Francesco Botrè

Publications | Phd and Masters theses

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61 publications

In press
 
Does blood tube filling influence the Athlete Biological Passport variables?
Krumm Bastien, Mettraux Léna, Moreillon Basile, Botrè Francesco, Faiss Raphael Clinical Chemistry and Laboratory Medicine (CCLM). Peer-reviewed.
[DOI][Pmid][serval:BIB_A7B39C29C899]
 
Detection of thyroid hormones in urine by liquid chromatography coupled to tandem mass spectrometry
Martinez Brito Dayamin, Leogrande Patrizia, de la Torre Xavier, Botrè Francesco Drug Testing and Analysis. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4EE3857A56F4]
2024
 
A SNP‐based genotyping strategy to detect the abuse of homologous blood transfusion from dried blood spots
Donati Francesco, Natalucci Alice, Concetti Livia, de la Torre Xavier, Botrè Francesco, 2024/11. Drug Testing and Analysis, 16 (11) pp. 1306-1311. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C3C69D75833D]
Yearly intrasubject variability of hematological biomarkers in elite athletes for the Athlete Biological Passport
Krumm Bastien, Lundby Carsten, Hansen Joar, Bejder Jacob, Sørensen Henrik, Equey Tristan, Saugy Jonas, Botrè Francesco, Faiss Raphael, 2024/11. Drug Testing and Analysis, 16 (11) pp. 1285-1294. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_78F498623A43]
 
Characterization and quantitation of a sulfoconjugated metabolite for detection of methyltestosterone misuse and direct identification by LC-MS
Sun Yanan, Giacomello Ginevra, Girreser Ulrich, Steff Jakob, Bureik Matthias, de la Torre Xavier, Botrè Francesco, Parr Maria Kristina, 2024/09. The Journal of Steroid Biochemistry and Molecular Biology, 242 p. 106527. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A3A2D39E6428]
High‐level performances following low altitude training and tapering in warm environments in elite racewalkers
Krumm Bastien, Vallance Brent, Burke Louise, Garcia Johan, Bouten Janne, Brocherie Franck, Saugy Jonas J., Botrè Francesco, Faiss Raphael, 2024/08. European Journal of Sport Science, 24 (8) pp. 1120-1129. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1B5902AA5BB1]
 
Routine application of SFC‐MS in doping control: Analysis of 3 × 1000 urine samples using three different SFC‐MS instruments
Gavrilović Ivana, Wüst Bernhard, Danaceau Jonathan, Braidman Emmanuelle, de la Torre Xavier, Botrè Francesco, Parr Maria Kristina, Cowan David, 2024/07. Drug Testing and Analysis, 16 (7) pp. 726-736. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8559CCD7AF7A]
 
Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach
Isenmann Eduard, Yuliandra Tasha, Touvleliou Konstantina, Broekmann Matthias, de la Torre Xavier, Botrè Francesco, Diel Patrick, Parr Maria Kristina, 2024/06. Archiv der Pharmazie, 357 (6). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E25232CEFCFD]
 
Liquid vs dried blood matrices: Application to longitudinal monitoring of androstenedione, testosterone, and IGF-1 by LC–MS-based techniques
Mazzarino Monica, Al-Mohammed Hana, Al-Darwish Sara Khalid, Salama Sofia, Al-Kaabi AlAnoud, Samsam Waseem, Kraiem Suhail, Botré Francesco, Beotra Alka, Mohamed-Ali Vidya et al., 2024/05. Journal of Pharmaceutical and Biomedical Analysis, 242 p. 116007. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_279547900769]
 
Simultaneous quantification of endogenous biomarkers and detection of testosterone esters in human serum using gas chromatography–high‐resolution mass spectrometry
Martínez-Brito Dayamín, Leogrande Patrizia, Jardines Daniel, de la Torre Xavier, Botrè Francesco, 2024/03/30. Rapid Communications in Mass Spectrometry, 38 (6). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_33235CB12C74]
 
Biotransformation of anabolic androgenic steroids in human skin cells.
Liu L., Karim Z., Schlörer N., Torre X., Botrè F., Zoschke C., Parr M.K., 2024/03. The Journal of steroid biochemistry and molecular biology, 237 p. 106444. Peer-reviewed.
[DOI][Pmid][serval:BIB_D3DDF8768831]
Impact of low-volume blood withdrawal on hematological biomarkers for the athlete biological passport.
Krumm B., Saugy J.J., Botrè F., Faiss R., 2024/02. Drug testing and analysis, 16 (2) pp. 168-173. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_29EE2DC8267A]
Indirect biomarkers of blood doping: A systematic review.
Krumm B., Saugy J.J., Botrè F., Donati F., Faiss R., 2024/01. Drug testing and analysis, 16 (1) pp. 49-64. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_364C21F125EB]
Serum myokines as potential biomarkers of myostatin inhibition in sport doping: a preliminary study on their baseline levels in elite athletes
Donati Francesco, Biasini Giorgia Morgan, de la Torre Xavier, Botrè Francesco, 2024. Biology of Sport, 41 (2) pp. 175-183.
[URN][DOI][WoS][Pmid][serval:BIB_162D4D8C7DC2]
2023
Age-Markers on the Red Blood Cell Surface and Erythrocyte Microparticles may Constitute a Multi-parametric Strategy for Detection of Autologous Blood Transfusion.
Biasini G.M., Botrè F., de la Torre X., Donati F., 2023/12/01. Sports medicine - open, 9 (1) p. 113. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1D9106149779]
Prediction of plasma volume and total hemoglobin mass with machine learning.
Moreillon B., Krumm B., Saugy J.J., Saugy M., Botrè F., Vesin J.M., Faiss R., 2023/10. Physiological reports, 11 (19) pp. e15834. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_0A1CFCC7BBFC]
Creating equality through differentiation in doping control
Viret Marjolaine, Botre Francesco, Saugy Martial, 2023/09/04. International Sports Law Journal, 23 pp. 293-313. Peer-reviewed.
[URN][serval:BIB_7527A6AB643E]
A new multimodal paradigm for biomarkers longitudinal monitoring: a clinical application to women steroid profiles in urine and blood.
de Figueiredo M., Saugy J., Saugy M., Faiss R., Salamin O., Nicoli R., Kuuranne T., Rudaz S., Botrè F., Boccard J., 2023/08/01. Analytica chimica acta, 1267 p. 341389. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0F385D101987]
 
LC-HRMS-based metabolomics workflow: An alternative strategy for metabolite identification in the antidoping field.
Leogrande P., Jartdines D., Martinez-Brito D., de la Torre X., Parr M.K., Botrè F., 2023/07/30. Rapid communications in mass spectrometry, 37 (14) pp. e9532. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BAE0BD795D2F]
 
Urinary Excretion of Ecdysterone and Its Metabolites Following Spinach Consumption.
Yuliandra T., Touvleliou K., de la Torre X., Botrè F., Loke S., Isenmann E., Valder S., Diel P., Parr M.K., 2023/07. Molecular nutrition & food research, 67 (14) pp. e2200518. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_30AE106C4C6C]
Should We be Concerned with Nicotine in Sport? Analysis from 60,802 Doping Control Tests in Italy.
Zandonai T., Botrè F., Abate M.G., Peiró A.M., Mündel T., 2023/06. Sports medicine, 53 (6) pp. 1273-1279. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CBD905D3FAA7]
 
Analysis of doping control samples using supercritical fluid chromatography-tandem mass spectrometry: Ready for routine use.
Wuest B., Gavrilović I., Cowan D., Torre X., Botrè F., Parr M.K., 2023/04. Journal of separation science, 46 (7) pp. e2200880. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E271C6921828]
 
Capillary blood as a complementary matrix for doping control purposes. Application to the definition of the individual longitudinal profile of IGF-1.
Stacchini C., Botrè F., de la Torre X., Mazzarino M., 2023/04/01. Journal of pharmaceutical and biomedical analysis, 227 p. 115274. Peer-reviewed.
[DOI][Pmid][serval:BIB_6E3F37848B13]
 
Effect of low-volume blood withdrawal on hematological biomarkers
Krumm Bastien, Saugy Jonas, Botrè Francesco, Faiss Raphael, 2023/02/14. Current Issues in Sport Science (CISS), 8 (2) p. 017. Peer-reviewed.
[DOI][serval:BIB_503B5759141D]
 
Correction of the urinary testosterone to epitestosterone ratio measurement in antidoping analyses by chromatographic and mass spectrometric techniques.
Martínez Brito D., Vidal T.C., de la Torre X., de Oca Porto R.M., Botrè F., 2023. Drug testing and analysis, 15 (11-12) pp. 1382-1391. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_EC793DF41CED]
 
Effect of thyroid hormones administration on urinary endogenous steroid profile of the athlete biological passport.
Martínez Brito D., de la Torre X., Botrè F., 2023. Drug testing and analysis, 15 (11-12) pp. 1361-1370. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3E8D7F33FA86]
 
Tramadol and Cycling: Is It the End of a "Painful" Relationship? An Insight From 60,802 Doping-Control Samples From 2012 to 2020.
Zandonai T., Peiró A.M., Covelli C., de la Torre X., Botré F., 2023/01/01. International journal of sports physiology and performance, 18 (1) pp. 95-98. Peer-reviewed.
[DOI][Pmid][serval:BIB_76C42F8C855B]
2022
 
Evaluation of longitudinal <sup>13</sup> C isotope ratio mass spectrometric data in antidoping analysis.
de la Torre X., Jardines D., Botrè F., 2022/11. Drug testing and analysis, 14 (11-12) pp. 1877-1890. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_47B225CFCE3D]
Urinary excretion profile of prednisolone and prednisone after rectal administration: Significance in antidoping analysis.
Iannella L., Comunità F., Botrè F., Colamonici C., Curcio D., de la Torre X., Mazzarino M., 2022/11. Drug testing and analysis, 14 (11-12) pp. 2007-2016. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3F95C9381EB3]
UHPLC-HRMS Method for the Simultaneous Screening of 235 Drugs in Capillary Blood for Doping Control Purpose: Comparative Evaluation of Volumetric and Non-volumetric Dried Blood Spotting Devices.
Mazzarino M., Di Costanzo L., Comunità F., Stacchini C., de la Torre X., Botrè F., 2022/09/13. ACS omega, 7 (36) pp. 31845-31868. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7E102A23BB61]
 
Quantification of thyroid hormones and analogs by liquid chromatography coupled to mass spectrometry. Preliminary results in athletes and non-athletes serum samples.
Martínez Brito D., Leogrande P., Donati F., de la Torre X., Botrè F., 2022/08. Drug testing and analysis, 14 (8) pp. 1438-1450. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_88210525B3F8]
In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice.
Tirri M., Arfè R., Bilel S., Corli G., Marchetti B., Fantinati A., Vincenzi F., De-Giorgio F., Camuto C., Mazzarino M. et al., 2022/07/21. International journal of molecular sciences, 23 (14). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BB8B93BEDC23]
 
Thyroid metabolism and supplementation: A review framed in sports environment.
Martínez Brito D., Botrè F., Romanelli F., de la Torre X., 2022/07. Drug testing and analysis, 14 (7) pp. 1176-1186. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AA59794443C1]
 
Development and validation of a liquid chromatography–tandem mass spectrometry method for the simultaneous analysis of androgens, estrogens, glucocorticoids and progestagens in human serum
Iannone Michele, Dima Anna Pia, Sciarra Francesca, Botrè Francesco, Isidori Andrea M, 2022/05. Biomedical Chromatography.
[DOI][serval:BIB_765C4F8597A5]
In vitro metabolic profile of mexedrone, a mephedrone analog, studied by high- and low-resolution mass spectrometry.
Camuto C., Guglielmelli A., De-Giorgio F., de la Torre X., Mazzarino M., Marti M., Botrè F., 2022/02. Drug testing and analysis, 14 (2) pp. 269-276. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BD4F47AEB286]
 
Metabolomics workflow as a driven tool for rapid detection of metabolites in doping analysis. Development and validation.
Leogrande P., Jardines D., Martinez-Brito D., Domenici E., de la Torre X., Parr M.K., Botrè F., 2022/01/30. Rapid communications in mass spectrometry, 36 (2) pp. e9217. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C740320D3AD7]
Altitude and Erythropoietin: Comparative Evaluation of Their Impact on Key Parameters of the Athlete Biological Passport: A Review.
Saugy J.J., Schmoutz T., Botrè F., 2022. Frontiers in sports and active living, 4 p. 864532. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_99E2DCFFFC23]
Editorial: OMICS-based approaches in sports research volume II.
Elrayess M.A., Botrè F., Palermo A., 2022. Frontiers in molecular biosciences, 9 p. 1104142. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_AB0EE5521070]
Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells.
Alheidous S., Al-Muraikhy S., Rizk N., Sellami M., Donati F., Botre F., Al-Mansoori L., Elrayess M.A., 2022. Frontiers in molecular biosciences, 9 p. 943034. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8911E550F95F]
 
Future opportunities for the Athlete Biological Passport.
Krumm B., Botrè F., Saugy J.J., Faiss R., 2022. Frontiers in sports and active living, 4 p. 986875. Peer-reviewed.
[DOI][Pmid][serval:BIB_6DDAE8E1662C]
 
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry.
Martínez Brito D., Leogrande P., de la Torre X., Botrè F., 2022. Journal of pharmacological and toxicological methods, 115 p. 107169. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7176D102D9DB]
2021
 
Low-energy electron ionization optimization for steroidomics analysis using high-resolution mass spectrometry.
Leogrande P., Jardines D., Martinez-Brito D., de la Torre X., Parr M.K., Botrè F., 2021/12/15. Rapid communications in mass spectrometry, 35 (23) pp. e9196. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A7D234977910]
 
5α‐reductase inhibitors: Evaluation of their potential confounding effect on GC‐C‐IRMS doping analysis
Iannella Loredana, Colamonici Cristiana, Curcio Davide, Botrè Francesco, Torre Xavier, 2021/11. Drug Testing and Analysis, 13 (11-12) pp. 1852-1861. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5628AC2A339E]
 
Controlled administration of dehydrochloromethyltestosterone in humans: Urinary excretion and long-term detection of metabolites for anti-doping purpose.
Loke S., de la Torre X., Iannone M., La Piana G., Schlörer N., Botrè F., Bureik M., Parr M.K., 2021/11. The Journal of steroid biochemistry and molecular biology, 214 p. 105978. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_42A0E9B9AD5A]
 
Effects of the administration of miconazole by different routes on the biomarkers of the "steroidal module" of the Athlete Biological Passport.
Mazzarino M., Comunità F., de la Torre X., Molaioni F., Botrè F., 2021/10. Drug testing and analysis, 13 (10) pp. 1712-1726. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E390B2AC4028]
Worsening of the Toxic Effects of (±)Cis-4,4'-DMAR Following Its Co-Administration with (±)Trans-4,4'-DMAR: Neuro-Behavioural, Physiological, Immunohistochemical and Metabolic Studies in Mice.
Tirri M., Frisoni P., Bilel S., Arfè R., Trapella C., Fantinati A., Corli G., Marchetti B., De-Giorgio F., Camuto C. et al., 2021/08/16. International journal of molecular sciences, 22 (16). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4D92C3CAF74D]
 
Arimistane: Degradation product or metabolite of 7-oxo-DHEA?
Martínez Brito D., Leogrande P., Colamonici C., Curcio D., Botre F., de la Torre X., 2021/07. Drug testing and analysis, 13 (7) pp. 1430-1439. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E5853F9D6A8F]
 
Detection of urinary arimistane metabolites in humans using liquid chromatography-mass spectrometry: Complementary results to gas chromatography mass spectrometric data and its application to antidoping analyses.
Martinez Brito D., Leogrande P., Botrè F., de la Torre X., 2021/06/30. Rapid communications in mass spectrometry, 35 (12) pp. e9080. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9394BAB0B049]
Urinary Elimination of Ecdysterone and Its Metabolites Following a Single-Dose Administration in Humans.
Ambrosio G., Yuliandra T., Wuest B., Mazzarino M., de la Torre X., Botrè F., Diel P., Isenmann E., Parr M.K., 2021/06/09. Metabolites, 11 (6). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4BAFE24974F6]
 
Coupling high-resolution mass spectrometry and chemometrics for the structural characterization of anabolic-androgenic steroids and the early detection of unknown designer structures
Patrizia Leogrande, Francesco Botrè, Xavier de la Torre, Daniel Jardines, Maria Kristina Parr, Federico Marini, 2021/05. Talanta.
[DOI][serval:BIB_9BBBF068FD4D]
 
Detecting the abuse of 19‐norsteroids in doping controls: A new gas chromatography coupled to isotope ratio mass spectrometry method for the analysis of 19‐norandrosterone and 19‐noretiocholanolone
Loredana Iannella, Cristiana Colamonici, Davide Curcio, Francesco Botrè, Xavier Torre, 2021/04/08. Drug Testing and Analysis.
[DOI][serval:BIB_BAE43B20D873]
 
Simultaneous detection of different chemical classes of selective androgen receptor modulators in urine by liquid chromatography-mass spectrometry-based techniques.
Stacchini C., Botrè F., Comunità F., de la Torre X., Dima A.P., Ricci M., Mazzarino M., 2021/02/20. Journal of pharmaceutical and biomedical analysis, 195 p. 113849. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D9A987355DE2]
 
Improving the detection of anabolic steroid esters in human serum by LC-MS.
de la Torre X., Iannone M., Botrè F., 2021/02/05. Journal of pharmaceutical and biomedical analysis, 194 p. 113807. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_65397D17D6A8]
 
Influence of Saw palmetto and Pygeum africana extracts on the urinary concentrations of endogenous anabolic steroids: Relevance to doping analysis
Michele Iannone, Amelia Palermo, Xavier de la Torre, Monica Mazzarino, Francesco Molaioni, Francesco Botrè, 2021/02. Phytomedicine Plus.
[DOI][serval:BIB_151A94D93FEB]
 
Metabolic profile of the synthetic drug 4,4′-dimethylaminorex in urine by LC–MS-based techniques: selection of the most suitable markers of its intake
Claudia Chieffi, Cristian Camuto, Fabio De-Giorgio, Xavier de la Torre, Francesca Diamanti, Monica Mazzarino, Claudio Trapella, Matteo Marti, Francesco Botrè, 2021/01/19. Forensic Toxicology.
[DOI][serval:BIB_10BE044D2FC8]
 
Urinary excretion profile of methiopropamine in mice following intraperitoneal administration: A liquid chromatography–tandem mass spectrometry investigation
Camuto Cristian, Pellegrini Sheila, De-Giorgio Fabio, de la Torre Xavier, Marti Matteo, Mazzarino Monica, Botrè Francesco, 2021/01/07. Drug Testing and Analysis.
[DOI][serval:BIB_2CD2CA37B52D]
 
Age and sport intensity-dependent changes in cytokines and telomere length in elite athletes
Botrè Francesco, 2021. Antioxidants.
[DOI][serval:BIB_DADC793D5B05]
Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase.
Loke S., Stoll A., Machalz D., Botrè F., Wolber G., Bureik M., Parr M.K., 2021. Frontiers in endocrinology, 12 p. 633785. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F6132C388818]
2020
 
In‐depth gas chromatography/tandem mass spectrometry fragmentation analysis of formestane and evaluation of mass spectral discrimination of isomeric 3‐keto‐4‐ene hydroxy steroids
Annette Sophie Kollmeier, Xavier Torre, Christian Müller, Francesco Botrè, Maria Kristina Parr, 2020/12/30. Rapid Communications in Mass Spectrometry.
[DOI][serval:BIB_BF44419282B7]
 
Carbon isotopic characterization of prednisolone and prednisone pharmaceutical formulations: Implications in antidoping analysis
Iannella Loredana, Botrè Francesco, Colamonici Cristiana, Curcio Davide, Ciccarelli Chiara, Mazzarino Monica, de la Torre Xavier, 2020/11. Drug Testing and Analysis, 12 (11-12) pp. 1587-1598.
[DOI][WoS][Pmid][serval:BIB_7DCF26BFFDEE]
2019
 
Synthetic isoflavones and doping: A novel class of aromatase inhibitors?
Iannone Michele, Botrè Francesco, Cardillo Nicoletta, de la Torre Xavier, 2019/02. Drug Testing and Analysis, 11 (2) pp. 208-214.
[DOI][WoS][Pmid][serval:BIB_E4298DE9415E]
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