Nicolas Guex

Publications | Phd and Masters theses

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102 publications

En préparation | In press | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1995 | 1993 |
En préparation
 
CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen-related receptor (ERR)-driven oxidative metabolism in skeletal muscle
Barquissau Valentin, Zanou Nadège, Geller Sarah, Castillo-Armengol Judit, Marzetta Flavia, Huber Katharina, Ziegler Dorian, Lopez-Mejia Isabel, Fernandez Joan Blanco, Roger Catherine et al..
[DOI][serval:BIB_2CA3F1A4A423]
Repairing a deleterious domestication variant in a floral regulator of tomato by base editing
Glaus Anna N., Brechet Marion, Lebeigle Ludivine, Iwaszkiewicz Justyna, Ambrosini Giovanna, Julca Irene, Zhang Jing, Roberts Robyn, Iseli Christian, Guex Nicolas et al..
[URN][DOI][serval:BIB_D6B8B598E8AC]
In press
 
MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays.
Meurs R., De Matos M., Bothe A., Guex N., Weber T., Teleman A.A., Ban N., Gatfield D. The EMBO journal. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_49566FFF461F]
 
Can we accurately predict the distribution of soil microorganism presence and relative abundance?
Verdon Valentin, Malard Lucie, Collart Flavien, Adde Antoine, Yashiro Erika, Lara Pandi Enrique, Mod Heidi, Singer David, Niculita-Hirzel Hélène, Guex Nicolas et al. Ecography. Peer-reviewed.
[DOI][WoS][serval:BIB_9607C43737E4]
2025
 
Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing.
Glaus A.N., Brechet M., Swinnen G., Lebeigle L., Iwaszkiewicz J., Ambrosini G., Julca I., Zhang J., Roberts R., Iseli C. et al., 2025/01. Nature genetics, 57 (1) pp. 231-241. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5755A1C0CE68]
2024
DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen.
Martin S., Fournes F., Ambrosini G., Iseli C., Bojkowska K., Marquis J., Guex N., Collier J., 2024/10/28. Nucleic acids research, 52 (19) pp. 11519-11535. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0C3DF5C03B52]
Phosphate deficiency alters transcript isoforms via alternative transcription start sites.
Reis R.S., Clúa J., Jaskolowski A., Deforges J., Jacques-Vuarambon D., Guex N., Poirier Y., 2024/10. The Plant journal, 120 (1) pp. 218-233. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_DFA16258AAE3]
tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice.
Brozzi F., Jacovetti C., Cosentino C., Menoud V., Wu K., Bayazit M.B., Abdulkarim B., Iseli C., Guex N., Guay C. et al., 2024/10. Diabetologia, 67 (10) pp. 2260-2274. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BF3CD8D4736F]
Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles.
Bassani S., Chrast J., Ambrosini G., Voisin N., Schütz F., Brusco A., Sirchia F., Turban L., Schubert S., Abou Jamra R. et al., 2024/05/30. Genome medicine, 16 (1) p. 72. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2A129453D91A]
Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase.
Bibert S., Quinodoz M., Perriot S., Krebs F.S., Jan M., Malta R.C., Collinet E., Canales M., Mathias A., Faignart N. et al., 2024/05/10. Nature communications, 15 (1) p. 3969. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_63AF76DC891D]
Comparative assessment of cytometry by time-of-flight and full spectral flow cytometry based on a 33-color antibody panel.
Schäfer A., D'Almeida S.M., Dorier J., Guex N., Villard J., Garcia M., 2024/04. Journal of immunological methods, 527 p. 113641. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_2897FE5D053E]
2023
 
DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen
Martin Sandra, Fournes Florian, Ambrosini Giovanna, Iseli Christian, BOJKOWSKA Karolina, Marquis Julien, Guex Nicolas, Collier Justine, 2023/11/28..
[DOI][serval:BIB_336924D9FAFA]
Mechanopathology of biofilm-like Mycobacterium tuberculosis cords.
Mishra R., Hannebelle M., Patil V.P., Dubois A., Garcia-Mouton C., Kirsch G.M., Jan M., Sharma K., Guex N., Sordet-Dessimoz J. et al., 2023/11/09. Cell, 186 (23) pp. 5135-5150.e28. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A264D4C42F48]
Biallelic variants in NSUN6 cause an autosomal recessive neurodevelopmental disorder.
Mattioli F., Worpenberg L., Li C.T., Ibrahim N., Naz S., Sharif S., Firouzabadi S.G., Vosoogh S., Saraeva-Lamri R., Raymond L. et al., 2023/09. Genetics in medicine, 25 (9) p. 100900. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D38F5D2EC77B]
DNA modifications impact natural transformation of Acinetobacter baumannii.
Vesel N., Iseli C., Guex N., Lemopoulos A., Blokesch M., 2023/06/23. Nucleic acids research, 51 (11) pp. 5661-5677. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C242A3B7D937]
A Biallelic Truncating Variant in the TPR Domain of GEMIN5 Associated with Intellectual Disability and Cerebral Atrophy.
Ibrahim N., Naz S., Mattioli F., Guex N., Sharif S., Iqbal A., Ansar M., Reymond A., 2023/03/13. Genes, 14 (3) p. 707. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_73E78E497318]
Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach.
Strefeler A., Jan M., Quadroni M., Teav T., Rosenberg N., Chatton J.Y., Guex N., Gallart-Ayala H., Ivanisevic J., 2023/01/09. Alzheimer's research & therapy, 15 (1) p. 8. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5426CE38C858]
Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING.
Pinjusic K., Ambrosini G., Lourenco J., Fournier N., Iseli C., Guex N., Egorova O., Nassiri S., Constam D.B., 2023. Frontiers in immunology, 14 p. 1335207. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_B5ECAE9D66D5]
2022
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity.
Lashuel H.A., Mahul-Mellier A.L., Novello S., Hegde R.N., Jasiqi Y., Altay M.F., Donzelli S., DeGuire S.M., Burai R., Magalhães P. et al., 2022/10/20. NPJ Parkinson's disease, 8 (1) p. 136. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_36AEA1313356]
Comparative analysis of diversity and environmental niches of soil bacterial, archaeal, fungal and protist communities reveal niche divergences along environmental gradients in the Alps
Malard Lucie A., Mod Heidi K., Guex Nicolas, Broennimann Olivier, Yashiro Erika, Lara Enrique, Mitchell Edward A.D., Niculita-Hirzel Helene, Guisan Antoine, 2022/06. Soil Biology and Biochemistry, 169 p. 108674. Peer-reviewed.
[URN][DOI][WoS][serval:BIB_A5F0BBE17FCC]
Essential role of Cp190 in physical and regulatory boundary formation.
Kaushal A., Dorier J., Wang B., Mohana G., Taschner M., Cousin P., Waridel P., Iseli C., Semenova A., Restrepo S. et al., 2022/05/13. Science advances, 8 (19) pp. eabl8834. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EEEA9AFE8EED]
Soil protist function varies with elevation in the Swiss Alps.
Mazel F., Malard L., Niculita-Hirzel H., Yashiro E., Mod H.K., Mitchell EAD, Singer D., Buri A., Pinto E., Guex N. et al., 2022/04. Environmental microbiology, 24 (4) pp. 1689-1702. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4C32247201A1]
Genomic consequences of colonisation, migration and genetic drift in barn owl insular populations of the eastern Mediterranean.
Machado A.P., Topaloudis A., Cumer T., Lavanchy E., Bontzorlos V., Ceccherelli R., Charter M., Kassinis N., Lymberakis P., Manzia F. et al., 2022/03. Molecular ecology, 31 (5) pp. 1375-1388. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E06218648494]
SPICA: Swiss portal for immune cell analysis.
Andreatta M., David FPA, Iseli C., Guex N., Carmona S.J., 2022/01/07. Nucleic acids research, 50 (D1) pp. D1109-D1114. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1425D341196A]
Unexpected post-glacial colonisation route explains the white colour of barn owls (Tyto alba) from the British Isles.
Machado A.P., Cumer T., Iseli C., Beaudoing E., Ducrest A.L., Dupasquier M., Guex N., Dichmann K., Lourenço R., Lusby J. et al., 2022/01. Molecular ecology, 31 (2) pp. 482-497. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_59DDCB29C598]
2021
 
A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root.
Graeff M., Rana S., Wendrich J.R., Dorier J., Eekhout T., Aliaga Fandino A.C., Guex N., Bassel G.W., De Rybel B., Hardtke C.S., 2021/12/06. Molecular plant, 14 (12) pp. 1985-1999. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6A28C040E088]
Blood virosphere in febrile Tanzanian children.
Cordey S., Laubscher F., Hartley M.A., Junier T., Keitel K., Docquier M., Guex N., Iseli C., Vieille G., Le Mercier P. et al., 2021/12. Emerging microbes & infections, 10 (1) pp. 982-993. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B0B6B061E9F0]
Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome.
De Nittis P., Efthymiou S., Sarre A., Guex N., Chrast J., Putoux A., Sultan T., Raza Alvi J., Ur Rahman Z., Zafar F. et al., 2021/12. Journal of medical genetics, 58 (12) pp. 815-831. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D9A4B043FC02]
Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss.
Bassani S., van Beelen E., Rossel M., Voisin N., Morgan A., Arribat Y., Chatron N., Chrast J., Cocca M., Delprat B. et al., 2021/09/15. Human molecular genetics, 30 (19) pp. 1785-1796. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1B6DF3F33981]
Predicting spatial patterns of soil bacteria under current and future environmental conditions.
Mod H.K., Buri A., Yashiro E., Guex N., Malard L., Pinto-Figueroa E., Pagni M., Niculita-Hirzel H., van der Meer J.R., Guisan A., 2021/09. The ISME journal, 15 (9) pp. 2547-2560. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_595C7D7FADB0]
 
Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.
Voisin N., Schnur R.E., Douzgou S., Hiatt S.M., Rustad C.F., Brown N.J., Earl D.L., Keren B., Levchenko O., Geuer S. et al., 2021/05/06. American journal of human genetics, 108 (5) pp. 857-873. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_A61CD673B3D6]
DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies.
Bararpour N., Gilardi F., Carmeli C., Sidibe J., Ivanisevic J., Caputo T., Augsburger M., Grabherr S., Desvergne B., Guex N. et al., 2021/03/11. Scientific reports, 11 (1) p. 5657. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C00E7D1EAE17]
CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions.
Kaushal A., Mohana G., Dorier J., Özdemir I., Omer A., Cousin P., Semenova A., Taschner M., Dergai O., Marzetta F. et al., 2021/02/12. Nature communications, 12 (1) p. 1011. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6E8BCA9FDAE9]
 
Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction.
den Hoed J., de Boer E., Voisin N., Dingemans AJM, Guex N., Wiel L., Nellaker C., Amudhavalli S.M., Banka S., Bena F.S. et al., 2021/02/04. American journal of human genetics, 108 (2) pp. 346-356. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_0EBEF17D8EA2]
Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.
Caputo T., Tran VDT, Bararpour N., Winkler C., Aguileta G., Trang KB, Giordano Attianese GMP, Wilson A., Thomas A., Pagni M. et al., 2021/01. Cellular and molecular life sciences, 78 (1) pp. 227-247. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_713DAFDC1C95]
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.
Bibert S., Guex N., Lourenco J., Brahier T., Papadimitriou-Olivgeris M., Damonti L., Manuel O., Liechti R., Götz L., Tschopp J. et al., 2021. Frontiers in immunology, 12 p. 666163. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_91CEC9119F7E]
Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery.
Baumgaertner P., Sankar M., Herrera F.G, Benedetti F., Barras D., Thierry A.C., Dangaj D., Kandalaft L.E., Coukos G., Xenarios I. et al., 2021. Frontiers in immunology, 12 p. 633910. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E707FFE34C52]
2020
 
PamgeneAnalyzeR: open and reproducible pipeline for kinase profiling.
Bekkar A., Nasrallah A., Guex N., Fajas L., Xenarios I., Lopez-Mejia I.C., 2020/12/22. Bioinformatics, 36 (20) pp. 5117-5119. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F6B4F7EFAFFB]
Greater topoclimatic control of above- versus below-ground communities.
Mod H.K., Scherrer D., Di Cola V., Broennimann O., Blandenier Q., Breiner F.T., Buri A., Goudet J., Guex N., Lara E. et al., 2020/12. Global change biology, 26 (12) pp. 6715-6728. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_858D58CF6336]
Virosaurus A Reference to Explore and Capture Virus Genetic Diversity.
Gleizes A., Laubscher F., Guex N., Iseli C., Junier T., Cordey S., Fellay J., Xenarios I., Kaiser L., Mercier P.L., 2020/11/01. Viruses, 12 (11) pp. E1248. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_5E9093826570]
 
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.
Wells D.K., van Buuren M.M., Dang K.K., Hubbard-Lucey V.M., Sheehan KCF, Campbell K.M., Lamb A., Ward J.P., Sidney J., Blazquez A.B. et al., 2020/10/29. Cell, 183 (3) pp. 818-834.e13. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F6095670EC38]
Visualization and normalization of drift effect across batches in metabolome-wide association studies
Bararpour N., Gilardi F., Carmeli C., Sidibe J., Ivanisevic J., Caputo T., Augsburger M., Grabherr S., Desvergne B., Guex N. et al., 2020/01/22..
[URN][DOI][serval:BIB_45680B563CA2]
2019
 
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding.
Hannich J.T., Haribowo A.G., Gentina S., Paillard M., Gomez L., Pillot B., Thibault H., Abegg D., Guex N., Zumbuehl A. et al., 2019/10. Nature metabolism, 1 (10) pp. 996-1008. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_62B2442C63AD]
Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae
Matthey Noémie, Stutzmann Sandrine, Stoudmann Candice, Guex Nicolas, Iseli Christian, Blokesch Melanie, 2019/09/03. eLife, 8.
[URN][DOI][WoS][Pmid][serval:BIB_A98B4B2C6A99]
 
Correction for Minocha et al., "Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes".
Minocha S., Villeneuve D., Praz V., Moret C., Lopes M., Pinatel D., Rib L., Guex N., Herr W., 2019/05/15. Molecular and cellular biology, 39 (10). Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_8E933260533C]
Differential regulation of RNA polymerase III genes during liver regeneration.
Yeganeh M., Praz V., Carmeli C., Villeneuve D., Rib L., Guex N., Herr W., Delorenzi M., Hernandez N., CycliX consortium, 2019/02/28. Nucleic Acids Research, 47 (4) pp. 1786-1796. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_014840C5C9E3]
Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes
Minocha S., Villeneuve D., Praz V., Moret C., Lopes M., Pinatel D., Rib L., Guex N., Herr W., 2019/02/15. Molecular and cellular biology, 39 (5) pp. UNSP e00405. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_212558107C3D]
2018
Cycles of gene expression and genome response during mammalian tissue regeneration.
Rib L., Villeneuve D., Minocha S., Praz V., Hernandez N., Guex N., Herr W., CycliX Consortium, 2018/09/12. Epigenetics & chromatin, 11 (1) p. 52. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B98F4A2BF637]
A systems genetics resource and analysis of sleep regulation in the mouse.
Diessler S., Jan M., Emmenegger Y., Guex N., Middleton B., Skene D.J., Ibberson M., Burdet F., Götz L., Pagni M. et al., 2018/08. PLoS biology, 16 (8) pp. e2005750. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BD5E621589B6]
 
Towards in the Field Fast Pathogens Detection Using FPGAs
Casale Brunet Simone, Schuepbach Thierry, Guex Nicolas, Iseli Christian, Bridge Alan, Kuznetsov Dmitry, Sigrist Christian, Lemercier Philippe, Xenarios Ioannis, Bezati Endri, 2018/08. 2018 28th International Conference on Field Programmable Logic and Applications (FPL).
[DOI][serval:BIB_31D324852D5A]
KIAA1109 Variants Are Associated with a Severe Disorder of Brain Development and Arthrogryposis.
Gueneau L., Fish R.J., Shamseldin H.E., Voisin N., Tran Mau-Them F., Preiksaitiene E., Monroe G.R., Lai A., Putoux A., Allias F. et al., 2018/01/04. American journal of human genetics, 102 (1) pp. 116-132. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_D335250BB897]
 
Intellectual developmental disorder with cardiac arrhythmia syndrome in a child with compound heterozygous GNB5 variants.
Vernon H., Cohen J., De Nittis P., Fatemi A., McClellan R., Goldstein A., Malerba N., Guex N., Reymond A., Merla G., 2018. Clinical Genetics, 93 (6) pp. 1254-1256. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_78C45F133C17]
2017
Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.
Faget J., Groeneveld S., Boivin G., Sankar M., Zangger N., Garcia M., Guex N., Zlobec I., Steiner L., Piersigilli A. et al., 2017/12/12. Cell reports, 21 (11) pp. 3190-3204. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1781FEB17DE0]
Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock.
Mange F., Praz V., Migliavacca E., Willis I.M., Schütz F., Hernandez N., CycliX Consortium, 2017/06. Genome research, 27 (6) pp. 973-984. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_240C54C8CA8A]
Cell-free DNA testing of an extended range of chromosomal anomalies: clinical experience with 6,388 consecutive cases
Pescia Graziano, Guex Nicolas, Iseli Christian, Brennan Liam, Osteras Magne, Xenarios Ioannis, Farinelli Laurent, Conrad Bernard, 2017/02. Genetics in Medicine, 19 (2) pp. 169-175.
[URN][DOI][WoS][Pmid][serval:BIB_7424A736A2C2]
 
Genomic Data Clustering on FPGAs for Compression
Petraglio Enrico, Wertenbroek Rick, Capitao Flavio, Guex Nicolas, Iseli Christian, Thoma Yann, 2017. pp. 229-240 dans Lecture Notes in Computer Science, Springer International Publishing.
[DOI][serval:BIB_C8E691FC1CE1]
Segregated hepatocyte proliferation and metabolic states within the regenerating mouse liver.
Minocha S., Villeneuve D., Rib L., Moret C., Guex N., Herr W., 2017. Hepatology Communications, 1 (9) pp. 871-885. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_6C2F58697FCC]
2016
 
GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.
Lodder E.M., De Nittis P., Koopman C.D., Wiszniewski W., Moura de Souza C.F., Lahrouchi N., Guex N., Napolioni V., Tessadori F., Beekman L. et al., 2016/09/01. American journal of human genetics, 99 (3) pp. 704-710. Peer-reviewed.
[DOI][Pmid][serval:BIB_764CB1E0F6D0]
 
De novo PIK3R2 variant causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia.
Terrone G., Voisin N., Abdullah Alfaiz A., Cappuccio G., Vitiello G., Guex N., D'Amico A., James Barkovich A., Brunetti-Pierri N., Del Giudice E. et al., 2016/08. European journal of human genetics, 24 (9) pp. 1359-1362. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C9725B978C04]
 
West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1.
Alfaiz A.A., Müller V., Boutry-Kryza N., Ville D., Guex N., de Bellescize J., Rivier C., Labalme A., des Portes V., Edery P. et al., 2016/07. European journal of human genetics, 24 (7) pp. 1001-1008. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_83BC90BB9FA1]
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases.
SIB Swiss Institute of Bioinformatics Members, Bultet L.A., 2016/01/04. Nucleic acids research, 44 (D1) pp. D27-37. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_71EF45D9A3D9]
Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics.
Loviglio M.N., Beck C.R., White J.J., Leleu M., Harel T., Guex N., Niknejad A., Bi W., Chen E.S., Crespo I. et al., 2016. Genome medicine, 8 (1) p. 105. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_1820D72F7FFD]
TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer.
Bron S., Henry L., Faes-Van't Hull E., Turrini R., Vanhecke D., Guex N., Ifticene-Treboux A., Marina Iancu E., Semilietof A., Rufer N. et al., 2016. Oncoimmunology, 5 (2) pp. e1073882. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4C97ACD28497]
2015
Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches.
Guex N., Crespo I., Bron S., Ifticene-Treboux A., Faes-Van't Hull E., Kharoubi S., Liechti R., Werffeli P., Ibberson M., Majo F. et al., 2015. PLoS Computational Biology, 11 (3) pp. e1004050. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EC95917CF5CA]
 
Differential Dimerization of Variants Linked to Enhanced S-Cone Sensitivity Syndrome (ESCS) Located in the NR2E3 Ligand-Binding Domain.
von Alpen D., Tran H.V., Guex N., Venturini G., Munier F.L., Schorderet D.F., Haider N.B., Escher P., 2015. Human Mutation, 36 (6) pp. 599-610.
[DOI][WoS][Pmid][serval:BIB_C3924850735E]
 
Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis.
Scott C.C., Vossio S., Vacca F., Snijder B., Larios J., Schaad O., Guex N., Kuznetsov D., Martin O., Chambon M. et al., 2015. Embo Reports, 16 (6) pp. 741-752. Peer-reviewed.
[DOI][Pmid][serval:BIB_435435BD0282]
2014
Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals.
Gilardi F., Migliavacca E., Naldi A., Baruchet M., Canella D., Le Martelot G., Guex N., Desvergne B., CycliX Consortium, 2014. PLoS Genetics, 10 (3) pp. e1004155. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3BEC48D77E63]
Quantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization.
Bonhoure N., Bounova G., Bernasconi D., Praz V., Lammers F., Canella D., Willis I.M., Herr W., Hernandez N., Delorenzi M. et al., 2014. Genome Research, 24 (7) pp. 1157-1168. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4F25C7234592]
 
Soil fungal communities of grasslands are environmentally structured at a regional scale in the Alps.
Pellissier L., Niculita-Hirzel Hélène, Dubuis A., Pagni M., Guex N., Ndiribe C., Salamin N., Xenarios I., Goudet J., Sanders I.R. et al., 2014. Molecular Ecology, 23 (17) pp. 4274-4290. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_32F6B5977780]
2013
 
A robust second-generation genome-wide test for fetal aneuploidy based on shotgun sequencing cell-free DNA in maternal blood : A robust second-generation genome-wide test for fetal aneuploidy
Guex N., Iseli C., Syngelaki A., Deluen C., Pescia G., Nicolaides K. H., Xenarios I., Conrad B., 2013/07. Prenatal Diagnosis, 33 (7) pp. 707-710.
[DOI][WoS][Pmid][serval:BIB_61C3E493220A]
Recurrent structural motifs in non-homologous protein structures.
Johansson M.U., Zoete V., Guex N., 2013/04/10. International journal of molecular sciences, 14 (4) pp. 7795-7814. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FB91592FAE3A]
Critical assessment of automated flow cytometry data analysis techniques
Aghaeepour Nima, Finak Greg, Hoos Holger, Mosmann Tim R, Brinkman Ryan, Gottardo Raphael, Scheuermann Richard H, Dialogue for Reverse Engineering Assessment and Methods (DREAM) Consortium, 2013/03. Nature Methods, 10 (3) pp. 228-238.
[URN][DOI][WoS][Pmid][serval:BIB_86D904679F84]
Density-based hierarchical clustering of pyro-sequences on a large scale--the case of fungal ITS1.
Pagni M., Niculita-Hirzel Hélène, Pellissier L., Dubuis A., Xenarios I., Guisan A., Sanders I.R., Goudet J., Guex N., 2013. Bioinformatics, 29 (10) pp. 1268-1274. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AA89A39C702D]
Plant species distributions along environmental gradients: do belowground interactions with fungi matter?
Pellissier L., Pinto-Figueroa E., Niculita-Hirzel Hélène, Moora M., Villard L., Goudet J., Guex N., Pagni M., Xenarios I., Sanders I. et al., 2013. Frontiers In Plant Science, 4 (500) p. 500. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A4BFB3D30FC4]
PPARβ Interprets a Chromatin Signature of Pluripotency to Promote Embryonic Differentiation at Gastrulation.
Rotman N., Guex N., Gouranton E., Wahli W., 2013. PLoS One, 8 (12) pp. e83300.
[URN][DOI][WoS][Pmid][serval:BIB_778DADB5238A]
 
TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2-Expressing Monocytes in Human Breast Tumors.
Ibberson M., Bron S., Guex N., Faes-Van't Hull E., Ifticene-Treboux A., Henry L., Lehr H.A., Delaloye J.F., Coukos G., Xenarios I. et al., 2013. Clinical Cancer Research, 19 (13) pp. 3439-3449. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_168282AC4124]
2012
A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver.
Canella D., Bernasconi D., Gilardi F., LeMartelot G., Migliavacca E., Praz V., Cousin P., Delorenzi M., Hernandez N., CycliX Consortium, 2012. Genome Research, 22 (4) pp. 666-680. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AFFF7604F2F3]
Defining and searching for structural motifs using DeepView/Swiss-PdbViewer.
Johansson M.U., Zoete V., Michielin O., Guex N., 2012. BMC Bioinformatics, 13 p. 173. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_AF7C5749A380]
Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles.
Le Martelot G., Canella D., Symul L., Migliavacca E., Gilardi F., Liechti R., Martin O., Harshman K., Delorenzi M., Desvergne B. et al., 2012. PLoS Biology, 10 (11) pp. e1001442. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_ECE3D90701DA]
2011
 
A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy.
Hor H., Bartesaghi L., Kutalik Z., Vicário J.L., de Andrés C., Pfister C., Lammers G.J., Guex N., Chrast R., Tafti M. et al., 2011. American Journal of Human Genetics, 89 (3) pp. 474-479.
[DOI][WoS][Pmid][serval:BIB_74EAE8242716]
Hyaline fibromatosis syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors.
Deuquet J., Lausch E., Guex N., Abrami L., Salvi S., Lakkaraju A., Ramirez M.C., Martignetti J.A., Rokicki D., Bonafe L. et al., 2011. Embo Molecular Medicine, 3 (4) pp. 208-221.
[URN][DOI][WoS][Pmid][serval:BIB_27DB154B3E2F]
2010
Multiple imputations applied to the DREAM3 phosphoproteomics challenge: a winning strategy.
Guex N., Migliavacca E., Xenarios I., 2010. PLoS One, 5 (1) pp. e8012. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2D837D79DCAA]
2009
 
Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective.
Guex N., Peitsch M.C., Schwede T., 2009/06. Electrophoresis, 30 Suppl 1 pp. S162-73. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DE757FD3B1F6]
 
Evolutionary trajectories of primate genes involved in HIV pathogenesis.
Ortiz Millan, Ciuffi Angela, Xenarios Ioannis, Martin Olivier, Patin Etienne, Guex Nicolas, Quintana-Murci Luis, Telenti Amalio, 2009. Molecular Biology and Evolution, 26 (12) pp. 2865-2875.
[DOI][WoS][Pmid][serval:BIB_9538BDFBC951]
2008
 
Expression, purification, and characterization of multiple, multifunctional human glucocorticoid receptor proteins.
Simmons C.A., Bledsoe R.K., Guex N., Pearce K.H., 2008/11. Protein expression and purification, 62 (1) pp. 29-35. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AD700B476BC5]
 
ShapeFinder: a software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis.
Vasa S.M., Guex N., Wilkinson K.A., Weeks K.M., Giddings M.C., 2008/10. RNA, 14 (10) pp. 1979-1990. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_591EBB35D254]
Natural variation of potato allene oxide synthase 2 causes differential levels of jasmonates and pathogen resistance in Arabidopsis.
Pajerowska-Mukhtar K.M., Mukhtar M.S., Guex N., Halim V.A., Rosahl S., Somssich I.E., Gebhardt C., 2008/07. Planta, 228 (2) pp. 293-306. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_48207EA64800]
High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states.
Wilkinson K.A., Gorelick R.J., Vasa S.M., Guex N., Rein A., Mathews D.H., Giddings M.C., Weeks K.M., 2008/04/29. PLoS biology, 6 (4) pp. e96. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_60E25B0673B7]
 
A geographic variant of the Staphylococcus aureus Panton-Valentine leukocidin toxin and the origin of community-associated methicillin-resistant S. aureus USA300.
O'Hara F.P., Guex N., Word J.M., Miller L.A., Becker J.A., Walsh S.L., Scangarella N.E., West J.M., Shawar R.M., Amrine-Madsen H., 2008/01/15. The Journal of infectious diseases, 197 (2) pp. 187-194. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9751E0EB1455]
2006
 
Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding.
Scheib H., McLay I., Guex N., Clare J.J., Blaney F.E., Dale T.J., Tate S.N., Robertson G.M., 2006/09. Journal of molecular modeling, 12 (6) pp. 813-822. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F4B2217781B4]
2003
 
SWISS-MODEL: An automated protein homology-modeling server.
Schwede T., Kopp J., Guex N., Peitsch M.C., 2003/07/01. Nucleic acids research, 31 (13) pp. 3381-3385. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_999E22C2380F]
2002
 
Imaging Science in Biochemistry
Guex Nicolas, Schwede Torsten, Peitsch Manuel C., 2002/01/15..
[DOI][serval:BIB_55DD0F7A343D]
2001
 
Protein Tertiary Structure Modeling
Guex Nicolas, Schwede Torsten, Peitsch Manuel C., 2001/03. Current Protocols in Protein Science, 23 (1).
[DOI][Pmid][serval:BIB_8428F5E2F6AA]
2000
 
Automated protein modelling--the proteome in 3D.
Peitsch M.C., Schwede T., Guex N., 2000/08. Pharmacogenomics, 1 (3) pp. 257-266. Peer-reviewed.
[DOI][Pmid][serval:BIB_0DF1B2DEF0A3]
 
Protein structure computing in the genomic era.
Schwede T., Diemand A., Guex N., Peitsch M.C., 2000/03. Research in microbiology, 151 (2) pp. 107-112. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_B19021B39358]
1999
 
Protein modelling for all.
Guex N., Diemand A., Peitsch M.C., 1999/09. Trends in biochemical sciences, 24 (9) pp. 364-367. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_534721047187]
1998
 
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
Mehenni H., Gehrig C., Nezu J., Oku A., Shimane M., Rossier C., Guex N., Blouin J.L., Scott H.S., Antonarakis S.E., 1998/12. American journal of human genetics, 63 (6) pp. 1641-1650. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_26387EA42A29]
 
New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.
Duret L., Guex N., Peitsch M.C., Bairoch A., 1998/04. Genome research, 8 (4) pp. 348-353. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_1B3375E88195]
1997
 
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.
Guex N., Peitsch M.C., 1997/12. Electrophoresis, 18 (15) pp. 2714-2723. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_35C2EFFA82F1]
 
Large-Scale Comparative Protein Modelling
Peitsch Manuel C., Guex Nicolas, 1997. pp. 177-186 dans Proteome Research: New Frontiers in Functional Genomics, Springer Berlin Heidelberg.
[DOI][serval:BIB_25EB41BC1278]
1995
 
Glyoxysomal malate-dehydrogenase and malate synthase from Soybean cotyledons (Glycine max. L.): Enzyme association, antibody-production and cDNA cloning
Guex N., Henry H., Flach J., Richter H., Widmer F., 1995. Planta, 197 (2) pp. 369-375. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0B65EB7705F7]
1993
 
3D modelling of soybean glyoxysomal malate dehydrogenase
Guex N., Widmer F., Gaillard P., Carrupt P.A., Testa B., 1993. pp. 485-486 dans Wermuth C.G. (eds.) 9th European Symposium on Structure-Activity Relationships: QSAR and Molecular Modelling, Trends in QSAR and Molecular Modelling 92. Peer-reviewed, ESCOM Science Publishers.
[serval:BIB_6DDFC76DACFB]
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