Hans Acha-Orbea

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172 publications

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2024
 
The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation.
Ehirchiou D., Bernabei I., Pandian V.D., Nasi S., Chobaz V., Castelblanco M., So A., Martinon F., Li X., Acha-Orbea H. et al., 2024/06/11. Arthritis research & therapy, 26 (1) p. 119. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3A78C4905CEE]
2022
 
A Multi-Omics Approach Reveals Features That Permit Robust and Widespread Regulation of IFN-Inducible Antiviral Effectors.
Göczi L., Csumita M., Horváth A., Nagy G., Póliska S., Pigni M., Thelemann C., Dániel B., Mianesaz H., Varga T. et al., 2022/11/15. Journal of immunology, 209 (10) pp. 1930-1941. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3B0568108815]
SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.
Jha A., Ahad A., Mishra G.P., Sen K., Smita S., Minz A.P., Biswas V.K., Tripathy A., Senapati S., Gupta B. et al., 2022. Frontiers in immunology, 13 p. 910705. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F15ADD1BCF3A]
2021
 
Zbtb10 transcription factor is crucial for murine cDC1 activation and cytokine secretion.
Smita S., Ghosh A., Biswas V.K., Ahad A., Podder S., Jha A., Sen K., Acha-Orbea H., Raghav S.K., 2021/05. European journal of immunology, 51 (5) pp. 1126-1142. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_40DDE80854B5]
 
IL10- and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression
Koga Marianna M., Engel Adrien, Pigni Matteo, Lavanchy Christine, Stevanin Mathias, Laversenne Vanessa, Schneider Bernard L., Acha-Orbea Hans, 2021/02/17. Frontiers in Immunology, 12 p. 607315. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_505F034B5FD7]
2020
 
NCoR1 fine‐tunes type‐I IFN response in cDC1 dendritic cells by directly regulating Myd88‐IRF7 axis under TLR9
Ahad Abdul, Smita Shuchi, Mishra Gyan Prakash, Biswas Viplov Kumar, Sen Kaushik, Gupta Bhawna, Garcin Dominique, Acha-Orbea Hans, Raghav Sunil K., 2020/12. European Journal of Immunology, 50 (12) pp. 1959-1975. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CEF35453005F]
 
Novel Autoantibody Signatures in Sera of Patients with Pancreatic Cancer, Chronic Pancreatitis and Autoimmune Pancreatitis: A Protein Microarray Profiling Approach
Ghassem-Zadeh Sahar, Hufnagel Katrin, Bauer Andrea, Frossard Jean-Louis, Yoshida Masaru, Kutsumi Hiromu, Acha-Orbea Hans, Neulinger-Muñoz Matthias, Vey Johannes, Eckert Christoph et al., 2020/03/31. International Journal of Molecular Sciences, 21 (7) p. 2403. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_47438984F688]
2019
Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.
Kusano T., Ehirchiou D., Matsumura T., Chobaz V., Nasi S., Castelblanco M., So A., Lavanchy C., Acha-Orbea H., Nishino T. et al., 2019/10/28. Nature communications, 10 (1) p. 4904. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AB744ACBDD11]
 
NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance.
Ahad A., Stevanin M., Smita S., Mishra G.P., Gupta D., Waszak S., Sarkar U.A., Basak S., Gupta B., Acha-Orbea H. et al., 2019/09/27. iScience, 19 pp. 996-1011. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4F6E83D3A257]
2018
Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.
Dubrot J., Duraes F.V., Harlé G., Schlaeppi A., Brighouse D., Madelon N., Göpfert C., Stokar-Regenscheit N., Acha-Orbea H., Reith W. et al., 2018. Life Science Alliance, 1 (6) pp. e201800164. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_8398D98F5515]
Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line.
Pigni M., Ashok D., Stevanin M., Acha-Orbea H., 2018. Frontiers in immunology, 9 p. 1912. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_55E5B7D249E0]
Importance of EMT Factor ZEB1 in cDC1 "MutuDC Line" Mediated Induction of Th1 Immune Response.
Smita S., Ahad A., Ghosh A., Biswas V.K., Koga M.M., Gupta B., Acha-Orbea H., Raghav S.K., 2018. Frontiers in immunology, 9 p. 2604. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_72C00C1A0AE9]
2017
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Ciarlo E., Heinonen T., Lugrin J., Acha-Orbea H., Le Roy D., Auwerx J., Roger T., 2017/06/20. Scientific reports, 7 (1) p. 3853. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CE9836DB152C]
Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.
Ghassem-Zadeh S., Gaida M.M., Szanyi S., Acha-Orbea H., Frossard J.L., Hinz U., Hackert T., Strobel O., Felix K., 2017/06/02. Journal of translational medicine, 15 (1) p. 126. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0840277CD209]
 
CD11b regulates the Treg/Th17 balance in murine arthritis via IL-6.
Stevanin M., Busso N., Chobaz V., Pigni M., Ghassem-Zadeh S., Zhang L., Acha-Orbea H., Ehirchiou D., 2017/04. European journal of immunology, 47 (4) pp. 637-645. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7CEE79DC44F9]
Interleukin-35-Producing CD8α(+) Dendritic Cells Acquire a Tolerogenic State and Regulate T Cell Function.
Haller S., Duval A., Migliorini R., Stevanin M., Mack V., Acha-Orbea H., 2017. Frontiers in Immunology, 8 p. 98. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E7A621997879]
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.
Ciarlo E., Heinonen T., Théroude C., Herderschee J., Mombelli M., Lugrin J., Pfefferlé M., Tyrrell B., Lensch S., Acha-Orbea H. et al., 2017. Frontiers in immunology, 8 p. 1037. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_82B331441F15]
2016
 
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis.
Thelemann C., Haller S., Blyszczuk P., Kania G., Rosa M., Eriksson U., Rotman S., Reith W., Acha-Orbea H., 2016. European Journal of Immunology, 46 (3) pp. 656-664. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4200DDF12A73]
 
Derivation and Utilization of Functional CD8(+) Dendritic Cell Lines.
Pigni M., Ashok D., Acha-Orbea H., 2016. Methods in Molecular Biology, 1423 pp. 39-49. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8387433520A3]
 
Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.
Margaroli C., Oberle S., Lavanchy C., Scherer S., Rosa M., Strasser A., Pellegrini M., Zehn D., Acha-Orbea H., Ehirchiou D., 2016. European Journal of Immunology, 46 (6) pp. 1427-1437. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BE45D77E6215]
2015
Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.
Grosjean F., Nasi S., Schneider P., Chobaz V., Liu A., Mordasini V., Moullec K., Vezzoni P., Lavanchy C., Busso N. et al., 2015. Plos One, 10 (8) pp. e0133917. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B4230F15A8A5]
 
Maintaining dendritic cell viability in culture.
Vremec D., Hansen J., Strasser A., Acha-Orbea H., Zhan Y., O'Keeffe M., Shortman K., 2015. Molecular Immunology, 63 (2) pp. 264-267.
[DOI][WoS][Pmid][serval:BIB_7380D813A5B2]
 
TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State.
Széles L., Meissner F., Dunand-Sauthier I., Thelemann C., Hersch M., Singovski S., Haller S., Gobet F., Fuertes Marraco S.A., Mann M. et al., 2015. Journal of Immunology, 195 (3) pp. 1025-1033. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D509593DF5F7]
β-Catenin Signaling Drives Differentiation and Proinflammatory Function of IRF8-Dependent Dendritic Cells.
Cohen S.B., Smith N.L., McDougal C., Pepper M., Shah S., Yap G.S., Acha-Orbea H., Jiang A., Clausen B.E., Rudd B.D. et al., 2015. Journal of Immunology, 194 (1) pp. 210-222. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BA9728A16A7E]
2014
 
Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.
von Burg N., Chappaz S., Baerenwaldt A., Horvath E., Bose Dasgupta S., Ashok D., Pieters J., Tacchini-Cottier F., Rolink A., Acha-Orbea H. et al., 2014. Proceedings of the National Academy of Sciences of the United States of America, 111 (35) pp. 12835-12840.
[DOI][WoS][Pmid][serval:BIB_7879BB243E97]
 
Cross-presenting dendritic cells are required for control of Leishmania major infection.
Ashok D., Schuster S., Ronet C., Rosa M., Mack V., Lavanchy C., Marraco S.F., Fasel N., Murphy K.M., Tacchini-Cottier F. et al., 2014. European Journal of Immunology, 44 (5) pp. 1422-1432.
[DOI][WoS][Pmid][serval:BIB_465FF447B9AD]
Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing.
Seguín-Estévez Q., Dunand-Sauthier I., Lemeille S., Iseli C., Ibberson M., Ioannidis V., Schmid C.D., Rousseau P., Barras E., Geinoz A. et al., 2014. Nucleic Acids Research, 42 (15) pp. 9641-9655.
[URN][DOI][WoS][Pmid][serval:BIB_33FC79D5A0AA]
Interferon-γ Induces Expression of MHC Class II on Intestinal Epithelial Cells and Protects Mice from Colitis
Thelemann C., Eren R.O., Coutaz M., Brasseit J., Bouzourene H., Rosa M., Duval A., Lavanchy C., Mack V., Mueller C. et al., 2014. PLoS One, 9 (1) pp. e86844.
[URN][DOI][WoS][Pmid][serval:BIB_AECD2FC843E0]
Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.
Duval A., Fuertes Marraco S.A., Schwitter D., Leuenberger L., Acha-Orbea H., 2014. Frontiers in Immunology, 5 p. 338.
[URN][DOI][WoS][Pmid][serval:BIB_A2C5176008F7]
 
MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive Immunity.
Benasciutti E., Mariani E., Oliva L., Scolari M., Perilli E., Barras E., Milan E., Orfanelli U., Fazzalari N.L., Campana L. et al., 2014. Journal of Bone and Mineral Research, 29 (2) pp. 290-303.
[DOI][WoS][Pmid][serval:BIB_E9CA0B41D9E1]
 
Timing is everything: dendritic cell subsets in murine Leishmania infection.
Ashok D., Acha-Orbea H., 2014. Trends in Parasitology, 30 (10) pp. 499-507.
[DOI][WoS][Pmid][serval:BIB_5CA89D6B9998]
2013
Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization.
Kypriotou M., Rivero D., Haller S., Mariotto A., Huber M., Acha-Orbea H., Werner S., Hohl D., 2013. Frontiers in Immunology, 4 (246) pp. 1-10.
[URN][DOI][WoS][Pmid][serval:BIB_6CCA5A0A9918]
 
Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction.
Duraes F.V., Thelemann C., Sarter K., Acha-Orbea H., Hugues S., Reith W., 2013. Tissue Antigens, 82 (1) pp. 1-15.
[DOI][WoS][Pmid][serval:BIB_B04CB4C440C9]
2012
 
A novel Th cell epitope of Candida albicans mediates protection from fungal infection.
Bär E., Gladiator A., Bastidas S., Roschitzki B., Acha-Orbea H., Oxenius A., LeibundGut-Landmann S., 2012. Journal of Immunology, 188 (11) pp. 5636-5643.
[DOI][WoS][Pmid][serval:BIB_6B17E7D725E8]
Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.
Chevrier S., Genton C., Malissen B., Malissen M., Acha-Orbea H., 2012. Frontiers in Immunology, 3 p. 27.
[URN][DOI][WoS][Pmid][serval:BIB_E31976052164]
 
Impact of Sirtuin 2 knockout on innate immune responses
Ciarlo E., Lugrin J., dos Santos Pinheiro I., Le Roy D., Moulan N., Yamamoto H., Acha-Orbea H., Calandra T., Auwerx J., Roger T., 2012. p. 271 dans European Congress of Immunology, Immunology.
[WoS][serval:BIB_341182C1E1C5]
Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.
Fuertes Marraco S.A., Grosjean F., Duval A., Rosa M., Lavanchy C., Ashok D., Haller S., Otten L.A., Steiner Q.G., Descombes P. et al., 2012. Frontiers in Immunology, 3 p. 331.
[URN][DOI][Pmid][serval:BIB_516E3869FE16]
2011
 
An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells.
Cheng J.M., Chee S.H., Knight D.A., Acha-Orbea H., Hermans I.F., Timmer M.S., Stocker B.L., 2011. Carbohydrate Research, 346 (7) pp. 914-926.
[DOI][WoS][Pmid][serval:BIB_790E1353710F]
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.
Siegert S., Huang H.Y., Yang C.Y., Scarpellino L., Carrie L., Essex S., Nelson P.J., Heikenwalder M., Acha-Orbea H., Buckley C.D. et al., 2011. PLoS One, 6 (11) pp. e27618.
[URN][DOI][WoS][Pmid][serval:BIB_E37A5F5E8F2F]
 
IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.
Xu Y., Schnorrer P., Proietto A., Kowalski G., Febbraio M.A., Acha-Orbea H., Dickins R.A., Villadangos J.A., 2011. Journal of Immunology, 186 (6) pp. 3666-3673.
[DOI][WoS][Pmid][serval:BIB_EABC98F443B5]
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.
Ives A., Ronet C., Prevel F., Ruzzante G., Fuertes-Marraco S., Schutz F., Zangger H., Revaz-Breton M., Lye L.F., Hickerson S.M. et al., 2011. Science, 331 (6018) pp. 775-778.
[URN][DOI][WoS][Pmid][serval:BIB_8FAE2070D6E0]
 
Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function.
Dunand-Sauthier I., Santiago-Raber M.L., Capponi L., Vejnar C.E., Schaad O., Irla M., Seguín-Estévez Q., Descombes P., Zdobnov E.M., Acha-Orbea H. et al., 2011. Blood, 117 (17) pp. 4490-4500.
[DOI][WoS][Pmid][serval:BIB_AE1B6C7577EA]
Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.
Fuertes Marraco S.A., Scott C.L., Bouillet P., Ives A., Masina S., Vremec D., Jansen E.S., O'Reilly L.A., Schneider P., Fasel N. et al., 2011. PLoS One, 6 (6) pp. e20189.
[URN][DOI][WoS][Pmid][serval:BIB_C67177D06725]
2010
 
Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo.
Ramelli G., Fuertes S., Narayan S., Busso N., Acha-Orbea H., So A., 2010. Immunology, 129 (1) pp. 20-27. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4D3938E638B0]
2009
 
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.
Chevrier S., Genton C., Kallies A., Karnowski A., Otten L.A., Malissen B., Malissen M., Botto M., Corcoran L.M., Nutt S.L. et al., 2009. Proceedings of the National Academy of Sciences of the United States of America, 106 (10) pp. 3895-3900. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8477B6FA5A21]
 
Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.
Schmutz S., Bosco N., Chappaz S., Boyman O., Acha-Orbea H., Ceredig R., Rolink A.G., Finke D., 2009. Journal of immunology, 183 (4) pp. 2217-2221. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_33F1CBA3DEF4]
2008
 
In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis
Steiner Q. G., Otten L. A., Hicks M. J., Kaya G., Grosjean F., Saeuberli E., Lavanchy C., Beermann F., McClain K. L., Acha-Orbea H., 2008. Blood, 111 (4) pp. 2073-2082. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_828D2E0CFF98]
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.
Bossen C., Cachero T.G., Tardivel A., Ingold K., Willen L., Dobles M., Scott M.L., Maquelin A., Belnoue E., Siegrist C.A. et al., 2008. Blood, 111 (3) pp. 1004-1012. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_98D032586046]
 
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.
Wang Y., Kissenpfennig A., Mingueneau M., Richelme S., Perrin P., Chevrier S., Genton C., Lucas B., DiSanto J.P., Acha-Orbea H. et al., 2008. Journal of Immunology, 180 (3) pp. 1565-1575.
[WoS][Pmid][serval:BIB_85499E1E7FF4]
2007
 
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.
Meier D., Bornmann C., Chappaz S., Schmutz S., Otten L.A., Ceredig R., Acha-Orbea H., Finke D., 2007. Immunity, 26 (5) pp. 643-654.
[DOI][WoS][Pmid][serval:BIB_EA39B416A11C]
 
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
Link A., Vogt T.K., Favre S., Britschgi M.R., Acha-Orbea H., Hinz B., Cyster J.G., Luther S.A., 2007. Nature Immunology, 8 (11) pp. 1255-1265.
[DOI][WoS][Pmid][serval:BIB_148EBD80D7EE]
 
Immune response to MMTV infection.
Acha-Orbea H., Shakhov A.N., Finke D., 2007. Frontiers in Bioscience, 12 pp. 1594-1609.
[DOI][WoS][Pmid][serval:BIB_B7BA1999A792]
 
Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.
Luther S.A., Serre K., Cunningham A.F., Khan M., Acha-Orbea H., MacLennan I.C., Toellner K.M., 2007. European Journal of Immunology, 37 (6) pp. 1476-1484.
[DOI][WoS][Pmid][serval:BIB_8DC66A49F5C9]
2006
 
LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.
Gumy A., Aseffa A., Rachinel N., Breton M., Otten L., Tacchini-Cottier F., Röcken M., Doyen N., Acha-Orbea H., Locksley R.M. et al., 2006. European Journal of Immunology, 36 (6) pp. 1465-1473. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1F61C1DC2533]
 
Revisiting the specificity of the MHC class II transactivator CIITA in vivo.
Otten L.A., Leibundgut-Landmann S., Huarte J., Kos-Braun I.C., Lavanchy C., Barras E., Borisch B., Steimle V., Acha-Orbea H., Reith W., 2006. European Journal of Immunology, 36 (6) pp. 1548-1558.
[DOI][WoS][Pmid][serval:BIB_0DCB58DD80FC]
 
The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.
Genton C., Wang Y., Izui S., Malissen B., Delsol G., Fournié G.J., Malissen M., Acha-Orbea H., 2006. Journal of Immunology, 177 (4) pp. 2285-2293.
[WoS][Pmid][serval:BIB_CC42429FAA0F]
2005
Identification of proteoglycans as the APRIL-specific binding partners.
Ingold K., Zumsteg A., Tardivel A., Huard B., Steiner Q.G., Cachero T.G., Qiang F., Gorelik L., Kalled S.L., Acha-Orbea H. et al., 2005. Journal of Experimental Medicine, 201 (9) pp. 1375-1383.
[URN][DOI][WoS][Pmid][serval:BIB_2EEA140949C2]
2004
 
Attenuated poxviruses expressing a synthetic HIV protein stimulate HLA-A2-restricted cytotoxic T-cell responses.
Didierlaurent A., Ramirez J.C., Gherardi M., Zimmerli S.C., Graf M., Orbea H.A., Pantaleo G., Wagner R., Esteban M., Kraehenbuhl J.P. et al., 2004. Vaccine, 22 (25-26) pp. 3395-403. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1885A12AD4C6]
 
MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.
LeibundGut-Landmann S., Waldburger J.M., Reis e Sousa C., Acha-Orbea H., Reith W., 2004. Nature Immunology, 5 (9) pp. 899-908.
[DOI][WoS][Pmid][serval:BIB_B11F6E25F688]
 
Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes.
LeibundGut-Landmann S., Waldburger J.M., Krawczyk M., Otten L.A., Suter T., Fontana A., Acha-Orbea H., Reith W., 2004. European Journal of Immunology, 34 (6) pp. 1513-1525.
[DOI][WoS][Pmid][serval:BIB_115D56E8D31D]
2003
 
Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes.
Otten L.A., Tacchini-Cottier F., Lohoff M., Annunziato F., Cosmi L., Scarpellino L., Louis J., Steimle V., Reith W., Acha-Orbea H., 2003. Journal of Immunology, 170 (3) pp. 1150-1157.
[WoS][Pmid][serval:BIB_33B0D6CCD5D0]
 
Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle.
Mpandi M., Otten L.A., Lavanchy C., Acha-Orbea H., Finke D., 2003. Journal of virology, 77 (17) pp. 9369-77. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D29D8D137628]
 
Promoter IV of the class II transactivator gene is essential for positive selection of CD4+ T cells.
Waldburger J.M., Rossi S., Hollander G.A., Rodewald H.R., Reith W., Acha-Orbea H., 2003. Blood, 101 (9) pp. 3550-9. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9E6296400D17]
 
The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development.
Finke D., Luther S.A., Acha-Orbea H., 2003. Proceedings of the National Academy of Sciences of the United States of America, 100 (1) pp. 199-204.
[DOI][WoS][Pmid][serval:BIB_206D0680FE71]
 
Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration.
Ramirez J.C., Finke D., Esteban M., Kraehenbuhl J.P., Acha-Orbea H., 2003. Archives of virology, 148 (5) pp. 827-39. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C6BB160440A3]
2002
 
Can MMTV exploit TLR4?
Otten L.A., Finke D., Acha-Orbea H., 2002. Trends in Microbiology, 10 (7) pp. 303-306.
[DOI][WoS][Pmid][serval:BIB_117EF11310C2]
 
CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5.
Finke D., Acha-Orbea H., Mattis A., Lipp M., Kraehenbuhl J., 2002. Immunity, 17 (3) pp. 363-373.
[DOI][WoS][Pmid][serval:BIB_F466B252CBDD]
 
Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus.
Vacheron S., Luther S.A., Acha-Orbea H., 2002. Journal of Immunology, 168 (7) pp. 3470-3476.
[WoS][Pmid][serval:BIB_E08993B57D6F]
 
Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule.
Wirth S., Vessaz A., Krummenacher C., Baribaud F., Acha-Orbea H., Diggelmann H., 2002. Journal of Virology, 76 (21) pp. 11172-11175. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B68628BAB6DD]
 
Testing mouse mammary tumor virus superantigen as adjuvant in cytotoxic T-lymphocyte responses against a melanoma tumor antigen.
Wirth S., Bille F., Koenig S., Wehrli N., Miconnet I., Lévy F., Diggelmann H., Romero P., Acha-Orbea H., 2002. International Journal of Cancer, 99 (2) pp. 201-206. Peer-reviewed.
[DOI][Pmid][serval:BIB_9824F465087C]
 
Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.
Cunningham A.F., Fallon P.G., Khan M., Vacheron S., Acha-Orbea H., MacLennan I.C., McKenzie A.N., Toellner K.M., 2002. Journal of Immunology, 169 (6) pp. 2900-2906.
[WoS][Pmid][serval:BIB_DCEAEA4A6895]
 
The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.
Lens S.M., Kataoka T., Fortner K.A., Tinel A., Ferrero I., MacDonald R.H., Hahne M., Beermann F., Attinger A., Orbea H.A. et al., 2002. Molecular and Cellular Biology, 22 (15) pp. 5419-5433. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AE9D96F3DCE0]
 
Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigen-presenting cells are detected after nasal vaccination of mice with human papillomavirus type 16 virus-like particles.
Balmelli C., Demotz S., Acha-Orbea H., De Grandi P., Nardelli-Haefliger D., 2002. Journal of Virology, 76 (24) pp. 12596-12602. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3C8F1934B1D4]
2001
 
Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes.
Wehrli N., Legler D.F., Finke D., Toellner K.M., Loetscher P., Baggiolini M., MacLennan I.C., Acha-Orbea H., 2001. European Journal of Immunology, 31 (2) pp. 609-616. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_87F6B99531F8]
 
Complement facilitates early prion pathogenesis.
Klein M.A., Kaeser P.S., Schwarz P., Weyd H., Xenarios I., Zinkernagel R.M., Carroll M.C., Verbeek J.S., Botto M., Walport M.J. et al., 2001. Nature Medicine, 7 (4) pp. 488-492. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_18258]
 
Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs.
Finke D., Acha-Orbea H., 2001. European Journal of Immunology, 31 (9) pp. 2603-2611. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_5638C8638347]
 
Extrafollicular plasmablast B cells play a key role in carrying retroviral infection to peripheral organs.
Finke D., Baribaud F., Diggelmann H., Acha-Orbea H., 2001. Journal of Immunology, 166 (10) pp. 6266-6275.
[WoS][Pmid][serval:BIB_C7EC091A82A3]
 
Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice.
Maillard I., Launois P., Himmelrich H., Acha-Orbea H., Diggelmann H., Locksley R.M., Louis J.A., 2001. European Journal of Immunology, 31 (4) pp. 1288-1296.
[WoS][Pmid][serval:BIB_F01F8E2F0506]
 
Identification of key amino acids of the mouse mammary tumor virus superantigen involved in the specific interaction with T-cell receptor V(beta) domains.
Baribaud F., Wirth S., Maillard I., Valsesia S., Acha-Orbea H., Diggelmann H., 2001. Journal of Virology, 75 (16) pp. 7453-7461. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_4D623101234B]
 
Lymphoid environment limits superantigen and antigen-induced T cell proliferation at high precursor frequency.
Attinger A., MacDonald H.R., Acha-Orbea H., 2001. European Journal of Immunology, 31 (3) pp. 884-893. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_39D88E86D7CF]
 
Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered.
Bachmann M.F., Gallimore A., Jones E., Ecabert B., Acha-Orbea H., Kopf M., 2001. European Journal of Immunology, 31 (2) pp. 450-458. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BD9836E284EB]
Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.
Waldburger J.M., Suter T., Fontana A., Acha-Orbea H., Reith W., 2001. Journal of Experimental Medicine, 194 (4) pp. 393-406.
[URN][DOI][WoS][Pmid][serval:BIB_0FBF3F4EB26E]
2000
 
Cutting edge: cell autonomous rather than environmental factors control bacterial superantigen-induced T cell anergy in vivo.
Attinger A., Acha-Orbea H., MacDonald H.R., 2000. Journal of Immunology, 165 (3) pp. 1171-1174. Peer-reviewed.
[WoS][Pmid][serval:BIB_D327F0F0C033]
 
Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo.
Chapuis A.G., Paolo Rizzardi G., D'Agostino C., Attinger A., Knabenhans C., Fleury S., Acha-Orbea H., Pantaleo G., 2000. Nature Medicine, 6 (7) pp. 762-768. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_15103]
 
Pairing of Vbeta6 with certain Valpha2 family members prevents T cell deletion by Mtv-7 superantigen.
Aude-Garcia C., Attinger A., Housset D., MacDonald H.R., Acha-Orbea H., Marche P.N., Jouvin-Marche E., 2000. Molecular Immunology, 37 (16) pp. 1005-1012. Peer-reviewed.
[WoS][Pmid][serval:BIB_A4FA31B60E03]
 
Pseudoprolines: Targeting a cis Conformation in a Mimetic of the gp120 V3 Loop of HIV-1 We are grateful to Dipl.-Biol. Raymond Jacquet for helpful advice. This work was supported by the Swiss National Science Foundation.
Wittelsberger A., Keller M., Scarpellino L., Patiny L., Acha-Orbea H., Mutter M., 2000. Angewandte Chemie, 39 (6) pp. 1111-1115.
[DOI][WoS][Pmid][serval:BIB_395B402DAEA5]
1999
 
B cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection.
Ardavín C., Martín P., Ferrero I., Azcoitia I., Anjuère F., Diggelmann H., Luthi F., Luther S., Acha-Orbea H., 1999. Journal of Immunology, 162 (5) pp. 2538-2545.
[WoS][Pmid][serval:BIB_9A621E0CA32E]
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H. et al., 1999. Journal of Experimental Medicine, 189 (11) pp. 1747-1756.
[URN][DOI][WoS][Pmid][serval:BIB_53CE7E893D3E]
Development of T-B cell collaboration in neonatal mice.
Astori M., Finke D., Karapetian O., Acha-Orbea H., 1999. International Immunology, 11 (3) pp. 445-451.
[URN][DOI][WoS][Pmid][serval:BIB_10516]
 
Interplays between mouse mammary tumor virus and the cellular and humoral immune response.
Acha-Orbea H., Finke D., Attinger A., Schmid S., Wehrli N., Vacheron S., Xenarios I., Scarpellino L., Toellner K.M., MacLennan I.C. et al., 1999. Immunological Reviews, 168 pp. 287-303.
[DOI][WoS][Pmid][serval:BIB_FD0A307D70FA]
 
Preferential binding of mouse mammary tumor virus to B lymphocytes.
Baribaud F., Shaw A.V., Scarpellino L., Diggelmann H., Acha-Orbea H., 1999. Journal of Virology, 73 (9) pp. 7899-7902. Peer-reviewed.
[WoS][Pmid][serval:BIB_9234F23D0C3B]
 
Role of dendritic cells in the immune response induced by mouse mammary tumor virus superantigen.
Baribaud F., Maillard I., Vacheron S., Brocker T., Diggelmann H., Acha-Orbea H., 1999. Journal of Virology, 73 (10) pp. 8403-8410. Peer-reviewed.
[WoS][Pmid][serval:BIB_DAD6C5827009]
 
Systemic antibodies can inhibit mouse mammary tumor virus-driven superantigen response in mucosa-associated lymphoid tissues.
Velin D., Fotopoulos G., Kraehenbuhl J.P., Acha-Orbea H., 1999. Journal of Virology, 73 (2) pp. 1729-1733. Peer-reviewed.
[WoS][Pmid][serval:BIB_9DFB88E54072]
1998
 
Differential reactivity of TCR Vbeta10 alleles to a mouse mammary tumor virus superantigen.
Maillard I., Xenarios I., Diggelmann H., Orbea H.A., 1998. European Journal of Immunology, 28 (10) pp. 3075-3085. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9112C47D0CA4]
 
Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor.
Maillard I., Launois P., Xenarios I., Louis J.A., Acha-Orbea H., Diggelmann H., 1998. Journal of Virology, 72 (4) pp. 2638-2646.
[WoS][Pmid][serval:BIB_2104F6E09517]
 
Preactivation of B lymphocytes does not enhance mouse mammary tumor virus infection.
Finke D., Mortezavi L., Acha-Orbea H., 1998. Journal of Virology, 72 (9) pp. 7688-7691. Peer-reviewed.
[WoS][Pmid][serval:BIB_07B174E96073]
T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.
Toellner K.M., Luther S.A., Sze D.M., Choy R.K., Taylor D.R., MacLennan I.C., Acha-Orbea H., 1998. Journal of Experimental Medicine, 187 (8) pp. 1193-1204.
[URN][DOI][WoS][Pmid][serval:BIB_9ACADD245FD7]
1997
 
A highly sensitive in vitro infection assay to explore early stages of mouse mammary tumor virus infection.
Vacheron S., Renno T., Acha-Orbea H., 1997. Journal of Virology, 71 (10) pp. 7289-7294. Peer-reviewed.
[WoS][Pmid][serval:BIB_D483B952A5E8]
 
B cell response and histology of a retroviral infection in vivo.
Luther S.A., Gulbranson-Judge A., Acha-Orbea H., MacLennan I.C., 1997. Annals of the New York Academy of Sciences, 815 pp. 465-466.
[DOI][WoS][Pmid][serval:BIB_EF7BD6D458D3]
 
Early neutralizing antibody response against mouse mammary tumor virus: critical role of viral infection and superantigen-reactive T cells.
Luther S.A., Maillard I., Luthi F., Scarpellino L., Diggelmann H., Acha-Orbea H., 1997. Journal of Immunology, 159 (6) pp. 2807-2814.
[WoS][Pmid][serval:BIB_661]
 
IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.
Launois P., Maillard I., Pingel S., Swihart K.G., Xénarios I., Acha-Orbea H., Diggelmann H., Locksley R.M., MacDonald H.R., Louis J.A., 1997. Immunity, 6 (5) pp. 541-549. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3599BB2EC5FF]
 
Mouse mammary tumor virus: immunological interplays between virus and host.
Luther S.A., Acha-Orbea H., 1997. Advances in Immunology, 65 pp. 139-243.
[DOI][WoS][Pmid][serval:BIB_3DB9B0185A88]
 
Retrovirus-host interactions. The mouse mammary tumor virus model.
Acha-Orbea H., 1997. Medicina, 57 (Suppl 2) pp. 43-52.
[WoS][Pmid][serval:BIB_38CB33FA42B7]
 
Retrovirus-induced target cell activation in the early phases of infection: the mouse mammary tumor virus model.
Ardavin C., Luthi F., Andersson M., Scarpellino L., Martin P., Diggelmann H., Acha-Orbea H., 1997. Journal of Virology, 71 (10) pp. 7295-7299. Peer-reviewed.
[WoS][Pmid][serval:BIB_763467E00E63]
 
Role of the immune response induced by superantigens in the pathogenesis of microbial infections.
Maillard I., Luthi F., Acha-Orbea H., Diggelmann H., 1997. Parasitology, 115 Suppl pp. S67-78. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_7344]
 
The changing preference of T and B cells for partners as T-dependent antibody responses develop.
MacLennan I.C., Gulbranson-Judge A., Toellner K.M., Casamayor-Palleja M., Chan E., Sze D.M., Luther S.A., Orbea H.A., 1997. Immunological reviews, 156 pp. 53-66. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_280735E24952]
 
The role of superantigens in resistance to retroviral infection.
Acha-Orbea H., 1997. Trends in Microbiology, 5 (10) p. 385.
[DOI][WoS][Pmid][serval:BIB_94703048C331]
Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production.
Luther S.A., Gulbranson-Judge A., Acha-Orbea H., MacLennan I.C., 1997. Journal of Experimental Medicine, 185 (3) pp. 551-562.
[URN][DOI][WoS][Pmid][serval:BIB_71199D68E879]
1996
 
Superantigens of mouse mammary tumour virus: implications for diabetes?
Acha-Orbea H., 1996/07. Diabetes/metabolism reviews, 12 (2) pp. 111-119. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_69294FACBDCD]
 
Mouse mammary-tumor virus: the basics of an oncogenic retrovirus. Steiner Young Investigator Award Lecture 1995.
Acha-Orbea H., 1996/05/03. International journal of cancer, 66 (3) pp. 285-286. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_691C8BCEB2C4]
 
A V beta 4-specific superantigen encoded by a new exogenous mouse mammary tumor virus.
Maillard I., Erny K., Acha-Orbea H., Diggelmann H., 1996. European Journal of Immunology, 26 (5) pp. 1000-1006. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AC629BB011BD]
 
CD28/CTLA4-B7 interaction is dispensable for T cell stimulation by mouse mammary tumor virus superantigen but not for B cell differentiation and virus dissemination.
Champagne E., Scarpellino L., Lane P., Acha-Orbea H., 1996. European Journal of Immunology, 26 (7) pp. 1595-1602.
[DOI][WoS][Pmid][serval:BIB_0BA06B1850C3]
Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.
Braun M.Y., Lowin B., French L., Acha-Orbea H., Tschopp J., 1996. Journal of Experimental Medicine, 183 (2) pp. 657-661.
[URN][DOI][WoS][Pmid][serval:BIB_4E59D0A02228]
 
Expression and presentation of endogenous mouse mammary tumor virus superantigens by thymic and splenic dendritic cells and B cells.
Ardavín C., Waanders G., Ferrero I., Anjuère F., Acha-Orbea H., MacDonald H.R., 1996. Journal of Immunology, 157 (7) pp. 2789-2794. Peer-reviewed.
[WoS][Pmid][serval:BIB_831E578CB80D]
 
Immune response to mouse mammary tumour virus.
Luther S.A., Acha-Orbea H., 1996. Current Opinion in Immunology, 8 (4) pp. 498-502.
[DOI][WoS][Pmid][serval:BIB_7F5941084418]
 
In vivo effects of a recombinant vaccinia virus expressing a mouse mammary tumor virus superantigen.
Krummenacher C., Diggelmann H., Acha-Orbea H., 1996. Journal of Virology, 70 (5) pp. 3026-3031. Peer-reviewed.
[WoS][Pmid][serval:BIB_BC98CF36534A]
 
Superantigens in autoimmune diseases: still more shades of gray.
Renno T., Acha-Orbea H., 1996. Immunological Reviews, 154 pp. 175-191.
[DOI][WoS][Pmid][serval:BIB_E9AEACBA2294]
 
The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus.
Velin D., Acha-Orbea H., Kraehenbuhl J.P., 1996. Journal of Virology, 70 (10) pp. 7250-7254.
[WoS][Pmid][serval:BIB_5262BFD48C80]
1995
 
Superantigens of mouse mammary tumor virus.
Acha-Orbea H., MacDonald H.R., 1995. Annual Review of Immunology, 13 pp. 459-486. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_66F9FCE67FB1]
 
T cell receptor V beta repertoire in mice lacking endogenous mouse mammary tumor provirus.
Braun M.Y., Jouvin-Marche E., Marche P.N., MacDonald H.R., Acha-Orbea H., 1995. European Journal of Immunology, 25 (3) pp. 857-862. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D8CF4D428E62]
1994
 
Complete Nucleotide Sequence of Mouse Mammary Tumor Virus from JYG Chinese Wild Mice: Absence of Bacterial Insertion Sequences in the Cloned Viral gag Gene.
Nishio M., Xu L., Sasaki M., Haga S., Okumoto M., Mori N., Sarkar N.H., Acha-Orbea H., Enami J., Imai S., 1994. Breast Cancer, 1 (2) pp. 89-94.
[Pmid][serval:BIB_7F46A6DABB14]
 
Diabetes. Superantigen as suspect.
MacDonald H.R., Acha-Orbea H., 1994. Nature, 371 (6495) pp. 283-284.
[DOI][WoS][Pmid][serval:BIB_EFEB095AA4B9]
 
MHC class II hierarchy of superantigen presentation predicts efficiency of infection with mouse mammary tumor virus.
Held W., Waanders G.A., MacDonald H.R., Acha-Orbea H., 1994. International Immunology, 6 (9) pp. 1403-1407. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C9C8FBD9AFE2]
 
Mouse mammary tumor virus superantigens and murine autoimmune gastritis.
Claeys D., Karapetian O., Saraga E., Schreyer M., Louis J., Acha-Orbea H., Blum A.L., Kraehenbuhl J.P., 1994. Gastroenterology, 107 (4) pp. 924-933.
[WoS][Pmid][serval:BIB_AE5D749B4C65]
 
New infectious mammary tumor virus superantigen with V beta-specificity identical to staphylococcal enterotoxin B (SEB).
Luther S., Shakhov A.N., Xenarios I., Haga S., Imai S., Acha-Orbea H., 1994. European Journal of Immunology, 24 (8) pp. 1757-1764.
[DOI][WoS][Pmid][serval:BIB_A37111576A06]
Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.
Karapetian O., Shakhov A.N., Kraehenbuhl J.P., Acha-Orbea H., 1994. Journal of Experimental Medicine, 180 (4) pp. 1511-1516.
[URN][DOI][WoS][Pmid][serval:BIB_F28AFC10CD1E]
Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: implications for superantigen function.
Held W., Waanders G.A., Acha-Orbea H., MacDonald H.R., 1994. Journal of Experimental Medicine, 180 (6) pp. 2347-2351. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_624FE703C8B8]
 
Superantigens and retroviral infection: insights from mouse mammary tumor virus.
Held W., Acha-Orbea H., MacDonald H.R., Waanders G.A., 1994. Immunology Today, 15 (4) pp. 184-190. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B54116E7972E]
 
The primary in vivo immune response to Mls-1 (Mtv-7 sag). Route of injection determines the immune response pattern.
Andersson M., Acha-Orbea H., 1994. Immunology, 83 (3) pp. 438-443.
[WoS][Pmid][serval:BIB_D7CDD3D29A7D]
1993
 
A comparative study of T-cell receptor V beta usage in non-obese diabetic (NOD) and I-E transgenic NOD mice.
Parish N.M., Acha-Orbea H., Simpson E., Qin S.X., Lund T., Cooke A., 1993. Immunology, 78 (4) pp. 606-610.
[WoS][Pmid][serval:BIB_65710A8ADC89]
 
A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules.
Shakhov A.N., Wang H., Acha-Orbea H., Pauley R.J., Wei W.Z., 1993. European Journal of Immunology, 23 (11) pp. 2765-2769.
[DOI][WoS][Pmid][serval:BIB_8699CF82D6E0]
 
Anti-T-cell receptor V beta antibodies in autoimmunity.
Acha-Orbea H., 1993. Immunology Series, 59 pp. 193-202.
[Pmid][serval:BIB_D875CB4E00B1]
 
Bacterial and viral superantigens: roles in autoimmunity?
Acha-Orbea H., 1993. Annals of the Rheumatic Diseases, 52 Suppl 1 pp. S6-16.
[DOI][WoS][Pmid][serval:BIB_841DB1912D43]
 
Exogenous and endogenous mouse mammary tumor virus superantigens.
Acha-Orbea H., Held W., Waanders G.A., Shakhov A.N., Scarpellino L., Lees R.K., MacDonald H.R., 1993. Immunological Reviews, 131 (1) pp. 5-25.
[DOI][WoS][Pmid][serval:BIB_8C4921C5AC29]
Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus.
Waanders G.A., Shakhov A.N., Held W., Karapetian O., Acha-Orbea H., MacDonald H.R., 1993. Journal of Experimental Medicine, 177 (5) pp. 1359-1366. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B02AB919714B]
 
Roles of superantigens in microbial infections?
Acha-Orbea H., 1993. Research in Immunology, 144 (3) pp. 198-201; discussion 214-22.
[DOI][WoS][Pmid][serval:BIB_CAD8C9943F0D]
 
Subversion of host immune responses by viral superantigens.
Acha-Orbea H., MacDonald H.R., 1993. Trends in Microbiology, 1 (1) pp. 32-34.
[DOI][Pmid][serval:BIB_828AE3493C01]
 
Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission.
Held W., Waanders G.A., Shakhov A.N., Scarpellino L., Acha-Orbea H., MacDonald H.R., 1993. Cell, 74 (3) pp. 529-540. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_958C4C50E223]
Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus.
Held W., Shakhov A.N., Izui S., Waanders G.A., Scarpellino L., MacDonald H.R., Acha-Orbea H., 1993. Journal of Experimental Medicine, 177 (2) pp. 359-366. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_80C31902CC51]
 
Superantigens and their role in immune-mediated disease.
Hauser C., Orbea H.A., 1993. Journal of Investigative Dermatology, 101 (4) pp. 503-505.
[DOI][WoS][Pmid][serval:BIB_6903D2B0471E]
 
T-cell receptors in autoimmune disease.
Acha-Orbea H., 1993. Immunology Series, 59 pp. 131-142.
[Pmid][serval:BIB_B84016A30D69]
 
The 3' half of the mouse mammary tumor virus orf gene is not sufficient for its superantigen function in transgenic mice.
Lambert J.F., Acha-Orbea H., Kolb E., Diggelmann H., 1993. Molecular Immunology, 30 (16) pp. 1399-1404.
[DOI][WoS][Pmid][serval:BIB_DEFEF5960D96]
1992
An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7).
Held W., Shakhov A.N., Waanders G., Scarpellino L., Luethy R., Kraehenbuhl J.P., MacDonald H.R., Acha-Orbea H., 1992. Journal of Experimental Medicine, 175 (6) pp. 1623-1633.
[URN][DOI][WoS][Pmid][serval:BIB_34B1C10DA8A9]
 
Infectious minor lymphocyte stimulating (Mls) antigens.
Acha-Orbea H., Waanders G.A., Shakhov A.N., Held W., 1992. Seminars in Immunology, 4 (5) pp. 297-303.
[Pmid][serval:BIB_2A28C43D697E]
Inhibition of mouse mammary tumor virus-induced T cell responses in vivo by antibodies to an open reading frame protein.
Acha-Orbea H., Scarpellino L., Shakhov A.N., Held W., MacDonald H.R., 1992. Journal of Experimental Medicine, 176 (6) pp. 1769-1772.
[URN][DOI][WoS][Pmid][serval:BIB_35F3DCDA65DB]
 
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Koh D.R., Fung-Leung W.P., Ho A., Gray D., Acha-Orbea H., Mak T.W., 1992. Science, 256 (5060) pp. 1210-1213.
[DOI][WoS][Pmid][serval:BIB_3447826E6356]
 
Mls: a link between immunology and retrovirology.
Acha-Orbea H., Held W., Scarpellino L., Shakhov A.N., 1992. International Reviews of Immunology, 8 (4) pp. 327-336.
[Pmid][serval:BIB_52CCC12C0007]
 
Retroviral superantigens.
Acha-Orbea H., 1992. Chemical Immunology, 55 pp. 65-86.
[WoS][Pmid][serval:BIB_6D020D1AF8BD]
1991
 
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
Acha-Orbea H., Shakhov A.N., Scarpellino L., Kolb E., Müller V., Vessaz-Shaw A., Fuchs R., Blöchlinger K., Rollini P., Billotte J. et al., 1991. Nature, 350 (6315) pp. 207-211.
[DOI][WoS][Pmid][serval:BIB_8A25A981E53A]
 
Limited heterogeneity of autoantigens and T cells in autoimmune diseases?
Acha-Orbea H., 1991. Research in Immunology, 142 (5-6) pp. 487-490.
[DOI][WoS][Pmid][serval:BIB_94DEBA6EC840]
 
Mls--a retrovirus exploits the immune system.
Acha-Orbea H., Palmer E., 1991. Immunology Today, 12 (10) pp. 356-361.
[DOI][WoS][Pmid][serval:BIB_20A41FD42C31]
 
Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes.
Acha-Orbea H., Scarpellino L., 1991. Immunogenetics, 34 (1) pp. 57-59.
[DOI][WoS][Pmid][serval:BIB_5CB06B871A71]
1990
A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.
Jongeneel C.V., Acha-Orbea H., Blankenstein T., 1990. Journal of Experimental Medicine, 171 (6) pp. 2141-2146.
[URN][DOI][WoS][Pmid][serval:BIB_C5C84B9FE984]
 
Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.
Acha-Orbea H., Scarpellino L., Hertig S., Dupuis M., Tschopp J., 1990. EMBO Journal, 9 (12) pp. 3815-3819.
[WoS][Pmid][serval:BIB_80CCB8A48F89]
 
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.
Jacob C.O., Aiso S., Michie S.A., McDevitt H.O., Acha-Orbea H., 1990. Proceedings of the National Academy of Sciences of the United States of America, 87 (3) pp. 968-972.
[DOI][WoS][Pmid][serval:BIB_E7E1A402725C]
 
The role of class II molecules in development of insulin-dependent diabetes mellitus in mice, rats and humans.
Acha-Orbea H., McDevitt H.O., 1990. Current Topics in Microbiology and Immunology, 156 pp. 103-119.
[WoS][Pmid][serval:BIB_2517EA29CDF3]
1989
 
T cell receptors in autoimmune disease as targets for immune intervention.
Acha-Orbea H., Steinman L., McDevitt H.O., 1989. Genome / National Research Council Canada = Génome / Conseil National de Recherches Canada, 31 (2) pp. 656-661.
[WoS][Pmid][serval:BIB_51C624A7DFF9]
 
T cell receptors in murine autoimmune diseases.
Acha-Orbea H., Steinman L., McDevitt H.O., 1989. Annual Review of Immunology, 7 pp. 371-405.
[DOI][WoS][Pmid][serval:BIB_F4D34CAAF065]
 
T cell recognition as the target for immune intervention in autoimmune disease.
Wraith D.C., McDevitt H.O., Steinman L., Acha-Orbea H., 1989. Cell, 57 (5) pp. 709-715.
[WoS][Pmid][serval:BIB_E81DE9C68A49]
 
The V-region disease hypothesis: evidence from autoimmune encephalomyelitis.
Heber-Katz E., Acha-Orbea H., 1989. Immunology Today, 10 (5) pp. 164-169.
[DOI][WoS][Pmid][serval:BIB_7C8A99E7116B]
1988
 
Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.
Payne J., Huber B.T., Cannon N.A., Schneider R., Schilham M.W., Acha-Orbea H., MacDonald H.R., Hengartner H., 1988/10. Proceedings of the National Academy of Sciences of the United States of America, 85 (20) pp. 7695-7698.
[DOI][WoS][Pmid][serval:BIB_1AD6DEC16E67]
 
A molecular basis for MHC class II--associated autoimmunity.
Todd J.A., Acha-Orbea H., Bell J.I., Chao N., Fronek Z., Jacob C.O., McDermott M., Sinha A.A., Timmerman L., Steinman L. et al., 1988. Science, 240 (4855) pp. 1003-1009.
[DOI][WoS][Pmid][serval:BIB_D3698A9BB0E2]
 
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.
Acha-Orbea H., Mitchell D.J., Timmermann L., Wraith D.C., Tausch G.S., Waldor M.K., Zamvil S.S., McDevitt H.O., Steinman L., 1988. Cell, 54 (2) pp. 263-273.
[DOI][WoS][Pmid][serval:BIB_23794C1BD804]
 
Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.
Zamvil S.S., Mitchell D.J., Lee N.E., Moore A.C., Waldor M.K., Sakai K., Rothbard J.B., McDevitt H.O., Steinman L., Acha-Orbea H., 1988. Journal of Experimental Medicine, 167 (5) pp. 1586-1596.
[DOI][WoS][Pmid][serval:BIB_7ABE5914E496]
 
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
MacDonald H.R., Schneider R., Lees R.K., Howe R.C., Acha-Orbea H., Festenstein H., Zinkernagel R.M., Hengartner H., 1988. Nature, 332 (6159) pp. 40-45.
[DOI][WoS][Pmid][serval:BIB_004A420E788B]
1987
 
Fine specificity and T-cell receptor beta-chain gene rearrangements of five H-2Db-specific cytotoxic T-cell clones.
Schilham M.W., Lang R., Acha-Orbea H., Benner R., Joho R., Hengartner H., 1987. Immunogenetics, 25 (3) pp. 171-178.
[DOI][WoS][Pmid][serval:BIB_DD63F219842D]
 
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
Acha-Orbea H., McDevitt H.O., 1987. Proceedings of the National Academy of Sciences of the United States of America, 84 (8) pp. 2435-2439.
[DOI][WoS][Pmid][serval:BIB_A5C17F353B9E]
1985
 
Cytolytic T-cell granules: biochemical properties and functional specificity.
Podack E.R., Konigsberg P.J., Acha-Orbea H., Pircher H., Hengartner H., 1985. Advances in Experimental Medicine and Biology, 184 pp. 99-119.
[WoS][Pmid][serval:BIB_246AECD012BD]
 
Cytotoxic T cell clone-specific monoclonal antibodies used to select clonotypic antigen-specific cytotoxic T cells.
Acha-Orbea H., Zinkernagel R.M., Hengartner H., 1985. European Journal of Immunology, 15 (1) pp. 31-36.
[DOI][WoS][Pmid][serval:BIB_309CE1853B96]
 
Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.
Rupp F., Acha-Orbea H., Hengartner H., Zinkernagel R., Joho R., 1985. Nature, 315 (6018) pp. 425-427.
[DOI][WoS][Pmid][serval:BIB_E5B1BDF35B28]
1983
 
Characterization of cloned cytotoxic lymphocytes with NK-like activity.
Acha-Orbea H., Groscurth P., Lang R., Stitz L., Hengartner H., 1983. Journal of Immunology, 130 (6) pp. 2952-2959.
[WoS][Pmid][serval:BIB_C7CA509A2DED]
1980
 
Phosphorylation and dephosphorylation of spectrin from human erythrocyte ghosts under physiological conditions: autocatalysis rather than reaction with separate kinase and phosphatase.
Imhof B.A., Acha-Orbea H.J., Libermann T.A., Reber B.F., Lanz J.H., Winterhalter K.H., Birchmeier W., 1980. Proceedings of the National Academy of Sciences of the United States of America, 77 (6) pp. 3264-3268.
[DOI][WoS][Pmid][serval:BIB_8EB41967B909]
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