Laure Willen

Publications | Phd and Masters theses

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26 publications

2024 | 2023 | 2022 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 |
2024
 
Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody-producing cells in different tissues.
Eslami M., Schuepbach-Mallepell S., Diana D., Willen L., Kowalczyk-Quintas C., Desponds C., Peter B., Vigolo M., Renevey F., Donzé O. et al., 2024/07/16. Proceedings of the National Academy of Sciences of the United States of America, 121 (29) pp. e2404309121. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_B949D49C95C6]
2023
A Missense Mutation in the Collagen Triple Helix of EDA Is Associated with X-Linked Recessive Hypohidrotic Ectodermal Dysplasia in Fleckvieh Cattle.
Reinartz S., Weiß C., Heppelmann M., Hewicker-Trautwein M., Hellige M., Willen L., Feige K., Schneider P., Distl O., 2023/12/20. Genes, 15 (1) p. 8. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_B9CC7B1AD0C8]
2022
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
Smulski C.R., Zhang L., Burek M., Teixidó Rubio A., Briem J.S., Sica M.P., Sevdali E., Vigolo M., Willen L., Odermatt P. et al., 2022/03/29. Cell reports, 38 (13) p. 110583. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BF01BC2683F0]
Functional and clinical analysis of five EDA variants associated with ectodermal dysplasia but with a hard-to-predict significance.
Gökdere S., Schneider H., Hehr U., Willen L., Schneider P., Maier-Wohlfart S., 2022. Frontiers in genetics, 13 p. 934395. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_30C88A426776]
2020
BAFF 60-mer, and Differential BAFF 60-mer Dissociating Activities in Human Serum, Cord Blood and Cerebrospinal Fluid.
Eslami M., Meinl E., Eibel H., Willen L., Donzé O., Distl O., Schneider H., Speiser D.E., Tsiantoulas D., Yalkinoglu Ö. et al., 2020. Frontiers in cell and developmental biology, 8 p. 577662. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4C23317E84BA]
2019
No interactions between heparin and atacicept, an antagonist of B cell survival cytokines.
Kowalczyk-Quintas C., Willen D., Willen L., Golob M., Schuepbach-Mallepell S., Peter B., Eslami M., Vigolo M., Broly H., Samy E. et al., 2019/10. British journal of pharmacology, 176 (20) pp. 4019-4033. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_72714CC62B0C]
2018
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Vigolo M., Chambers M.G., Willen L., Chevalley D., Maskos K., Lammens A., Tardivel A., Das D., Kowalczyk-Quintas C., Schuepbach-Mallepell S. et al., 2018/03/23. Nature communications, 9 (1) p. 1199. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_46E3DDBA1F92]
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab.
Kowalczyk-Quintas C., Chevalley D., Willen L., Jandus C., Vigolo M., Schneider P., 2018. Frontiers in immunology, 9 p. 2698. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CF7EAEC93BBA]
2017
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
Smulski C.R., Kury P., Seidel L.M., Staiger H.S., Edinger A.K., Willen L., Seidl M., Hess H., Salzer U., Rolink A.G. et al., 2017/02/28. Cell reports, 18 (9) pp. 2189-2202. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1C83052CD3BC]
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling.
Smulski C.R., Decossas M., Chekkat N., Beyrath J., Willen L., Guichard G., Lorenzetti R., Rizzi M., Eibel H., Schneider P. et al., 2017/02/09. Cell death & disease, 8 (2) pp. e2601. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C6146EC93FF4]
Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia.
Podzus J., Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Staehlin G., Vigolo M., Tardivel A., Headon D., Kirby N., Mikkola M.L. et al., 2017. Journal of Dental Research, 96 (2) pp. 217-224. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4B9972635AE6]
2016
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Vigolo M., Willen L., Tardivel A., Smulski C.R., Zheng T.S., Gommerman J., Hess H., Gottenberg J.E. et al., 2016/09/16. The Journal of biological chemistry, 291 (38) pp. 19826-19834. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_5303DB297B39]
Characterization and application of two RANK-specific antibodies with different biological activities.
Chypre M., Seaman J., Cordeiro O.G., Willen L., Knoop K.A., Buchanan A., Sainson R.C., Williams I.R., Yagita H., Schneider P. et al., 2016. Immunology Letters, 171 pp. 5-14. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EFA8CC9CE127]
2015
Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.
Kowalczyk-Quintas C., Schuepbach-Mallepell S., Willen L., Smith T.K., Huttner K., Kirby N., Headon D.J., Schneider P., 2015. Journal of Investigative Dermatology, 135 (2) pp. 359-368.
[URN][DOI][WoS][Pmid][serval:BIB_5CBFC64D4700]
Stoichiometry of heteromeric BAFF and APRIL cytokines dictates their receptor binding and signaling properties.
Schuepbach-Mallepell S., Das D., Willen L., Vigolo M., Tardivel A., Lebon L., Kowalczyk-Quintas C., Nys J., Smulski C., Zheng T.S. et al., 2015. Journal of Biological Chemistry, 290 (26) pp. 16330-16342. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0DDA43F69087]
2014
Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.
Kowalczyk-Quintas C., Willen L., Dang A.T., Sarrasin H., Tardivel A., Hermes K., Schneider H., Gaide O., Donzé O., Kirby N. et al., 2014. Journal of Biological Chemistry, 289 (7) pp. 4273-4285. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_128AA3C5C25E]
 
Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members.
Schneider P., Willen L., Smulski C.R., 2014. Methods in Enzymology, 545 pp. 103-125.
[DOI][WoS][Pmid][serval:BIB_6B30FEFF2933]
2013
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
Smith W., Tomasec P., Aicheler R., Loewendorf A., Nemčovičová I., Wang E.C., Stanton R.J., Macauley M., Norris P., Willen L. et al., 2013. Cell Host and Microbe, 13 (3) pp. 324-335.
[URN][DOI][WoS][Pmid][serval:BIB_4FC90177222F]
No Evidence That Soluble TACI Induces Signalling via Membrane-Expressed BAFF and APRIL in Myeloid Cells.
Nys J., Smulski C.R., Tardivel A., Willen L., Kowalczyk C., Donzé O., Huard B., Hess H., Schneider P., 2013. PLoS One, 8 (4) pp. e61350.
[URN][DOI][WoS][Pmid][serval:BIB_42710DAB7136]
Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.
Pellegrini M., Willen L., Perroud M., Krushinskie D., Strauch K., Cuervo H., Day E.S., Schneider P., Zheng T.S., 2013. FEBS Journal, 280 (8) pp. 1818-1829.
[URN][DOI][WoS][Pmid][serval:BIB_EF3E28010192]
2011
Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies.
Kowalczyk C., Dunkel N., Willen L., Casal M.L., Mauldin E.A., Gaide O., Tardivel A., Badic G., Etter A.L., Favre M. et al., 2011. Journal of Biological Chemistry, 286 (35) pp. 30769-30779.
[URN][DOI][WoS][Pmid][serval:BIB_9E190030D736]
 
Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.
Bossen C., Tardivel A., Willen L., Fletcher C.A., Perroud M., Beermann F., Rolink A.G., Scott M.L., Mackay F., Schneider P., 2011. European Journal of Immunology, 41 (3) pp. 787-797.
[DOI][WoS][Pmid][serval:BIB_BD399095B9AF]
2010
Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis.
Mues G., Tardivel A., Willen L., Kapadia H., Seaman R., Frazier-Bowers S., Schneider P., D'Souza R.N., 2010. European Journal of Human Genetics, 18 (1) pp. 19-25. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_51AF6267FC85]
2009
Biological activity of ectodysplasin A is conditioned by its collagen and heparan sulfate proteoglycan-binding domains.
Swee L.K., Ingold-Salamin K., Tardivel A., Willen L., Gaide O., Favre M., Demotz S., Mikkola M., Schneider P., 2009/10. Journal of Biological Chemistry, 284 (40) pp. 27567-27576. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B2ADDBE57545]
 
Structure-function analysis of Eiger, the Drosophila TNF homolog.
Narasimamurthy R., Geuking P., Ingold K., Willen L., Schneider P., Basler K., 2009/02. Cell Research, 19 (3) pp. 392-394. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AF972E96F140]
2008
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
Bossen C., Cachero T.G., Tardivel A., Ingold K., Willen L., Dobles M., Scott M.L., Maquelin A., Belnoue E., Siegrist C.A. et al., 2008. Blood, 111 (3) pp. 1004-1012. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_98D032586046]
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