Stephan Gruber

Publications | Phd and Masters theses

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58 publications

2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2009 | 2006 | 2004 | 2003 |
2025
 
4G cloning: rapid gene assembly for expression of multisubunit protein complexes in diverse hosts.
Taschner M., Dickinson J.B., Roisné-Hamelin F., Gruber S., 2025/01. Life science alliance, 8 (1). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BA8E24BE4E11]
2024
 
DNA supercoiling enhances DNA condensation by ParB proteins.
Martin-Gonzalez A., Tišma M., Analikwu B.T., Barth A., Janissen R., Antar H., Kemps G., Gruber S., Dekker C., 2024/11/27. Nucleic acids research, 52 (21) pp. 13255-13268. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9F0306AB2E80]
Author Correction: Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells.
Tišma M., Bock F.P., Kerssemakers J., Antar H., Japaridze A., Gruber S., Dekker C., 2024/04/16. Nature communications, 15 (1) p. 3262. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_6A104A5997DB]
Direct observation of a crescent-shape chromosome in expanded Bacillus subtilis cells.
Tišma M., Bock F.P., Kerssemakers J., Antar H., Japaridze A., Gruber S., Dekker C., 2024/03/28. Nature communications, 15 (1) p. 2737. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4DFF04DA4876]
 
A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection.
Liu X., Van Maele L., Matarazzo L., Soulard D., Alves Duarte da Silva V., de Bakker V., Dénéréaz J., Bock F.P., Taschner M., Ou J. et al., 2024/03/13. Cell host & microbe, 32 (3) pp. 304-314.e8. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8FC71E910A82]
 
Structural basis for plasmid restriction by SMC JET nuclease.
Roisné-Hamelin F., Liu H.W., Taschner M., Li Y., Gruber S., 2024/03/07. Molecular cell, 84 (5) pp. 883-896.e7. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_39FEBB8303EA]
Connecting the dots: key insights on ParB for chromosome segregation from single-molecule studies.
Tišma M., Kaljević J., Gruber S., Le TBK, Dekker C., 2024/01/12. FEMS microbiology reviews, 48 (1). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5237C9726795]
2023
Dynamic ParB-DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation.
Tišma M., Janissen R., Antar H., Martin-Gonzalez A., Barth R., Beekman T., van der Torre J., Michieletto D., Gruber S., Dekker C., 2023/11/27. Nucleic acids research, 51 (21) pp. 11856-11875. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_EEFC3A3FAD6F]
VirB, a transcriptional activator of virulence in Shigella flexneri, uses CTP as a cofactor.
Antar H., Gruber S., 2023/11/25. Communications biology, 6 (1) p. 1204. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A73E455C7348]
SMC-based immunity against extrachromosomal DNA elements.
Liu H.W., Roisné-Hamelin F., Gruber S., 2023/08/31. Biochemical Society transactions, 51 (4) pp. 1571-1583. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6D567F950048]
DNA segment capture by Smc5/6 holocomplexes.
Taschner M., Gruber S., 2023/05. Nature structural & molecular biology, 30 (5) pp. 619-628. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E4AD008053CC]
2022
 
DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.
Liu H.W., Roisné-Hamelin F., Beckert B., Li Y., Myasnikov A., Gruber S., 2022/12/15. Molecular cell, 82 (24) pp. 4727-4740.e6. Peer-reviewed.
[DOI][Pmid][serval:BIB_0D3204747A97]
Chromosome remodelling by SMC/Condensin in B. subtilis is regulated by monomeric Soj/ParA during growth and sporulation.
Roberts D.M., Anchimiuk A., Kloosterman T.G., Murray H., Wu L.J., Gruber S., Errington J., 2022/10/11. Proceedings of the National Academy of Sciences of the United States of America, 119 (41) pp. e2204042119. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_DD6E45BF5EF5]
A joint-ParB interface promotes Smc DNA recruitment.
Bock F.P., Liu H.W., Anchimiuk A., Diebold-Durand M.L., Gruber S., 2022/08/30. Cell reports, 40 (9) p. 111273. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_202D0C656B23]
ParB proteins can bypass DNA-bound roadblocks via dimer-dimer recruitment.
Tišma M., Panoukidou M., Antar H., Soh Y.M., Barth R., Pradhan B., Barth A., van der Torre J., Michieletto D., Gruber S. et al., 2022/07. Science advances, 8 (26) pp. eabn3299. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8BE4A8F64584]
DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations.
Nomidis S.K., Carlon E., Gruber S., Marko J.F., 2022/05/20. Nucleic acids research, 50 (9) pp. 4974-4987. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6486FE868A87]
2021
 
Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly.
Antar H., Soh Y.M., Zamuner S., Bock F.P., Anchimiuk A., Rios P.L., Gruber S., 2021/10/08. Science advances, 7 (41) pp. eabj2854. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_20D31F118858]
CcrZ is a pneumococcal spatiotemporal cell cycle regulator that interacts with FtsZ and controls DNA replication by modulating the activity of DnaA.
Gallay C., Sanselicio S., Anderson M.E., Soh Y.M., Liu X., Stamsås G.A., Pelliciari S., van Raaphorst R., Dénéréaz J., Kjos M. et al., 2021/09. Nature microbiology, 6 (9) pp. 1175-1187. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_40674097E50D]
 
A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis.
Anchimiuk A., Lioy V.S., Bock F.P., Minnen A., Boccard F., Gruber S., 2021/08/04. eLife, 10 pp. e65467. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_049AF7648880]
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
Taschner M., Basquin J., Steigenberger B., Schäfer I.B., Soh Y.M., Basquin C., Lorentzen E., Räschle M., Scheltema R.A., Gruber S., 2021/08/02. The EMBO journal, 40 (15) pp. e107807. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_43B3495591E9]
 
Gradual opening of Smc arms in prokaryotic condensin.
Vazquez Nunez R., Polyhach Y., Soh Y.M., Jeschke G., Gruber S., 2021/04/27. Cell reports, 35 (4) p. 109051. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AC9DF70CFFD7]
 
A rod conformation of the Pyrococcus furiosus Rad50 coiled coil.
Soh Y.M., Basquin J., Gruber S., 2021/02. Proteins, 89 (2) pp. 251-255. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E5C92095B881]
2020
Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.
Yahya G., Wu Y., Peplowska K., Röhrl J., Soh Y.M., Bürmann F., Gruber S., Storchova Z., 2020/08. PLoS genetics, 16 (8) pp. e1008569. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D23C2314CE14]
Evidence for binary Smc complexes lacking kite subunits in archaea.
Jeon J.H., Lee H.S., Shin H.C., Kwak M.J., Kim Y.G., Gruber S., Oh B.H., 2020/03/01. IUCrJ, 7 (Pt 2) pp. 193-206. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0E1B2C047AE8]
 
Decision Making in Phagocytosis.
Prassler J., Simon F., Ecke M., Gruber S., Gerisch G., 2020. Advances in experimental medicine and biology, 1246 pp. 71-81. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3CCDAECBDE69]
2019
 
Self-organization of parS centromeres by the ParB CTP hydrolase.
Soh Y.M., Davidson I.F., Zamuner S., Basquin J., Bock F.P., Taschner M., Veening J.W., De Los Rios P., Peters J.M., Gruber S., 2019/11/29. Science, 366 (6469) pp. 1129-1133. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9E013C97CC59]
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes.
Marko J.F., De Los Rios P., Barducci A., Gruber S., 2019/07/26. Nucleic acids research, 47 (13) pp. 6956-6972. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B273DE7A00DB]
 
Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin.
Vazquez Nunez R., Ruiz Avila L.B., Gruber S., 2019/07/25. Molecular cell, 75 (2) pp. 209-223.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6B7EB2A633CA]
 
High-Throughput Allelic Replacement Screening in Bacillus subtilis
Diebold-Durand Marie-Laure, Bürmann Frank, Gruber Stephan, 2019. pp. 49-61 dans Methods in Molecular Biology, Springer New York.
[DOI][WoS][Pmid][serval:BIB_9C99FD65C519]
2018
 
SMC complexes sweeping through the chromosome: going with the flow and against the tide.
Gruber S., 2018/04. Current opinion in microbiology, 42 pp. 96-103. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_38E4210F8957]
The complete and fully assembled genome sequence of Aeromonas salmonicida subsp. pectinolytica and its comparative analysis with other Aeromonas species: investigation of the mobilome in environmental and pathogenic strains.
Pfeiffer F., Zamora-Lagos M.A., Blettinger M., Yeroslaviz A., Dahl A., Gruber S., Habermann B.H., 2018/01/05. BMC genomics, 19 (1) p. 20. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BF2A2E62E4A5]
Optimization of sample preparation and green color imaging using the mNeonGreen fluorescent protein in bacterial cells for photoactivated localization microscopy.
Stockmar I., Feddersen H., Cramer K., Gruber S., Jung K., Bramkamp M., Shin J.Y., 2018. Scientific Reports, 8 (1) p. 10137. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AF489DBA71A2]
2017
 
Shaping chromosomes by DNA capture and release: gating the SMC rings.
Gruber S., 2017/06. Current opinion in cell biology, 46 pp. 87-93. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5B0C94116F35]
 
A Chromosome Co-Entrapment Assay to Study Topological Protein-DNA Interactions.
Wilhelm L., Gruber S., 2017. pp. 117-126 dans Methods in molecular biology chap. 10, Springer.
[DOI][Pmid][serval:BIB_F71D641D5A42]
Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.
Diebold-Durand M.L., Lee H., Ruiz Avila L.B., Noh H., Shin H.C., Im H., Bock F.P., Bürmann F., Durand A., Basfeld A. et al., 2017. Molecular Cell, 67 (2) pp. 334-347.e5. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C182D6166CED]
Tuned SMC Arms Drive Chromosomal Loading of Prokaryotic Condensin.
Bürmann F., Basfeld A., Vazquez Nunez R., Diebold-Durand M.L., Wilhelm L., Gruber S., 2017. Molecular Cell, 65 (5) pp. 861-872.e9. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6CA09AC28052]
2016
 
Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA.
Minnen A., Bürmann F., Wilhelm L., Anchimiuk A., Diebold-Durand M.L., Gruber S., 2016. Cell Reports, 14 (8) pp. 2003-2016. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_ED22B290CD8E]
 
SnapShot: SMC Protein Complexes Part I.
Haering C.H., Gruber S., 2016. Cell, 164 (1-2) pp. 326-6.e1.
[DOI][WoS][Pmid][serval:BIB_1FB96509A2D6]
 
SnapShot: SMC Protein Complexes Part II.
Haering C.H., Gruber S., 2016. Cell, 164 (4) p. 818.e1.
[DOI][WoS][Pmid][serval:BIB_278CA32D7CAF]
2015
 
Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination.
Kang H.A., Shin H.C., Kalantzi A.S., Toseland C.P., Kim H.M., Gruber S., Peraro M.D., Oh B.H., 2015. Nucleic Acids Research, 43 (7) pp. 3841-3856. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C987AB7FF934]
 
Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes.
Palecek J.J., Gruber S., 2015. Structure, 23 (12) pp. 2183-2190. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9DE12A6FA869]
 
Molecular basis for SMC rod formation and its dissolution upon DNA binding.
Soh Y.M., Bürmann F., Shin H.C., Oda T., Jin K.S., Toseland C.P., Kim C., Lee H., Kim S.J., Kong M.S. et al., 2015. Molecular Cell, 57 (2) pp. 290-303. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_177609129EF8]
 
SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis.
Wilhelm L., Bürmann F., Minnen A., Shin H.C., Toseland C.P., Oh B.H., Gruber S., 2015. Elife, 4 pp. e06659. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F252E28CF587]
 
SMC condensin: promoting cohesion of replicon arms.
Bürmann F., Gruber S., 2015. Nature Structural and Molecular Biology, 22 (9) pp. 653-655.
[DOI][WoS][Pmid][serval:BIB_497537C23E4E]
 
The ParB-parS Chromosome Segregation System Modulates Competence Development in Streptococcus pneumoniae.
Attaiech L., Minnen A., Kjos M., Gruber S., Veening J.W., 2015. mBio, 6 (4) pp. e00662. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2CEA84E4DF3B]
2014
 
Closing the cohesin ring: structure and function of its Smc3-kleisin interface.
Gligoris T.G., Scheinost J.C., Bürmann F., Petela N., Chan K.L., Uluocak P., Beckouët F., Gruber S., Nasmyth K., Löwe J., 2014. Science, 346 (6212) pp. 963-967. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_15481644001C]
 
Interlinked sister chromosomes arise in the absence of condensin during fast replication in B. subtilis.
Gruber S., Veening J.W., Bach J., Blettinger M., Bramkamp M., Errington J., 2014. Current Biology, 24 (3) pp. 293-298. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_41E90C2572DF]
 
Multilayer chromosome organization through DNA bending, bridging and extrusion.
Gruber S., 2014. Current Opinion in Microbiology, 22 pp. 102-110.
[DOI][WoS][Pmid][serval:BIB_56291B298CCB]
2013
 
An asymmetric SMC-kleisin bridge in prokaryotic condensin.
Bürmann F., Shin H.C., Basquin J., Soh Y.M., Giménez-Oya V., Kim Y.G., Oh B.H., Gruber S., 2013. Nature Structural and Molecular Biology, 20 (3) pp. 371-379. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F9ABB4C3B4F6]
2011
 
MukBEF on the march: taking over chromosome organization in bacteria?
Gruber S., 2011. Molecular Microbiology, 81 (4) pp. 855-859.
[DOI][WoS][Pmid][serval:BIB_8982FDC1A1C6]
 
SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae.
Minnen A., Attaiech L., Thon M., Gruber S., Veening J.W., 2011. Molecular Microbiology, 81 (3) pp. 676-688. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8461B14D48C3]
2009
 
Recruitment of condensin to replication origin regions by ParB/SpoOJ promotes chromosome segregation in B. subtilis.
Gruber S., Errington J., 2009. Cell, 137 (4) pp. 685-696. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CA638E2C15CF]
2006
 
Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.
Arumugam P., Nishino T., Haering C.H., Gruber S., Nasmyth K., 2006. Current Biology, 16 (20) pp. 1998-2008. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1D374F049182]
 
Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.
Gruber S., Arumugam P., Katou Y., Kuglitsch D., Helmhart W., Shirahige K., Nasmyth K., 2006. Cell, 127 (3) pp. 523-537. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4654023B7BA7]
2004
 
Is chromatin remodeling required to build sister-chromatid cohesion?
Riedel C.G., Gregan J., Gruber S., Nasmyth K., 2004. Trends in Biochemical Sciences, 29 (8) pp. 389-392.
[DOI][WoS][Pmid][serval:BIB_33C8BE89ECE8]
2003
 
ATP hydrolysis is required for cohesin's association with chromosomes.
Arumugam P., Gruber S., Tanaka K., Haering C.H., Mechtler K., Nasmyth K., 2003. Current Biology, 13 (22) pp. 1941-1953. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C0C2D0E9DA4C]
 
Chromosomal cohesin forms a ring.
Gruber S., Haering C.H., Nasmyth K., 2003. Cell, 112 (6) pp. 765-777. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C38B04644C81]
 
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Buonomo S.B., Rabitsch K.P., Fuchs J., Gruber S., Sullivan M., Uhlmann F., Petronczki M., Tóth A., Nasmyth K., 2003. Developmental Cell, 4 (5) pp. 727-739. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_17953E7CF7FE]
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