Jolanda van Leeuwen

Publications | Phd and Masters theses

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28 publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2012 | 2011 |
2024
Meta-analysis of dispensable essential genes and their interactions with bypass suppressors.
Pons C., van Leeuwen J., 2024/01. Life science alliance, 7 (1) pp. e202302192. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CD1659604115]
2023
Global analysis of suppressor mutations that rescue human genetic defects.
Ünlü B., Pons C., Ho U.L., Batté A., Aloy P., van Leeuwen J., 2023/10/12. Genome medicine, 15 (1) p. 78. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4F41E796432C]
 
Highlights from the 1st European cancer dependency map symposium and workshop
Trastulla Lucia, Savino Aurora, Beltrao Pedro, Ciriano Isidro Cortés, Fenici Peter, Garnett Mathew J., Guerini Ilaria, Bigas Nuria Lòpez, Mattaj Iain, Petsalaki Evangelia et al., 2023/08. FEBS Letters, 597 (15) pp. 1921-1927.
[DOI][WoS][Pmid][serval:BIB_A872D5F04069]
2022
Exploring conditional gene essentiality through systems genetics approaches in yeast.
Bosch-Guiteras N., van Leeuwen J., 2022/10. Current opinion in genetics & development, 76 p. 101963. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_279A9057F643]
Predicting base editing outcomes using position-specific sequence determinants.
Pallaseni A., Peets E.M., Koeppel J., Weller J., Vanderstichele T., Ho U.L., Crepaldi L., van Leeuwen J., Allen F., Parts L., 2022/04/08. Nucleic acids research, 50 (6) pp. 3551-3564. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E80CB0AB76D9]
Chl1 helicase controls replication fork progression by regulating dNTP pools.
Batté A., van der Horst S.C., Tittel-Elmer M., Sun S.M., Sharma S., van Leeuwen J., Chabes A., van Attikum H., 2022/04. Life science alliance, 5 (4) pp. e202101153. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_388048BE3334]
2021
Natural variants suppress mutations in hundreds of essential genes.
Parts L., Batté A., Lopes M., Yuen M.W., Laver M., San Luis B.J., Yue J.X., Pons C., Eray E., Aloy P. et al., 2021/05. Molecular systems biology, 17 (5) pp. e10138. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BE5BF0EA2DDC]
2020
Systematic analysis of bypass suppression of essential genes.
van Leeuwen J., Pons C., Tan G., Wang J.Z., Hou J., Weile J., Gebbia M., Liang W., Shuteriqi E., Li Z. et al., 2020/09. Molecular systems biology, 16 (9) pp. e9828. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E6E9FA206068]
 
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.
Kuzmin E., VanderSluis B., Nguyen Ba A.N., Wang W., Koch E.N., Usaj M., Khmelinskii A., Usaj M.M., van Leeuwen J., Kraus O. et al., 2020/06/26. Science, 368 (6498). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EAC98FA8B96B]
2019
 
Global Genetic Networks and the Genotype-to-Phenotype Relationship.
Costanzo M., Kuzmin E., van Leeuwen J., Mair B., Moffat J., Boone C., Andrews B., 2019/03/21. Cell, 177 (1) pp. 85-100. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2F6F7F80AA32]
2018
 
Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression.
Hou J., van Leeuwen J., Andrews B.J., Boone C., 2018/08. Trends in genetics, 34 (8) pp. 578-586. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_21A52EBB86BF]
 
Systematic analysis of complex genetic interactions.
Kuzmin E., VanderSluis B., Wang W., Tan G., Deshpande R., Chen Y., Usaj M., Balint A., Mattiazzi Usaj M., van Leeuwen J. et al., 2018/04/20. Science, 360 (6386). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C1022D51E7B4]
 
Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
Shin M., van Leeuwen J., Boone C., Bretscher A., 2018/04/15. Molecular biology of the cell, 29 (8) pp. 923-936. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2648266C4AB3]
2017
 
Mapping a diversity of genetic interactions in yeast.
van Leeuwen J., Boone C., Andrews B.J., 2017/12. Current opinion in systems biology, 6 pp. 14-21. Peer-reviewed.
[DOI][Pmid][serval:BIB_5AE903AE7B6C]
 
Functional annotation of chemical libraries across diverse biological processes.
Piotrowski J.S., Li S.C., Deshpande R., Simpkins S.W., Nelson J., Yashiroda Y., Barber J.M., Safizadeh H., Wilson E., Okada H. et al., 2017/09. Nature chemical biology, 13 (9) pp. 982-993. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4D734EBBD9B9]
 
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.
Hart T., Tong AHY, Chan K., Van Leeuwen J., Seetharaman A., Aregger M., Chandrashekhar M., Hustedt N., Seth S., Noonan A. et al., 2017/08/07. G3, 7 (8) pp. 2719-2727. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D01144D2489C]
 
Mechanisms of suppression: The wiring of genetic resilience.
van Leeuwen J., Pons C., Boone C., Andrews B.J., 2017/07. BioEssays, 39 (7). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_26408E7BBB10]
 
The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae.
Huseinovic A., van Leeuwen J.S., van Welsem T., Stulemeijer I., van Leeuwen F., Vermeulen N.P., Kooter J.M., Vos J.C., 2017. PloS one, 12 (3) pp. e0173573. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_2E7640243563]
2016
 
Exploring genetic suppression interactions on a global scale.
van Leeuwen J., Pons C., Mellor J.C., Yamaguchi T.N., Friesen H., Koschwanez J., Ušaj M.M., Pechlaner M., Takar M., Ušaj M. et al., 2016/11/04. Science, 354 (6312). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CF7164F33625]
 
A global genetic interaction network maps a wiring diagram of cellular function.
Costanzo M., VanderSluis B., Koch E.N., Baryshnikova A., Pons C., Tan G., Wang W., Usaj M., Hanchard J., Lee S.D. et al., 2016/09/23. Science, 353 (6306). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1A8881DA9334]
2015
 
Construction of Multifragment Plasmids by Homologous Recombination in Yeast.
van Leeuwen J., Andrews B., Boone C., Tan G., 2015/09/01. Cold Spring Harbor protocols, 2015 (9) pp. pdb.top084111.
[DOI][Pmid][serval:BIB_941960596A88]
 
Rapid and Efficient Plasmid Construction by Homologous Recombination in Yeast.
van Leeuwen J., Andrews B., Boone C., Tan G., 2015/09/01. Cold Spring Harbor protocols, 2015 (9) pp. pdb.prot085100.
[DOI][Pmid][serval:BIB_B722E812F733]
2012
 
Yeast as a humanized model organism for biotransformation-related toxicity.
van Leeuwen J.S., Vermeulen N.P., Chris Vos J., 2012/12. Current drug metabolism, 13 (10) pp. 1464-1475. Peer-reviewed.
[WoS][Pmid][serval:BIB_1D7B50F9B05C]
 
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
van Leeuwen J.S., Unlü B., Vermeulen N.P., Vos J.C., 2012/03. Toxicology in vitro, 26 (2) pp. 197-205. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_058287FB6D38]
2011
 
Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space.
Reinen J., van Leeuwen J.S., Li Y., Sun L., Grootenhuis P.D., Decker C.J., Saunders J., Vermeulen N.P., Commandeur J.N., 2011/09. Drug metabolism and disposition, 39 (9) pp. 1568-1576. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7910DCEABC05]
 
Involvement of the pleiotropic drug resistance response, protein kinase C signaling, and altered zinc homeostasis in resistance of Saccharomyces cerevisiae to diclofenac.
van Leeuwen J.S., Vermeulen N.P., Vos J.C., 2011/09. Applied and environmental microbiology, 77 (17) pp. 5973-5980. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AFF70ED71DA2]
 
Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction.
van Leeuwen J.S., Orij R., Luttik M.A., Smits G.J., Vermeulen N.P., Vos J.C., 2011/03. Microbiology, 157 (Pt 3) pp. 685-694. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_ABC65A17AE6B]
 
Metabolism related toxicity of diclofenac in yeast as model system.
van Leeuwen J.S., Vredenburg G., Dragovic S., Tjong T.F., Vos J.C., Vermeulen N.P., 2011/02/05. Toxicology letters, 200 (3) pp. 162-168. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_047224B1F4FB]
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