Kanellopoulos A.K., Aiello G., Lo A.C., Legius E., Achsel T., Bagni C., 2023/02/20. Nature communications, 14 (1) p. 763. Peer-reviewed.
 
Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism.
Avolio E., Olivito I., Rosina E., Romano L., Angelone T., De Bartolo A., Scimeca M., Bellizzi D., D'Aquila P., Passarino G. et al., 2022/08/21. Neuroscience, 498 pp. 174-189. Peer-reviewed.
FMRP modulates the Wnt signalling pathway in glioblastoma.
Pedini G., Buccarelli M., Bianchi F., Pacini L., Cencelli G., D'Alessandris Q.G., Martini M., Giannetti S., Sasso F., Melocchi V. et al., 2022/08/18. Cell death & disease, 13 (8) p. 719. Peer-reviewed.
 
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
O'Neill A.C., Uzbas F., Antognolli G., Merino F., Draganova K., Jäck A., Zhang S., Pedini G., Schessner J.P., Cramer K. et al., 2022/06/17. Science, 376 (6599) pp. eabf9088. Peer-reviewed.
 
Epigenetic switch controls social actions.
Pedini G., Bagni C., 2022/04/06. Neuron, 110 (7) pp. 1085-1087. Peer-reviewed.
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.
Kallergi E., Daskalaki A.D., Kolaxi A., Camus C., Ioannou E., Mercaldo V., Haberkant P., Stein F., Sidiropoulou K., Dalezios Y. et al., 2022/02/03. Nature communications, 13 (1) p. 680. Peer-reviewed.
 
A white paper on a neurodevelopmental framework for drug discovery in autism and other neurodevelopmental disorders.
Díaz-Caneja C.M., State M.W., Hagerman R.J., Jacquemont S., Marín O., Bagni C., Umbricht D., Simonoff E., de Andrés-Trelles F., Kaale A. et al., 2021/07. European neuropsychopharmacology, 48 pp. 49-88. Peer-reviewed.
Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge.
Carotti S., Zingariello M., Francesconi M., D'Andrea L., Latasa M.U., Colyn L., Fernandez-Barrena M.G., Flammia R.S., Falchi M., Righi D. et al., 2021/06. Oncogene, 40 (23) pp. 4033-4049. Peer-reviewed.
Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.
Lo A.C., Rajan N., Gastaldo D., Telley L., Hilal M.L., Buzzi A., Simonato M., Achsel T., Bagni C., 2021/04/07. EMBO reports, 22 (4) pp. e51404. Peer-reviewed.
Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula.
Nuno-Perez A., Trusel M., Lalive A.L., Congiu M., Gastaldo D., Tchenio A., Lecca S., Soiza-Reilly M., Bagni C., Mameli M., 2021/03/17. Neuron, 109 (6) pp. 947-956.e5. Peer-reviewed.
Adenosine A<sub>2A</sub> receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice.
Ferrante A., Boussadia Z., Borreca A., Mallozzi C., Pedini G., Pacini L., Pezzola A., Armida M., Vincenzi F., Varani K. et al., 2021/02/05. Translational psychiatry, 11 (1) p. 112. Peer-reviewed.
The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis.
Di Grazia A., Marafini I., Pedini G., Di Fusco D., Laudisi F., Dinallo V., Rosina E., Stolfi C., Franzè E., Sileri P. et al., 2021. Cellular and molecular gastroenterology and hepatology, 11 (2) pp. 639-658. Peer-reviewed.
Spatial control of nucleoporin condensation by fragile X-related proteins.
Agote-Aran A., Schmucker S., Jerabkova K., Jmel Boyer I., Berto A., Pacini L., Ronchi P., Kleiss C., Guerard L., Schwab Y. et al., 2020/10/15. The EMBO journal, 39 (20) pp. e104467. Peer-reviewed.
Modelling Learning and Memory in Drosophila to Understand Intellectual Disabilities.
Mariano V., Achsel T., Bagni C., Kanellopoulos A.K., 2020/10/01. Neuroscience, 445 pp. 12-30. Peer-reviewed.
 
Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits.
Kanellopoulos A.K., Mariano V., Spinazzi M., Woo Y.J., McLean C., Pech U., Li K.W., Armstrong J.D., Giangrande A., Callaerts P. et al., 2020/03/19. Cell, 180 (6) pp. 1178-1197.e20. Peer-reviewed.
Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila.
Hu C., Kanellopoulos A.K., Richter M., Petersen M., Konietzny A., Tenedini F.M., Hoyer N., Cheng L., Poon CLC, Harvey K.F. et al., 2020/02/26. The Journal of neuroscience, 40 (9) pp. 1819-1833. Peer-reviewed.
 
Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Antisense Protein (ASP) RNA Transcripts in Patients by Strand-Specific RT-PCR.
Mancarella A., Procopio F.A., Achsel T., De Crignis E., Foley B.T., Corradin G., Bagni C., Pantaleo G., Graziosi C., 2019/11/27. Journal of visualized experiments 153. Peer-reviewed.
 
Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage.
Woo Y.J., Kanellopoulos A.K., Hemati P., Kirschen J., Nebel R.A., Wang T., Bagni C., Abrahams B.S., 2019/08/15. Biological psychiatry, 86 (4) pp. 306-314. Peer-reviewed.
 
A Light Touch on Sociability.
Domínguez-Iturza N., Bagni C., 2019/08/08. Cell, 178 (4) pp. 769-771. Peer-reviewed.
The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour.
Domínguez-Iturza N., Lo A.C., Shah D., Armendáriz M., Vannelli A., Mercaldo V., Trusel M., Li K.W., Gastaldo D., Santos A.R. et al., 2019/08/01. Nature communications, 10 (1) p. 3454. Peer-reviewed.
 
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
Koopmans F., van Nierop P., Andres-Alonso M., Byrnes A., Cijsouw T., Coba M.P., Cornelisse L.N., Farrell R.J., Goldschmidt H.L., Howrigan D.P. et al., 2019/07/17. Neuron, 103 (2) pp. 217-234.e4. Peer-reviewed.
Detection of antisense protein (ASP) RNA transcripts in individuals infected with human immunodeficiency virus type 1 (HIV-1).
Mancarella A., Procopio F.A., Achsel T., De Crignis E., Foley B.T., Corradin G., Bagni C., Pantaleo G., Graziosi C., 2019/05. The Journal of general virology, 100 (5) pp. 863-876. Peer-reviewed.
A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders.
Bagni C., Zukin R.S., 2019/03/20. Neuron, 101 (6) pp. 1070-1088. Peer-reviewed.
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism.
Rosina E., Battan B., Siracusano M., Di Criscio L., Hollis F., Pacini L., Curatolo P., Bagni C., 2019/01/31. Translational psychiatry, 9 (1) p. 50. Peer-reviewed.
 
Maintenance mechanisms of circuit-integrated axons.
Mariano V., Domínguez-Iturza N., Neukomm L.J., Bagni C., 2018/12. Current opinion in neurobiology, 53 pp. 162-173. Peer-reviewed.
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome.
Jacquemont S., Pacini L., Jønch A.E., Cencelli G., Rozenberg I., He Y., D'Andrea L., Pedini G., Eldeeb M., Willemsen R. et al., 2018/11/01. Human Molecular Genetics, 27 (21) p. 3825. Peer-reviewed.
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome.
Jacquemont S., Pacini L., Jønch A.E., Cencelli G., Rozenberg I., He Y., D'Andrea L., Pedini G., Eldeeb M., Willemsen R. et al., 2018/06/15. Human molecular genetics, 27 (12) pp. 2039-2051. Peer-reviewed.
 
Editorial overview: Neurobiology of disease (2018).
Bagni C., Kreitzer A.C., 2018/02. Current opinion in neurobiology, 48 pp. iv-vi. Peer-reviewed.
Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs
Comhair J., Devoght J., Morelli G., Harvey R.J., Briz V., Borrie S.C., Bagni C., Rigo J.-M., Schiffmann S.N., Gall D. et al., 2018. Frontiers in Molecular Neuroscience, 11 p. 380. Peer-reviewed.
FXS-Like Phenotype in Two Unrelated Patients Carrying a Methylated Premutation of the <i>FMR1</i> Gene.
Fernández E., Gennaro E., Pirozzi F., Baldo C., Forzano F., Turolla L., Faravelli F., Gastaldo D., Coviello D., Grasso M. et al., 2018. Frontiers in Genetics, 9 p. 442. Peer-reviewed.
The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells.
Zalfa F., Panasiti V., Carotti S., Zingariello M., Perrone G., Sancillo L., Pacini L., Luciani F., Roberti V., D'Amico S. et al., 2017/11/16. Cell death & disease, 8 (11) pp. e3169. Peer-reviewed.
 
Gender Equality from a European Perspective: Myth and Reality.
Salinas P.C., Bagni C., 2017/11/15. Neuron, 96 (4) pp. 721-729. Peer-reviewed.
 
Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.
Santini E., Huynh T.N., Longo F., Koo S.Y., Mojica E., D'Andrea L., Bagni C., Klann E., 2017/11/07. Science signaling, 10 (504) pp. NA. Peer-reviewed.
Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse.
Filippini A., Bonini D., Lacoux C., Pacini L., Zingariello M., Sancillo L., Bosisio D., Salvi V., Mingardi J., La Via L. et al., 2017/11/02. RNA biology, 14 (11) pp. 1580-1591. Peer-reviewed.
 
Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.
Fernández E., Collins M.O., Frank RAW, Zhu F., Kopanitsa M.V., Nithianantharajah J., Lemprière S.A., Fricker D., Elsegood K.A., McLaughlin C.L. et al., 2017/10/17. Cell reports, 21 (3) pp. 679-691. Peer-reviewed.
 
Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways.
Borrie S.C., Brems H., Legius E., Bagni C., 2017/08/31. Annual review of genomics and human genetics, 18 pp. 115-142. Peer-reviewed.
The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning.
Briz V., Restivo L., Pasciuto E., Juczewski K., Mercaldo V., Lo A.C., Baatsen P., Gounko N.V., Borreca A., Girardi T. et al., 2017/08/17. Nature communications, 8 (1) p. 293. Peer-reviewed.
 
Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.
Hollis F., Kanellopoulos A.K., Bagni C., 2017/08. Current opinion in neurobiology, 45 pp. 178-187. Peer-reviewed.
 
Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice.
Sabanov V., Braat S., D'Andrea L., Willemsen R., Zeidler S., Rooms L., Bagni C., Kooy R.F., Balschun D., 2017/04. Neuropharmacology, 116 pp. 71-81. Peer-reviewed.
Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.
Geuens T., De Winter V., Rajan N., Achsel T., Mateiu L., Almeida-Souza L., Asselbergh B., Bouhy D., Auer-Grumbach M., Bagni C. et al., 2017/01/11. Acta neuropathologica communications, 5 (1) p. 5. Peer-reviewed.
 
New insights into the metastatic behavior after breast cancer surgery, according to well-established clinicopathological variables and molecular subtypes.
Buonomo O.C., Caredda E., Portarena I., Vanni G., Orlandi A., Bagni C., Petrella G., Palombi L., Orsaria P., 2017. PloS one, 12 (9) pp. e0184680. Peer-reviewed.
 
Neurons acetylate their way to migration.
Borrie S.C., Bagni C., 2016/12. EMBO reports, 17 (12) pp. 1674-1676. Peer-reviewed.
 
Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome.
Juczewski K., von Richthofen H., Bagni C., Celikel T., Fisone G., Krieger P., 2016/12. Neurobiology of disease, 96 pp. 201-215. Peer-reviewed.
 
Cooperativity in RNA-protein interactions: the complex is more than the sum of its partners.
Achsel T., Bagni C., 2016/08. Current opinion in neurobiology, 39 pp. 146-151. Peer-reviewed.
 
Altered neuronal network and rescue in a human MECP2 duplication model
Nageshappa S., Carromeu C., Trujillo C. A., Mesci P., Espuny-Camacho I., Pasciuto E., Vanderhaeghen P., Verfaillie C. M., Raitano S., Kumar A. et al., 2016/02. Mol Psychiatry, 21 (2) pp. 178-88.
Clinical and Molecular Assessment in a Female with Fragile X Syndrome and Tuberous Sclerosis.
Yrigollen C.M., Pacini L., Nobile V., Lozano R., Hagerman R.J., Bagni C., Tassone F., 2016. Journal of genetic disorders & genetic reports, 5 (3) p. 0. Peer-reviewed.
 
Synaptopathy--From Biology to Therapy.
Grant S.G., Bagni C., O'Dell T.J., 2016/01. Neuropharmacology, 100 p. 1.
 
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.
Stepniak B., Kästner A., Poggi G., Mitjans M., Begemann M., Hartmann A., Van der Auwera S., Sananbenesi F., Krueger-Burg D., Matuszko G. et al., 2015/12. EMBO molecular medicine, 7 (12) pp. 1565-1579.
 
Autism Spectrum Disorders: Translating human deficits into mouse behavior
Pasciuto E., Borrie S. C., Kanellopoulos A. K., Santos A. R., Cappuyns E., D'Andrea L., Pacini L., Bagni C., 2015/10. Neurobiol Learn Mem, 124 pp. 71-87.
 
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.
Di Marino D., D'Annessa I., Tancredi H., Bagni C., Gallicchio E., 2015/09. Protein science : a publication of the Protein Society, 24 (9) pp. 1370-1382.
 
MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion.
Di Marino D., Chillemi G., De Rubeis S., Tramontano A., Achsel T., Bagni C., 2015/07/14. Journal of chemical theory and computation, 11 (7) pp. 3401-3410.
 
FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.
Fernández E., Li K.W., Rajan N., De Rubeis S., Fiers M., Smit A.B., Achsel T., Bagni C., 2015/06/24. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35 (25) pp. 9402-9408.
 
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.
Pasciuto E., Ahmed T., Wahle T., Gardoni F., D'Andrea L., Pacini L., Jacquemont S., Tassone F., Balschun D., Dotti C.G. et al., 2015. Neuron, 87 (2) pp. 382-398. Peer-reviewed.
 
Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS
Rossi S., Serrano A., Gerbino V., Giorgi A., Di Francesco L., Nencini M., Bozzo F., Schinina M. E., Bagni C., Cestra G. et al., 2015. J Cell Sci, 128 (9) pp. 1787-99.
 
The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome.
Braat S., D'Hulst C., Heulens I., De Rubeis S., Mientjes E., Nelson D.L., Willemsen R., Bagni C., Van Dam D., De Deyn P.P. et al., 2015. Cell cycle (Georgetown, Tex.), 14 (18) pp. 2985-2995.
 
FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.
La Fata G., Gärtner A., Domínguez-Iturza N., Dresselaers T., Dawitz J., Poorthuis R.B., Averna M., Himmelreich U., Meredith R.M., Achsel T. et al., 2014/12. Nature neuroscience, 17 (12) pp. 1693-1700.
Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.
Panja D., Kenney J.W., D'Andrea L., Zalfa F., Vedeler A., Wibrand K., Fukunaga R., Bagni C., Proud C.G., Bramham C.R., 2014/11/20. Cell reports, 9 (4) pp. 1430-1445.
 
Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.
Santos A.R., Kanellopoulos A.K., Bagni C., 2014/10. Learning & memory (Cold Spring Harbor, N.Y.), 21 (10) pp. 543-555.
SnapShot: FMRP interacting proteins.
Pasciuto E., Bagni C., 2014/09/25. Cell, 159 (1) pp. 218-218.e1.
 
SnapShot: FMRP mRNA targets and diseases.
Pasciuto E., Bagni C., 2014/09/11. Cell, 158 (6) pp. 1446-1446.e1. Peer-reviewed.
 
Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.
Hsia H.E., Kumar R., Luca R., Takeda M., Courchet J., Nakashima J., Wu S., Goebbels S., An W., Eickholt B.J. et al., 2014/09/09. Proceedings of the National Academy of Sciences of the United States of America, 111 (36) pp. 13205-13210.
 
Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function.
Di Marino D., Achsel T., Lacoux C., Falconi M., Bagni C., 2014. Journal of biomolecular structure & dynamics, 32 (3) pp. 337-350.
 
The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses.
Janusz A., Milek J., Perycz M., Pacini L., Bagni C., Kaczmarek L., Dziembowska M., 2013/11/13. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 (46) pp. 18234-18241.
 
Fragile X syndrome: From protein function to therapy.
Bagni C., Oostra B.A., 2013/11. American journal of medical genetics. Part A, 161A (11) pp. 2809-2821.
 
The FMRP regulon: from targets to disease convergence.
Fernández E., Rajan N., Bagni C., 2013/10/24. Frontiers in neuroscience, 7 p. 191.
 
The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation
Luca R., Averna M., Zalfa F., Vecchi M., Bianchi F., La Fata G., Del Nonno F., Nardacci R., Bianchi M., Nuciforo P. et al., 2013/10. EMBO molecular medicine, 5 (10) pp. 1523-36. Peer-reviewed.
 
CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
De Rubeis S., Pasciuto E., Li K.W., Fernández E., Di Marino D., Buzzi A., Ostroff L.E., Klann E., Zwartkruis F.J., Komiyama N.H. et al., 2013/09/18. Neuron, 79 (6) pp. 1169-1182.
 
Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.
Trovò L., Ahmed T., Callaerts-Vegh Z., Buzzi A., Bagni C., Chuah M., Vandendriessche T., D'Hooge R., Balschun D., Dotti C.G., 2013/04. Nature neuroscience, 16 (4) pp. 449-455.
 
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.
De Keersmaecker K., Atak Z.K., Li N., Vicente C., Patchett S., Girardi T., Gianfelici V., Geerdens E., Clappier E., Porcu M. et al., 2013/02. Nature genetics, 45 (2) pp. 186-190.
 
Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B.
Iannilli F., Zalfa F., Gartner A., Bagni C., Dotti C.G., 2013. PloS one, 8 (6) pp. e66602.
 
KIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner.
Charalambous D.C., Pasciuto E., Mercaldo V., Pilo Boyl P., Munck S., Bagni C., Santama N., 2013/01. Cellular and molecular life sciences : CMLS, 70 (2) pp. 335-356.
 
Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics.
Bagni C., Tassone F., Neri G., Hagerman R., 2012/12. The Journal of clinical investigation, 122 (12) pp. 4314-4322.
 
Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome.
Till S.M., Wijetunge L.S., Seidel V.G., Harlow E., Wright A.K., Bagni C., Contractor A., Gillingwater T.H., Kind P.C., 2012/05/15. Human molecular genetics, 21 (10) pp. 2143-2156.
 
BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses.
Lacoux C., Di Marino D., Boyl P.P., Zalfa F., Yan B., Ciotti M.T., Falconi M., Urlaub H., Achsel T., Mougin A. et al., 2012/05. Nucleic acids research, 40 (9) pp. 4086-4096.
 
Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.
Miroci H., Schob C., Kindler S., Ölschläger-Schütt J., Fehr S., Jungenitz T., Schwarzacher S.W., Bagni C., Mohr E., 2012/01/06. The Journal of biological chemistry, 287 (2) pp. 1322-1334.
 
Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.
De Rubeis S., Fernández E., Buzzi A., Di Marino D., Bagni C., 2012. Advances in experimental medicine and biology, 970 pp. 517-551.
 
Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
De Rubeis S., Bagni C., 2011/09. J Neurodev Disord, 3 (3) pp. 257-69.
 
Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles.
Tassone F., De Rubeis S., Carosi C., La Fata G., Serpa G., Raske C., Willemsen R., Hagerman P.J., Bagni C., 2011/08. Nucleic acids research, 39 (14) pp. 6172-6185.
 
Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.
Maccarrone M., Rossi S., Bari M., De Chiara V., Rapino C., Musella A., Bernardi G., Bagni C., Centonze D., 2010/06. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35 (7) pp. 1500-1509.
 
Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability.
De Rubeis S., Bagni C., 2010/01. Molecular and cellular neurosciences, 43 (1) pp. 43-50.
 
Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control.
di Penta A., Mercaldo V., Florenzano F., Munck S., Ciotti M.T., Zalfa F., Mercanti D., Molinari M., Bagni C., Achsel T., 2009/02/09. The Journal of cell biology, 184 (3) pp. 423-435.
 
Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
Fazi B., Melino S., De Rubeis S., Bagni C., Paci M., Piacentini M., Di Sano F., 2009. Oncogene, 28 (43) pp. 3814-24. Peer-reviewed.
 
Signals, synapses, and synthesis: how new proteins control plasticity.
Zukin R.S., Richter J.D., Bagni C., 2009. Frontiers in neural circuits, 3 p. 14.
 
Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations.
Tabolacci E., Moscato U., Zalfa F., Bagni C., Chiurazzi P., Neri G., 2008/12. European journal of human genetics : EJHG, 16 (12) pp. 1487-1498.
 
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.
Napoli I., Mercaldo V., Boyl P.P., Eleuteri B., Zalfa F., De Rubeis S., Di Marino D., Mohr E., Massimi M., Falconi M. et al., 2008/09/19. Cell, 134 (6) pp. 1042-1054.
 
Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome.
Centonze D., Rossi S., Mercaldo V., Napoli I., Ciotti M.T., De Chiara V., Musella A., Prosperetti C., Calabresi P., Bernardi G. et al., 2008/05/15. Biological psychiatry, 63 (10) pp. 963-973.
 
On BC1 RNA and the fragile X mental retardation protein.
Bagni C., 2008/04/29. Proceedings of the National Academy of Sciences of the United States of America, 105 (17) pp. E19.
 
Cortical and subcortical distribution of ionotropic purinergic receptor subunit type 1 (P2X(1)R) immunoreactive neurons in the rat forebrain.
Florenzano F., Carrive P., Viscomi M.T., Ferrari F., Latini L., Conversi D., Cabib S., Bagni C., Molinari M., 2008/02/06. Neuroscience, 151 (3) pp. 791-801.
 
The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum.
Centonze D., Rossi S., Napoli I., Mercaldo V., Lacoux C., Ferrari F., Ciotti M.T., De Chiara V., Prosperetti C., Maccarrone M. et al., 2007/08/15. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 (33) pp. 8885-8892.
 
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.
Zalfa F., Eleuteri B., Dickson K.S., Mercaldo V., De Rubeis S., di Penta A., Tabolacci E., Chiurazzi P., Neri G., Grant S.G. et al., 2007/05. Nature neuroscience, 10 (5) pp. 578-587.
 
Elevated FMR1 mRNA in premutation carriers is due to increased transcription
Tassone F., Beilina A., Carosi C., Albertosi S., Bagni C., Li L., Glover K., Bentley D., Hagerman P. J., 2007/04. RNA, 13 (4) pp. 555-62.
 
The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines.
Ferrari F., Mercaldo V., Piccoli G., Sala C., Cannata S., Achsel T., Bagni C., 2007/03. Molecular and cellular neurosciences, 34 (3) pp. 343-354.
 
P2X2R purinergic receptor subunit mRNA and protein are expressed by all hypothalamic hypocretin/orexin neurons.
Florenzano F., Viscomi M.T., Mercaldo V., Longone P., Bernardi G., Bagni C., Molinari M., Carrive P., 2006/09/01. The Journal of comparative neurology, 498 (1) pp. 58-67.
 
mRNPs, polysomes or granules: FMRP in neuronal protein synthesis.
Zalfa F., Achsel T., Bagni C., 2006/06. Current opinion in neurobiology, 16 (3) pp. 265-269.
 
The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes.
Paronetto M.P., Zalfa F., Botti F., Geremia R., Bagni C., Sette C., 2006/01. Molecular biology of the cell, 17 (1) pp. 14-24.
 
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.
Zalfa F., Adinolfi S., Napoli I., Kühn-Hölsken E., Urlaub H., Achsel T., Pastore A., Bagni C., 2005/09/30. The Journal of biological chemistry, 280 (39) pp. 33403-33410.
 
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.
Restivo L., Ferrari F., Passino E., Sgobio C., Bock J., Oostra B.A., Bagni C., Ammassari-Teule M., 2005/08/09. Proceedings of the National Academy of Sciences of the United States of America, 102 (32) pp. 11557-11562.
 
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome.
Bagni C., Greenough W.T., 2005/05. Nature reviews. Neuroscience, 6 (5) pp. 376-387.
 
Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth.
Baldini P.M., De Vito P., D'aquilio F., Vismara D., Zalfa F., Bagni C., Fiaccavento R., Di Nardo P., 2005/04. Molecular and cellular biochemistry, 272 (1-2) pp. 19-28.
 
Molecular dissection of the events leading to inactivation of the FMR1 gene.
Pietrobono R., Tabolacci E., Zalfa F., Zito I., Terracciano A., Moscato U., Bagni C., Oostra B., Chiurazzi P., Neri G., 2005/01/15. Human molecular genetics, 14 (2) pp. 267-277.
 
Another view of the role of FMRP in translational regulation.
Zalfa F., Bagni C., 2005/01. Cellular and molecular life sciences : CMLS, 62 (2) pp. 251-252.
 
Atrial natriuretic peptide effects on intracellular pH changes and ROS production in HEPG2 cells: role of p38 MAPK and phospholipase D.
Baldini P.M., De Vito P., Vismara D., Bagni C., Zalfa F., Minieri M., Di Nardo P., 2005. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 15 (1-4) pp. 77-88.
 
Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase.
Baldini P.M., De Vito P., Antenucci D., Vismara D., D'Aquilio F., Luly P., Zalfa F., Bagni C., Di Nardo P., 2004/12. Cell death and differentiation, 11 Suppl 2 pp. S210-2.
 
FMRP and its target RNAs: fishing for the specificity.
Veneri M., Zalfa F., Bagni C., 2004/11/15. Neuroreport, 15 (16) pp. 2447-2450.
 
Molecular insights into mental retardation: multiple functions for the Fragile X mental retardation protein?
Zalfa F., Bagni C., 2004/07. Current issues in molecular biology, 6 (2) pp. 73-88.
 
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.
Zalfa F., Giorgi M., Primerano B., Moro A., Di Penta A., Reis S., Oostra B., Bagni C., 2003/02/07. Cell, 112 (3) pp. 317-327.
 
Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations
Primerano B., Tassone F., Hagerman R. J., Hagerman P., Amaldi F., Bagni C., 2002/12. RNA, 8 (12) pp. 1482-8. Peer-reviewed.
 
The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development.
Bagni C., Bray S., Gogos J.A., Kafatos F.C., Hsu T., 2002/09. Mechanisms of development, 117 (1-2) pp. 265-268.
 
A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency.
Signori E., Bagni C., Papa S., Primerano B., Rinaldi M., Amaldi F., Fazio V.M., 2001/07/27. Oncogene, 20 (33) pp. 4596-4600.
 
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.
Schenck A., Bardoni B., Moro A., Bagni C., Mandel J.L., 2001/07/17. Proceedings of the National Academy of Sciences of the United States of America, 98 (15) pp. 8844-8849.
 
Fibrillin-1 (FBN1) gene frameshift mutations in Marfan patients: genotype-phenotype correlation
Pepe G., Giusti B., Evangelisti L., Porciani M. C., Brunelli T., Giurlani L., Attanasio M., Fattori R., Bagni C., Comeglio P. et al., 2001/06. Clin Genet, 59 (6) pp. 444-50.
 
Nerve-independence of limb regeneration in larval Xenopus laevis is correlated to the level of fgf-2 mRNA expression in limb tissues.
Cannata S.M., Bagni C., Bernardini S., Christen B., Filoni S., 2001/03/15. Developmental biology, 231 (2) pp. 436-446.
 
Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes.
Bagni C., Mannucci L., Dotti C.G., Amaldi F., 2000/05/15. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20 (10) pp. RC76. Peer-reviewed.
 
Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation.
Mariottini P., Shah Z.H., Toivonen J.M., Bagni C., Spelbrink J.N., Amaldi F., Jacobs H.T., 1999/11/05. The Journal of biological chemistry, 274 (45) pp. 31853-31862.
 
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains
Adinolfi S., Bagni C., Musco G., Gibson T., Mazzarella L., Pastore A., 1999/09. RNA, 5 (9) pp. 1248-58.
 
Novel RNA-binding motif: the KH module
Adinolfi S., Bagni C., Castiglione Morelli M. A., Fraternali F., Musco G., Pastore A., 1999. Biopolymers, 51 (2) pp. 153-64.
 
Gar1p binds to the small nucleolar RNAs snR10 and snR30 in vitro through a nontypical RNA binding element
Bagni C., Lapeyre B., 1998. J Biol Chem, 273 (18) pp. 10868-73.
 
The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis.
Hsu T., Bagni C., Sutherland J.D., Kafatos F.C., 1996/06/01. Genes & development, 10 (11) pp. 1411-1421.
 
Identification of a segment of the small nucleolar ribonucleoprotein-associated protein GAR1 that is sufficient for nucleolar accumulation.
Girard J.P., Bagni C., Caizergues-Ferrer M., Amalric F., Lapeyre B., 1994/07/15. The Journal of biological chemistry, 269 (28) pp. 18499-18506.
 
Human ribosomal protein L4: Cloning and sequencing of the cDNA and primary structure of the protein
Bagni Claudia, Mariottini Paolo, Annesi Flavia, Amaldi Francesco, 1993/12. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1216 (3) pp. 475-478. Peer-reviewed.
 
Sequence of the gene coding for ribosomal protein S8 of Xenopus laevis.
Mariottini P., Bagni C., Francesconi A., Cecconi F., Serra M.J., Chen Q.M., Loreni F., Annesi F., Amaldi F., 1993/10/15. Gene, 132 (2) pp. 255-260.
 
The pyrimidine sequence encompassing the transcription start point of Xenopus laevis ribosomal-protein-encoding genes is not obligatory for activity in oocytes.
Chen Q.M., Mariottini P., Bagni C., Amaldi F., 1992/10/01. Gene, 119 (2) pp. 283-286.
 
Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis.
Bagni C., Mariottini P., Terrenato L., Amaldi F., 1992/07. Molecular & general genetics : MGG, 234 (1) pp. 60-64.
 
Structure of Xenopus laevis ribosomal protein L32 and its expression during development.
Bagni C., Mariottini P., Annesi F., Amaldi F., 1990/08/11. Nucleic acids research, 18 (15) pp. 4423-4426.
 
Isolation and nucleotide sequences of cDNAs for Xenopus laevis ribosomal protein S8: similarities in the 5' and 3' untranslated regions of mRNAs for various r-proteins
Mariottini P., Bagni C., Annesi F., Amaldi F., 1988. Gene, 67 (1) pp. 69-74.
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