Philippe Abdel-Sayed

Publications | Phd and Masters theses

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55 publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2009 |
 
Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process.
Jeannerat A., Peneveyre C., Jaccoud S., Philippe V., Scaletta C., Hirt-Burri N., Abdel-Sayed P., Martin R., Applegate L.A., Pioletti D.P. et al., 2024/09/29. Pharmaceutics, 16 (10) p. 1274. Peer-reviewed.
Pilot Clinical Safety and Efficacy Evaluation of a Topical 3% Tranexamic Acid Cream and Serum Protocol for Managing Facial Hyperpigmentation in Caucasian Patients
Hsin Sarah, Lourenço Kelly, Porcello Alexandre, Marques Cíntia, Rodriguez Clara, Raffoul Wassim, Scaletta Corinne, Abdel-Sayed Philippe, Hadjab Basste, Applegate Lee Ann et al., 2024/09/28. Cosmetics, 11 (5) p. 168. Peer-reviewed.
Medicalized Aesthetic Uses of Exosomes and Cell Culture-Conditioned Media: Opening an Advanced Care Era for Biologically Inspired Cutaneous Prejuvenation and Rejuvenation
Rodriguez Clara, Porcello Alexandre, Chemali Michèle, Raffoul Wassim, Marques Cíntia, Scaletta Corinne, Lourenço Kelly, Abdel-Sayed Philippe, Applegate Lee Ann, Pelissier Vatter Fanny et al., 2024/09/07. Cosmetics, 11 (5) p. 154.
 
Sustainable Primary Cell Banking for Topical Compound Cytotoxicity Assays: Protocol Validation on Novel Biocides and Antifungals for Optimized Burn Wound Care.
Liao Z., Laurent N., Hirt-Burri N., Scaletta C., Abdel-Sayed P., Raffoul W., Luo S., Krysan D.J., Laurent A., Applegate L.A., 2024/08/06. European burn journal, 5 (3) pp. 249-270. Peer-reviewed.
 
Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3: Efficient Combination of Bio-Stimulation Properties with Hydrogel System Resilience Enhancement.
Porcello A., Chemali M., Marques C., Scaletta C., Lourenço K., Abdel-Sayed P., Raffoul W., Hirt-Burri N., Applegate L.A., Laurent A., 2024/05/24. Gels, 10 (6). Peer-reviewed.
Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products.
Marques C., Hadjab F., Porcello A., Lourenço K., Scaletta C., Abdel-Sayed P., Hirt-Burri N., Applegate L.A., Laurent A., 2024/03/30. Antioxidants, 13 (4). Peer-reviewed.
Ex Vivo Functional Benchmarking of Hyaluronan-Based Osteoarthritis Viscosupplement Products: Comprehensive Assessment of Rheological, Lubricative, Adhesive, and Stability Attributes.
Porcello A., Hadjab F., Ajouaou M., Philippe V., Martin R., Abdel-Sayed P., Hirt-Burri N., Scaletta C., Raffoul W., Applegate L.A. et al., 2023/10/09. Gels, 9 (10) p. 808. Peer-reviewed.
Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification.
Philippe V., Jeannerat A., Peneveyre C., Jaccoud S., Scaletta C., Hirt-Burri N., Abdel-Sayed P., Raffoul W., Darwiche S., Applegate L.A. et al., 2023/09/16. Pharmaceutics, 15 (9) p. 2333. Peer-reviewed.
Cutaneous Cell Therapy Manufacturing Timeframe Rationalization: Allogeneic Off-the-Freezer Fibroblasts for Dermo-Epidermal Combined Preparations (DE-FE002-SK2) in Burn Care.
Chen X., Laurent A., Liao Z., Jaccoud S., Abdel-Sayed P., Flahaut M., Scaletta C., Raffoul W., Applegate L.A., Hirt-Burri N., 2023/09/16. Pharmaceutics, 15 (9) p. 2334. Peer-reviewed.
Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine.
Jeannerat A., Meuli J., Peneveyre C., Jaccoud S., Chemali M., Thomas A., Liao Z., Abdel-Sayed P., Scaletta C., Hirt-Burri N. et al., 2023/07/03. Pharmaceutics, 15 (7) p. 1873. Peer-reviewed.
 
Thermo-Responsive Hyaluronan-Based Hydrogels Combined with Allogeneic Cytotherapeutics for the Treatment of Osteoarthritis.
Porcello A., Gonzalez-Fernandez P., Jeannerat A., Peneveyre C., Abdel-Sayed P., Scaletta C., Raffoul W., Hirt-Burri N., Applegate L.A., Allémann E. et al., 2023/05/18. Pharmaceutics, 15 (5) p. 1528. Peer-reviewed.
Primary Chondroprogenitors: Standardized & Versatile Allogeneic Cytotherapeutics
Laurent Alexis, Jeannerat Annick, Peneveyre Cédric, Scaletta Corinne, Philippe Virginie, Abdel-Sayed Philippe, Raffoul Wassim, Martin Robin, Hirt-Burri Nathalie, Applegate Lee Ann, 2023/05/17. Encyclopedia, 3 (2) pp. 622-641.
 
Process Optimization and Efficacy Assessment of Standardized PRP for Tendinopathies in Sports Medicine: Retrospective Study of Clinical Files and GMP Manufacturing Records in a Swiss University Hospital.
Sebbagh P., Hirt-Burri N., Scaletta C., Abdel-Sayed P., Raffoul W., Gremeaux V., Laurent A., Applegate L.A., Gremion G., 2023/03/25. Bioengineering, 10 (4) p. 409. Peer-reviewed.
Primary Progenitor Tenocytes: Cytotherapeutics and Cell-Free Derivatives
Laurent Alexis, Scaletta Corinne, Abdel-Sayed Philippe, Raffoul Wassim, Hirt-Burri Nathalie, Applegate Lee Ann, 2023/03/16. Encyclopedia, 3 (1) pp. 340-361.
 
Current Status of PRP Manufacturing Requirements & European Regulatory Frameworks: Practical Tools for the Appropriate Implementation of PRP Therapies in Musculoskeletal Regenerative Medicine.
Sebbagh P., Cannone A., Gremion G., Gremeaux V., Raffoul W., Hirt-Burri N., Michetti M., Abdel-Sayed P., Laurent A., Wardé N. et al., 2023/02/24. Bioengineering, 10 (3) p. 292. Peer-reviewed.
Industrial Biotechnology Conservation Processes: Similarities with Natural Long-Term Preservation of Biological Organisms.
Laurent A., Scaletta C., Abdel-Sayed P., Raffoul W., Hirt-Burri N., Applegate L.A., 2023/01/31. Biotech, 12 (1) p. 15. Peer-reviewed.
Lyophilized Progenitor Tenocyte Extracts: Sterilizable Cytotherapeutic Derivatives with Antioxidant Properties and Hyaluronan Hydrogel Functionalization Effects.
Laurent A., Porcello A., Jeannerat A., Peneveyre C., Coeur A., Abdel-Sayed P., Scaletta C., Michetti M., de Buys Roessingh A., Jordan O. et al., 2023/01/10. Antioxidants, 12 (1) p. 163. Peer-reviewed.
Retrospectives on Three Decades of Safe Clinical Experience with Allogeneic Dermal Progenitor Fibroblasts: High Versatility in Topical Cytotherapeutic Care.
Laurent A., Rey M., Scaletta C., Abdel-Sayed P., Michetti M., Flahaut M., Raffoul W., de Buys Roessingh A., Hirt-Burri N., Applegate L.A., 2023/01/04. Pharmaceutics, 15 (1) p. 184. Peer-reviewed.
 
Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine
Porcello Alexandre, Laurent Alexis, Hirt-Burri Nathalie, Abdel-Sayed Philippe, de Buys Roessingh Anthony, Raffoul Wassim, Jordan Olivier, Allémann Eric, Applegate Lee Ann, 2022/03/29. pp. 119-148 dans Nanopharmaceuticals in Regenerative Medicine, CRC Press.
Retrospective Analysis of Autologous Chondrocyte-Based Cytotherapy Production for Clinical Use: GMP Process-Based Manufacturing Optimization in a Swiss University Hospital.
Philippe V., Laurent A., Hirt-Burri N., Abdel-Sayed P., Scaletta C., Schneebeli V., Michetti M., Brunet J.F., Applegate L.A., Martin R., 2022/03/17. Cells, 11 (6) p. 1016. Peer-reviewed.
Synergistic effects of antimicrobial peptide dendrimer-chitosan polymer conjugates against Pseudomonas aeruginosa.
Patrulea V., Gan B.H., Perron K., Cai X., Abdel-Sayed P., Sublet E., Ducret V., Nerhot N.P., Applegate L.A., Borchard G. et al., 2022/03/15. Carbohydrate polymers, 280 p. 119025. Peer-reviewed.
Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling.
Nasrollahzadeh N., Karami P., Wang J., Bagheri L., Guo Y., Abdel-Sayed P., Laurent-Applegate L., Pioletti D.P., 2022/03/08. eLife, 11 pp. e72068. Peer-reviewed.
 
Biotechnology and Cytotherapeutics: The Swiss Progenitor-Cell Transplantation Program
Laurent Alexis, Scaletta Corinne, Abdel-Sayed Philippe, Michetti Murielle, de Buys Roessingh Anthony, Raffoul Wassim, Hirt-Burri Nathalie, Applegate Lee Ann, 2022/01/30. Encyclopedia, 2 (1) pp. 336-364.
Combination of Hyaluronan and Lyophilized Progenitor Cell Derivatives: Stabilization of Functional Hydrogel Products for Therapeutic Management of Tendinous Tissue Disorders.
Laurent A., Porcello A., Fernandez P.G., Jeannerat A., Peneveyre C., Abdel-Sayed P., Scaletta C., Hirt-Burri N., Michetti M., de Buys Roessingh A. et al., 2021/12/19. Pharmaceutics, 13 (12) p. 2196. Peer-reviewed.
Back to the Cradle of Cytotherapy: Integrating a Century of Clinical Research and Biotechnology-Based Manufacturing for Modern Tissue-Specific Cellular Treatments in Switzerland.
Laurent A., Abdel-Sayed P., Scaletta C., Laurent P., Laurent E., Michetti M., de Buys Roessingh A., Raffoul W., Hirt-Burri N., Applegate L.A., 2021/12/17. Bioengineering, 8 (12) p. 221. Peer-reviewed.
Human Platelet Lysate as an Alternative to Autologous Serum for Human Chondrocyte Clinical Use.
Philippe V., Laurent A., Abdel-Sayed P., Hirt-Burri N., Ann Applegate L., Martin R., 2021/12. Cartilage, 13 (1_suppl) pp. 509S-518S. Peer-reviewed.
Burn Center Organization and Cellular Therapy Integration: Managing Risks and Costs.
Chemali M., Laurent A., Scaletta C., Waselle L., Simon J.P., Michetti M., Brunet J.F., Flahaut M., Hirt-Burri N., Raffoul W. et al., 2021/09/30. Journal of burn care & research, 42 (5) pp. 911-924. Peer-reviewed.
Corrigendum to: Burn Center Organization and Cellular Therapy Integration: Managing Risks and Costs.
Chemali M., Laurent A., Scaletta C., Waselle L., Simon J.P., Michetti M., Brunet J.F., Flahaut M., Hirt-Burri N., Raffoul W. et al., 2021/09/30..
 
Effective Management Of Topical Nosocomial Aspergillus Spp. Infections In Three Severely Burned Patients.
Pantet O., Laurent A., Abdel-Sayed P., Hirt-Burri N., Michetti M., Raffoul W., Monod M., Applegate L.A., de Buys Roessingh A.S., 2021/09/30. Annals of burns and fire disasters, 34 (3) pp. 235-239. Peer-reviewed.
 
Evolution of Diploid Progenitor Lung Cell Applications: From Optimized Biotechnological Substrates to Potential Active Pharmaceutical Ingredients in Respiratory Tract Regenerative Medicine.
Laurent A., Abdel-Sayed P., Hirt-Burri N., Scaletta C., Michetti M., de Buys Roessingh A., Raffoul W., Applegate L.A., 2021/09/24. Cells, 10 (10) p. 2526. Peer-reviewed.
Optimized Manufacture of Lyophilized Dermal Fibroblasts for Next-Generation Off-the-Shelf Progenitor Biological Bandages in Topical Post-Burn Regenerative Medicine.
Laurent A., Scaletta C., Abdel-Sayed P., Michetti M., Flahaut M., Simon J.P., Roessingh A.B., Raffoul W., Hirt-Burri N., Applegate L.A., 2021/08/23. Biomedicines, 9 (8) p. 1072. Peer-reviewed.
 
Bonnes Pratiques de Fabrication et thérapies cellulaires au chevet des grands brûlés romands
Laurent Alexis, Abdel-Sayed Philippe, Chemale Michèle, Hirt-Burri Nathalie, Raffoul Wassim, Applegate Lee Ann, de Buys Roesingh Anthony S, 2021/07/01. PharmaJournal Suisse, 2021 (6/7) pp. 10-14.
Design optimization of bidirectional arterial perfusion cannula.
Abdel-Sayed S., Ferrari E., Abdel-Sayed P., Wilhelm M., von Segesser L.K., Berdajs D., 2021/04/26. Journal of cardiothoracic surgery, 16 (1) p. 114. Peer-reviewed.
Industrial Development of Standardized Fetal Progenitor Cell Therapy for Tendon Regenerative Medicine: Preliminary Safety in Xenogeneic Transplantation.
Laurent A., Abdel-Sayed P., Grognuz A., Scaletta C., Hirt-Burri N., Michetti M., de Buys Roessingh A.S., Raffoul W., Kronen P., Nuss K. et al., 2021/04/03. Biomedicines, 9 (4) p. 380. Peer-reviewed.
Retrospective Evaluation of Progenitor Biological Bandage Use: A Complementary and Safe Therapeutic Management Option for Prevention of Hypertrophic Scarring in Pediatric Burn Care.
Al-Dourobi K., Laurent A., Deghayli L., Flahaut M., Abdel-Sayed P., Scaletta C., Michetti M., Waselle L., Simon J.P., Ezzi O.E. et al., 2021/02/28. Pharmaceuticals, 14 (3) p. 201. Peer-reviewed.
Development of Standardized Fetal Progenitor Cell Therapy for Cartilage Regenerative Medicine: Industrial Transposition and Preliminary Safety in Xenogeneic Transplantation.
Laurent A., Abdel-Sayed P., Ducrot A., Hirt-Burri N., Scaletta C., Jaccoud S., Nuss K., Roessingh ASB, Raffoul W., Pioletti D. et al., 2021/02/09. Biomolecules, 11 (2) p. 250. Peer-reviewed.
Implications of chlorhexidine use in burn units for wound healing.
Abdel-Sayed P., Tornay D., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2020/08. Burns, 46 (5) pp. 1150-1156. Peer-reviewed.
 
Effect of blood viscosity on the performance of virtually wall-less venous cannulas.
Abdel-Sayed S., Abdel-Sayed P., Berdaj D., Ferrari E., Halbe M., von Segesser L.K., Maisano F., 2020/07. Perfusion, 35 (5) pp. 393-396. Peer-reviewed.
 
New bidirectional arterial perfusion device.
Abdel-Sayed S., Ferrari E., Abdel-Sayed P., Wilhelm M., Halbe M., von Segesser L.K., Maisano F., Berdajs D., 2020/07. The International journal of artificial organs, 43 (7) pp. 433-436. Peer-reviewed.
 
Reply to the Letter to the Editor on "The use of antiseptics in burn wounds - our perspective".
Abdel-Sayed P., Tornay D., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2020/06. Burns, 46 (4) pp. 981-982. Peer-reviewed.
Surgical Management Evolution Between 2 Massive Burn Cases at 17-Year Interval: Contribution of Cell Therapies in Improving the Surgical Care.
Monnier S., Abdel-Sayed P., Roessingh A.B., Hirt-Burri N., Chemali M., Applegate L.A., Raffoul W., 2020. Cell transplantation, 29 p. 963689720973642. Peer-reviewed.
Evolution of Biological Bandages as First Cover for Burn Patients.
Abdel-Sayed P., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2019/11/01. Advances in wound care, 8 (11) pp. 555-564. Peer-reviewed.
Cell therapies for skin regeneration: an overview of 40 years of experience in burn units.
Abdel-Sayed P., Michetti M., Scaletta C., Flahaut M., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A., 2019/05/06. Swiss medical weekly, 149 pp. w20079. Peer-reviewed.
 
Fabrication of an Open Microfluidic Device for Immunoblotting.
Abdel-Sayed P., Yamauchi K.A., Gerver R.E., Herr A.E., 2017/09/19. Analytical chemistry, 89 (18) pp. 9643-9648. Peer-reviewed.
Corrigendum: Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.
Abdel-Sayed P., Kaeppeli A., Siriwardena T., Darbre T., Perron K., Jafari P., Reymond J.L., Pioletti D.P., Applegate L.A., 2016/04/07. Scientific reports, 6 p. 23872. Peer-reviewed.
Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages.
Abdel-Sayed P., Kaeppeli A., Siriwardena T., Darbre T., Perron K., Jafari P., Reymond J.L., Pioletti D.P., Applegate L.A., 2016/02/25. Scientific reports, 6 p. 22020. Peer-reviewed.
 
Impact of synovial fluid flow on temperature regulation in knee cartilage.
Moghadam M.N., Abdel-Sayed P., Camine V.M., Pioletti D.P., 2015/01/21. Journal of biomechanics, 48 (2) pp. 370-374. Peer-reviewed.
 
Strategies for improving the repair of focal cartilage defects.
Abdel-Sayed P., Pioletti D.P., 2015. Nanomedicine, 10 (18) pp. 2893-2905. Peer-reviewed.
 
Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading.
Abdel-Sayed P., Moghadam M.N., Salomir R., Tchernin D., Pioletti D.P., 2014/02. Journal of the mechanical behavior of biomedical materials, 30 pp. 123-130. Peer-reviewed.
 
The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression.
Abdel-Sayed P., Darwiche S.E., Kettenberger U., Pioletti D.P., 2014/02. Biomaterials, 35 (6) pp. 1890-1897. Peer-reviewed.
 
Comparison of radial deformability of stent posts of different aortic bioprostheses.
Kalejs M., Lacis R., Kasyanov V., Ozolanta I., Abdel Sayed P., Stradins P., von Segesser L.K., 2013/02. Interactive cardiovascular and thoracic surgery, 16 (2) pp. 129-133. Peer-reviewed.
 
Cartilage self-heating contributes to chondrogenic expression
Abdel-Sayed Philippe, 2013. European Cells and Materials.
 
Dissipation can act as a mechanobiological signal in cartilage differentiation
Abdel-Sayed Philippe, 2013. dans ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE).
 
Rapid Prototyping for Training Purposes in Cardiovascular Surgery
Abdel-Sayed Philippe, von Segesser Ludwig Karl, 2011/09/22. dans Advanced Applications of Rapid Prototyping Technology in Modern Engineering, InTech.
 
A new training set-up for trans-apical aortic valve replacement.
Abdel-Sayed P., Kalejs M., von Segesser L.K., 2009/06. Interactive cardiovascular and thoracic surgery, 8 (6) pp. 599-601. Peer-reviewed.
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