Daniel Kaufmann

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163 publications

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000 | 1999 | 1998 |
2024
 
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies.
Richard J., Sannier G., Zhu L., Prévost J., Marchitto L., Benlarbi M., Beaudoin-Bussières G., Kim H., Sun Y., Chatterjee D. et al., 2024/11/13. mBio, 15 (11) pp. e0182724. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8B81A83C3D19]
 
Artificial antigen-presenting cell system reveals CD28's role in modulating T cell functions during human immunodeficiency virus infection.
Kabakibo T.S., Arnold E., Padhan K., Lemieux A., Ortega-Delgado G.G., Routy J.P., Shoukry N., Dubé M., Kaufmann D.E., 2024/10/18. iScience, 27 (10) p. 110947. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_310A31AAAF6B]
 
Using virtual patient cohorts to uncover immune response differences in cancer and immunosuppressed COVID-19 patients
Gazeau Sonia, Deng Xiaoyan, Brunet-Ratnasingham Elsa, Kaufmann Daniel E., Larochelle Catherine, Morel Penelope A., Heffernan Jane M., Davis Courtney L., Smith Amber M., Jenner Adrianne L. et al., 2024/08/02..
[DOI][Pmid][serval:BIB_71A2D641C052]
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Brunet-Ratnasingham E., Morin S., Randolph H.E., Labrecque M., Bélair J., Lima-Barbosa R., Pagliuzza A., Marchitto L., Hultström M., Niessl J. et al., 2024/05/16. Nature communications, 15 (1) p. 4177. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B53A83071D51]
 
Editorial introduction
Debyser Zeger, Perreau Matthieu, Kaufmann Daniel, 2024/05. Current Opinion in HIV and AIDS, 19 (3) pp. v-vi.
[DOI][WoS][Pmid][serval:BIB_99A4353F3026]
 
La révolution des médicaments à action prolongée.
Kaufmann D., Kaiser L., 2024/04/10. Revue medicale suisse, 20 (869) pp. 731-732. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_DDE70980D508]
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.
Benlarbi M., Richard J., Bourassa C., Tolbert W.D., Chartrand-Lefebvre C., Gendron-Lepage G., Sylla M., El-Far M., Messier-Peet M., Guertin C. et al., 2024/03/14. The Journal of infectious diseases, 229 (3) pp. 763-774. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1562E22CAF46]
Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.
Fournelle D., Mostefai F., Brunet-Ratnasingham E., Poujol R., Grenier J.C., Gálvez J.H., Pagliuzza A., Levade I., Moreira S., Benlarbi M. et al., 2024/02/23. Viruses, 16 (3). Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F51EF3385B1B]
Enhanced detection of antigen-specific T cells by a multiplexed AIM assay.
Lemieux A., Sannier G., Nicolas A., Nayrac M., Delgado G.G., Cloutier R., Brassard N., Laporte M., Duchesne M., Sreng Flores A.M. et al., 2024/01/22. Cell reports methods, 4 (1) p. 100690. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C139321FCEE8]
2023
Humoral Responses Elicited after a Fifth Dose of SARS-CoV-2 mRNA Bivalent Vaccine.
Tauzin A., Beaudoin-Bussières G., Benlarbi M., Nayrac M., Bo Y., Gendron-Lepage G., Medjahed H., Perreault J., Gokool L., Arlotto P. et al., 2023/09/15. Viruses, 15 (9) p. 1926. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C892A237D914]
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells.
Dubé M., Tastet O., Dufour C., Sannier G., Brassard N., Delgado G.G., Pagliuzza A., Richard C., Nayrac M., Routy J.P. et al., 2023/09/13. Cell host & microbe, 31 (9) pp. 1507-1522.e5. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AFE4FC5A5F3C]
A second update on mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative, Kanai M., 2023/09. Nature, 621 (7977) pp. E7-E26. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C6E7B9F9EADA]
Circulating proteins to predict COVID-19 severity.
Su C.Y., Zhou S., Gonzalez-Kozlova E., Butler-Laporte G., Brunet-Ratnasingham E., Nakanishi T., Jeon W., Morrison D.R., Laurent L., Afilalo J. et al., 2023/04/17. Scientific reports, 13 (1) p. 6236. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CABA50A49D9F]
Le retour d’une vieille compagne
Kaiser L., Kaufmann D., 2023/04/12. Revue medicale suisse, 19 (822) pp. 699-700. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_52782FC4D2C3]
A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4<sup>+</sup> T cell profile.
Sannier G., Nicolas A., Dubé M., Marchitto L., Nayrac M., Tastet O., Chatterjee D., Tauzin A., Lima-Barbosa R., Laporte M. et al., 2023/03/21. Cell reports. Medicine, 4 (3) p. 100955. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B9943D70F95B]
 
On-demand, hospital-based, severe acute respiratory coronavirus virus 2 (SARS-CoV-2) genomic epidemiology to support nosocomial outbreak investigations: A prospective molecular epidemiology study.
Benoit P, Jolicoeur G, Point F, Soucy C, Normand K, Morency-Potvin P, Gagnon S, Kaufmann DE, Tremblay C, Coutlée F et al., 2023/03. Antimicrobial stewardship & healthcare epidemiology : ASHE.
[DOI][Pmid][serval:BIB_3FF82B050096]
 
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.
Richard J, Prévost J, Bourassa C, Brassard N, Boutin M, Benlarbi M, Goyette G, Medjahed H, Gendron-Lepage G, Gaudette F et al., 2023/03. Cell chemical biology.
[DOI][Pmid][serval:BIB_76AF28FB3A2F]
Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine.
Tauzin A., Nicolas A., Ding S., Benlarbi M., Medjahed H., Chatterjee D., Dionne K., Gong S.Y., Gendron-Lepage G., Bo Y. et al., 2023/01/31. Cell reports, 42 (1) p. 111998. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FDEE91F35350]
Humoral Responses against BQ.1.1 Elicited after Breakthrough Infection and SARS-CoV-2 mRNA Vaccination.
Tauzin A., Benlarbi M., Medjahed H., Grégoire Y., Perreault J., Gendron-Lepage G., Gokool L., Morrisseau C., Arlotto P., Tremblay C. et al., 2023/01/21. Vaccines, 11 (2) p. 242. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8EA88413CEE6]
An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells.
Nicolas A., Sannier G., Dubé M., Nayrac M., Tauzin A., Painter M.M., Goel R.R., Laporte M., Gendron-Lepage G., Medjahed H. et al., 2023/01/20. iScience, 26 (1) p. 105904. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B8AD085B16C1]
Plasma SARS-CoV-2 RNA elimination and RAGE kinetics distinguish COVID-19 severity.
Deng X., Gantner P., Forestell J., Pagliuzza A., Brunet-Ratnasingham E., Durand M., Kaufmann D.E., Chomont N., Craig M., 2023. Clinical & translational immunology, 12 (11) pp. e1468. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BFFFAA39AF38]
 
Predicting severity in COVID-19 disease using sepsis blood gene expression signatures.
Baghela A, An A, Zhang P, Acton E, Gauthier J, Brunet-Ratnasingham E, Blimkie T, Freue GC, Kaufmann D, Lee AHY et al., 2023/01. Scientific reports.
[DOI][Pmid][serval:BIB_0E3CB9B147FF]
2022
 
Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-Cells in the Context of HIV-1 Infection
Kim Doyon-Laliberté, Matheus Aranguren, Michelle Byrns, Josiane Chagnon-Choquet, Matteo Paniconi, Jean-Pierre Routy, Cécile Tremblay, Marie-Claude Quintal, Nathalie Brassard, Daniel Elias Kaufmann et al., 2022/12. International Journal of Molecular Sciences.
[DOI][serval:BIB_C0551FA36354]
 
Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.
Butler-Laporte G, Gonzalez-Kozlova E, Su CY, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L, Aflalo J, Aflalo M et al., 2022/11. Clinical proteomics.
[DOI][Pmid][serval:BIB_E520103E40B8]
 
A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two doses.
Tauzin A, Gong SY, Chatterjee D, Ding S, Painter MM, Goel RR, Beaudoin-Bussières G, Marchitto L, Boutin M, Laumaea A et al., 2022/10. Cell reports.
[DOI][Pmid][serval:BIB_338AE2691A7C]
 
Genome-wide association studies of COVID-19: Connecting the dots.
Ferreira LC, Gomes CEM, Rodrigues-Neto JF, Jeronimo SMB, 2022/10. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
[DOI][Pmid][serval:BIB_7CCB27B3567B]
 
Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function.
Brunet-Ratnasingham E, Morou A, Dubé M, Niessl J, Baxter AE, Tastet O, Brassard N, Ortega-Delgado G, Charlebois R, Freeman GJ et al., 2022/09. EBioMedicine.
[DOI][Pmid][serval:BIB_79D15E9CC965]
 
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.
Butler-Laporte G, Gonzalez-Kozlova E, Su CY, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L, Afilalo J, Afilalo M et al., 2022/09. Clinical proteomics.
[DOI][Pmid][serval:BIB_EAE845542422]
 
Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients.
Tauzin A, Beaudoin-Bussières G, Gong SY, Chatterjee D, Gendron-Lepage G, Bourassa C, Goyette G, Racine N, Khrifi Z, Turgeon J et al., 2022/08. iScience.
[DOI][Pmid][serval:BIB_378CB032A0B5]
 
Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis Patients.
Valentini N, Marchitto L, Raymond M, Goyette G, Goyette G, Kaufmann DE, Finzi A, Suri RS, Lamarche C, 2022/08. Kidney360.
[DOI][Pmid][serval:BIB_6B3D8778DD36]
 
Detecting Sources of Immune Activation and Viral Rebound in HIV Infection.
Wietgrefe SW, Duan L, Anderson J, Marqués G, Sanders M, Cummins NW, Badley AD, Dobrowolski C, Karn J, Pagliuzza A et al., 2022/07. Journal of virology.
[DOI][Pmid][serval:BIB_A725FF5AA40B]
 
Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen.
Nayrac M, Dubé M, Sannier G, Nicolas A, Marchitto L, Tastet O, Tauzin A, Brassard N, Lima-Barbosa R, Beaudoin-Bussières G et al., 2022/06. Cell reports.
[DOI][Pmid][serval:BIB_4B4DCB0DEB8A]
 
Covid-19 vaccine immunogenicity in people living with HIV-1.
Nault L, Marchitto L, Goyette G, Tremblay-Sher D, Fortin C, Martel-Laferrière V, Trottier B, Richard J, Durand M, Kaufmann D et al., 2022/05. Vaccine.
[DOI][Pmid][serval:BIB_79EF6F742B7F]
 
Evolution of Anti-RBD IgG Avidity following SARS-CoV-2 Infection
Alexandra Tauzin, Gabrielle Gendron-Lepage, Manon Nayrac, Sai Priya Anand, Catherine Bourassa, Halima Medjahed, Guillaume Goyette, Mathieu Dubé, Renée Bazin, Daniel Elias Kaufmann et al., 2022/03. Viruses.
[DOI][serval:BIB_EBE74C2BC1B7]
 
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J et al., 2022/03. Nature.
[DOI][Pmid][serval:BIB_D4F0C3CD020F]
 
SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between doses.
Chatterjee D, Tauzin A, Marchitto L, Gong SY, Boutin M, Bourassa C, Beaudoin-Bussières G, Bo Y, Ding S, Laumaea A et al., 2022/02. Cell reports.
[DOI][Pmid][serval:BIB_548438B21610]
 
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.
Bégin P, Callum J, Jamula E, Cook R, Heddle NM, Tinmouth A, Zeller MP, Beaudoin-Bussières G, Amorim L, Bazin R et al., 2022/01. Nature medicine.
[DOI][Pmid][serval:BIB_12BA237A24A0]
 
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19.
Bégin P, Callum J, Cook R, Jamula E, Liu Y, Finzi A, CONCOR-1 Study Group, Arnold DM, 2022/01. Nature medicine.
[DOI][Pmid][serval:BIB_5FAEF68B17F1]
 
Single-Cell Multiparametric Analysis of Rare HIV-Infected Cells Identified by Duplexed RNAflow-FISH
Dubé Mathieu, Kaufmann Daniel E., 2022. pp. 291-313 dans Methods in Molecular Biology chap. 20, Springer US.
[DOI][Pmid][serval:BIB_994EA19B419C]
2021
 
Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses.
Tauzin A, Gong SY, Beaudoin-Bussières G, Vézina D, Gasser R, Nault L, Marchitto L, Benlarbi M, Chatterjee D, Nayrac M et al., 2021/12. Cell host & microbe.
[DOI][Pmid][serval:BIB_EBD8F972F42D]
 
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality.
Brunet-Ratnasingham E, Anand SP, Gantner P, Dyachenko A, Moquin-Beaudry G, Brassard N, Beaudoin-Bussières G, Pagliuzza A, Gasser R, Benlarbi M et al., 2021/11. Science advances.
[DOI][Pmid][serval:BIB_C5A3E1B1D201]
 
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.
Bégin P, Callum J, Jamula E, Cook R, Heddle NM, Tinmouth A, Zeller MP, Beaudoin-Bussières G, Amorim L, Bazin R et al., 2021/09. Nature medicine.
[DOI][Pmid][serval:BIB_E5B202A915C2]
 
Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity.
Sannier G, Dubé M, Dufour C, Richard C, Brassard N, Delgado GG, Pagliuzza A, Baxter AE, Niessl J, Brunet-Ratnasingham E et al., 2021/08. Cell reports.
[DOI][Pmid][serval:BIB_90A0673243D6]
 
Impact of cobas PCR Media freezing on SARS-CoV-2 viral RNA integrity and whole genome sequencing analyses.
Benoit P, Point F, Gagnon S, Kaufmann DE, Tremblay C, Harrigan RP, Hardy I, Coutlée F, Lapierre SG, 2021/08. Diagnostic microbiology and infectious disease.
[DOI][Pmid][serval:BIB_2D0CDF4FCD77]
 
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.
Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S et al., 2021/08. Immunity.
[DOI][Pmid][serval:BIB_B8EB6B1B24E8]
 
Translocated microbiome composition determines immunological outcome in treated HIV infection.
Nganou-Makamdop K, Talla A, Sharma AA, Darko S, Ransier A, Laboune F, Chipman JG, Beilman GJ, Hoskuldsson T, Fourati S et al., 2021/07. Cell.
[DOI][Pmid][serval:BIB_ED266E073A89]
 
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.
Tauzin A, Nayrac M, Benlarbi M, Gong SY, Gasser R, Beaudoin-Bussières G, Brassard N, Laumaea A, Vézina D, Prévost J et al., 2021/06. Cell host & microbe.
[DOI][Pmid][serval:BIB_5472E8A18937]
 
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, Brassard N, Laumaea A, Gong SY, Bourassa C et al., 2021/05. Cell reports. Medicine.
[DOI][Pmid][serval:BIB_2D05A9F59968]
 
Loss of CD96 Expression as a Marker of HIV-Specific CD8<sup>+</sup> T-Cell Differentiation and Dysfunction.
Bunet R, Nayrac M, Ramani H, Sylla M, Durand M, Chartrand-Lefebvre C, Routy JP, Landay AL, Gauchat JF, Chomont N et al., 2021/05. Frontiers in immunology.
[DOI][Pmid][serval:BIB_D40D0140389A]
 
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.
Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H et al., 2021/05. Cell host & microbe.
[DOI][Pmid][serval:BIB_047E6CF6A88E]
 
The Biobanque québécoise de la COVID-19 (BQC19)-A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories.
Tremblay K, Rousseau S, Zawati MH, Auld D, Chassé M, Coderre D, Falcone EL, Gauthier N, Grandvaux N, Gros-Louis F et al., 2021/05. PloS one.
[DOI][Pmid][serval:BIB_B5483DDAE89A]
 
Identification of SARS-CoV-2-specific immune alterations in acutely ill patients.
Rébillard RM, Charabati M, Grasmuck C, Filali-Mouhim A, Tastet O, Brassard N, Daigneault A, Bourbonnière L, Anand SP, Balthazard R et al., 2021/04. The Journal of clinical investigation.
[DOI][Pmid][serval:BIB_F2EC576F0B51]
 
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M, Kerrison N, Zhao K et al., 2021/02. Nature medicine.
[DOI][Pmid][serval:BIB_D4F6D811B9B4]
2020
 
Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals.
Beaudoin-Bussières G, Laumaea A, Anand SP, Prévost J, Gasser R, Goyette G, Medjahed H, Perreault J, Tremblay T, Lewin A et al., 2020/10. mBio.
[DOI][Pmid][serval:BIB_4736735D1DA6]
 
Daily variations of gut microbial translocation markers in ART-treated HIV-infected people.
Ouyang J, Isnard S, Lin J, Fombuena B, Chatterjee D, Wiche Salinas TR, Planas D, Cattin A, Fert A, Moreira Gabriel E et al., 2020/05. AIDS research and therapy.
[DOI][Pmid][serval:BIB_BCB9BEC8F953]
 
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy.
Niessl J, Baxter AE, Morou A, Brunet-Ratnasingham E, Sannier G, Gendron-Lepage G, Richard J, Delgado GG, Brassard N, Turcotte I et al., 2020/04. EBioMedicine.
[DOI][Pmid][serval:BIB_5631B113571D]
 
VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA.
Jia M, Liberatore RA, Guo Y, Chan KW, Pan R, Lu H, Waltari E, Mittler E, Chandran K, Finzi A et al., 2020/04. Cell host & microbe.
[DOI][Pmid][serval:BIB_B6C92D5AC895]
 
HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells.
Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F et al., 2020/03. Journal of virology.
[DOI][Pmid][serval:BIB_4D4AA7D54C2B]
 
Single-Cell Technologies Applied to HIV-1 Research: Reaching Maturity.
Sannier G, Dubé M, Kaufmann DE, 2020/03. Frontiers in microbiology.
[DOI][Pmid][serval:BIB_7197A936164A]
 
Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.
Niessl J, Baxter AE, Mendoza P, Jankovic M, Cohen YZ, Butler AL, Lu CL, Dubé M, Shimeliovich I, Gruell H et al., 2020/02. Nature medicine.
[DOI][Pmid][serval:BIB_FAB8273FB0C1]
2019
 
Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda
H. Rubin Leah, Deanna Saylor, Gertrude Nakigozi, Noeline Nakasujja, Kevin Robertson, Alice Kisakye, James Batte, Richard Mayanja, Aggrey Anok, M. Lofgren Sarah et al., 2019/12. Journal of NeuroVirology.
[DOI][serval:BIB_5DC8480BD77A]
 
Altered differentiation is central to HIV-specific CD4<sup>+</sup> T cell dysfunction in progressive disease.
Morou A, Brunet-Ratnasingham E, Dubé M, Charlebois R, Mercier E, Darko S, Brassard N, Nganou-Makamdop K, Arumugam S, Gendron-Lepage G et al., 2019/07. Nature immunology.
[DOI][Pmid][serval:BIB_F24938FDB26C]
 
Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.
Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D et al., 2019/06. mBio.
[DOI][Pmid][serval:BIB_2165270B9647]
 
Immune Correlates of Disease Progression in Linked HIV-1 Infection.
Tuen M, Bimela JS, Banin AN, Ding S, Harkins GW, Weiss S, Itri V, Durham AR, Porcella SF, Soni S et al., 2019/05. Frontiers in immunology.
[DOI][Pmid][serval:BIB_C627CB2360B5]
 
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.
Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD et al., 2019/04. Cell host & microbe.
[DOI][Pmid][serval:BIB_827F77BE75D7]
 
Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets.
Monette A, Morou A, Al-Banna NA, Rousseau L, Lattouf JB, Rahmati S, Tokar T, Routy JP, Cailhier JF, Kaufmann DE et al., 2019/03. The Journal of clinical investigation.
[DOI][Pmid][serval:BIB_CBFF61B3512C]
 
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N, 2019/02. PLoS pathogens.
[DOI][Pmid][serval:BIB_E68F137DDCFC]
2018
 
Targeting Mitochondria to Revive Dysfunctional Regulatory T Cells.
Brunet-Ratnasingham E, Dubé M, Kaufmann DE, 2018/11. Trends in molecular medicine.
[DOI][Pmid][serval:BIB_A5B65BD35EF6]
 
Harnessing T Follicular Helper Cell Responses for HIV Vaccine Development
Kaufmann Daniel, 2018/06. Viruses.
[DOI][serval:BIB_A54BC4A01525]
 
Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells.
Porichis F, Hart MG, Massa A, Everett HL, Morou A, Richard J, Brassard N, Veillette M, Hassan M, Ly NL et al., 2018/06. Journal of immunology (Baltimore, Md. : 1950).
[DOI][Pmid][serval:BIB_4DF6A38C551F]
 
5' Rapid Amplification of cDNA Ends and Illumina MiSeq Reveals B Cell Receptor Features in Healthy Adults, Adults With Chronic HIV-1 Infection, Cord Blood, and Humanized Mice.
Waltari E, Jia M, Jiang CS, Lu H, Huang J, Fernandez C, Finzi A, Kaufmann DE, Markowitz M, Tsuji M et al., 2018/03. Frontiers in immunology.
[DOI][Pmid][serval:BIB_B2E36376710D]
 
Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses.
Richard J, Prévost J, Baxter AE, von Bredow B, Ding S, Medjahed H, Delgado GG, Brassard N, Stürzel CM, Kirchhoff F et al., 2018/03. mBio.
[DOI][Pmid][serval:BIB_3A59C4EAD63E]
 
Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs.
Baxter AE, O'Doherty U, Kaufmann DE, 2018/02. Retrovirology.
[DOI][Pmid][serval:BIB_7C4F8B1CE98B]
 
Tools for Visualizing HIV in Cure Research.
Niessl J, Baxter AE, Kaufmann DE, 2018/02. Current HIV/AIDS reports.
[DOI][Pmid][serval:BIB_C177F4B842C9]
2017
 
Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals.
Prévost J, Richard J, Ding S, Pacheco B, Charlebois R, Hahn BH, Kaufmann DE, Finzi A, 2017/12. Virology.
[DOI][Pmid][serval:BIB_36097CF92206]
 
Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells.
Reiss S, Baxter AE, Cirelli KM, Dan JM, Morou A, Daigneault A, Brassard N, Silvestri G, Routy JP, Havenar-Daughton C et al., 2017/10. PloS one.
[DOI][Pmid][serval:BIB_E29BE90453B5]
 
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A et al., 2017/09. Nature protocols.
[DOI][Pmid][serval:BIB_5163E03B220A]
 
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.
Baxter AE, Niessl J, Morou A, Kaufmann DE, 2017/09. AIDS research and therapy.
[DOI][Pmid][serval:BIB_75EC82054DE8]
 
The Canadian HIV and aging cohort study - determinants of increased risk of cardio-vascular diseases in HIV-infected individuals: rationale and study protocol.
Durand M, Chartrand-Lefebvre C, Baril JG, Trottier S, Trottier B, Harris M, Walmsley S, Conway B, Wong A, Routy JP et al., 2017/09. BMC infectious diseases.
[DOI][Pmid][serval:BIB_0AB6B55FEFF9]
 
Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Alsahafi N, Richard J, Prévost J, Coutu M, Brassard N, Parsons MS, Kaufmann DE, Brockman M, Finzi A, 2017/07. Journal of virology.
[DOI][Pmid][serval:BIB_38068866B991]
 
BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH et al., 2017/05. Journal of virology.
[DOI][Pmid][serval:BIB_D7C0ED4A63F6]
 
HIV-1 gp120 envelope glycoprotein determinants for cytokine burst in human monocytes.
Levast B, Barblu L, Coutu M, Prévost J, Brassard N, Peres A, Stegen C, Madrenas J, Kaufmann DE, Finzi A, 2017/03. PloS one.
[DOI][Pmid][serval:BIB_0636EDFB32AC]
 
Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses.
Prévost J, Zoubchenok D, Richard J, Veillette M, Pacheco B, Coutu M, Brassard N, Parsons MS, Ruxrungtham K, Bunupuradah T et al., 2017/03. Journal of virology.
[DOI][Pmid][serval:BIB_97FB188F50DF]
 
Circulating CXCR5<sup>+</sup>CXCR3<sup>+</sup>PD-1<sup>lo</sup> Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth.
Martin-Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb KE, Schulze Zur Wiesch J, Cubas R, Porichis F, Shalek AK et al., 2017/01. JCI insight.
[DOI][Pmid][serval:BIB_B457EDDE5EDF]
2016
 
Antiviral CD8<sup>+</sup> T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.
Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C et al., 2016/10. Immunity.
[DOI][Pmid][serval:BIB_98A4FF17D0F9]
 
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M et al., 2016/09. EBioMedicine.
[DOI][Pmid][serval:BIB_19394B750001]
 
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado GG et al., 2016/08. Cell host & microbe.
[DOI][Pmid][serval:BIB_ED9659172F3E]
 
Tumor-necrosis factor is a master of T cell exhaustion.
Baxter AE, Kaufmann DE, 2016/05. Nature immunology.
[DOI][Pmid][serval:BIB_2CB88ADEF85E]
 
Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era.
Cao W, Mehraj V, Kaufmann DE, Li T, Routy JP, 2016/03. Journal of the International AIDS Society.
[DOI][Pmid][serval:BIB_B00FAF22A774]
 
Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.
Gandhi RT, Kwon DS, Macklin EA, Shopis JR, McLean AP, McBrine N, Flynn T, Peter L, Sbrolla A, Kaufmann DE et al., 2016/03. Journal of acquired immune deficiency syndromes (1999).
[DOI][Pmid][serval:BIB_10289A3CA0E7]
 
CXCL13 is a plasma biomarker of germinal center activity.
Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS et al., 2016/02. Proceedings of the National Academy of Sciences of the United States of America.
[DOI][Pmid][serval:BIB_6501F8FA124B]
2015
 
Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.
Lee WS, Richard J, Lichtfuss M, Smith AB, Park J, Courter JR, Melillo BN, Sodroski JG, Kaufmann DE, Finzi A et al., 2015/12. Journal of virology.
[DOI][Pmid][serval:BIB_2E8C4C6F8EA3]
 
Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.
Heesters BA, Lindqvist M, Vagefi PA, Scully EP, Schildberg FA, Altfeld M, Walker BD, Kaufmann DE, Carroll MC, 2015/12. PLoS pathogens.
[DOI][Pmid][serval:BIB_EFEF8CBA3AB4]
 
HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.
Ranasinghe S, Soghoian DZ, Lindqvist M, Ghebremichael M, Donaghey F, Carrington M, Seaman MS, Kaufmann DE, Walker BD, Porichis F, 2015/12. Journal of virology.
[DOI][Pmid][serval:BIB_67616766F780]
 
Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity.
Alsahafi N, Ding S, Richard J, Markle T, Brassard N, Walker B, Lewis GK, Kaufmann DE, Brockman MA, Finzi A, 2015/12. Journal of virology.
[DOI][Pmid][serval:BIB_4BAE7B53532B]
 
Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity.
Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, Brassard N, Park J, Courter JR, Melillo B et al., 2015/12. EBioMedicine.
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CD4 mimetics sensitize HIV-1-infected cells to ADCC.
Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP et al., 2015/05. Proceedings of the National Academy of Sciences of the United States of America.
[DOI][Pmid][serval:BIB_E098E0E477AD]
 
Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1.
Berger CT, Llano A, Carlson JM, Brumme ZL, Brockman MA, Cedeño S, Harrigan PR, Kaufmann DE, Heckerman D, Meyerhans A et al., 2015/01. Journal of virology.
[DOI][Pmid][serval:BIB_873F8D72E036]
2014
 
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.
Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K et al., 2014/12. Immunity.
[DOI][Pmid][serval:BIB_B06F629CE096]
 
High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry.
Porichis F, Hart MG, Griesbeck M, Everett HL, Hassan M, Baxter AE, Lindqvist M, Miller SM, Soghoian DZ, Kavanagh DG et al., 2014/12. Nature communications.
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Macrophage infection via selective capture of HIV-1-infected CD4+ T cells.
Baxter AE, Russell RA, Duncan CJ, Moore MD, Willberg CB, Pablos JL, Finzi A, Kaufmann DE, Ochsenbauer C, Kappes JC et al., 2014/11. Cell host & microbe.
[DOI][Pmid][serval:BIB_0225FCB578A5]
 
Short communication: Anti-HIV-1 envelope immunoglobulin Gs in blood and cervicovaginal samples of Beninese commercial sex workers.
Batraville LA, Richard J, Veillette M, Labbé AC, Alary M, Guédou F, Kaufmann DE, Poudrier J, Finzi A, Roger M, 2014/11. AIDS research and human retroviruses.
[DOI][Pmid][serval:BIB_724748DAD9D1]
 
Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection.
Chetty S, Porichis F, Govender P, Zupkosky J, Ghebremichael M, Pillay M, Walker BD, Ndung'u T, Kaufmann DE, Kasprowicz VO, 2014/11. AIDS (London, England).
[DOI][Pmid][serval:BIB_8BA65DAE12AF]
 
The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals.
Veillette M, Coutu M, Richard J, Batraville LA, Dagher O, Bernard N, Tremblay C, Kaufmann DE, Roger M, Finzi A, 2014/10. Journal of virology.
[DOI][Pmid][serval:BIB_22446C8D6486]
 
Distinctive features of CD4+ T cell dysfunction in chronic viral infections.
Morou A, Palmer BE, Kaufmann DE, 2014/09. Current opinion in HIV and AIDS.
[DOI][Pmid][serval:BIB_6B7EF478565F]
 
Editorial overview: cell dysfunction and exhaustion in HIV infection.
Seddiki N, Kaufmann DE, 2014/09. Current opinion in HIV and AIDS.
[DOI][Pmid][serval:BIB_57B3FDDD75F9]
 
Flow cytometry-based assay to study HIV-1 gp120 specific antibody-dependent cellular cytotoxicity responses.
Richard J, Veillette M, Batraville LA, Coutu M, Chapleau JP, Bonsignori M, Bernard N, Tremblay C, Roger M, Kaufmann DE et al., 2014/08. Journal of virological methods.
[DOI][Pmid][serval:BIB_04BF84D3E803]
2013
 
Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions.
Porichis F, Hart MG, Zupkosky J, Barblu L, Kwon DS, McMullen A, Brennan T, Ahmed R, Freeman GJ, Kavanagh DG et al., 2013/12. Journal of virology.
[DOI][Pmid][serval:BIB_03F8087DF14B]
 
Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity.
Veillette M, Désormeaux A, Medjahed H, Gharsallah NE, Coutu M, Baalwa J, Guan Y, Lewis G, Ferrari G, Hahn BH et al., 2013/12. Journal of virology.
[DOI][Pmid][serval:BIB_029C0346529A]
 
In vitro assay to evaluate the impact of immunoregulatory pathways on HIV-specific CD4 T cell effector function.
Porichis F, Hart MG, Zupkosky J, Barblu L, Kaufmann DE, 2013/10. Journal of visualized experiments : JoVE.
[DOI][Pmid][serval:BIB_C319CB9947C2]
 
Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells.
Pacheco Y, McLean AP, Rohrbach J, Porichis F, Kaufmann DE, Kavanagh DG, 2013/08. Journal of immunology (Baltimore, Md. : 1950).
[DOI][Pmid][serval:BIB_E4432D81F04D]
 
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM et al., 2013/06. Journal of immunology (Baltimore, Md. : 1950).
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2012
 
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG et al., 2012/12. Blood.
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A Blueprint for HIV Vaccine Discovery.
Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B et al., 2012/10. Cell host & microbe.
[DOI][Pmid][serval:BIB_DD66D075AE23]
 
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A et al., 2012/06. Nature immunology.
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CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes.
Kwon DS, Angin M, Hongo T, Law KM, Johnson J, Porichis F, Hart MG, Pavlik DF, Tighe DP, Kavanagh DG et al., 2012/04. Journal of virology.
[DOI][Pmid][serval:BIB_C2256D02ECEE]
 
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, Law K, Hongo TC, Pyo A, Piechocka-Trocha A et al., 2012/03. The Journal of infectious diseases.
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Role of PD-1 in HIV pathogenesis and as target for therapy.
Porichis F, Kaufmann DE, 2012/03. Current HIV/AIDS reports.
[DOI][Pmid][serval:BIB_36A4FD1425BC]
2011
 
Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.
Naicker DD, Wang B, Losina E, Zupkosky J, Bryan S, Reddy S, Jaggernath M, Mokgoro M, Goulder PJ, Kaufmann DE et al., 2011/11. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
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Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report.
Chartoff EH, Damez-Werno D, Sonntag KC, Hassinger L, Kaufmann DE, Peterson J, McPhie D, Cataldo AM, Cohen BM, 2011/11. Stem cells international.
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HIV controllers: a multifactorial phenotype of spontaneous viral suppression.
Thèze J, Chakrabarti LA, Vingert B, Porichis F, Kaufmann DE, 2011/08. Clinical immunology (Orlando, Fla.).
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High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Berger CT, Frahm N, Price DA, Mothe B, Ghebremichael M, Hartman KL, Henry LM, Brenchley JM, Ruff LE, Venturi V et al., 2011/07. Journal of virology.
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Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ et al., 2011/06. Blood.
[DOI][Pmid][serval:BIB_936D804EDBB2]
 
HIV-specific CD4 T cells and immune control of viral replication.
Porichis F, Kaufmann DE, 2011/05. Current opinion in HIV and AIDS.
[DOI][Pmid][serval:BIB_DDCB58947ACD]
 
Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions.
Streeck H, Kwon DS, Pyo A, Flanders M, Chevalier MF, Law K, Jülg B, Trocha K, Jolin JS, Anahtar MN et al., 2011/03. Blood.
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2010
 
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Grenningloh R, Tai TS, Frahm N, Hongo TC, Chicoine AT, Brander C, Kaufmann DE, Ho IC, 2010/12. Journal of immunology (Baltimore, Md. : 1950).
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Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.
Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG, 2010/11. Journal of leukocyte biology.
[DOI][Pmid][serval:BIB_70F00D7BB1B0]
 
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S et al., 2010/10. Nature medicine.
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Protective and detrimental roles of IL-10 in HIV pathogenesis.
Kwon DS, Kaufmann DE, 2010/08. European cytokine network.
[DOI][Pmid][serval:BIB_DA7BE4131583]
 
Impaired replication capacity of acute/early viruses in persons who become HIV controllers.
Miura T, Brumme ZL, Brockman MA, Rosato P, Sela J, Brumme CJ, Pereyra F, Kaufmann DE, Trocha A, Block BL et al., 2010/05. Journal of virology.
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Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.
Berger CT, Carlson JM, Brumme CJ, Hartman KL, Brumme ZL, Henry LM, Rosato PC, Piechocka-Trocha A, Brockman MA, Harrigan PR et al., 2010/01. The Journal of experimental medicine.
[DOI][Pmid][serval:BIB_3571171BEC12]
2009
 
Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.
Salisch NC, Kaufmann DE, Awad AS, Reeves RK, Tighe DP, Li Y, Piatak M, Lifson JD, Evans DT, Pereyra F et al., 2009/11. Journal of immunology (Baltimore, Md. : 1950).
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PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
Kaufmann DE, Walker BD, 2009/05. Journal of immunology (Baltimore, Md. : 1950).
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IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K et al., 2009/04. Blood.
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Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES et al., 2009/04. PloS one.
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In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.
Lubong Sabado R, Kavanagh DG, Kaufmann DE, Fru K, Babcock E, Rosenberg E, Walker B, Lifson J, Bhardwaj N, Larsson M, 2009/01. PloS one.
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2008
 
Programmed death-1 as a factor in immune exhaustion and activation in HIV infection.
Kaufmann DE, Walker BD, 2008/05. Current opinion in HIV and AIDS.
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Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, Baker B, Trocha A, Rosenberg R, Mackey E et al., 2008/02. The Journal of infectious diseases.
[DOI][Pmid][serval:BIB_04A12AD4326E]
2007
 
Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Frahm N, Kaufmann DE, Yusim K, Muldoon M, Kesmir C, Linde CH, Fischer W, Allen TM, Li B, McMahon BH et al., 2007/11. Journal of immunology (Baltimore, Md. : 1950).
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Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A et al., 2007/09. Nature immunology.
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Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S et al., 2007/02. Journal of virology.
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Treatment interruption to boost specific HIV immunity in acute infection.
Kaufmann DE, Walker BD, 2007/01. Current opinion in HIV and AIDS.
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2006
 
Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.
Kim AY, Schulze zur Wiesch J, Kuntzen T, Timm J, Kaufmann DE, Duncan JE, Jones AM, Wurcel AG, Davis BT, Gandhi RT et al., 2006/12. PLoS medicine.
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Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
Zaunders JJ, Ip S, Munier ML, Kaufmann DE, Suzuki K, Brereton C, Sasson SC, Seddiki N, Koelsch K, Landay A et al., 2006/10. Journal of virology.
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C et al., 2006/08. Nature.
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Structured treatment interruptions following immediate initiation of HAART in eight patients with acute HIV-1 seroconversion.
Vogel M, Lichterfeld M, Kaufmann DE, Mui SK, Altfeld M, Voigt E, Ahlenstiel G, Kupfer B, Walker B, Spengler U et al., 2006/07. European journal of medical research.
[Pmid][serval:BIB_5AA516CA4A16]
2005
 
Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication.
Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW, 2005/11. Journal of immunology (Baltimore, Md. : 1950).
[DOI][Pmid][serval:BIB_9C7D21C8BB72]
 
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL et al., 2005/11. Journal of virology.
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Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.
Kavanagh DG, Kaufmann DE, Sunderji S, Frahm N, Le Gall S, Boczkowski D, Rosenberg ES, Stone DR, Johnston MN, Wagner BS et al., 2005/10. Blood.
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Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.
Zaunders JJ, Munier ML, Kaufmann DE, Ip S, Grey P, Smith D, Ramacciotti T, Quan D, Finlayson R, Kaldor J et al., 2005/05. Blood.
[DOI][Pmid][serval:BIB_C28DCE5CFB7E]
 
2.3 Supervised Treatment Interruptions in Acute HIV Infection
Kaufmann Daniel, 2005. dans Jessen Heiko, Jaeger Hans (eds.) Primary HIV Infection – Pathology, Diagnosis, Management, Georg Thieme Verlag.
[DOI][serval:BIB_5DB65B285AAC]
2004
 
Limited durability of viral control following treated acute HIV infection.
Kaufmann DE, Lichterfeld M, Altfeld M, Addo MM, Johnston MN, Lee PK, Wagner BS, Kalife ET, Strick D, Rosenberg ES et al., 2004/10. PLoS medicine.
[DOI][Pmid][serval:BIB_7BCBF55E6C90]
 
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G et al., 2004/09. The Journal of experimental medicine.
[DOI][Pmid][serval:BIB_5A7B1E7B7109]
 
Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.
Norris PJ, Moffett HF, Yang OO, Kaufmann DE, Clark MJ, Addo MM, Rosenberg ES, 2004/08. Journal of virology.
[DOI][Pmid][serval:BIB_7730449C9377]
 
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Kaufmann DE, Bailey PM, Sidney J, Wagner B, Norris PJ, Johnston MN, Cosimi LA, Addo MM, Lichterfeld M, Altfeld M et al., 2004/05. Journal of virology.
[DOI][Pmid][serval:BIB_58E7A9585F30]
 
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
Norris PJ, Moffett HF, Brander C, Allen TM, O'Sullivan KM, Cosimi LA, Kaufmann DE, Walker BD, Rosenberg ES, 2004/03. AIDS research and human retroviruses.
[DOI][Pmid][serval:BIB_7B9813F9E71B]
2003
 
The value of preserving HIV-specific immune responses.
Kaufmann DE, Rosenberg ES, 2003/02. Journal of HIV therapy.
[Pmid][serval:BIB_9CE90F4979B7]
2002
 
Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection
Harari A., Rizzardi G. P., Ellefsen K., Ciuffreda D., Champagne P., Bart P. A., Kaufmann D., Telenti A., Sahli R., Tambussi G. et al., 2002/08. Blood, 100 (4) pp. 1381-7.
[DOI][WoS][Pmid][serval:BIB_A47337CF723B]
2000
 
Virological and immunological characteristics of HIV treatment failure.
Kaufmann D., Muñoz M., Bleiber G., Fleury S., Lotti B., Martinez R., Pichler W., Meylan P., Telenti A., 2000/08. AIDS, 14 (12) pp. 1767-74. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_3330EC65069D]
 
Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality
Soudeyns H., Campi G., Rizzardi G. P., Lenge C., Demarest J. F., Tambussi G., Lazzarin A., Kaufmann D., Casorati G., Corey L. et al., 2000/03. Blood, 95 (5) pp. 1743-51.
[WoS][Pmid][serval:BIB_9BF24D6C52A7]
1999
 
AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study.
Ledergerber B., Egger M., Erard V., Weber R., Hirschel B., Furrer H., Battegay M., Vernazza P., Bernasconi E., Opravil M. et al., 1999. JAMA, 282 (23) pp. 2220-2226. Peer-reviewed.
[WoS][Pmid][serval:BIB_FD3163EB5953]
 
Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study.
Bürgisser P., Hammann C., Kaufmann D., Battegay M., Rutschmann O.T., 1999. Clinical and Experimental Immunology, 115 (3) pp. 458-463.
[WoS][Pmid][serval:BIB_12088]
1998
 
CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART). Swiss HIV Cohort Study
Kaufmann D., Pantaleo G., Sudre P., Telenti A., 1998/03. Lancet, 351 (9104) pp. 723-4.
[DOI][WoS][Pmid][serval:BIB_6B668C183A88]
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