Petr Broz

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105 publications

2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2005 | 2003 |
2025
CCDC134 controls TLR biogenesis through the ER chaperone Gp96
Bernaleau Léa, Drobek Michaela, Blank Fenja, Walch Philipp, Delacrétaz Maeva, Drobek Ales, Monguió-Tortajada Marta, Broz Petr, Majer Olivia, Rebsamen Manuele, 2025/03/03. Journal of Experimental Medicine, 222 (3). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_02463DF581EB]
2024
 
Viral-bacterial co-infections screen in vitro reveals molecular processes affecting pathogen proliferation and host cell viability.
Walch P., Broz P., 2024/10/04. Nature communications, 15 (1) p. 8595. Peer-reviewed.
[DOI][Pmid][serval:BIB_9A754395BCC1]
 
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation.
Hartenian E., Broz P., 2024/10. Cell research, 34 (10) pp. 675-676. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_126D06EA773F]
 
Gasdermins as evolutionarily conserved executors of inflammation and cell death.
Chen K.W., Broz P., 2024/09. Nature cell biology, 26 (9) pp. 1394-1406. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_19AC3AC64FEE]
 
NLRP1-dependent activation of Gasdermin D in neutrophils controls cutaneous leishmaniasis.
Goris M., Passelli K., Peyvandi S., Díaz-Varela M., Billion O., Prat-Luri B., Demarco B., Desponds C., Termote M., Iniguez E. et al., 2024/09. PLoS pathogens, 20 (9) pp. e1012527. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7C4D97BB2E62]
 
Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture.
Ramos S., Hartenian E., Broz P., 2024/08. Trends in biochemical sciences, 49 (8) pp. 717-728. Peer-reviewed.
[DOI][Pmid][serval:BIB_B7387FE546AF]
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis.
Ramos S., Hartenian E., Santos J.C., Walch P., Broz P., 2024/04. The EMBO journal, 43 (7) pp. 1164-1186. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_E885446D4A15]
Selective induction of programmed cell death using synthetic biology tools.
Shkarina K., Broz P., 2024/03/15. Seminars in cell & developmental biology, 156 pp. 74-92. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_2EE059EAF4AC]
 
Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions.
Sollier J., Basler M., Broz P., Dittrich P.S., Drescher K., Egli A., Harms A., Hierlemann A., Hiller S., King C.G. et al., 2024/01. Nature microbiology, 9 (1) pp. 1-3. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EB304466645B]
2023
E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.
Pruenster M., Immler R., Roth J., Kuchler T., Bromberger T., Napoli M., Nussbaumer K., Rohwedder I., Wackerbarth L.M., Piantoni C. et al., 2023/12. Nature immunology, 24 (12) pp. 2021-2031. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_738C3585C874]
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Fattinger S.A., Maurer L., Geiser P., Bernard E.M., Enz U., Ganguillet S., Gül E., Kroon S., Demarco B., Mack V. et al., 2023/11/28. Proceedings of the National Academy of Sciences of the United States of America, 120 (48) pp. e2315503120. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_5D7AB13847DD]
Unconventional protein secretion by gasdermin pores.
Broz P., 2023/09. Seminars in immunology, 69 p. 101811. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_C83DC8D8B0B6]
 
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.
Bernard E.M., Broz P., 2023/08/03. Molecular cell, 83 (15) pp. 2621-2623. Peer-reviewed.
[DOI][Pmid][serval:BIB_DF61EFC56003]
Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines.
Shkarina K., Broz P., 2023/07/20. Bio-protocol, 13 (14) pp. e4762. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_CA11157AA004]
The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death.
Hasel de Carvalho E., Dharmadhikari S.S., Shkarina K., Xiong J.R., Reversade B., Broz P., Leptin M., 2023/07/07. eLife, 12 pp. e86373. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D9A90FC8CC5C]
Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
Degen M., Santos J.C., Pluhackova K., Cebrero G., Ramos S., Jankevicius G., Hartenian E., Guillerm U., Mari S.A., Kohl B. et al., 2023/06. Nature, 618 (7967) pp. 1065-1071. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EC6DA0B4AD39]
 
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale I., Pietrocola F., Guilbaud E., Aaronson S.A., Abrams J.M., Adam D., Agostini M., Agostinis P., Alnemri E.S., Altucci L. et al., 2023/05. Cell death and differentiation, 30 (5) pp. 1097-1154. Peer-reviewed.
[DOI][Pmid][serval:BIB_5886312BEF39]
 
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure.
Leinardi R., Pochet A., Uwambayinema F., Yakoub Y., Quesniaux V., Ryffel B., Broz P., Pavan C., Huaux F., 2023/04. Archives of toxicology, 97 (4) pp. 1001-1015. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F76FD63F5D54]
 
Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria
Dilucca Marisa, Broz Petr, 2023. pp. 49-65 dans Pyroptosis, Springer US.
[DOI][Pmid][serval:BIB_E522DEB8F2BC]
2022
 
Optogenetic activators of apoptosis, necroptosis, and pyroptosis.
Shkarina K., Hasel de Carvalho E., Santos J.C., Ramos S., Leptin M., Broz P., 2022/06/06. The Journal of cell biology, 221 (6) pp. e202109038. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2987155B2350]
 
Viral protein activates the NLRP1 inflammasome.
Hartenian E., Broz P., 2022/06. Nature immunology, 23 (6) pp. 822-824. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_21857F591F35]
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections.
Bernard E.M., Broz P., 2022/04/14. The Biochemical journal, 479 (7) pp. 867-882. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F5EFACC64C78]
 
Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores.
Rühl S., Broz P., 2022/02/28. Journal of molecular biology, 434 (4) p. 167246. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_84772DDF6481]
 
Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3.
Huot-Marchand S., Nascimento M., Culerier E., Bourenane M., Savigny F., Panek C., Serdjebi C., Le Bert M., Quesniaux VFJ, Ryffel B. et al., 2022. Frontiers in immunology, 13 p. 918507. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_03B6B717FE36]
 
Detection of Gasdermin Activation and Lytic Cell Death During Pyroptosis and Apoptosis
Demarco Benjamin, Ramos Saray, Broz Petr, 2022. pp. 209-237 dans Effector-Triggered Immunity, Springer.
[DOI][WoS][Pmid][serval:BIB_A6C3ABD5FE08]
2021
 
The Card19 locus of murine chromosome 13 regulates terminal cell lysis downstream of caspase activation and Gasdermin-D cleavage
Bjanes Elisabet, Sillas Reyna Garcia, Matsuda Rina, Demarco Benjamin, Fettrelet Timothée, DeLaney Alexandra A., Rodriguez Lopez Eric M., Grubaugh Daniel, Wynosky-Dolfi Meghan A., Philip Naomi H. et al., 2021/10/21..
[DOI][serval:BIB_4C11E79A49D0]
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection.
Bjanes E., Sillas R.G., Matsuda R., Demarco B., Fettrelet T., DeLaney A.A., Kornfeld O.S., Lee B.L., Rodríguez López E.M., Grubaugh D. et al., 2021/10. PLoS pathogens, 17 (10) pp. e1009967. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5746E3C0A927]
Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation.
Dilucca M., Ramos S., Shkarina K., Santos J.C., Broz P., 2021/08/31. mBio, 12 (4) pp. e0205421. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_78967419823A]
 
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.
Chen K.W., Demarco B., Ramos S., Heilig R., Goris M., Grayczyk J.P., Assenmacher C.A., Radaelli E., Joannas L.D., Henao-Mejia J. et al., 2021/07/13. Proceedings of the National Academy of Sciences of the United States of America, 118 (28) p. 34260403. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_595417C2F004]
Active membrane rupture spurs a range of cell deaths.
Hiller S., Broz P., 2021/03/08. Nature, 591 (7848) pp. 36-37. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2B6721A8AAE8]
2020
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.
Demarco B., Grayczyk J.P., Bjanes E., Le Roy D., Tonnus W., Assenmacher C.A., Radaelli E., Fettrelet T., Mack V., Linkermann A. et al., 2020/11. Science advances, 6 (47) pp. eabc3465. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1DC0C3FF12E6]
Cross talk between intracellular pathogens and cell death.
Demarco B., Chen K.W., Broz P., 2020/09. Immunological reviews, 297 (1) pp. 174-193. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_456F4BB4C5ED]
Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose.
Muri J., Wolleb H., Broz P., Carreira E.M., Kopf M., 2020/09. Redox biology, 36 p. 101647. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FBF85D95AF9E]
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Santos J.C., Boucher D., Schneider L.K., Demarco B., Dilucca M., Shkarina K., Heilig R., Chen K.W., Lim RYH, Broz P., 2020/06/24. Nature communications, 11 (1) p. 3276. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_241083E0FA4C]
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD.
Heilig R., Dilucca M., Boucher D., Chen K.W., Hancz D., Demarco B., Shkarina K., Broz P., 2020/06. Life science alliance, 3 (6) pp. e202000735. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0F375D8FC416]
 
Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways.
Muri J., Feng Q., Wolleb H., Shamshiev A., Ebner C., Tortola L., Broz P., Carreira E.M., Kopf M., 2020/03/31. Cell reports, 30 (13) pp. 4399-4417.e7. Peer-reviewed.
[DOI][Pmid][serval:BIB_FFBFA88A7B04]
The gasdermins, a protein family executing cell death and inflammation.
Broz P., Pelegrín P., Shao F., 2020/03. Nature reviews. Immunology, 20 (3) pp. 143-157. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CBCAA3D61F5E]
Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation.
Chen K.W., Demarco B., Broz P., 2020/02. European journal of immunology, 50 (2) pp. 170-177. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_27CA2505F865]
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.
Chen K.W., Demarco B., Broz P., 2020/01/15. The EMBO journal, 39 (2) pp. e103397. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_82D60FA890A5]
2019
 
NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.
Radulovic K., Ayata C.K., Mak'Anyengo R., Lechner K., Wuggenig P., Kaya B., Hruz P., Gomez de Agüero M., Broz P., Weigmann B. et al., 2019/07/15. Journal of immunology, 203 (2) pp. 544-556. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FB1F4EA9ABB0]
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
Chen K.W., Demarco B., Heilig R., Shkarina K., Boettcher A., Farady C.J., Pelczar P., Broz P., 2019/05/15. The EMBO journal, 38 (10). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5A6F55CD6B0E]
Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.
Chen K.W., Boucher D., Broz P., 2019/03. Cell research, 29 (3) pp. 181-182. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_ECC2D5987BCD]
 
Recognition of Intracellular Bacteria by Inflammasomes.
Broz P., 2019/03. Microbiology spectrum, 7 (2). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9706BF5CAE4E]
 
A Surface-Induced Asymmetric Program Promotes Tissue Colonization by Pseudomonas aeruginosa.
Laventie B.J., Sangermani M., Estermann F., Manfredi P., Planes R., Hug I., Jaeger T., Meunier E., Broz P., Jenal U., 2019/01/09. Cell host & microbe, 25 (1) pp. 140-152.e6. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8C7565359992]
 
An integrative protocol for the structure determination of the mouse ASC-PYD filament.
Mazur A., Broz P., Hiller S., 2019. Methods in enzymology, 625 pp. 205-222. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8490B4FAC262]
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.
Demarco B., Chen K.W., Broz P., 2019. Molecular & cellular oncology, 6 (4) p. 1610324. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_30F06BA65EA3]
2018
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
Cerqueira D.M., Gomes MTR, Silva ALN, Rungue M., Assis NRG, Guimarães E.S., Morais S.B., Broz P., Zamboni D.S., Oliveira S.C., 2018/12. PLoS pathogens, 14 (12) pp. e1007519. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_657DFCFBDA80]
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D., Bartok E., Gaidt M.M., Bock F.J., Herrmann J., Seeger J.M., Broz P., Beckmann R., Kashkar H., Tait SWG et al., 2018/11/27. Cell reports, 25 (9) pp. 2354-2368.e5. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6A46ECA09273]
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.
Rühl S., Shkarina K., Demarco B., Heilig R., Santos J.C., Broz P., 2018/11/23. Science, 362 (6417) pp. 956-960. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EC1D001C7201]
 
Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.
Santos J.C., Broz P., 2018/10. Journal of leukocyte biology, 104 (4) pp. 729-735. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F183C2E25CDD]
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.
Chen K.W., Monteleone M., Boucher D., Sollberger G., Ramnath D., Condon N.D., von Pein J.B., Broz P., Sweet M.J., Schroder K., 2018/08/24. Science immunology, 3 (26) pp. eaar6676. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_96CCEAA6A9DE]
Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament
Sborgi Lorenzo, Ude Johanna, Dick Mathias S., Vesin Jonathan, Chambon Marc, Turcatti Gerardo, Broz Petr, Hiller Sebastian, 2018/04/09. Cell Stress, 2 (4) pp. 82-90.
[URN][DOI][Pmid][serval:BIB_30C0C0C6A9A5]
 
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Santos J.C., Dick M.S., Lagrange B., Degrandi D., Pfeffer K., Yamamoto M., Meunier E., Pelczar P., Henry T., Broz P., 2018/03/15. The EMBO journal, 37 (6) pp. 1-19. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C2F39FFB50CB]
 
Function and mechanism of the pyrin inflammasome.
Heilig R., Broz P., 2018/02. European journal of immunology, 48 (2) pp. 230-238. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9CB85942D08B]
 
Mechanisms and Consequences of Inflammasome Activation.
Schroder K., Kanneganti T.D., Shao F., Broz P., 2018/01/19. Journal of molecular biology, 430 (2) pp. 131-132. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_111380FE9173]
 
Detecting Release of Bacterial dsDNA into the Host Cytosol Using Fluorescence Microscopy.
Dreier R.F., Santos J.C., Broz P., 2018. pp. 199-213 dans Methods in molecular biology chap. 13, Springer.
[DOI][Pmid][serval:BIB_14D54D75F8C7]
 
Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics.
Dreier R.F., Ahrné E., Broz P., Schmidt A., 2018. Journal of Proteome Research, 18 (1) pp. 493-507. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_09A1E7AB864E]
Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida.
Brodmann M., Heilig R., Broz P., Basler M., 2018. Frontiers in cellular and infection microbiology, 8 p. 284. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F65C630A1941]
 
The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice.
Heilig R., Dick M.S., Sborgi L., Meunier E., Hiller S., Broz P., 2018. European Journal of Immunology, 48 (4) pp. 584-592. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F4DB5E21C5FE]
2017
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Schneider K.S., Groß C.J., Dreier R.F., Saller B.S., Mishra R., Gorka O., Heilig R., Meunier E., Dick M.S., Ćiković T. et al., 2017/12/26. Cell reports, 21 (13) pp. 3846-3859. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0FB097000CD4]
 
Evolutionary Convergence and Divergence in NLR Function and Structure.
Meunier E., Broz P., 2017/10. Trends in immunology, 38 (10) pp. 744-757. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1CDD0C7777E0]
Corrigendum: ASC filament formation serves as a signal amplification mechanism for inflammasomes.
Dick M.S., Sborgi L., Rühl S., Hiller S., Broz P., 2017. Nature Communications, 8 p. 15030. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E56AD42B0596]
Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape.
Brodmann M., Dreier R.F., Broz P., Basler M., 2017. Nature Communications, 8 p. 15853. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DD0E858F0323]
IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.
Wallet P., Benaoudia S., Mosnier A., Lagrange B., Martin A., Lindgren H., Golovliov I., Michal F., Basso P., Djebali S. et al., 2017. PLoS Pathogens, 13 (10) pp. e1006630. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C56F249390E0]
2016
 
Inflammasomes in Host Defense and Autoimmunity.
Broz P., 2016/12/21. Chimia, 70 (12) pp. 853-855. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D7DFB5CC8C78]
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.
Di Micco A., Frera G., Lugrin J., Jamilloux Y., Hsu E.T., Tardivel A., De Gassart A., Zaffalon L., Bujisic B., Siegert S. et al., 2016/08/09. Proceedings of the National Academy of Sciences of the United States of America, 113 (32) pp. E4671-80. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_29BEBCA2CFB2]
Immune Response: Intracellular pathogens under attack.
Broz P., 2016/02/19. eLife, 5 pp. -. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9446206C396E]
ASC filament formation serves as a signal amplification mechanism for inflammasomes.
Dick M.S., Sborgi L., Rühl S., Hiller S., Broz P., 2016. Nature Communications, 7 p. 11929. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1F376E063F34]
 
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
Sborgi L., Rühl S., Mulvihill E., Pipercevic J., Heilig R., Stahlberg H., Farady C.J., Müller D.J., Broz P., Hiller S., 2016. The EMBO Journal, 35 (16) pp. 1766-1778. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5D469A46BEF0]
 
Inflammasomes: Intracellular detection of extracellular bacteria.
Broz P., 2016. Cell Research, 26 (8) pp. 859-860. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_269AD66482F2]
 
Inflammasomes: mechanism of assembly, regulation and signalling.
Broz P., Dixit V.M., 2016. Nature reviews. Immunology, 16 (7) pp. 407-420. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0EE04AC88A5C]
 
Interferon-inducible GTPases in cell autonomous and innate immunity.
Meunier E., Broz P., 2016. Cellular Microbiology, 18 (2) pp. 168-180. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DA7C39FB51A3]
 
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
Groß C.J., Mishra R., Schneider K.S., Médard G., Wettmarshausen J., Dittlein D.C., Shi H., Gorka O., Koenig P.A., Fromm S. et al., 2016. Immunity, 45 (4) pp. 761-773. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DBC2755173A5]
 
Sequence-specific solid-state NMR assignments of the mouse ASC PYRIN domain in its filament form.
Ravotti F., Sborgi L., Cadalbert R., Huber M., Mazur A., Broz P., Hiller S., Meier B.H., Böckmann A., 2016. Biomolecular NMR Assignments, 10 (1) pp. 107-115. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_03ECE6599B4F]
The gasdermin-D pore: Executor of pyroptotic cell death.
Rühl S., Broz P., 2016. Oncotarget, 7 (36) pp. 57481-57482. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C0DF27C78F36]
2015
 
Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux.
Rühl S., Broz P., 2015. European Journal of Immunology, 45 (10) pp. 2927-2936. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B5C3C3D62C3E]
 
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Meunier E., Wallet P., Dreier R.F., Costanzo S., Anton L., Rühl S., Dussurgey S., Dick M.S., Kistner A., Rigard M. et al., 2015. Nature Immunology, 16 (5) pp. 476-484. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3CC7B50D4A9A]
 
Immunology: Caspase target drives pyroptosis.
Broz P., 2015. Nature, 526 (7575) pp. 642-643. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BD96A0273FA0]
 
Inflammasome assembly: The wheels are turning.
Broz P., 2015. Cell Research, 25 (12) pp. 1277-1278. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6D35030418EC]
 
Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.
Meunier E., Broz P., 2015. DNA and Cell Biology, 34 (1) pp. 1-5. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8F0B113BC936]
 
Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization.
Meunier E., Broz P., 2015. Journal of Visualized Experiments 101 pp. e52960. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_837C61C4E7B0]
 
Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.
Sborgi L., Ravotti F., Dandey V.P., Dick M.S., Mazur A., Reckel S., Chami M., Scherer S., Huber M., Böckmann A. et al., 2015. Proceedings of the National Academy of Sciences of the United States of America, 112 (43) pp. 13237-13242. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2D34457006B7]
2014
 
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Meunier E., Dick M.S., Dreier R.F., Schürmann N., Kenzelmann Broz D., Warming S., Roose-Girma M., Bumann D., Kayagaki N., Takeda K. et al., 2014. Nature, 509 (7500) pp. 366-370. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C0792B694F4F]
 
Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes.
Broz P., 2014. Cell Host & Microbe, 16 (2) pp. 153-155. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A28DEB2FA279]
 
Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.
O'Donnell H., Pham O.H., Li L.X., Atif S.M., Lee S.J., Ravesloot M.M., Stolfi J.L., Nuccio S.P., Broz P., Monack D.M. et al., 2014. Immunity, 40 (2) pp. 213-224. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EE48781B2052]
2013
 
A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.
Xiao J., Broz P., Puri A.W., Deu E., Morell M., Monack D.M., Bogyo M., 2013. Journal of the American Chemical Society, 135 (24) pp. 9130-9138. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_708202802675]
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop.
Juruj C., Lelogeais V., Pierini R., Perret M., Py B.F., Jamilloux Y., Broz P., Ader F., Faure M., Henry T., 2013. Frontiers in Cellular and Infection Microbiology, 3 p. 14. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1245AFD27327]
 
Measuring inflammasome activation in response to bacterial infection.
Broz P., Monack D.M., 2013. pp. 65-84 dans Methods in Molecular Biology chap. 6, Springer.
[DOI][Pmid][serval:BIB_2040569D7217]
 
Newly described pattern recognition receptors team up against intracellular pathogens.
Broz P., Monack D.M., 2013. Nature Reviews. Immunology, 13 (8) pp. 551-565. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2A2740B42BE8]
Noncanonical inflammasomes: caspase-11 activation and effector mechanisms.
Broz P., Monack D.M., 2013. PLoS Pathogens, 9 (2) pp. e1003144. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B5FBA71E5DC7]
2012
 
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
Puri A. W., Broz P., Shen A., Monack D. M., Bogyo M., 2012/09. Nat Chem Biol, 8 (9) pp. 745-7.
[DOI][Pmid][serval:BIB_3BA105C2A9B6]
 
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Broz P., Ruby T., Belhocine K., Bouley D.M., Kayagaki N., Dixit V.M., Monack D.M., 2012. Nature, 490 (7419) pp. 288-291. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5E61DC5CF598]
 
Innate immune response to Salmonella typhimurium, a model enteric pathogen.
Broz P., Ohlson M.B., Monack D.M., 2012. Gut Microbes, 3 (2) pp. 62-70. Peer-reviewed.
[DOI][Pmid][serval:BIB_97D2125B4CFF]
2011
 
Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis.
Peng K., Broz P., Jones J., Joubert L.M., Monack D., 2011. Cellular Microbiology, 13 (10) pp. 1586-1600. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8C5CB24445D8]
Innate immune recognition of francisella tularensis: activation of type-I interferons and the inflammasome.
Jones J.W., Broz P., Monack D.M., 2011. Frontiers in Microbiology, 2 p. 16. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_74385AAE11FA]
 
Molecular mechanisms of inflammasome activation during microbial infections.
Broz P., Monack D.M., 2011. Immunological Reviews, 243 (1) pp. 174-190. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AE100B0296E4]
2010
 
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.
Jones J.W., Kayagaki N., Broz P., Henry T., Newton K., O'Rourke K., Chan S., Dong J., Qu Y., Roose-Girma M. et al., 2010. Proceedings of the National Academy of Sciences of the United States of America, 107 (21) pp. 9771-9776. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FA9D8A005A28]
 
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.
Broz P., von Moltke J., Jones J.W., Vance R.E., Monack D.M., 2010. Cell Host & Microbe, 8 (6) pp. 471-483. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A07BA81A5FA5]
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.
Broz P., Newton K., Lamkanfi M., Mariathasan S., Dixit V.M., Monack D.M., 2010. Journal of Experimental Medicine, 207 (8) pp. 1745-1755. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8855542139E7]
2008
 
The type III secretion system tip complex and translocon.
Mueller C.A., Broz P., Cornelis G.R., 2008. Molecular Microbiology, 68 (5) pp. 1085-1095. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E55332556FF5]
2007
 
Function and molecular architecture of the Yersinia injectisome tip complex.
Broz P., Mueller C.A., Müller S.A., Philippsen A., Sorg I., Engel A., Cornelis G.R., 2007. Molecular Microbiology, 65 (5) pp. 1311-1320. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9A8CE65AE586]
 
YscU recognizes translocators as export substrates of the Yersinia injectisome.
Sorg I., Wagner S., Amstutz M., Müller S.A., Broz P., Lussi Y., Engel A., Cornelis G.R., 2007. The EMBO Journal, 26 (12) pp. 3015-3024. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BB4308686C43]
2005
 
Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes.
Goure J., Broz P., Attree O., Cornelis G.R., Attree I., 2005. Journal of Infectious Diseases, 192 (2) pp. 218-225. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9C52D5CBA3ED]
 
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.
Mueller C.A., Broz P., Müller S.A., Ringler P., Erne-Brand F., Sorg I., Kuhn M., Engel A., Cornelis G.R., 2005. Science, 310 (5748) pp. 674-676. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_064DBD07026C]
2003
 
The needle length of bacterial injectisomes is determined by a molecular ruler
Journet L., Agrain C., Broz P., Cornelis G. R., 2003. Science, 302 (5651) pp. 1757-60.
[DOI][Pmid][serval:BIB_A6C6BEB8BAD1]
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