Margot Thome Miazza

Publications | Mémoires et thèses

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88 publications

Sous presse | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 |
Sous presse
 
PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation.
Chmiest D., Podavini S., Ioannidou K., Vallois D., Décaillet C., Gonzalez M., Quadroni M., Blackney K., Schairer R., de Leval L.L. et al. Blood advances. Peer-reviewed.
[DOI][Pmid][serval:BIB_E176D0DCD829]
2023
Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
Juilland M., Alouche N., Ubezzi I., Gonzalez M., Rashid H.O., Scarpellino L., Erdmann T., Grau M., Lenz G., Luther S.A. et al., 2023/12/26. Proceedings of the National Academy of Sciences of the United States of America, 120 (52) pp. e2301155120. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_9C724DAA6D7C]
MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans.
Vérièpe-Salerno J., Podavini S., Long MJC, Kolotuev I., Cuendet M., Thome M., 2023/11/09. Autophagy reports, 2 (1) p. 2277584. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_D6E4081D3FDA]
2021
ASB2 is a direct target of FLI1 that sustains NF-κB pathway activation in germinal center-derived diffuse large B-cell lymphoma.
Sartori G., Napoli S., Cascione L., Chung EYL, Priebe V., Arribas A.J., Mensah A.A., Dall'Angelo M., Falzarano C., Barnabei L. et al., 2021/11/11. Journal of experimental & clinical cancer research, 40 (1) p. 357. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_EA8A538A1370]
2020
Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type.
Priebe V., Sartori G., Napoli S., Chung EYL, Cascione L., Kwee I., Arribas A.J., Mensah A.A., Rinaldi A., Ponzoni M. et al., 2020/07/15. Cancers, 12 (7). Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_85A502AF6D6C]
 
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.
Minina E.A., Staal J., Alvarez V.E., Berges J.A., Berman-Frank I., Beyaert R., Bidle K.D., Bornancin F., Casanova M., Cazzulo J.J. et al., 2020/03/05. Molecular cell, 77 (5) pp. 927-929. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_DC38FFDBB184]
 
Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.
Schairer R., Hall G., Zhang M., Cowan R., Baravalle R., Muskett F.W., Coombs P.J., Mpamhanga C., Hale L.R., Saxty B. et al., 2020/02/11. Proceedings of the National Academy of Sciences of the United States of America, 117 (6) pp. 3093-3102. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_6A8AD2C81958]
 
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.
Cheng J., Klei L.R., Hubel N.E., Zhang M., Schairer R., Maurer L.M., Klei H.B., Kang H., Concel V.J., Delekta P.C. et al., 2020/02/03. The Journal of clinical investigation, 130 (2) pp. 1036-1051. Peer-reviewed.
[DOI][Pmid][serval:BIB_FFB7B759EC40]
Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts.
Govender L., Mikulic J., Wyss J.C., Gaide O., Thome M., Golshayan D., 2020. Frontiers in immunology, 11 p. 576651. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_67419B803F44]
2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia.
Luong-Gardiol N., Siddiqui I., Pizzitola I., Jeevan-Raj B., Charmoy M., Huang Y., Irmisch A., Curtet S., Angelov G.S., Danilo M. et al., 2019/04/15. Cancer cell, 35 (4) pp. 649-663.e10. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B56A0F7637FF]
2018
CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo.
Mellett M., Meier B., Mohanan D., Schairer R., Cheng P., Satoh T.K., Kiefer B., Ospelt C., Nobbe S., Thome M. et al., 2018/09. The Journal of investigative dermatology, 138 (9) pp. 2010-2023. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_3EF8D0F9BAD4]
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells.
Vallois D., Dupuy A., Lemonnier F., Allen G., Missiaglia E., Fataccioli V., Ortonne N., Clavert A., Delarue R., Rousselet M.C. et al., 2018/08. Haematologica, 103 (8) pp. e360-e363. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FC43A0A259F5]
 
Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma.
Battistello E., Katanayeva N., Dheilly E., Tavernari D., Donaldson M.C., Bonsignore L., Thome M., Christie A.L., Murakami M.A., Michielin O. et al., 2018/05/24. Blood, 131 (21) pp. 2345-2356. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_628039C698E5]
Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
Juilland M., Thome M., 2018. Frontiers in immunology, 9 p. 1927. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_7A5968ADA94D]
MALT1 protease activity in primary effusion lymphoma.
Juilland M., Bonsignore L., Thome M., 2018. Oncotarget, 9 (16) pp. 12542-12543. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_85FD8BC9D797]
2017
B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.
Dai B., Grau M., Juilland M., Klener P., Höring E., Molinsky J., Schimmack G., Aukema S.M., Hoster E., Vogt N. et al., 2017/01/19. Blood, 129 (3) pp. 333-346. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4B730E70EDA4]
A role for MALT1 activity in Kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma.
Bonsignore L., Passelli K., Pelzer C., Perroud M., Konrad A., Thurau M., Stürzl M., Dai L., Trillo-Tinoco J., Del Valle L. et al., 2017. Leukemia, 31 (3) pp. 614-624. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F6A79A51D676]
2016
Raptor hunted by caspases.
Martin R., Thome M., Martinon F., Fasel N., 2016/06/02. Cell death & disease, 7 (6) pp. e2242. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_F08DA0F683EB]
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
Vallois D., Dobay M.P., Morin R.D., Lemonnier F., Missiaglia E., Juilland M., Iwaszkiewicz J., Fataccioli V., Bisig B., Roberti A. et al., 2016. Blood, 128 (11) pp. 1490-1502. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_A7AD3DD77F83]
CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
Juilland M., Gonzalez M., Erdmann T., Banz Y., Jevnikar Z., Hailfinger S., Tzankov A., Grau M., Lenz G., Novak U. et al., 2016. Blood, 127 (14) pp. 1780-1789. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_52D653869A41]
Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death.
Martin R., Desponds C., Eren R.O., Quadroni M., Thome M., Fasel N., 2016. Cell Death Discovery, 2 p. 16024. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_C5D8230CED35]
Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies.
Juilland M., Thome M., 2016. Current Opinion in Hematology, 23 (4) pp. 402-409.
[URN][DOI][WoS][Pmid][serval:BIB_2480F31D02BC]
The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Jaworski M., Thome M., 2016. Cellular and Molecular Life Sciences, 73 (3) pp. 459-473.
[URN][DOI][WoS][Pmid][serval:BIB_B68EA67B0DAA]
2014
Detection and measurement of paracaspase MALT1 activity.
Hailfinger S., Pelzer C., Thome M., 2014. Methods in Molecular Biology, 1133 pp. 177-188.
[URN][DOI][WoS][Pmid][serval:BIB_9AC18801792B]
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.
Baens M., Bonsignore L., Somers R., Vanderheydt C., Weeks S.D., Gunnarsson J., Nilsson E., Roth R.G., Thome M., Marynen P., 2014. PLoS One, 9 (8) pp. e103774.
[URN][DOI][WoS][Pmid][serval:BIB_857E2176783D]
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
Jaworski M., Marsland B.J., Gehrig J., Held W., Favre S., Luther S.A., Perroud M., Golshayan D., Gaide O., Thome M., 2014. EMBO Journal, 33 (23) pp. 2765-2781.
[URN][DOI][WoS][Pmid][serval:BIB_9401281135B4]
NOTCH1 can initiate NF-κB activation via cytosolic interactions with components of the T cell Signalosome.
Shin H.M., Tilahun M.E., Cho O.H., Chandiran K., Kuksin C.A., Keerthivasan S., Fauq A.H., Golde T.E., Miele L., Thome M. et al., 2014. Frontiers in Immunology, 5 p. 249.
[URN][DOI][WoS][Pmid][serval:BIB_8263EB04C4BB]
Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.
Hailfinger S., Lenz G., Thome M., 2014. Current Opinion in Chemical Biology, 23C pp. 47-55. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1406CC096C11]
2013
 
IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL.
Nogai H., Wenzel S.S., Hailfinger S., Grau M., Kaergel E., Seitz V., Wollert-Wulf B., Pfeifer M., Wolf A., Frick M. et al., 2013. Blood, 122 (13) pp. 2242-2250.
[DOI][WoS][Pmid][serval:BIB_75DB9068E081]
 
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Wenzel S.S., Grau M., Mavis C., Hailfinger S., Wolf A., Madle H., Deeb G., Dörken B., Thome M., Lenz P. et al., 2013. Leukemia, 27 (6) pp. 1381-1390.
[DOI][WoS][Pmid][serval:BIB_DB67B14B9EA5]
Monoubiquitination and Activity of the Paracaspase MALT1 Requires Glutamate 549 in the Dimerization Interface.
Cabalzar K., Pelzer C., Wolf A., Lenz G., Iwaszkiewicz J., Zoete V., Hailfinger S., Thome M., 2013. PLoS One, 8 (8) pp. e72051.
[URN][DOI][WoS][Pmid][serval:BIB_6267E5758CF1]
 
Paracaspase
Hailfinger S., Thome M, 2013. pp. 2295-2300 dans Rawlings N.D., Salvesen G.S. (eds.) Handbook of proteolytic enzymes chap. 515, Academic Press.
[DOI][WoS][serval:BIB_0AABF0624F9A]
PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.
Thuille N., Wachowicz K., Hermann-Kleiter N., Kaminski S., Fresser F., Lutz-Nicoladoni C., Leitges M., Thome M., Massoumi R., Baier G., 2013. PLoS One, 8 (1) pp. e53709.
[URN][DOI][WoS][Pmid][serval:BIB_C675F24FFBA8]
 
The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.
Pelzer C., Cabalzar K., Wolf A., Gonzalez M., Lenz G., Thome M., 2013. Nature Immunology, 14 (4) pp. 337-345.
[DOI][WoS][Pmid][serval:BIB_6A6A58953F95]
2012
 
The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.
Marion S., Mazzolini J., Herit F., Bourdoncle P., Kambou-Pene N., Hailfinger S., Sachse M., Ruland J., Benmerah A., Echard A. et al., 2012. Developmental Cell, 23 (5) pp. 954-967.
[DOI][WoS][Pmid][serval:BIB_4934393C622D]
2011
Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.
Mühlethaler-Mottet A, Flahaut M, Bourloud KB, Nardou K, Coulon A, Liberman J, Thome M, Gross N, 2011/03. Cell death & disease. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_FAD3E0711522]
 
Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.
Jevnikar Z., Obermajer N., Doljak B., Turk S., Gobec S., Svajger U., Hailfinger S., Thome M., Kos J., 2011. Journal of Leukocyte Biology, 90 (1) pp. 99-109.
[DOI][WoS][Pmid][serval:BIB_3008CBF44450]
 
IKKα takes control of canonical NF-κB activation.
Pelzer C., Thome M., 2011. Nature Immunology, 12 (9) pp. 815-816.
[DOI][WoS][Pmid][serval:BIB_C05ADD3E84A5]
 
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.
Hailfinger S., Nogai H., Pelzer C., Jaworski M., Cabalzar K., Charton J.E., Guzzardi M., Décaillet C., Grau M., Dörken B. et al., 2011. Proceedings of the National Academy of Sciences of the United States of America, 108 (35) pp. 14596-14601.
[DOI][WoS][Pmid][serval:BIB_4C1E52575884]
2010
 
Antigen Receptor Signaling to NF-kappa B via CARMA1, BCL10, and MALT1
Thome M., Charton J. E., Pelzer C., Hailfinger S., 2010. Cold Spring Harbor Perspectives in Biology, 2 (9) pp. a003004. Peer-reviewed.
[DOI][WoS][serval:BIB_41B78E27731C]
 
Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.
Schmid D.A., Irving M.B., Posevitz V., Hebeisen M., Posevitz-Fejfar A., Sarria J.C., Gomez-Eerland R., Thome M., Schumacher T.N., Romero P. et al., 2010. Journal of Immunology, 184 (9) pp. 4936-4946. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6F3E1D237CD2]
2009
 
Adapter and enzymatic functions of proteases in T-cell activation.
Hailfinger S., Rebeaud F., Thome M., 2009. Immunological reviews, 232 (1) pp. 334-347. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CB71AECF33A5]
 
Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.
Hailfinger S., Lenz G., Ngo V., Posvitz-Fejfar A., Rebeaud F., Guzzardi M., Penas E.M., Dierlamm J., Chan W.C., Staudt L.M. et al., 2009. Proceedings of the National Academy of Sciences of the United States of America, 106 (47) pp. 19946-19951.
[DOI][WoS][Pmid][serval:BIB_A505E083DE2B]
 
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
Brenner D., Brechmann M., Röhling S., Tapernoux M., Mock T., Winter D., Lehmann W.D., Kiefer F., Thome M., Krammer P.H. et al., 2009. Proceedings of the National Academy of Sciences of the United States of America, 106 (34) pp. 14508-14513. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_E5D02DE469D6]
 
Viral inhibitor of apoptosis vFLIP/K13 protects endothelial cells against superoxide-induced cell death.
Thurau M., Marquardt G., Gonin-Laurent N., Weinländer K., Naschberger E., Jochmann R., Alkharsah K.R., Schulz T.F., Thome M., Neipel F. et al., 2009. Journal of virology, 83 (2) pp. 598-611. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_9C698DF0DE9E]
2008
 
Multifunctional roles for MALT1 in T-cell activation
Thome M., 2008. Nature Reviews Immunology, 8 (7) pp. 495-500. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_CBCB15FD6DF9]
 
Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression
Torgler R., Bongfen S. E., Romero J. C., Tardivel A., Thome M., Corradin G., 2008. Journal of Immunology, 180 (6) pp. 3990-3999. Peer-reviewed.
[WoS][Pmid][serval:BIB_E1DD33F82039]
 
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
Rebeaud F., Hailfinger S., Posevitz-Fejfar A., Tapernoux M., Moser R., Rueda D., Gaide O., Guzzardi M., Iancu E. M., Rufer N. et al., 2008. Nature Immunology, 9 (3) pp. 272-281. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_68ADE902DD96]
2007
 
Bcl10 controls TCR- and FcgammaR-induced actin polymerization.
Rueda D., Gaide O., Ho L., Lewkowicz E., Niedergang F., Hailfinger S., Rebeaud F., Guzzardi M., Conne B., Thelen M. et al., 2007. Journal of Immunology, 178 (7) pp. 4373-4384.
[WoS][Pmid][serval:BIB_AE9B7825A856]
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
Misra R.S., Russell J.Q., Koenig A., Hinshaw-Makepeace J.A., Wen R., Wang D., Huo H., Littman D.R., Ferch U., Ruland J. et al., 2007. Journal of Biological Chemistry, 282 (27) pp. 19365-19374. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1818F2EFBDB2]
 
Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
Rebeaud F., Hailfinger S., Thome M., 2007. Trends in Immunology, 28 (5) pp. 196-200.
[DOI][WoS][Pmid][serval:BIB_D0C5F473C657]
 
Post-translational modifications regulate distinct functions of CARMA1 and BCL10.
Thome M., Weil R., 2007. Trends in Immunology, 28 (6) pp. 281-288.
[DOI][WoS][Pmid][serval:BIB_0FFC473E6ECC]
2006
 
Mycobacterium tuberculosis subverts innate immunity to evade specific effectors.
Loeuillet C., Martinon F., Perez C., Munoz M., Thome M., Meylan P.R., 2006. Journal of Immunology, 177 (9) pp. 6245-6255.
[WoS][Pmid][serval:BIB_EF9D927AC4DD]
 
The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis.
Thurau M., Everett H., Tapernoux M., Tschopp J., Thome M., 2006. Cell Death and Differentiation, 13 (9) pp. 1577-1585.
[DOI][WoS][Pmid][serval:BIB_AB4EF3330FFE]
2005
 
Phosphorylation of CARMA1: the link(er) to NF-kappaB activation.
Rueda D., Thome M., 2005. Immunity, 23 (6) pp. 551-553.
[DOI][WoS][Pmid][serval:BIB_EE535738DC3E]
2004
 
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.
Thome M., 2004. Nature Reviews. Immunology, 4 (5) pp. 348-359.
[DOI][WoS][Pmid][serval:BIB_79CBE16D0EB0]
 
T cell division and death are segregated by mutation of TCRbeta chain constant domains.
Teixeiro E., Daniels M.A., Hausmann B., Schrum A.G., Naeher D., Luescher I., Thome M., Bragado R., Palmer E., 2004. Immunity, 21 (4) pp. 515-526. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_C18647EE725B]
2003
 
Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation.
Egawa T., Albrecht B., Favier B., Sunshine M.J., Mirchandani K., O'Brien W., Thome M., Littman D.R., 2003. Current Biology, 13 (14) pp. 1252-1258.
[DOI][WoS][Pmid][serval:BIB_C69E7B2460A0]
 
TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1.
Thome M., Tschopp J., 2003. Trends in Immunology, 24 (8) pp. 419-424.
[DOI][WoS][Pmid][serval:BIB_67E4C98E7A80]
 
The immunological synapse and actin assembly: a regulatory role for PKC theta.
Thome M., 2003. Developmental Cell, 4 (1) pp. 3-5.
[DOI][WoS][Pmid][serval:BIB_22993368F1BB]
2002
 
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis.
Aganna E., Martinon F., Hawkins P.N., Ross J.B., Swan D.C., Booth D.R., Lachmann H.J., Bybee A., Gaudet R., Woo P. et al., 2002. Arthritis and Rheumatism, 46 (9) pp. 2445-2452.
[DOI][WoS][Pmid][serval:BIB_179F75372E7A]
 
Bcl10.
Thome M., Tschopp J., 2002. Current Biology, 12 (2) pp. R45.
[DOI][WoS][Pmid][serval:BIB_F11DE9D28116]
 
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.
Gaide O., Favier B., Legler D.F., Bonnet D., Brissoni B., Valitutti S., Bron C., Tschopp J., Thome M., 2002. Nature Immunology, 3 (9) pp. 836-843.
[DOI][WoS][Pmid][serval:BIB_2613DA38921C]
 
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.
Meylan E., Martinon F., Thome M., Gschwendt M., Tschopp J., 2002. EMBO Reports, 3 (12) pp. 1201-1208.
[DOI][WoS][Pmid][serval:BIB_BB6B87F0CE62]
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.
Micheau O., Thome M., Schneider P., Holler N., Tschopp J., Nicholson D.W., Briand C., Grütter M.G., 2002. Journal of Biological Chemistry, 277 (47) pp. 45162-45171.
[URN][DOI][WoS][Pmid][serval:BIB_5A5C5C71FE16]
2001
 
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.
Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J., 2001. FEBS Letters, 496 (2-3) pp. 121-127.
[DOI][WoS][Pmid][serval:BIB_8AF1F1467937]
Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10.
Thome M., Gaide O., Micheau O., Martinon F., Bonnet D., Gonzalez M., Tschopp J., 2001. Journal of Cell Biology, 152 (5) pp. 1115-1122.
[URN][DOI][WoS][Pmid][serval:BIB_800EE5019494]
 
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway.
Siegmund D., Mauri D., Peters N., Juo P., Thome M., Reichwein M., Blenis J., Scheurich P., Tschopp J., Wajant H., 2001. Journal of Biological Chemistry, 276 (35) pp. 32585-32590.
[DOI][WoS][Pmid][serval:BIB_59FD27896329]
 
Regulation of lymphocyte proliferation and death by FLIP.
Thome M., Tschopp J., 2001. Nature Reviews. Immunology, 1 (1) pp. 50-58.
[DOI][WoS][Pmid][serval:BIB_92D5671A9800]
2000
 
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.L., Schneider P., Seed B., Tschopp J., 2000. Nature Immunology, 1 (6) pp. 489-495.
[DOI][WoS][Pmid][serval:BIB_618631F35AED]
 
The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.
Kataoka T., Budd R.C., Holler N., Thome M., Martinon F., Irmler M., Burns K., Hahne M., Kennedy N., Kovacsovics M. et al., 2000. Current Biology, 10 (11) pp. 640-648.
[DOI][WoS][Pmid][serval:BIB_F3D9BDE62A23]
1999
Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.
Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J., 1999. Journal of Biological Chemistry, 274 (15) pp. 9962-9968.
[URN][DOI][WoS][Pmid][serval:BIB_4257D9EF40E8]
1998
 
Anti-apoptotic strategies of lymphotropic viruses.
Meinl E., Fickenscher H., Thome M., Tschopp J., Fleckenstein B., 1998. Immunology Today, 19 (10) pp. 474-479.
[DOI][WoS][Pmid][serval:BIB_DBEC46BE0EC9]
 
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
Kataoka T., Schröter M., Hahne M., Schneider P., Irmler M., Thome M., Froelich C.J., Tschopp J., 1998. Journal of Immunology, 161 (8) pp. 3936-3942.
[WoS][Pmid][serval:BIB_8F08756AB04B]
 
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Thome M., Hofmann K., Burns K., Martinon F., Bodmer J.L., Mattmann C., Tschopp J., 1998. Current Biology, 8 (15) pp. 885-888.
[DOI][WoS][Pmid][serval:BIB_41D9A6840882]
 
Inhibition of fas death signals by FLIPs.
Tschopp J., Irmler M., Thome M., 1998. Current Opinion in Immunology, 10 (5) pp. 552-558.
[DOI][WoS][Pmid][serval:BIB_E59DFB495E51]
 
The fight of viruses against apoptosis.
Tschopp J., Thome M., Hofmann K., Meinl E., 1998. Current Opinion in Genetics and Development, 8 (1) pp. 82-87.
[DOI][WoS][Pmid][serval:BIB_A1E4DA0EFEBD]
1997
Characterization of two receptors for TRAIL.
Schneider P., Bodmer J.L., Thome M., Hofmann K., Holler N., Tschopp J., 1997. FEBS letters, 416 (3) pp. 329-34. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_25D695CC2FFE]
Inhibition of death receptor signals by cellular FLIP.
Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schröter M., Burns K., Mattmann C. et al., 1997. Nature, 388 (6638) pp. 190-195.
[URN][DOI][WoS][Pmid][serval:BIB_B780D8F4383C]
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Schneider P., Thome M., Burns K., Bodmer J.L., Hofmann K., Kataoka T., Holler N., Tschopp J., 1997. Immunity, 7 (6) pp. 831-836.
[URN][DOI][WoS][Pmid][serval:BIB_1D571B98E298]
 
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
Bodmer J.L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schröter M., Becker K. et al., 1997. Immunity, 6 (1) pp. 79-88.
[DOI][WoS][Pmid][serval:BIB_9C9827A6B3DC]
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
Thome M., Schneider P., Hofmann K., Fickenscher H., Meinl E., Neipel F., Mattmann C., Burns K., Bodmer J.L., Schröter M. et al., 1997. Nature, 386 (6624) pp. 517-521.
[URN][DOI][WoS][Pmid][serval:BIB_0C9041508C29]
1996
 
The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.
Thome M., Germain V., DiSanto J.P., Acuto O., 1996/09. European Journal of Immunology, 26 (9) pp. 2093-2100. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_AE7F628D8396]
1995
 
Molecular mechanism of T-cell activation: role of protein tyrosine kinases in antigen receptor-mediated signal transduction.
Thome M., Acuto O., 1995/06. Research in Immunology, 146 (4-5) pp. 291-307. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BBDAC4B6D2FA]
 
Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.
Thome M., Duplay P., Guttinger M., Acuto O., 1995. Journal of Experimental Medicine, 181 (6) pp. 1997-2006. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_585ED2ABC41F]
1994
 
Porcine T-cell receptors: molecular and biochemical characterization.
Thome M., Hirt W., Pfaff E., Reddehase M.J., Saalmüller A., 1994/10. Veterinary Immunology and Immunopathology, 43 (1-3) pp. 13-18. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_97B2702FF103]
 
P56LCK interacts via its src homology 2 domain with the ZAP-70 kinase.
Duplay P., Thome M., Hervé F., Acuto O., 1994. Journal of Experimental Medicine, 179 (4) pp. 1163-1172. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_F924EABF77C1]
1993
 
Molecular cloning of porcine T cell receptor alpha, beta, gamma and delta chains using polymerase chain reaction fragments of the constant regions.
Thome A., Saalmüller A., Pfaff E., 1993. European Journal of Immunology, 23 (5) pp. 1005-1010. Peer-reviewed.
[Pmid][serval:BIB_72F97E24DAA3]
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