Margret Schottelius

Publications | Phd and Masters theses

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103 publications

In press | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 |
In press
 
New Developments in Peptide Receptor Radionuclide Therapy.
Nicolas G.P., Morgenstern A., Schottelius M., Fani M. Journal of nuclear medicine. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0D0FD6FEB45A]
 
Correction to: Preclinical SPECT and PET: Joint EANM and ESMI procedure guideline for implementing an efficient quality control programme.
Vanhove C., Koole M., Fragoso Costa P., Schottelius M., Mannheim J., Kuntner C., Warnock G., McDougald W., Tavares A., Bernsen M. European journal of nuclear medicine and molecular imaging. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F7FB805FABE9]
2024
 
[99mTc]-PentixaTec SPECT/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction.
Liebich A., Bundschuh R.A., Pfob C.H., Kircher M., Wienand G., Raake P., Nekolla S.G., Schottelius M., Higuchi T., Rieger M. et al., 2024/11. Circulation. Cardiovascular imaging, 17 (11) pp. e016992. Peer-reviewed.
[DOI][Pmid][serval:BIB_56C05C3716CD]
 
Preclinical SPECT and PET: Joint EANM and ESMI procedure guideline for implementing an efficient quality control programme.
Vanhove C., Koole M., Fragoso Costa P., Schottelius M., Mannheim J., Kuntner C., Warnock G., McDougald W., Tavares A., Bernsen M., 2024/11. European journal of nuclear medicine and molecular imaging, 51 (13) pp. 3822-3839. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3AB01CCA6A0F]
 
C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy Using [99mTc]Tc-Pentixatec in Primary Aldosteronism: A Proof-of-Concept Study.
Enke J.S., Ritzel K., Asbach E., Reitsam N.G., Märkl B., Knösel T., Brüdgam D., Kircher M., Pfob C.H., Bundschuh R.A. et al., 2024/10/01. Journal of nuclear medicine, 65 (10) pp. 1640-1644. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BC4D38861002]
 
Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Petruzzella A., Bruand M., Santamaria-Martínez A., Katanayeva N., Reymond L., Wehrle S., Georgeon S., Inel D., van Dalen F.J., Viertl D. et al., 2024/09. Nature chemical biology, 20 (9) pp. 1188-1198. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_53F6283C97FD]
 
Validation of the C-X-C chemokine receptor 3 (CXCR3) as a target for PET imaging of T cell activation.
Martin S., Wendlinger L., Zitti B., Hicham M., Postupalenko V., Marx L., Giordano-Attianese G., Cribioli E., Irving M., Litvinenko A. et al., 2024/08/28. EJNMMI research, 14 (1) p. 77. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F843327A454B]
 
Lessons learned in application driven imaging agent design for image-guided surgery.
Buckle T., Rietbergen DDD, de Wit-van der Veen L., Schottelius M., 2024/08. European journal of nuclear medicine and molecular imaging, 51 (10) pp. 3040-3054. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CEF2F38719D5]
Validation of a size exclusion method for concomitant purification and formulation of peptide radiopharmaceuticals.
Martin S., Wendlinger L., Litvinenko A., Faizova R., Schottelius M., 2024/03/21. EJNMMI radiopharmacy and chemistry, 9 (1) p. 23. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A78AA760F062]
Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release.
Postupalenko V., Marx L., Pantin M., Viertl D., Gsponer N., Giudice G., Gasilova N., Schottelius M., Lévy F., Garrouste P. et al., 2024/01/24. Chemical science, 15 (4) pp. 1324-1337. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8187B492B6A1]
 
C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy of Multiple Myeloma Using [99mTc]Tc-PentixaTec.
Enke J.S., Reitsam N.G., Grosser B., Kircher M., Dierks A., Bundschuh R.A., Wienand G., Uhrmacher L., Trepel M., Schottelius M. et al., 2024/01/02. Journal of nuclear medicine, 65 (1) pp. 163-164. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3B044D2FE4DC]
 
Analyzing the Science Footprint of Richard P. Baum
Prior John O., Nicod Lalonde Marie, Schaefer Niklaus, Schottelius Margret, 2024. pp. 245-253 dans Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum, Springer International Publishing.
[DOI][serval:BIB_FC9CC0FEE129]
2023
 
Integration of DOTA as a bridging unit during solid-phase peptide synthesis
Wendlinger Lennard, Parzinger Mara, Schottelius Margret, Wester Hans-Jürgen, 2023/12. Results in Chemistry, 6 p. 101076.
[DOI][WoS][serval:BIB_3EEE97A88B66]
Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer.
Wang H., Remke M., Horn T., Schwamborn K., Chen Y., Steiger K., Weichert W., Wester H.J., Schottelius M., Weber W.A. et al., 2023/11/16. EJNMMI research, 13 (1) p. 99. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_54C39E31A537]
[99mTc]Tc-PentixaTec: development, extensive pre-clinical evaluation, and first human experience.
Konrad M., Rinscheid A., Wienand G., Nittbaur B., Wester H.J., Janzen T., Lapa C., Pfob C.H., Schottelius M., 2023/11. European journal of nuclear medicine and molecular imaging, 50 (13) pp. 3937-3948. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F01E355CA9DA]
Influence of corticosteroid treatment on CXCR4 expression in DLBCL.
Martin S., Viertl D., Janz A., Habringer S., Keller U., Schottelius M., 2023/05/10. EJNMMI research, 13 (1) p. 40. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_18B6F1DF4772]
2022
Perspectives on translational molecular imaging and therapy: an overview of key questions to be addressed.
van Leeuwen FWB, Schottelius M., Mottaghy F.M., Hyafil F., Lubberink M., Kramer-Marek G., Oyen WJG, 2022/06/02. EJNMMI research, 12 (1) p. 31. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2A304A93A29C]
CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett's esophagus.
Marcazzan S., Braz Carvalho M.J., Konrad M., Strangmann J., Tenditnaya A., Baumeister T., Schmid R.M., Wester H.J., Ntziachristos V., Gorpas D. et al., 2022/01/10. EJNMMI research, 12 (1) p. 2. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B9E2214CAD9F]
2021
In Vivo Targeting of CXCR4-New Horizons.
Schottelius M., Herrmann K., Lapa C., 2021/11/25. Cancers, 13 (23) p. 5920. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_768384A9D6F8]
 
The role of fluorescent and hybrid tracers in radioguided surgery in urogenital malignancies.
DE Vries H.M., Schottelius M., Brouwer O.R., Buckle T., 2021/09. The quarterly journal of nuclear medicine and molecular imaging, 65 (3) pp. 261-270. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5F5C6091280A]
 
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer.
Luker G.D., Yang J., Richmond A., Scala S., Festuccia C., Schottelius M., Wester H.J., Zimmermann J., 2021/05. Journal of leukocyte biology, 109 (5) pp. 969-989. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_55863C1885F3]
 
Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors.
Trotta A.M., Aurilio M., D'Alterio C., Ieranò C., Di Martino D., Barbieri A., Luciano A., Gaballo P., Santagata S., Portella L. et al., 2021/03/25. Journal of medicinal chemistry, 64 (6) pp. 3449-3461. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0CCD89795847]
2020
[99mTc]Tc-PSMA-I&S-SPECT/CT: experience in prostate cancer imaging in an outpatient center.
Werner P., Neumann C., Eiber M., Wester H.J., Schottelius M., 2020/05/07. EJNMMI research, 10 (1) p. 45. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5A12CBAF1DF6]
"Luke! Luke! Don't! It's a trap!"-spotlight on bias in animal experiments in nuclear oncology.
Nonnekens J., Schottelius M., 2020/05. European journal of nuclear medicine and molecular imaging, 47 (5) pp. 1024-1026. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7303AE979055]
 
From Theranostics to Immunotheranostics: the Concept
Schaefer Niklaus, Prior John O., Schottelius Margret, 2020/04. Nuclear Medicine and Molecular Imaging, 54 (2) pp. 81-85. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_343F8049FB6C]
 
Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?
Hensbergen Albertus Wijnand, van Willigen Danny M., van Beurden Florian, van Leeuwen Pim J., Buckle Tessa, Schottelius Margret, Maurer Tobias, Wester Hans-Jürgen, van Leeuwen Fijs W. B., 2020/02/19. Bioconjugate Chemistry, 31 (2) pp. 375-395.
[DOI][WoS][Pmid][serval:BIB_D719ABDCF775]
 
Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?
Hensbergen A.W., van Willigen D.M., van Beurden F., van Leeuwen P.J., Buckle T., Schottelius M., Maurer T., Wester H.J., van Leeuwen FWB, 2020/02/19. Bioconjugate chemistry, 31 (2) pp. 375-395. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_FA17BC2E52BF]
 
Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye–Protein Interaction
Hensbergen Albertus W., Buckle Tessa, van Willigen Danny M., Schottelius Margret, Welling Mick M., van der Wijk Felicia A., Maurer Tobias, van der Poel Henk G., van der Pluijm Gabri, van Weerden Wytske M. et al., 2020/02. Journal of Nuclear Medicine, 61 (2) pp. 234-241.
[DOI][WoS][Pmid][serval:BIB_A3338DC2AD18]
A new class of PentixaFor- and PentixaTher-based theranostic agents with enhanced CXCR4-targeting efficiency.
Osl T., Schmidt A., Schwaiger M., Schottelius M., Wester H.J., 2020. Theranostics, 10 (18) pp. 8264-8280. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0AB1FC103298]
 
Trending: Radioactive and Fluorescent Bimodal/Hybrid Tracers as Multiplexing Solutions for Surgical Guidance
van Leeuwen Fijs W.B., Schottelius Margret, Brouwer Oscar R., Vidal-Sicart Sergi, Achilefu Samuel, Klode Joachim, Wester Hans-Jurgen, Buckle Tessa, 2020/01. Journal of Nuclear Medicine, 61 (1) pp. 13-19.
[DOI][WoS][Pmid][serval:BIB_37C568C0D61E]
2019
 
Validation of [125I]CPCR4.3 as an investigative tool for the sensitive and specific detection of hCXCR4 and mCXCR4 expression in vitro and in vivo
Margret Schottelius, Marina Ludescher, Frauke Richter, Tobias Kapp, Horst Kessler, Hans-Jürgen Wester, 2019/12. EJNMMI Research.
[DOI][serval:BIB_C47E34F1EAE2]
 
Single Lesion on Prostate-specific Membrane Antigen-ligand Positron Emission Tomography and Low Prostate-specific Antigen Are Prognostic Factors for a Favorable Biochemical Response to Prostate-specific Membrane Antigen-targeted Radioguided Surgery in Recurrent Prostate Cancer.
Horn T., Krönke M., Rauscher I., Haller B., Robu S., Wester H.J., Schottelius M., van Leeuwen FWB, van der Poel H.G., Heck M. et al., 2019/10. European urology, 76 (4) pp. 517-523. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F8CC96E79923]
 
Click Chemistry in the Design and Production of Hybrid Tracers.
Hensbergen A.W., van Willigen D.M., Welling M.M., van der Wijk F.A., de Korne C.M., van Oosterom M.N., Schottelius M., Wester H.J., Buckle T., van Leeuwen FWB, 2019/07/31. ACS omega, 4 (7) pp. 12438-12448. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E68D9D482DFC]
 
PSMA-Targeted Radiopharmaceuticals for Imaging and Therapy.
Wester H.J., Schottelius M., 2019/07. Seminars in nuclear medicine, 49 (4) pp. 302-312. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AD08B1BDD14C]
 
99mTechnetium-based Prostate-specific Membrane Antigen–radioguided Surgery in Recurrent Prostate Cancer
Maurer Tobias, Robu Stephanie, Schottelius Margret, Schwamborn Kristina, Rauscher Isabel, van den Berg Nynke S., van Leeuwen Fijs W.B., Haller Bernhard, Horn Thomas, Heck Matthias M. et al., 2019/04. European Urology, 75 (4) pp. 659-666.
[DOI][WoS][Pmid][serval:BIB_817F13E572A0]
 
Entering the Era of Molecularly Targeted Precision Surgery in Recurrent Prostate Cancer
Maurer Tobias, van Leeuwen Fijs W.B., Schottelius Margret, Wester Hans-Jürgen, Eiber Matthias, 2019/02. Journal of Nuclear Medicine, 60 (2) pp. 156-157.
[DOI][WoS][Pmid][serval:BIB_FCB566137F72]
 
Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer
Schottelius Margret, Wurzer Alexander, Wissmiller Katharina, Beck Roswitha, Koch Maximilian, Gorpas Dimitrios, Notni Johannes, Buckle Tessa, van Oosterom Matthias N., Steiger Katja et al., 2019/01. Journal of Nuclear Medicine, 60 (1) pp. 71-78.
[DOI][WoS][Pmid][serval:BIB_07F7250F9330]
2018
 
Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity
Wirtz Martina, Schmidt Alexander, Schottelius Margret, Robu Stephanie, Günther Thomas, Schwaiger Markus, Wester Hans-Jürgen, 2018/12. EJNMMI Research, 8 (1).
[DOI][WoS][Pmid][serval:BIB_5D1C97A8CF6F]
 
Synthesis and preclinical evaluation of novel 18F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with 18F-DCFPyl and 18F-PSMA-1007
Robu Stephanie, Schmidt Alexander, Eiber Matthias, Schottelius Margret, Günther Thomas, Hooshyar Yousefi Behrooz, Schwaiger Markus, Wester Hans-Jürgen, 2018/12. EJNMMI Research, 8 (1).
[DOI][WoS][Pmid][serval:BIB_90A45B2725E6]
 
CXCR4-directed theranostics in oncology and inflammation
Kircher Malte, Herhaus Peter, Schottelius Margret, Buck Andreas K., Werner Rudolf A., Wester Hans-Jürgen, Keller Ulrich, Lapa Constantin, 2018/10. Annals of Nuclear Medicine, 32 (8) pp. 503-511.
[DOI][WoS][Pmid][serval:BIB_BF83614C3A37]
 
Effect of Carbohydration on the Theranostic Tracer PSMA I&T
Schmidt Alexander, Wirtz Martina, Färber Stefanie Felicitas, Osl Theresa, Beck Roswitha, Schottelius Margret, Schwaiger Markus, Wester Hans-Jürgen, 2018/07/31. ACS Omega, 3 (7) pp. 8278-8287.
[DOI][WoS][Pmid][serval:BIB_65E62F201867]
 
CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma
Fang Hsin-Yu, Münch Natasha Stephens, Schottelius Margret, Ingermann Jonas, Liu Haibo, Schauer Michael, Stangl Stefan, Multhoff Gabriele, Steiger Katja, Gerngroß Carlos et al., 2018/03/01. Clinical Cancer Research, 24 (5) pp. 1048-1061.
[DOI][WoS][Pmid][serval:BIB_2ED93BD84E36]
 
Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics
Habringer Stefan, Lapa Constantin, Herhaus Peter, Schottelius Margret, Istvanffy Rouzanna, Steiger Katja, Slotta-Huspenina Julia, Schirbel Andreas, Hänscheid Heribert, Kircher Stefan et al., 2018. Theranostics, 8 (2) pp. 369-383.
[DOI][WoS][Pmid][serval:BIB_130B1CEF39DD]
2017
 
[64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model
Poschenrieder Andreas, Schottelius Margret, Osl Theresa, Schwaiger Markus, Wester Hans-Jürgen, 2017/12. EJNMMI Radiopharmacy and Chemistry, 2 (1).
[DOI][WoS][Pmid][serval:BIB_638E8F362292]
 
Chemokine receptor – Directed imaging and therapy
Buck Andreas K., Stolzenburg Antje, Hänscheid Heribert, Schirbel Andreas, Lückerath Katharina, Schottelius Margret, Wester Hans-Jürgen, Lapa Constantin, 2017/11. Methods, 130 pp. 63-71.
[DOI][WoS][Pmid][serval:BIB_9DE38631A8DA]
 
Value of <sup>111</sup> In-prostate-specific membrane antigen (PSMA)-radioguided surgery for salvage lymphadenectomy in recurrent prostate cancer: correlation with histopathology and clinical follow-up
Rauscher Isabel, Düwel Charlotte, Wirtz Martina, Schottelius Margret, Wester Hans-Jürgen, Schwamborn Kristina, Haller Bernhard, Schwaiger Markus, Gschwend Jürgen E., Eiber Matthias et al., 2017/07. BJU International, 120 (1) pp. 40-47.
[DOI][WoS][Pmid][serval:BIB_784266F9A52D]
 
213Bi-Labeled Prostate-Specific Membrane Antigen-Targeting Agents Induce DNA Double-Strand Breaks in Prostate Cancer Xenografts
Nonnekens Julie, Chatalic Kristell L.S., Molkenboer-Kuenen Janneke D.M., Beerens Cecile E.M.T., Bruchertseifer Frank, Morgenstern Alfred, Veldhoven-Zweistra Joke, Schottelius Margret, Wester Hans-Jürgen, van Gent Dik C. et al., 2017/03. Cancer Biotherapy and Radiopharmaceuticals, 32 (2) pp. 67-73.
[DOI][WoS][Pmid][serval:BIB_F62F4C58731B]
 
Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer <sup>68</sup>Ga-Pentixafor for PET
Hyafil Fabien, Pelisek Jaroslav, Laitinen Iina, Schottelius Margret, Mohring Miriam, Döring Yvonne, van der Vorst Emiel P.C., Kallmayer Michael, Steiger Katja, Poschenrieder Andreas et al., 2017/03. Journal of Nuclear Medicine, 58 (3) pp. 499-506.
[DOI][WoS][Pmid][serval:BIB_B1C7AA4EACE0]
 
Preclinical Evaluation and First Patient Application of 99mTc-PSMA-I&amp;S for SPECT Imaging and Radioguided Surgery in Prostate Cancer
Robu Stephanie, Schottelius Margret, Eiber Matthias, Maurer Tobias, Gschwend Jürgen, Schwaiger Markus, Wester Hans-Jürgen, 2017/02. Journal of Nuclear Medicine, 58 (2) pp. 235-242.
[DOI][WoS][Pmid][serval:BIB_79536F62151D]
 
[177Lu]pentixather: Comprehensive Preclinical Characterization of a First CXCR4-directed Endoradiotherapeutic Agent
Schottelius Margret, Osl Theresa, Poschenrieder Andreas, Hoffmann Frauke, Beykan Seval, Hänscheid Heribert, Schirbel Andreas, Buck Andreas K., Kropf Saskia, Schwaiger Markus et al., 2017. Theranostics, 7 (9) pp. 2350-2362.
[DOI][WoS][Pmid][serval:BIB_94A2D7A26CBA]
 
CXCR4-directed endoradiotherapy induces high response rates in extramedullary relapsed Multiple Myeloma
Lapa Constantin, Herrmann Ken, Schirbel Andreas, Hänscheid Heribert, Lückerath Katharina, Schottelius Margret, Kircher Malte, Werner Rudolf A., Schreder Martin, Samnick Samuel et al., 2017. Theranostics, 7 (6) pp. 1589-1597.
[DOI][WoS][Pmid][serval:BIB_93AC079DD6B7]
 
Twins in spirit part IV – [177Lu] high affinity DOTATATE : A promising new tracer for peptide receptor radiotherapy?
Hartmann Holger, Wunderlich Gerd, Schottelius Margret, Wester Hans-Jürgen, Kotzerke Jörg, Brogsitter Claudia, 2017. Nuklearmedizin, 56 (01) pp. 1-8.
[DOI][WoS][Pmid][serval:BIB_B454A54C7EF3]
2016
 
Preclinical evaluation of [68Ga]NOTA-pentixafor for PET imaging of CXCR4 expression in vivo — a comparison to [68Ga]pentixafor
Poschenrieder Andreas, Schottelius Margret, Schwaiger Markus, Wester Hans-Jürgen, 2016/12. EJNMMI Research, 6 (1).
[DOI][WoS][Pmid][serval:BIB_4930D309A7AD]
 
The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity
Poschenrieder Andreas, Schottelius Margret, Schwaiger Markus, Kessler Horst, Wester Hans-Jürgen, 2016/12. EJNMMI Research, 6 (1).
[DOI][WoS][Pmid][serval:BIB_C4EEEFC143B5]
 
PSMA Theranostics Using PET and Subsequent Radioguided Surgery in Recurrent Prostate Cancer
Maurer Tobias, Schwamborn Kristina, Schottelius Margret, Wester Hans-Jürgen, Schwaiger Markus, Gschwend Jürgen E., Eiber Matthias, 2016/10. Clinical Genitourinary Cancer, 14 (5) pp. e549-e552.
[DOI][WoS][Pmid][serval:BIB_FA46A6E0EA35]
 
Intrapatient Comparison of 111In-PSMA I&T SPECT/CT and Hybrid 68Ga-HBED-CC PSMA PET in Patients With Early Recurrent Prostate Cancer
Rauscher Isabel, Maurer Tobias, Souvatzoglou Michael, Beer Ambros J., Vag Tibor, Wirtz Martina, Weirich Gregor, Wester Hans-Jürgen, Gschwend Jürgen E., Schwaiger Markus et al., 2016/09. Clinical Nuclear Medicine, 41 (9) pp. e397-e402.
[DOI][WoS][Pmid][serval:BIB_B67148969827]
 
Systemic Radioligand Therapy with <sup>177</sup> Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer
Heck Matthias M., Retz Margitta, D'Alessandria Calogero, Rauscher Isabel, Scheidhauer Klemens, Maurer Tobias, Storz Enno, Janssen Friederike, Schottelius Margret, Wester Hans-Jürgen et al., 2016/08. Journal of Urology, 196 (2) pp. 382-391.
[DOI][WoS][Pmid][serval:BIB_31CFD023CD98]
 
Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia
Herhaus P., Habringer S., Philipp-Abbrederis K., Vag T., Gerngross C., Schottelius M., Slotta-Huspenina J., Steiger K., Altmann T., Weisser T. et al., 2016/08/01. Haematologica, 101 (8) pp. 932-940.
[DOI][WoS][Pmid][serval:BIB_4DED020F9633]
 
<sup>177</sup>Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy
Baum Richard P., Kulkarni Harshad R., Schuchardt Christiane, Singh Aviral, Wirtz Martina, Wiessalla Stefan, Schottelius Margret, Mueller Dirk, Klette Ingo, Wester Hans-Jürgen, 2016/07. Journal of Nuclear Medicine, 57 (7) pp. 1006-1013.
[DOI][WoS][Pmid][serval:BIB_0B3B895E5EAE]
 
First 18F-Labeled Pentixafor-Based Imaging Agent for PET Imaging of CXCR4 Expression In Vivo
Poschenrieder Andreas, Osl Theresa, Schottelius Margret, Hoffmann Frauke, Wirtz Martina, Schwaiger Markus, Wester Hans-Jürgen, 2016/06/01. Tomography, 2 (2) pp. 85-93.
[DOI][Pmid][serval:BIB_8630CC101B5A]
 
First-in-Human Experience of CXCR4-Directed Endoradiotherapy with <sup>177</sup>Lu- and <sup>90</sup>Y-Labeled Pentixather in Advanced-Stage Multiple Myeloma with Extensive Intra- and Extramedullary Disease
Herrmann Ken, Schottelius Margret, Lapa Constantin, Osl Theresa, Poschenrieder Andreas, Hänscheid Heribert, Lückerath Katharina, Schreder Martin, Bluemel Christina, Knott Markus et al., 2016/02. Journal of Nuclear Medicine, 57 (2) pp. 248-251.
[DOI][WoS][Pmid][serval:BIB_8CDB972991E9]
 
Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI
Rischpler C., Nekolla S. G., Kossmann H., Dirschinger R. J., Schottelius M., Hyafil F., Wester H. J., Laugwitz K. L., Schwaiger M., 2016/02. Journal of Nuclear Cardiology, 23 (1) pp. 131-133.
[DOI][WoS][Pmid][serval:BIB_B6F138BD1CA4]
 
Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent
Chatalic Kristell L.S., Heskamp Sandra, Konijnenberg Mark, Molkenboer-Kuenen Janneke D.M., Franssen Gerben M., Groningen Marian C. Clahsen-van, Schottelius Margret, Wester Hans-Jürgen, van Weerden Wytske M., Boerman Otto C. et al., 2016. Theranostics, 6 (6) pp. 849-861.
[DOI][WoS][Pmid][serval:BIB_99B353395919]
2015
 
[111In]PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery
Schottelius Margret, Wirtz Martina, Eiber Matthias, Maurer Tobias, Wester Hans-Jürgen, 2015/12. EJNMMI Research, 5 (1).
[DOI][WoS][Pmid][serval:BIB_367D1CCF5BC1]
 
Twins in spirit - episode I: comparative preclinical evaluation of [68Ga]DOTATATE and [68Ga]HA-DOTATATE
Schottelius Margret, Šimeček Jakub, Hoffmann Frauke, Willibald Marina, Schwaiger Markus, Wester Hans-Jürgen, 2015/12. EJNMMI Research, 5 (1).
[DOI][WoS][Pmid][serval:BIB_5B966090CEE2]
 
An optimized strategy for the mild and efficient solution phase iodination of tyrosine residues in bioactive peptides
Schottelius Margret, Konrad Matthias, Osl Theresa, Poschenrieder Andreas, Wester Hans-Jürgen, 2015/11. Tetrahedron Letters, 56 (47) pp. 6602-6605.
[DOI][WoS][serval:BIB_E0BFCACF23BC]
 
Prostate-specific Membrane Antigen–radioguided Surgery for Metastatic Lymph Nodes in Prostate Cancer
Maurer Tobias, Weirich Gregor, Schottelius Margret, Weineisen Martina, Frisch Benjamin, Okur Asli, Kübler Hubert, Thalgott Mark, Navab Nassir, Schwaiger Markus et al., 2015/09. European Urology, 68 (3) pp. 530-534.
[DOI][WoS][Pmid][serval:BIB_767BF9C07BB7]
 
68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies
Weineisen Martina, Schottelius Margret, Simecek Jakub, Baum Richard P., Yildiz Akin, Beykan Seval, Kulkarni Harshad R., Lassmann Michael, Klette Ingo, Eiber Matthias et al., 2015/08. Journal of Nuclear Medicine, 56 (8) pp. 1169-1176.
[DOI][WoS][Pmid][serval:BIB_6834EC791AF9]
 
Biodistribution and Radiation Dosimetry for a Probe Targeting Prostate-Specific Membrane Antigen for Imaging and Therapy
Herrmann Ken, Bluemel Christina, Weineisen Martina, Schottelius Margret, Wester Hans-Jürgen, Czernin Johannes, Eberlein Uta, Beykan Seval, Lapa Constantin, Riedmiller Hubertus et al., 2015/06. Journal of Nuclear Medicine, 56 (6) pp. 855-861.
[DOI][WoS][Pmid][serval:BIB_BD03AC6372AD]
 
In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma
Philipp-Abbrederis Kathrin, Herrmann Ken, Knop Stefan, Schottelius Margret, Eiber Matthias, Lückerath Katharina, Pietschmann Elke, Habringer Stefan, Gerngroß Carlos, Franke Katharina et al., 2015/04. EMBO Molecular Medicine, 7 (4) pp. 477-487.
[DOI][WoS][Pmid][serval:BIB_2A7F59353476]
 
Biodistribution and Radiation Dosimetry for the Chemokine Receptor CXCR4-Targeting Probe 68Ga-Pentixafor
Herrmann Ken, Lapa Constantin, Wester Hans-Juergen, Schottelius Margret, Schiepers Christiaan, Eberlein Uta, Bluemel Christina, Keller Ulrich, Knop Stefan, Kropf Saskia et al., 2015/03. Journal of Nuclear Medicine, 56 (3) pp. 410-416.
[DOI][WoS][Pmid][serval:BIB_12181056A8AD]
 
Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging
Wester Hans Jürgen, Keller Ulrich, Schottelius Margret, Beer Ambros, Philipp-Abbrederis Kathrin, Hoffmann Frauke, Šimeček Jakub, Gerngross Carlos, Lassmann Michael, Herrmann Ken et al., 2015. Theranostics, 5 (6) pp. 618-630.
[DOI][WoS][Pmid][serval:BIB_609E99F5D8D8]
2014
 
Synthesis and preclinical evaluation of DOTAGA-conjugated PSMA ligands for functional imaging and endoradiotherapy of prostate cancer
Weineisen Martina, Simecek Jakub, Schottelius Margret, Schwaiger Markus, Wester Hans-Jürgen, 2014/12. EJNMMI Research, 4 (1).
[DOI][WoS][Pmid][serval:BIB_D7CB5A831725]
 
Twins in spirit part II: DOTATATE and high-affinity DOTATATE—the clinical experience
Brogsitter Claudia, Zöphel Klaus, Hartmann Holger, Schottelius Margret, Wester Hans-Jürgen, Kotzerke Jörg, 2014/06. European Journal of Nuclear Medicine and Molecular Imaging, 41 (6) pp. 1158-1165.
[DOI][WoS][Pmid][serval:BIB_ED5D7919928E]
 
Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity
Neubauer Stefanie, Rechenmacher Florian, Brimioulle Richard, Di Leva Francesco Saverio, Bochen Alexander, Sobahi Tariq R., Schottelius Margret, Novellino Ettore, Mas-Moruno Carlos, Marinelli Luciana et al., 2014/04/24. Journal of Medicinal Chemistry, 57 (8) pp. 3410-3417.
[DOI][WoS][Pmid][serval:BIB_86D40A3591F4]
 
Dosimetric measurements of 68Ga-High Affinity DOTATATE : Twins in spirit – part III
Freudenberg R, Oehme L., Zöphel K., Schottelius M., Wester H.-J., Wunderlich G., Kotzerke J., Brogsitter C., Hartmann H., 2014. Nuklearmedizin, 53 (05) pp. 211-216.
[DOI][WoS][Pmid][serval:BIB_8F3A27CDB153]
2013
 
Twins in spirit: DOTATATE and high-affinity DOTATATE
Brogsitter Claudia, Schottelius Margret, Zöphel Klaus, Kotzerke Jörg, Wester Hans-Jürgen, 2013/10. European Journal of Nuclear Medicine and Molecular Imaging, 40 (11) pp. 1789-1789.
[DOI][WoS][Pmid][serval:BIB_C229BED5B097]
 
Orthogonally Protected Artificial Amino Acid as Tripod Ligand for Automated Peptide Synthesis and Labeling with [99mTc(OH2)3CO)3]+
Shen Yunjun, Schottelius Margret, Zelenka Karel, De Simone Mariarosaria, Pohle Karolin, Kessler Horst, Wester Hans-Jürgen, Schmutz Paul, Alberto Roger, 2013/01/16. Bioconjugate Chemistry, 24 (1) pp. 26-35.
[DOI][WoS][Pmid][serval:BIB_B832BAD4E6A7]
2012
 
A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
Demmer Oliver, Frank Andreas O., Hagn Franz, Schottelius Margret, Marinelli Luciana, Cosconati Sandro, Brack-Werner Ruth, Kremb Stephan, Wester Hans-Jürgen, Kessler Horst, 2012/08/06. Angewandte Chemie International Edition, 51 (32) pp. 8110-8113.
[DOI][WoS][Pmid][serval:BIB_FA1E773D5A27]
2011
 
PET of CXCR4 Expression by a 68Ga-Labeled Highly Specific Targeted Contrast Agent
Gourni Eleni, Demmer Oliver, Schottelius Margret, D'Alessandria Calogero, Schulz Stefan, Dijkgraaf Ingrid, Schumacher Udo, Schwaiger Markus, Kessler Horst, Wester Hans-Jürgen, 2011/11. Journal of Nuclear Medicine, 52 (11) pp. 1803-1810.
[DOI][WoS][Pmid][serval:BIB_CB8411FF8679]
2009
 
18F-Fluoroglucosylation of peptides, exemplified on cyclo(RGDfK)
Hultsch Christina, Schottelius Margret, Auernheimer Jörg, Alke Andrea, Wester Hans-Jürgen, 2009/09. European Journal of Nuclear Medicine and Molecular Imaging, 36 (9) pp. 1469-1474.
[DOI][WoS][Pmid][serval:BIB_F2B2B0D7A5DB]
 
Ligands for Mapping αvβ3-Integrin Expression in Vivo
Schottelius Margret, Laufer Burkhardt, Kessler Horst, Wester Hans-Jürgen, 2009/07/21. Accounts of Chemical Research, 42 (7) pp. 969-980.
[DOI][WoS][Pmid][serval:BIB_56F5CB8CF012]
 
Molecular imaging targeting peptide receptors
Schottelius Margret, Wester Hans-Jürgen, 2009/06. Methods, 48 (2) pp. 161-177.
[DOI][WoS][Pmid][serval:BIB_9374D457232C]
2008
 
Development of Novel 68Ga- and 18F-Labeled GnRH-I Analogues with High GnRHR-Targeting Efficiency
Schottelius Margret, Berger Sebastian, Poethko Thorsten, Schwaiger Markus, Wester Hans-Jürgen, 2008/06/01. Bioconjugate Chemistry, 19 (6) pp. 1256-1268.
[DOI][WoS][Pmid][serval:BIB_A61908EEACE1]
 
Introduction of Functional Groups into Peptides via N-Alkylation
Demmer O., Dijkgraaf I., Schottelius M., Wester H.-J., Kessler H., 2008/05/01. Organic Letters, 10 (10) pp. 2015-2018.
[DOI][WoS][Pmid][serval:BIB_094A3BC5C696]
2007
 
Synthesis of Novel 1,4,7,10-Tetraazacyclodecane-1,4,7,10-Tetraacetic Acid (DOTA) Derivatives for Chemoselective Attachment to Unprotected Polyfunctionalized Compounds
Knör Sebastian, Modlinger Armin, Poethko Thorsten, Schottelius Margret, Wester Hans-Jürgen, Kessler Horst, 2007/07/16. Chemistry - A European Journal, 13 (21) pp. 6082-6090.
[DOI][WoS][Pmid][serval:BIB_FE8F3D63E81A]
 
Fusion of a recombinant antibody fragment with a homo-amino-acid polymer: effects on biophysical properties and prolonged plasma half-life
Schlapschy M., Theobald I., Mack H., Schottelius M., Wester H.-J., Skerra A., 2007/06/21. Protein Engineering Design and Selection, 20 (6) pp. 273-284.
[DOI][WoS][Pmid][serval:BIB_C4E32DEA00F6]
 
Fluorine-18 Labeling of Peptides and Proteins
Wester H. J., Schottelius M., 2007. Ernst Schering Research Foundation Workshop pp. 79-111.
[DOI][Pmid][serval:BIB_A6F5D492812E]
2006
 
Gluc-Lys([18F]FP)-TOCA PET in patients with SSTR-positive tumors: biodistribution and diagnostic evaluation compared with [111In]DTPA-octreotide.
Meisetschläger G., Poethko T., Stahl A., Wolf I., Scheidhauer K., Schottelius M., Herz M., Wester H.J., Schwaiger M., 2006/04. Journal of nuclear medicine, 47 (4) pp. 566-573. Peer-reviewed.
[WoS][Pmid][serval:BIB_D4735080AC46]
 
Chemoselective hydrazone formation between HYNIC-functionalized peptides and 18F-fluorinated aldehydes
Bruus-Jensen Kjerstin, Poethko Thorsten, Schottelius Margret, Hauser Andrea, Schwaiger Markus, Wester Hans-Jürgen, 2006/02. Nuclear Medicine and Biology, 33 (2) pp. 173-183.
[DOI][WoS][Pmid][serval:BIB_42D464BCCCC3]
 
[123I]Mtr-TOCA, a radioiodinated and carbohydrated analogue of octreotide: scintigraphic comparison with [111In]octreotide
Stahl Alexander, Meisetschläger Günther, Schottelius Margret, Bruus-Jensen Kjerstin, Wolf Ingo, Scheidhauer Klemens, Schwaiger Markus, 2006/01. European Journal of Nuclear Medicine and Molecular Imaging, 33 (1) pp. 45-52.
[DOI][WoS][Pmid][serval:BIB_78703F50D97A]
 
Synthesis and Evaluation of Glycosylated Octreotate Analogues Labeled with Radioiodine and 211At via a Tin Precursor
Vaidyanathan G., Affleck D. J., Schottelius M., Wester H., Friedman H. S., Zalutsky M. R., 2006/01/01. Bioconjugate Chemistry, 17 (1) pp. 195-203.
[DOI][WoS][Pmid][serval:BIB_73E817F94729]
2005
 
N-Terminal Sugar Conjugation and C-Terminal Thr-for-Thr(ol) Exchange in Radioiodinated Tyr3-octreotide: Effect on Cellular Ligand Trafficking in Vitro and Tumor Accumulation in Vivo
Schottelius Margret, Reubi Jean Claude, Eltschinger Veronique, Schwaiger Markus, Wester Hans-Jürgen, 2005/04/01. Journal of Medicinal Chemistry, 48 (8) pp. 2778-2789.
[DOI][WoS][Pmid][serval:BIB_32D841357FCA]
 
Modulation of Pharmacokinetics of Radioiodinated Sugar-Conjugated Somatostatin Analogues by Variation of Peptide Net Charge and Carbohydration Chemistry
Schottelius Margret, Rau Friederike, Reubi Jean Claude, Schwaiger Markus, Wester Hans-Jürgen, 2005/03/01. Bioconjugate Chemistry, 16 (2) pp. 429-437.
[DOI][WoS][serval:BIB_D7D131910E55]
2004
 
Proof of principle for the use of 11C-labelled peptides in tumour diagnosis with PET
Henriksen Gjermund, Schottelius Margret, Poethko Thorsten, Hauser Andrea, Wolf Ingo, Schwaiger Markus, Wester Hans-Juergen, 2004/12. European Journal of Nuclear Medicine and Molecular Imaging, 31 (12) pp. 1653-1657.
[DOI][WoS][serval:BIB_6E90D67EDE0E]
 
First 18F-Labeled Tracer Suitable for Routine Clinical Imaging of sst Receptor-Expressing Tumors Using Positron Emission Tomography
Schottelius Margret, Poethko Thorsten, Herz Michael, Reubi Jean-Claude, Kessler Horst, Schwaiger Markus, Wester Hans-Jürgen, 2004/06/01. Clinical Cancer Research, 10 (11) pp. 3593-3606.
[DOI][WoS][Pmid][serval:BIB_3200A006D1D4]
 
Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.
Poethko T., Schottelius M., Thumshirn G., Hersel U., Herz M., Henriksen G., Kessler H., Schwaiger M., Wester H.J., 2004/05. Journal of nuclear medicine, 45 (5) pp. 892-902. Peer-reviewed.
[WoS][Pmid][serval:BIB_1A2DB5EDF361]
 
Radiolabeled carbohydrated somatostatin analogs: a review of the current status.
Wester H.J., Schottelius M., Poethko T., Bruus-Jensen K., Schwaiger M., 2004/04. Cancer biotherapy & radiopharmaceuticals, 19 (2) pp. 231-244. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0EE77BFB4DE5]
2003
 
Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts.
Vaidyanathan G., Friedman H.S., Affleck D.J., Schottelius M., Wester H.J., Zalutsky M.R., 2003/05. Clinical cancer research, 9 (5) pp. 1868-1876. Peer-reviewed.
[WoS][Pmid][serval:BIB_111AE9FFB891]
 
Rapid and high-yield solution-phase synthesis of DOTA-Tyr3-octreotide and DOTA-Tyr3-octreotate using unprotected DOTA
Schottelius Margret, Schwaiger Markus, Wester Hans-Jürgen, 2003/03. Tetrahedron Letters, 44 (11) pp. 2393-2396.
[DOI][serval:BIB_8D41871D72BC]
 
PET imaging of somatostatin receptors: design, synthesis and preclinical evaluation of a novel 18 F-labelled, carbohydrated analogue of octreotide
Hans-Juergen Wester, Margret Schottelius, Klemens Scheidhauer, Guenther Meisetschlaeger, Michael Herz, Friederike Rau, Jean-Claude Reubi, Markus Schwaiger, 2003/01/01. European Journal of Nuclear Medicine and Molecular Imaging, 30 (1) pp. 117-122.
[DOI][WoS][Pmid][serval:BIB_D74C4158EDEB]
2002
 
Improvement of Pharmacokinetics of Radioiodinated Tyr<sup>3</sup>-Octreotide by Conjugation with Carbohydrates
Schottelius Margret, Wester Hans-Jürgen, Reubi Jean Claude, Senekowitsch-Schmidtke Reingard, Schwaiger Markus, 2002/09/01. Bioconjugate Chemistry, 13 (5) pp. 1021-1030.
[DOI][WoS][Pmid][serval:BIB_464AE0478E91]
 
Comparison of radioiodinated TOC, TOCA and Mtr-TOCA: the effect of carbohydration on the pharmacokinetics
Wester Hans-Jürgen, Schottelius Margret, Scheidhauer Klemens, Reubi Jean-Claude, Wolf Ingo, Schwaiger Markus, 2002/01. European Journal of Nuclear Medicine and Molecular Imaging, 29 (1) pp. 28-38.
[DOI][WoS][Pmid][serval:BIB_10587E68E94A]
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