Research directions
Harnessing innate immune training to improve sepsis management
SNF #310030_207418 / 1
SPHN/PHRT National Data Streams. Personalized Swiss Sepsis Study
Personalized Swiss Sepsis Study Molecular biomarker discovery, immunphenoytyping and monitoring of the host response to infection
H2020 ImmunoSep. Personalized immuno-therapy in sepsis: a precision medicine based approach
Programme(s): H2020-EU.3.1.3. - Treating and managing disease.
Topic(s): SC1-BHC-14-2019 - Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases.
HDM-FUN. Host directed medicine in invasive fungal infection
Programme(s): H2020-EU.3.1.3. - Treating and managing disease.
Topic(s): SC1-BHC-14-2019 - Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases.
Maladies Infectieuses
The innate immune system is at the vanguard of host defense mechanisms. Breaking the dogma that immunological memory is a privilege of the adaptive immune system, the innate immune system was recently shown to be skilled of "memory", a phenomenon termed trained immunity. The molecular mechanisms underlying trained immunity include metabolic, epigenetic and functional reprogramming of innate immune cells. Our objective is to define whether trained immunity-based strategies might be used to improve host defenses against infections.
