Christian-Heinrich Simon

Publications | Phd and Masters theses

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149 publications

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Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study.
Ansarin M., Pietrobon G., Tagliabue M., Mossinelli C., Ruju F., Maffini F., Rocca M.C., Alterio D., Simon C., Zorzi S.F. European archives of oto-rhino-laryngology. Peer-reviewed.
 
Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels J.P., Tao Y., Licitra L., Burtness B., Tahara M., Rischin D., Alves G., Lima IPF, Hughes BGM, Pointreau Y. et al. The Lancet. Oncology. Peer-reviewed.
 
ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.
Mazzeo L., Ghosh S., Di Cicco E., Isma J., Tavernari D., Samarkina A., Ostano P., Youssef M.K., Simon C., Dotto G.P., 2024/02/03. Nature communications, 15 (1) p. 1038. Peer-reviewed.
COVID-19 isolation measures did not prevent vancomycin-resistant enterococci transmissions.
Van Singer M., Senn L., Blanc D.S., Koenig I., Simon C., Grandbastien B., 2023/11. The Journal of hospital infection, 141 pp. 129-131. Peer-reviewed.
Preoperative CT-Based Skeletal Muscle Mass Depletion and Outcomes after Total Laryngectomy.
Salati V., Mandralis K., Becce F., Koerfer J., Lambercy K., Simon C., Gorostidi F., 2023/07/08. Cancers, 15 (14) p. 3538. Peer-reviewed.
The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome.
Goruppi S., Clocchiatti A., Bottoni G., Di Cicco E., Ma M., Tassone B., Neel V., Demehri S., Simon C., Paolo Dotto G., 2023/02/16. Nature communications, 14 (1) p. 887. Peer-reviewed.
VoiceS: voice quality after transoral CO<sub>2</sub> laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer-a randomized phase III trial.
Reinhardt P., Giger R., Seifert E., Shelan M., Riggenbach E., Terribilini D., Joosten A., Schanne D.H., Aebersold D.M., Manser P. et al., 2022/10/27. Trials, 23 (1) p. 906. Peer-reviewed.
 
Transoral Robotic Surgery for Recurrent Tumors of the Upper Aerodigestive Tract (RECUT): An International Cohort Study.
Hardman J.C., Holsinger F.C., Brady G.C., Beharry A., Bonifer A.T., D'Andréa G., Dabas S.K., de Almeida J.R., Duvvuri U., Floros P. et al., 2022/10/06. Journal of the National Cancer Institute, 114 (10) pp. 1400-1409. Peer-reviewed.
Diagnostic génétique moléculaire des enfants implantés cochléaires en Suisse romande [Molecular genetic diagnosis in children with cochlear implants in the Western french speaking part of Switzerland]
Fries S., Unger S., Cina V., Strom A., Paoloni-Giacobino A., Simon C., Senn P., Cao Van H., 2022/10/05. Revue medicale suisse, 18 (798) pp. 1855-1859. Peer-reviewed.
La démultiplication de l’offre de soins fait-elle sens?
Simon C., Senn P., 2022/10/05. Revue medicale suisse, 18 (798) p. 1835. Peer-reviewed.
 
Caution Regarding Assessment of Toxic Effects and Survival in Treatment De-escalation With Radiotherapy vs Transoral Surgery for Human Papillomavirus-Associated Oropharyngeal Cancer.
Paleri V., Simon C., Gorphe P., 2022/10/01. JAMA oncology, 8 (10) pp. 1512-1513. Peer-reviewed.
 
European Head and Neck Society recommendations for head and neck cancer survivorship care.
Verdonck-de Leeuw I., Dawson C., Licitra L., Eriksen J.G., Hosal S., Singer S., Laverty D.P., Golusinski W., Machczynski P., Varges Gomes A. et al., 2022/10. Oral oncology, 133 p. 106047. Peer-reviewed.
The robotic-assisted extended "Sistrunk" approach for tumors of the upper aerodigestive tract with limited transoral access: First description of oncological and functional outcomes.
Simon C., Beharry A., Paleri V., Dübi P., Lambercy K., Holsinger F.C., Todic J., 2022/10. Head & neck, 44 (10) pp. 2335-2341. Peer-reviewed.
Second primary squamous cell carcinomas treated with trans oral robotic surgery: Oncological and functional results.
Soldati F., Lambercy K., Simon C., 2022/06. Laryngoscope investigative otolaryngology, 7 (3) pp. 746-750. Peer-reviewed.
Unmet Needs and Perspectives in Oral Cancer Prevention.
Bouaoud J., Bossi P., Elkabets M., Schmitz S., van Kempen L.C., Martinez P., Jagadeeshan S., Breuskin I., Puppels G.J., Hoffmann C. et al., 2022/04/02. Cancers, 14 (7) p. 1815. Peer-reviewed.
Free flap for soft palate reconstruction: long-term functional evaluation of a new technique.
Colliard A., Pincet L., Simon C., May L., Lambercy K., 2022/03. European archives of oto-rhino-laryngology, 279 (3) pp. 1445-1452. Peer-reviewed.
Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale.
Singer S., Hammerlid E., Tomaszewska I.M., Amdal C.D., Bjordal K., Herlofson B.B., Santos M., Silva J.C., Mehanna H., Fullerton A. et al., 2022/03. Quality of life research, 31 (3) pp. 841-853. Peer-reviewed.
Treatment Stratification in First-Line Recurrent or Metastatic Head and Neck Cancer, on Behalf of the EORTC Young Investigator Head and Neck Cancer Group.
Klinghammer K., Lorini L., Nevens D., Simon C., Machiels J.P., Bossi P., 2022. Frontiers in oncology, 12 p. 730785. Peer-reviewed.
 
Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery.
COVIDSurg Collaborative, Schache A.G., 2021/11/09. BJS open, 5 (6). Peer-reviewed.
Quality of life and health-related utility after trans-oral surgery for head and neck cancers.
Parimbelli E., Simon C., Soldati F., Duchoud L., Armas G.L., de Almeida J.R., Quaglini S., 2021/11/03. Health and quality of life outcomes, 19 (1) p. 250. Peer-reviewed.
 
Treatment patterns in older patients with locally advanced head and neck squamous cell carcinoma: Results from an EORTC led survey.
Oosting S.F., Desideri I., Staelens D., Caballero C., Tribius S., Simon C., Singer S., Grégoire V., Fortpied C., Luciani A. et al., 2021/11. Journal of geriatric oncology, 12 (8) pp. 1261-1265. Peer-reviewed.
Cost-utility of two minimally-invasive surgical techniques for operable oropharyngeal cancer: transoral robotic surgery versus transoral laser microsurgery.
Parimbelli E., Soldati F., Duchoud L., Armas G.L., de Almeida J., Broglie M., Quaglini S., Simon C., 2021/10/29. BMC health services research, 21 (1) p. 1173. Peer-reviewed.
Atteintes ORL liées au Covid : prise en charge aiguë et enjeux de la stratégie rééducative [COVID-related ENT affections: acute management and issues of rehabilitation strategy]
Ishii A., Reinhard A., Simon C., Schweizer V., Todic J., 2021/10/06. Revue medicale suisse, 17 (753) pp. 1681-1683. Peer-reviewed.
Le Covid : un enjeu pour la société et aussi pour les ORL
Senn P., Simon C., 2021/10/06. Revue medicale suisse, 17 (753) p. 1679. Peer-reviewed.
 
CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors.
Labiano S., Roh V., Godfroid C., Hiou-Feige A., Romero J., Sum E., Rapp M., Boivin G., Wyss T., Simon C. et al., 2021/07/15. Clinical cancer research, 27 (14) pp. 4054-4065. Peer-reviewed.
 
Head and neck cancer surgery during the COVID‐19 pandemic: An international, multicenter, observational cohort study
Shaw Richard, Winter Stuart C, Glasbey James, Ho Michael Wing Sung, Jackson Richard, Cicconi Silvia, Ganly Ian, Batstone Martin, Rey Biel Juan, Nankivell Paul C et al., 2021/07/15. Cancer, 127 (14) pp. 2476-2488.
UK Head and neck cancer surgical capacity during the second wave of the COVID—19 pandemic: Have we learned the lessons? COVIDSurg collaborative
Shaw Richard, Schache Andrew G, Ho Michael Wing Sung, Winter Stuart C, Glasbey James, Ganly Ian, Batstone Martin, Biel Juan Rey, Nankivell Paul C, Simon Christian et al., 2021/07. Clinical Otolaryngology, 46 (4) pp. 729-735.
 
Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis.
Petit C., Lacas B., Pignon J.P., Le Q.T., Grégoire V., Grau C., Hackshaw A., Zackrisson B., Parmar MKB, Lee J.W. et al., 2021/05. The Lancet. Oncology, 22 (5) pp. 727-736. Peer-reviewed.
Quality assurance of radiotherapy in the ongoing EORTC 1420 "Best of" trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure.
Stelmes J.J., Vu E., Grégoire V., Simon C., Clementel E., Kazmierska J., Grant W., Ozsahin M., Tomsej M., Vieillevigne L. et al., 2021/05/01. Radiation oncology, 16 (1) p. 81. Peer-reviewed.
 
A systematic review of the primary squamous cell carcinoma of the external auditory canal: survival outcome based on T-staging and proposal of a new classification.
George M., Borsotti F., Gereige R., Kolethekkat A.A., Das A., Messerer M., Mahasampath G., Simon C., 2021/02. The Journal of laryngology and otology, 135 (2) pp. 96-103. Peer-reviewed.
Safety and Feasibility of Surgery for Oropharyngeal Cancers During the SARS-CoV-2-Pandemic.
Gorphe P., Grandbastien B., Dietz A., Duvvuri U., Ferris R.L., Golusinski W., Holsinger F.C., Hosal S., Lawson G., Mehanna H. et al., 2021. Frontiers in oncology, 11 p. 651123. Peer-reviewed.
Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model
Domingos-Pereira Sonia, Roh Vincent, Hiou-Feige Agnès, Galliverti Gabriele, Simon Christian, Tolstonog Genrich V., Nardelli-Haefliger Denise, 2021/01/01. OncoImmunology, 10 (1) p. 1912473.
Assessing Preferences in Patients with Head and Neck Squamous Cell Carcinoma: Phase I and II of Questionnaire Development.
Bonomo P., Maruelli A., Saieva C., Taylor K., Singer S., Patelli Z., Rogers S., Mattavelli D., Simon C., Scotté F. et al., 2020/11/30. Cancers, 12 (12) pp. E3577. Peer-reviewed.
 
Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer.
Musoro J.Z., Coens C., Singer S., Tribius S., Oosting S.F., Groenvold M., Simon C., Machiels J.P., Grégoire V., Velikova G. et al., 2020/11. Head & neck, 42 (11) pp. 3141-3152. Peer-reviewed.
L’ORL, une discipline plurivalente []
Simon C., Senn P., 2020/10/07. Revue medicale suisse, 16 (709) p. 1843. Peer-reviewed.
 
A new endoscopic surgical approach to the larynx, hypopharynx, and neck lymphatics: The robotic-assisted extended "Sistrunk" approach (RESA).
Simon C., Holsinger F.C., Rheinwald M., Kemper J., Lambercy K., 2020/09. Head & neck, 42 (9) pp. 2750-2756. Peer-reviewed.
Proposal of a timing strategy for cholesteatoma surgery during the COVID-19 pandemic.
George M., Alexander A., Mathew J., Iyer A., Waterval J., Simon C., Marchioni D., Maire R., 2020/09. European archives of oto-rhino-laryngology, 277 (9) pp. 2619-2623. Peer-reviewed.
 
Development and validation of a multivariable prediction model for the identification of occult lymph node metastasis in oral squamous cell carcinoma.
Mermod M., Jourdan E.F., Gupta R., Bongiovanni M., Tolstonog G., Simon C., Clark J., Monnier Y., 2020/08. Head & neck, 42 (8) pp. 1811-1820. Peer-reviewed.
Emergency changes in international guidelines on treatment for head and neck cancer patients during the COVID-19 pandemic.
Chaves ALF, Castro A.F., Marta G.N., Junior G.C., Ferris R.L., Giglio R.E., Golusinski W., Gorphe P., Hosal S., Leemans C.R. et al., 2020/08. Oral oncology, 107 p. 104734. Peer-reviewed.
Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus.
Mehanna H., Hardman J.C., Shenson J.A., Abou-Foul A.K., Topf M.C., AlFalasi M., Chan JYK, Chaturvedi P., Chow VLY, Dietz A. et al., 2020/07. The Lancet. Oncology, 21 (7) pp. e350-e359. Peer-reviewed.
 
Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412.
Machiels J.P., Tao Y., Burtness B., Tahara M., Licitra L., Rischin D., Waldron J., Simon C., Gregoire V., Harrington K. et al., 2020/06. Future oncology, 16 (18) pp. 1235-1243. Peer-reviewed.
Best Practice in Surgical Treatment of Malignant Head and Neck Tumors.
Simon C., Nicolai P., Paderno A., Dietz A., 2020. Frontiers in oncology, 10 p. 140. Peer-reviewed.
Follow-Up of Head and Neck Cancer Survivors: Tipping the Balance of Intensity.
Szturz P., Van Laer C., Simon C., Van Gestel D., Bourhis J., Vermorken J.B., 2020. Frontiers in oncology, 10 p. 688. Peer-reviewed.
 
The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma.
Roh V., Hiou-Feige A., Misetic V., Rivals J.P., Sponarova J., Teh M.T., Ferreira Lopes S., Truan Z., Mermod M., Monnier Y. et al., 2020/01. The Journal of pathology, 250 (1) pp. 107-119. Peer-reviewed.
 
Squamous cell carcinoma of the head and neck - screening in patients who misuse alcohol and tobacco in Switzerland: a prospective pilot study.
Mermod M., Adam A., Clair C., Faouzi M., Simon C., Daeppen J.B., Bertholet N., Monnier Y., 2019/12. The British journal of oral & maxillofacial surgery, 57 (10) pp. 1053-1057. Peer-reviewed.
 
A systematic review and meta-analysis of margins in transoral surgery for oropharyngeal carcinoma.
Gorphe P., Simon C., 2019/11. Oral oncology, 98 pp. 69-77. Peer-reviewed.
 
Nodules et cancers différenciés de la thyroïde: mise à jour sur le diagnostic et le traitement chirurgical [Thyroid nodules and thyroid differentiated cancers: an update on diagnosis and surgical management.]
De Sandre-Mouly C., Sykiotis G.P., Simon C., Gorostidi F., 2019/10/02. Revue medicale suisse, 15 (665) pp. 1752-1759. Peer-reviewed.
Nouveautés dans les prises en charge des pathologies de la sphère ORL.
Simon C., Senn P., 2019/10/02. Revue medicale suisse, 15 (665) p. 1735. Peer-reviewed.
 
Otogenic Pneumocephalus Presenting as Pneumatocele of the Scalp.
George M., Dunet V., Alzuphar S., Borsotti F., Daniel R.T., Simon C., 2019/10. The American journal of medicine, 132 (10) pp. 1170-1172. Peer-reviewed.
 
Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer.
Dauzier E., Lacas B., Blanchard P., Le Q.T., Simon C., Wolf G., Janot F., Horiuchi M., Tobias J.S., Moon J. et al., 2019/08. Oral oncology, 95 pp. 106-114. Peer-reviewed.
 
Quality assurance in head and neck cancer surgery: where are we, and where are we going?
Simon C., Dietz A., Leemans C.R., 2019/04. Current opinion in otolaryngology & head and neck surgery, 27 (2) pp. 151-156. Peer-reviewed.
Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis.
Farooq S., Khandavilli S., Dretzke J., Moore D., Nankivell P.C., Sharma N., Almeida J.R., Winter S.C., Simon C., Paleri V. et al., 2019/04. Oral oncology, 91 pp. 97-106. Peer-reviewed.
 
Practical clinical guidelines for contouring the trigeminal nerve (V) and its branches in head and neck cancers.
Biau J., Dunet V., Lapeyre M., Simon C., Ozsahin M., Grégoire V., Bourhis J., 2019/02. Radiotherapy and oncology, 131 pp. 192-201. Peer-reviewed.
 
Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification.
Mermod M., Bongiovanni M., Petrova T., Goun E., Simon C., Tolstonog G., Monnier Y., 2019/02. Otolaryngology: head and neck surgery, 160 (2) pp. 277-283. Peer-reviewed.
A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study-Part 1 (Head and Neck Surgery).
Dulguerov P., Broglie M.A., Henke G., Siano M., Putora P.M., Simon C., Zwahlen D., Huber G.F., Ballerini G., Beffa L. et al., 2019. Frontiers in oncology, 9 p. 1125. Peer-reviewed.
A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study-Part 2 (Radiation Oncology).
Elicin O., Putora P.M., Siano M., Broglie M.A., Simon C., Zwahlen D., Huber G.F., Ballerini G., Beffa L., Giger R. et al., 2019. Frontiers in oncology, 9 p. 1126. Peer-reviewed.
A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study-Part 3 (Medical Oncology).
Siano M., Dulguerov P., Broglie M.A., Henke G., Putora P.M., Simon C., Zwahlen D., Huber G.F., Ballerini G., Beffa L. et al., 2019. Frontiers in oncology, 9 p. 1127. Peer-reviewed.
A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study-Part 4 (Biomarkers).
Broglie M.A., Dulguerov P., Henke G., Siano M., Putora P.M., Simon C., Zwahlen D., Huber G.F., Ballerini G., Beffa L. et al., 2019. Frontiers in oncology, 9 p. 1128. Peer-reviewed.
Cisplatin Eligibility Issues and Alternative Regimens in Locoregionally Advanced Head and Neck Cancer: Recommendations for Clinical Practice.
Szturz P., Cristina V., Herrera Gómez R.G., Bourhis J., Simon C., Vermorken J.B., 2019. Frontiers in oncology, 9 p. 464. Peer-reviewed.
Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the "Best of" Trial.
Stelmes J.J., Gregoire V., Poorten V.V., Golusiñski W., Szewczyk M., Jones T., Ansarin M., Broglie M.A., Giger R., Klussmann J.P. et al., 2019. Frontiers in oncology, 9 p. 999. Peer-reviewed.
 
Treatment challenges in and outside a network setting: Head and neck cancers.
Orlandi E., Alfieri S., Simon C., Trama A., Licitra L., RARECAREnet Working Group, 2019/01. European journal of surgical oncology, 45 (1) pp. 40-45. Peer-reviewed.
Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma.
Roh V., Abramowski P., Hiou-Feige A., Cornils K., Rivals J.P., Zougman A., Aranyossy T., Thielecke L., Truan Z., Mermod M. et al., 2018/11/20. Cell reports, 25 (8) pp. 2208-2222.e7. Peer-reviewed.
 
Surgical quality assurance in head and neck cancer trials: an EORTC Head and Neck Cancer Group position paper based on the EORTC 1420 'Best of' and 24954 'larynx preservation' study.
Simon C., Caballero C., Gregoire V., Thurnher D., Koivunen P., Ceruse P., Spriano G., Nicolai P., Licitra L., Machiels J.P. et al., 2018/11. European journal of cancer, 103 pp. 69-77. Peer-reviewed.
 
Transoral robotic-assisted supracricoid partial laryngectomy with cricohyoidoepiglottopexy: Procedure development and outcomes of initial cases.
Morisod B., Guinchard A.C., Gorphe P., Schweizer V., Sandu K., Simon C., 2018/10. Head & neck, 40 (10) pp. 2254-2262. Peer-reviewed.
 
Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer.
Mermod M., Hiou-Feige A., Bovay E., Roh V., Sponarova J., Bongiovanni M., Vermeer D.W., Lee J.H., Petrova T.V., Rivals J.P. et al., 2018/06/15. International journal of cancer, 142 (12) pp. 2518-2528. Peer-reviewed.
 
Quality Assurance and Improvement in Head and Neck Cancer Surgery: From Clinical Trials to National Healthcare Initiatives.
Simon C., Caballero C., 2018/05/24. Current treatment options in oncology, 19 (7) p. 34. Peer-reviewed.
 
Holographic Visualisation and Interaction of Fused CT, PET and MRI Volumetric Medical Imaging Data Using Dedicated Remote GPGPU Ray Casting
Fröhlich Magali, Bolinhas Christophe, Depeursinge Adrien, Widmer Antoine, Chevrey Nicolas, Hagmann Patric, Simon Christian, Kokje Vivianne B. C., Gobron Stéphane, 2018. pp. 102-110 dans Simulation, Image Processing, and Ultrasound Systems for Assisted Diagnosis and Navigation, Springer International Publishing.
 
L’examen de fin de formation : une absurdité ou devons-nous former des tricheurs ? []
Guyot J.P., Simon C., 2017/10/04. Revue medicale suisse, 13 (577) pp. 1675-1676. Peer-reviewed.
 
Trends in Surgical Research in Head and Neck Cancer.
Tolstonog G., Simon C., 2017/06. Current treatment options in oncology, 18 (6) p. 38. Peer-reviewed.
 
Minimizing adjuvant treatment after transoral robotic surgery through surgical margin revision and exclusion of radiographic extracapsular extension: A Prospective observational cohort study.
Morisod B., Venara-Vulpe I.I., Alzuphar S., Monnier Y., Bongiovanni M., Hagmann P., Bouchaab H., Bourhis J., Simon C., 2017/05. Head & neck, 39 (5) pp. 965-973. Peer-reviewed.
 
Optimal Perioperative Care in Major Head and Neck Cancer Surgery With Free Flap Reconstruction: A Consensus Review and Recommendations From the Enhanced Recovery After Surgery Society.
Dort J.C., Farwell D.G., Findlay M., Huber G.F., Kerr P., Shea-Budgell M.A., Simon C., Uppington J., Zygun D., Ljungqvist O. et al., 2017/04/01. JAMA otolaryngology-- head & neck surgery, 143 (3) pp. 292-303. Peer-reviewed.
 
Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis.
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y., 2017/01. Head & neck, 39 (1) pp. 98-108. Peer-reviewed.
 
Establishing a formal sarcoma center for children and adults at the Lausanne University Hospital
Bosisio Francesca, Matter Maurice, Fortin Aurélie, CHUV Multidisciplinary Sarcoma Team, 2017. Swiss Knife 3 pp. 16-19. Peer-reviewed.
 
Behandlung eines Glomus caroticum mit perkutaner Embolisation und Ultraschallschere [Percutaneous embolization and ultrasound scissors for removal of a carotid body tumor]
Venara-Vulpe I.I., Morisod B., Morand G.B., Zerlauth J.B., Simon C., 2016/12. HNO, 64 (12) pp. 917-921. Peer-reviewed.
 
Extracapsular spread in head and neck squamous cell carcinoma: A systematic review and meta-analysis.
Mermod M., Tolstonog G., Simon C., Monnier Y., 2016/11. Oral oncology, 62 pp. 60-71. Peer-reviewed.
 
Three-dimensional endoscopic visualization in functional endoscopic sinus surgery.
Albrecht T., Baumann I., Plinkert P.K., Simon C., Sertel S., 2016/11. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 273 (11) pp. 3753-3758. Peer-reviewed.
 
Quand l’éthique marche à l’envers et tue l’enthousiasme de la recherche []
Guyot J.P., Simon C., 2016/10/05. Revue medicale suisse, 12 (533) pp. 1643-1644. Peer-reviewed.
 
Neue Aspekte in der Therapie von Schilddrüsenkarzinomen : Highlights des ASCO-Kongresses 2016 [New aspects in the treatment of thyroid cancer : Highlights of the ASCO Annual Meeting 2016]
Lörincz B.B., Simon C., Möckelmann N., Knecht R., 2016/10. HNO, 64 (10) pp. 736-740. Peer-reviewed.
 
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification.
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y., 2016/09. Head & neck, 38 (9) pp. 1407-1415. Peer-reviewed.
 
Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer.
Monnier Y., Schoettker P., Morisod B., Ikonomidis C., Simon C., 2016/08. Head & neck, 38 (8) pp. 1286-1289. Peer-reviewed.
 
Telemedicine Provides Noninferior Research Informed Consent for Remote Study Enrollment: A Randomized Controlled Trial.
Bobb M.R., Van Heukelom P.G., Faine B.A., Ahmed A., Messerly J.T., Bell G., Harland K.K., Simon C., Mohr N.M., 2016/07. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 23 (7) pp. 759-765. Peer-reviewed.
 
Management of Pharyngeal Fistulas After Anterior Cervical Spine Surgery: A Treatment Algorithm for Severe Complications.
Simon C., Fürstenberg C.H., Eichler M., Rohde S., Bulut C., Wiedenhöfer B., 2016/05/18. Clinical spine surgery, 30 (1) pp. E25-E30. Peer-reviewed.
 
Meta-analysis on survival of patients treated with transoral surgery versus radiotherapy for early-stage squamous cell carcinoma of the oropharynx.
Morisod B., Simon C., 2016/04. Head & neck, 38 Suppl 1 pp. E2143-50. Peer-reviewed.
 
Extended endoscopic endonasal approach to clival and paraclival tumors: Indications and limits.
Messerer M., Cossu G., Pasche P., Ikonomidis C., Simon C., Pralong E., George M., Levivier M., Daniel R.T., 2016/03. Neuro-Chirurgie, 62 (3) pp. 136-145. Peer-reviewed.
 
Are virtual planning and guided surgery for head and neck reconstruction economically viable?
Zweifel D.F., Simon C., Hoarau R., Pasche P., Broome M., 2015. Journal of Oral and Maxillofacial Surgery, 73 (1) pp. 170-175. Peer-reviewed.
 
Congenital lobar emphysema presenting as an airway foreign body.
Gorostidi F., de Buys Roessingh A., Gonzalez M., Simon C., Monnier Y., 2015. International Journal of Pediatric Otorhinolaryngology, 79 (12) pp. 2450-2452. Peer-reviewed.
 
Delayed presentation of deep penetrating trauma to the subaxial cervical spine.
Zaldivar-Jolissaint J.F., Bobinski L., Van Dommelen Y., Levivier M., Simon C., Duff J.M., 2015. European Spine Journal, 24 (Suppl 4) pp. 540-543. Peer-reviewed.
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Seidensaal K., Nollert A., Feige A.H., Muller M., Fleming T., Gunkel N., Zaoui K., Grabe N., Weichert W., Weber K.J. et al., 2015. Molecular Cancer, 14 (1) p. 204. Peer-reviewed.
 
Something more sinister: middle fossa meningioma.
Mermod M., Simon C., Daniel R.T., Pasche P., Levivier M., George M., 2015. American Journal of Medicine, 128 (1) pp. 27-29. Peer-reviewed.
 
Surgery Versus Radiotherapy for Early Oropharyngeal Tumors: a Never-Ending Debate.
Monnier Y., Simon C., 2015. Current Treatment Options In Oncology, 16 (9) p. 42. Peer-reviewed.
 
Veränderung von Inzidenz und Mortalität von Kopf-Hals-Malignomen in Rheinland-Pfalz, 2000-2009 [Changes in Incidence and Mortality Trends of Head and Neck Cancer in Rhineland-Palatinate, 2000-2009].
Bayer O., Krüger M., Koutsimpelas D., Emrich K., Ressing M., Zeissig S.R., Simon C., Singer S., 2015. Laryngo- Rhino- Otologie, 94 (7) pp. 451-458. Peer-reviewed.
 
Acute neurorehabilitation: does a neurosensory and coordinated interdisciplinary programme reduce tracheostomy weaning time and weaning failure?
Berney L., Wasserfallen J.B., Grant K., Levivier M., Simon C., Faouzi M., Paillex R., Schweizer V., Diserens K., 2014. Neurorehabilitation, 34 (4) pp. 809-817. Peer-reviewed.
 
Clinical and molecular characteristics of HNSCC patients with brain metastases: a retrospective study.
Bulut O.C., Lindel K., Hauswald H., Brandt R., Klauschen F., Wolf J., Wolf T., Plinkert P.K., Simon C., Weichert W. et al., 2014. European Archives of Oto-rhino-laryngology, 271 (6) pp. 1715-1722.
 
Clinicobiological progression and prognosis of oral squamous cell carcinoma in relation to the tumor invasive front: impact on prognosis
Sandu K., Nisa L., Monnier P., Simon C., Andrejevic-Blant S., Bron L., 2014. Acta Oto-laryngologica, 134 (4) pp. 416-424.
Cricotracheal resection for laryngeal invasion by thyroid carcinoma: our experience.
Morisod B., Monnier P., Simon C., Sandu K., 2014. European Archives of Oto-rhino-laryngology, 271 (8) pp. 2261-2266.
 
Endoscopic extraction of a prevertebral migrated guidewire after posterior cervical instrumentation.
Yamgoue Tchameni Y.T., Morisod B., Simon C., Levivier M., Duff J.M., 2014. Spine Journal, 14 (8) pp. 1800-1801. Peer-reviewed.
 
Use of combined suspension laryngoscopy and jet ventilation for Y-shaped airway stents delivery.
Monnier Y., Chollet-Rivier M., Gonzalez M., Nicod L., Simon C., Lovis A., 2014. Annals of Thoracic Surgery, 97 (6) pp. 2208-2210. Peer-reviewed.
 
Applications de la chirurgie robotique transorale dans les tumeurs de la sphère ORL [The role of transoral robotic surgery in head and neck cancer].
Morisod B., Simon C., 2013. Revue Médicale Suisse, 9 (400) pp. 1765-1769.
 
Mikrovaskulär anastomosierte Transplantate : Verwendung in der Kopf-Hals-Region nach Bestrahlung und Gefäßdepletion [Grafts with microvascular anastomosis : Their use in the head and neck region following radiotherapy and vessel depletion].
Zaoui K., Federspil P., Plinkert P.K., Simon C., 2013. HNO, 61 (7) pp. 573-579.
Rekonstruktion von Oberkieferdefekten mit einem freien Skapula-angle-Lappen [Reconstruction of maxillary defects using a free scapular angle flap].
Bulut O.C., Federspil P.A., Plinkert P.K., Simon C., 2013. HNO, 61 (4) pp. 321-326.
 
Unmasked: when a clinically malignant disease turns out infectious. A rare case of tularemia.
Bulut O.C., Dyckhoff G., Splettstoesser W., Nemeth J., Klauschen F., Penzel R., Plinkert P.K., Simon C., Weichert W., Stenzinger A., 2013. International Journal of Surgical Pathology, 21 (1) pp. 76-81.
Acquired form of angioedema of the head and neck related to a deficiency in c1-inhibitor: a case report with a review of the literature.
Hallak B., Konu P., Lang F., Simon C., Monnier P., 2012/12/10. Case Reports in Otolaryngology, 2012 (405824) pp. 1-3.
 
A microRNA link between tumor invasion and radioresistance in head-and-neck squamous cell carcinoma
Hofner P., Simon C., Debus J., Abdollahi A., 2012. pp. 51-52 dans Annual Congress of the German Society for Radiation Oncology, Strahlentherapie und Onkologie.
Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.
Acuña Sanhueza G.A., Faller L., George B., Koffler J., Misetic V., Flechtenmacher C., Dyckhoff G., Plinkert P.P., Angel P., Simon C. et al., 2012. BMC Cancer, 12 (72) pp. 1-10.
 
Radiochemoimmunotherapie as intensity-modulated radiotherapy (IMRT) with concomitant boost: interim analysis of the reach study
Jensen A., Krauss J., Potthoff K., Simon C., Nikoghosyan A.V., Lossner K., Debus J., Munter M.W., 2012. p. 102 dans Annual Congress of the German Society for Radiation Oncology, Strahlentherapie und Onkologie.
Radiochemoimmunotherapy with intensity-modulated concomitant boost: interim analysis of the REACH trial.
Jensen A.D., Krauss J., Potthoff K., Simon C., Nikoghosyan A.V., Lossner K., Debus J., Münter M.W., 2012. Radiation Oncology, 7 (57) pp. 1-9.
Assessment of peri- and postoperative complications and Karnofsky-performance status in head and neck cancer patients after radiation or chemoradiation that underwent surgery with regional or free-flap reconstruction for salvage, palliation, or to improve function.
Simon C., Bulut C., Federspil P.A., Münter M.W., Lindel K., Bergmann Z., Sertel S., Leitzbach S., Plinkert P.K., 2011. Radiation Oncology, 6 (109) pp. 1-7.
Long-term outcome and patterns of failure in patients with advanced head and neck cancer.
Hauswald H., Simon C., Hecht S., Debus J., Lindel K., 2011. Radiation Oncology, 6 (70) pp. 1-7.
 
Vakuumversiegelungstherapie im Kopf-Hals-Bereich [Vacuum-assisted closure of head and neck wounds].
Palm H.G., Hauer T., Simon C., Willy C., 2011. HNO, 59 (8) pp. 819-830.
 
Development of an oral cancer recurrence mouse model after surgical resection.
Behren A., Kamenisch Y., Muehlen S., Flechtenmacher C., Haberkorn U., Hilber H., Myers J.N., Bergmann Z., Plinkert P.K., Simon C., 2010. International Journal of Oncology, 36 (4) pp. 849-855.
 
Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9.
Mühlen S., Behren A., Iftner T., Simon C., 2010. International Journal of Oncology, 37 (2) pp. 337-345.
 
Pharmacogenomic identification of c-Myc/Max-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines.
Sertel S., Eichhorn T., Simon C.H., Plinkert P.K., Johnson S.W., Efferth T., 2010. Molecules, 15 (4) pp. 2886-2910.
 
Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras-MKK3-p38 to regulate in vitro cellular invasion.
Behren A., Mühlen S., Acuna Sanhueza G.A., Schwager C., Plinkert P.K., Huber P.E., Abdollahi A., Simon C., 2010. Oncogene, 29 (10) pp. 1519-1530.
Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol.
Habl G., Jensen A.D., Potthoff K., Uhl M., Hof H., Hajda J., Simon C., Debus J., Krempien R., Münter M.W., 2010. BMC Cancer, 10 (651) pp. 1-8.
 
Additional use of acupuncture to NSAID effectively reduces post-tonsillectomy pain.
Sertel S., Herrmann S., Greten H.J., Haxsen V., El-Bitar S., Simon C.H., Baumann I., Plinkert P.K., 2009. European Archives of Oto-Rhino-Laryngology, 266 (6) pp. 919-925.
 
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Mühlen S., Behren A., Iftner T., Plinkert P.K., Simon C., 2009. Virus Research, 139 (1) pp. 100-105.
 
Cutaneous human papillomavirus in head and neck squamous cell carcinomas.
Lindel K., Helmke B., Simon C., Weber K.J., Debus J., de Villiers E.M., 2009. Cancer Investigation, 27 (7) pp. 781-787.
 
In the long-term follow-up combined radiochemotherapy does not improve loco-regional control or distant metastases-free survival of patients with locally advanced head and neck carcinomas compared to radiotherapy alone
Lindel K., Hecht S., Simon C., Dietz A., Debus J., 2009. pp. S429 dans Proceedings of the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, International Journal of Radiation, Oncology, Biology, Physics.
 
Development of distant metastases after radiochemotherapy of advanced head and neck cancer (HNSCC)
Hauswald H., Hecht S., Simon C., Debus J., Lindel K., 2008. pp. S400 dans 50th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, International Journal of Radiation, Oncology, Biology, Physics.
 
Multimodale Therapiestrategien bei der Behandlung von Kopf- und Halskarzinomen [Combined modality approaches in the treatment of head and neck cancer patients].
Simon C., Plinkert P.K., 2008. HNO, 56 (6) pp. 575-584.
 
Fernmetastasen und Zweitkarzinome
Simon C., Plinkert P.K., 2007. p. 42 dans Dietz A. (eds.) Kopf-Hals-Tumoren : Therapie des Larynx-, Hypopharynxkarzinoms unter besonderer Berücksichtigung des Larynxorganerhalts chap. 5.6, UNI-MED.
 
Gibt es tumorbiologische Besonderheiten, die ein bevorzugtes Auftreten von Rezidiven bei Kopf-Hals-Tumoren begünstigen: Tumorinvasion "revisited" [What makes "Head-and-Neck-Cancers" recur: Tumorinvasion "revisited"].
Simon C., Koitschev A., Plinkert P.K., 2007. Laryngo-Rhino-Otologie, 86 (3) pp. 172-175.
 
Tracheal stenosis after percutaneous dilational tracheostomy : a reply
Koitschev A., Simon C., Graumüller S., 2007. Anaesthesia, 62 (3) p. 293.
 
Long time follow-up of patients with unresectable head and neck squamous cell carcinomas (HNSCC) treated with primary radiotherapy
Linde K., Hecht S., Simon C., Dietz A., Debus J., 2006. p. 60 dans 10th Annual Meeting of the Scientific Association of Swiss Radiation Oncology (SASRO), Strahlentherapie und Onkologie.
 
Management and outcome after internal carotid artery laceration during surgery of the paranasal sinuses.
Koitschev A., Simon C., Löwenheim H., Naegele T., Ernemann U., 2006. Acta Oto-laryngologica, 126 (7) pp. 730-738.
 
Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival.
Simon C., Goepfert H., Rosenthal D.I., Roberts D., El-Naggar A., Old M., Diaz E.M., Myers J.N., 2006. European Archives of Oto-rhino-laryngology, 263 (4) pp. 313-318.
 
Suprastomal tracheal stenosis after dilational and surgical tracheostomy in critically ill patients.
Koitschev A., Simon C., Blumenstock G., Mach H., Graumüller S., 2006. Anaesthesia, 61 (9) pp. 832-837.
 
Surgical technique affects the risk for tracheostoma-related complications in post-ICU patients.
Koitschev A., Simon C., Blumenstock G., Mach H., Graumueller S., 2006. Acta Oto-laryngologica, 126 (12) pp. 1303-1308.
 
Transorale Resektion lokal fortgeschrittener Plattenepithelkarzinome der Oropharynxseitenwand: Multimodale Behandlungskonzepte im Wandel [Transoral resection of locally advanced squamous cell carcinoma of the side wall of the oropharynx: multimodal treatment concepts in transition].
Simon C., Plinkert P.K., 2006. HNO, 54 (8) pp. 589-590.
 
Delayed otogenic hydrocephalus after acute otitis media in pediatric patients: the changing presentation of a serious otologic complication.
Koitschev A., Simon C., Löwenheim H., Kumpf M., Besch D., Ernemann U., 2005. Acta Oto-laryngologica, 125 (11) pp. 1230-1235.
 
In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages.
Löwenheim H., Reichl J., Winter H., Hahn H., Simon C., Gültig K., Müller A., Zenner H.P., Zimmermann U., Knipper M., 2005. Tissue Engineering, 11 (1-2) pp. 64-75.
 
Magnetisches Drug-Targeting. Neue Wege zur lokalen Wirkstoffanreicherung in Kopf- und Halskarzinomen [Magnetic drug targeting. New paths for the local concentration of drugs for head and neck cancer].
Simon C., 2005. HNO, 53 (7) pp. 600-601.
 
Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/activator protein-1 signaling pathway.
Behren A., Simon C., Schwab R.M., Loetzsch E., Brodbeck S., Huber E., Stubenrauch F., Zenner H.P., Iftner T., 2005. Cancer Research, 65 (24) pp. 11613-11621.
 
The p38 SAPK pathway is required for Ha-ras induced in vitro invasion of NIH3T3 cells.
Behren A., Binder K., Vucelic G., Herberhold S., Hirt B., Loewenheim H., Preyer S., Zenner H.P., Simon C., 2005. Experimental Cell Research, 303 (2) pp. 321-330.
 
Die Tracheostomie in der Intensivmedizin. Wird der HNO-Arzt noch gebraucht [Tracheostomy in intensive care medicine. Is the ENT specialist still needed?].
Koitschev A., Graumueller S., Dommerich S., Kiotschev C.h., Simon C., 2003. HNO, 51 (8) pp. 616-620.
 
Tracheal stenosis and obliteration above the tracheostoma after percutaneous dilational tracheostomy.
Koitschev A., Graumueller S., Zenner H.P., Dommerich S., Simon C., 2003. Critical Care Medicine, 31 (5) pp. 1574-1576.
 
Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression.
Simon M., Simon C., Köster G., Hans V.H., Schramm J., 2002. Journal of Neuro-Oncology, 60 (1) pp. 1-12.
 
Hemmung zellulärer Signaltransduktionskaskaden. Eine zukünftige antiinvasive Therapiestrategie für Karzinome in der Kopf- und Halsregion [Inhibition of cellular signal transduction cascades. A future anti-invasive therapeutic strategy for cancers of the head and neck region].
Simon C., Simon M., Zenner H.P., 2002. HNO, 50 (1) pp. 14-20.
 
Karzinome der Kopf- und Halsregion: Epidemiologische Aspekte
Simon C, Hilber H., 2002. Medizinische Genetik, 14 (1) pp. 58-61.
 
Mechanismen der Invasion von Karzinomen der Kopf- und Halsregion [Mechanisms of invasiveness of cancers of the head and neck region].
Simon C., Simon M., Zenner H.P., 2001. HNO, 49 (11) pp. 902-909.
 
The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation.
Simon C., Simon M., Vucelic G., Hicks M.J., Plinkert P.K., Koitschev A., Zenner H.P., 2001. Experimental Cell Research, 271 (2) pp. 344-355.
 
PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma.
Simon C., Hicks M.J., Nemechek A.J., Mehta R., O'Malley B.W., Goepfert H., Flaitz C.M., Boyd D., 1999. British Journal of Cancer, 80 (9) pp. 1412-1419.
 
A novel ERK-pathway inhibitor (PD098059) arrests invasion and growth of HNSCC in a murine model
Simon C., Hicks J., Nemechek A., Mehta R., O'Malley B.W., Féaitz C., Goepfert H., Boyd D., 1998. p. 47 dans International Symposium on Metastases in Head and Neck Cancer, British Journal of Cancer.
 
An orthotopic floor-of-mouth cancer model allows quantification of tumor invasion.
Simon C., Nemechek A.J., Boyd D., O'Malley B.W., Goepfert H., Flaitz C.M., Hicks M.J., 1998. Laryngoscope, 108 (11 Pt 1) pp. 1686-1691.
 
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Simon C., Goepfert H., Boyd D., 1998. Cancer Research, 58 (6) pp. 1135-1139.
 
Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Lengyel E., Wang H., Gum R., Simon C., Wang Y., Boyd D., 1997. Oncogene, 14 (21) pp. 2563-2573.
 
DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a Turkish family.
Meyer C.G., May J., Simon C., Böhm B.O., Loeliger C.C., 1996. Tissue Antigens, 48 (3) pp. 231-232.
 
Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion.
Simon C., Juarez J., Nicolson G.L., Boyd D., 1996. Cancer Research, 56 (23) pp. 5369-5374.
 
Quantification of mixed chimersim in blood and bone marrow
Simon C., Loeliger C.C., Zander A.R., Kuehnl P., 1994. pp. 298-301 dans Bär W., Fiori A., Rossi U. (eds.) 15th Congress of the International Society for Forensic Haemogenetics : Venezia, 13-15 October 1993, Springer.
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