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68 publications

 
Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease.
Caporali A., Anwar M., Devaux Y., Katare R., Martelli F., Srivastava P.K., Pedrazzini T., Emanueli C. Nature reviews. Cardiology. Peer-reviewed.
 
Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia.
Spertini C., Bénéchet A.P., Birch F., Bellotti A., Román-Trufero M., Arber C., Auner H.W., Mitchell R.A., Spertini O., Smirnova T., 2024/03/28. Cell death discovery, 10 (1) p. 157. Peer-reviewed.
 
Identifying individuals at risk of needing CKD associated medications in a European kidney disease cohort.
Stamellou E., Saritas T., Froissart M., Kronenberg F., Stenvinkel P., Wheeler D.C., Eckardt K.U., Floege J., Fotheringham J., 2024/02/20. BMC nephrology, 25 (1) p. 60. Peer-reviewed.
Immune Monitoring-Guided Versus Fixed Duration of Antiviral Prophylaxis Against Cytomegalovirus in Solid-Organ Transplant Recipients: A Multicenter, Randomized Clinical Trial.
Manuel O., Laager M., Hirzel C., Neofytos D., Walti L.N., Hoenger G., Binet I., Schnyder A., Stampf S., Koller M. et al., 2024/02/17. Clinical infectious diseases, 78 (2) pp. 312-323. Peer-reviewed.
 
Performance of GFR Estimating Equations in Young Adults.
Inker L.A., Tighiouart H., Adingwupu O.M., Ng D.K., Estrella M.M., Maahs D., Yang W., Froissart M., Mauer M., Kalil R. et al., 2024/02. American journal of kidney diseases, 83 (2) pp. 272-276. Peer-reviewed.
CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas.
Bakaric A., Cironi L., Praz V., Sanalkumar R., Broye L.C., Favre-Bulle K., Letovanec I., Digklia A., Renella R., Stamenkovic I. et al., 2024/01/21. Cancers, 16 (2) p. 457. Peer-reviewed.
DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins.
Xing Y.H., Dong R., Lee L., Rengarajan S., Riggi N., Boulay G., Rivera M.N., 2024/01. Nature biotechnology, 42 (1) pp. 52-64. Peer-reviewed.
Use of Analog and Human Insulin in a European Hemodialysis Cohort With Type 2 Diabetes: Associations With Mortality, Hospitalization, MACE, and Hypoglycemia.
Ebert T., Sattar N., Greig M., Lamina C., Froissart M., Eckardt K.U., Floege J., Kronenberg F., Stenvinkel P., Wheeler D.C. et al., 2024/01. American journal of kidney diseases, 83 (1) pp. 18-27. Peer-reviewed.
 
CKD-EPI and EKFC GFR Estimating Equations: Performance and Other Considerations for Selecting Equations for Implementation in Adults.
Inker L.A., Tighiouart H., Adingwupu O.M., Shlipak M.G., Doria A., Estrella M.M., Froissart M., Gudnason V., Grubb A., Kalil R. et al., 2023/12/01. Journal of the American Society of Nephrology, 34 (12) pp. 1953-1964. Peer-reviewed.
 
The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males.
Rogala S., Ali T., Melissari M.T., Währisch S., Schuster P., Sarre A., Emídio R.C., Boettger T., Rogg E.M., Kaur J. et al., 2023/11/02. Nature communications, 14 (1) p. 7024. Peer-reviewed.
Discordance Between Creatinine-Based and Cystatin C-Based Estimated GFR: Interpretation According to Performance Compared to Measured GFR.
Wang Y., Adingwupu O.M., Shlipak M.G., Doria A., Estrella M.M., Froissart M., Gudnason V., Grubb A., Kalil R., Mauer M. et al., 2023/10. Kidney medicine, 5 (10) p. 100710. Peer-reviewed.
 
Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA.
Aghagolzadeh P., Plaisance I., Bernasconi R., Treibel T.A., Pulido Quetglas C., Wyss T., Wigger L., Nemir M., Sarre A., Chouvardas P. et al., 2023/08/29. Circulation, 148 (9) pp. 778-797. Peer-reviewed.
A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification.
Plaisance I., Chouvardas P., Sun Y., Nemir M., Aghagolzadeh P., Aminfar F., Shen S., Shim W.J., Rochais F., Johnson R. et al., 2023/06/13. Cardiovascular research, 119 (6) pp. 1361-1376. Peer-reviewed.
Integration of epigenetic regulatory mechanisms in heart failure.
Sopic M., Robinson E.L., Emanueli C., Srivastava P., Angione C., Gaetano C., Condorelli G., Martelli F., Pedrazzini T., Devaux Y. et al., 2023/05/04. Basic research in cardiology, 118 (1) p. 16. Peer-reviewed.
Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice.
Boukenna M., Rougier J.S., Aghagolzadeh P., Pradervand S., Guichard S., Hämmerli A.F., Pedrazzini T., Abriel H., 2023/04/01. American journal of physiology. Heart and circulatory physiology, 324 (4) pp. H504-H518. Peer-reviewed.
Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity.
Sanalkumar R., Dong R., Lee L., Xing Y.H., Iyer S., Letovanec I., La Rosa S., Finzi G., Musolino E., Papait R. et al., 2023/03/31. Science advances, 9 (13) pp. eabo3789. Peer-reviewed.
 
Clear cell sarcoma: state-of-the art and perspectives.
Wetterwald L., Riggi N., Kyriazoglou A., Dei Tos G., Dei Tos A., Digklia A., 2023/03. Expert review of anticancer therapy, 23 (3) pp. 235-242. Peer-reviewed.
FIMICS: A panel of long noncoding RNAs for cardiovascular conditions.
Firat H., Zhang L., Baksi S., Leszek P., Schordan E., Ounzain S., Kottwitz J., Patriki D., Heidecker B., Lüscher T.F. et al., 2023/01. Heliyon, 9 (1) pp. e13087. Peer-reviewed.
 
The conserved long non-coding RNA CARMA regulates cardiomyocyte differentiation.
Kay M., Soltani B.M., Nemir M., Aghagolzadeh P., Pezzuto I., Chouvardas P., Ruberto F., Movahedi F., Ansari H., Baharvand H. et al., 2022/07/27. Cardiovascular research, 118 (10) pp. 2339-2353. Peer-reviewed.
Effect of acute iron infusion on insulin secretion: A randomized, double-blind, placebo-controlled trial.
Jaccard E., Seyssel K., Gouveia A., Vergely C., Baratali L., Gubelmann C., Froissart M., Favrat B., Marques-Vidal P., Tappy L. et al., 2022/06. EClinicalMedicine, 48 p. 101434. Peer-reviewed.
EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma.
Möller E., Praz V., Rajendran S., Dong R., Cauderay A., Xing Y.H., Lee L., Fusco C., Broye L.C., Cironi L. et al., 2022/04/27. Nature communications, 13 (1) p. 2267. Peer-reviewed.
Inhibition of the NOTCH1 Pathway in the Stressed Heart Limits Fibrosis and Promotes Recruitment of Non-Myocyte Cells into the Cardiomyocyte Fate.
Nemir M., Kay M., Maison D., Berthonneche C., Sarre A., Plaisance I., Pedrazzini T., 2022/04/07. Journal of cardiovascular development and disease, 9 (4) p. 111. Peer-reviewed.
Dissecting the transcriptome in cardiovascular disease.
Robinson E.L., Baker A.H., Brittan M., McCracken I., Condorelli G., Emanueli C., Srivastava P.K., Gaetano C., Thum T., Vanhaverbeke M. et al., 2022/03/16. Cardiovascular research, 118 (4) pp. 1004-1019. Peer-reviewed.
Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity.
Quinodoz M., Peter V.G., Cisarova K., Royer-Bertrand B., Stenson P.D., Cooper D.N., Unger S., Superti-Furga A., Rivolta C., 2022/03/03. American journal of human genetics, 109 (3) pp. 457-470. Peer-reviewed.
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis.
Katakam S., Anand S., Martin P., Riggi N., Stamenkovic I., 2022/03. Life science alliance, 5 (3) pp. e202101256. Peer-reviewed.
 
Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease.
Bischof C., Mirtschink P., Yuan T., Wu M., Zhu C., Kaur J., Pham M.D., Gonzalez-Gonoggia S., Hammer M., Rogg E.M. et al., 2021/12/08. Science translational medicine, 13 (623) pp. eabi7964. Peer-reviewed.
Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome.
De Nittis P., Efthymiou S., Sarre A., Guex N., Chrast J., Putoux A., Sultan T., Raza Alvi J., Ur Rahman Z., Zafar F. et al., 2021/12. Journal of medical genetics, 58 (12) pp. 815-831. Peer-reviewed.
New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.
Inker L.A., Eneanya N.D., Coresh J., Tighiouart H., Wang D., Sang Y., Crews D.C., Doria A., Estrella M.M., Froissart M. et al., 2021/11/04. The New England journal of medicine, 385 (19) pp. 1737-1749. Peer-reviewed.
Time-dependent lipid profile inversely associates with mortality in hemodialysis patients - independent of inflammation/malnutrition.
Ebert T., Qureshi A.R., Lamina C., Fotheringham J., Froissart M., Eckardt K.U., Wheeler D.C., Floege J., Kronenberg F., Stenvinkel P., 2021/10. Journal of internal medicine, 290 (4) pp. 910-921. Peer-reviewed.
Broadening INPP5E phenotypic spectrum: detection of rare variants in syndromic and non-syndromic IRD.
Sangermano R., Deitch I., Peter V.G., Ba-Abbad R., Place E.M., Zampaglione E., Wagner N.E., Fulton A.B., Coutinho-Santos L., Rosin B. et al., 2021/06/29. NPJ genomic medicine, 6 (1) p. 53. Peer-reviewed.
5-Hydroxymethylcytosine Loss in Conjunctival Melanoma.
Stahl A., Riggi N., Nardou K., Nicolas M., Kaya G., Moulin A., 2021/06/05. Dermatopathology, 8 (2) pp. 176-184. Peer-reviewed.
Longitudinal Bone Loss Occurs at the Radius in CKD.
Cailleaux P.E., Ostertag A., Metzger M., Stengel B., Boucquemont J., Houillier P., Flamant M., Ureña-Torres P., Cohen-Solal M., NephroTest Study group, 2021/06. Kidney international reports, 6 (6) pp. 1525-1536. Peer-reviewed.
 
Distinct fission signatures predict mitochondrial degradation or biogenesis.
Kleele T., Rey T., Winter J., Zaganelli S., Mahecic D., Perreten Lambert H., Ruberto F.P., Nemir M., Wai T., Pedrazzini T. et al., 2021/05. Nature, 593 (7859) pp. 435-439. Peer-reviewed.
 
Ewing's Sarcoma. Reply.
Riggi N., Suvà M.L., Stamenkovic I., 2021/04/15. The New England journal of medicine, 384 (15) pp. 1477-1478. Peer-reviewed.
 
New clinical and molecular evidence linking mutations in ARSG to Usher syndrome type IV.
Peter V.G., Quinodoz M., Sadio S., Held S., Rodrigues M., Soares M., Sousa A.B., Coutinho Santos L., Damme M., Rivolta C., 2021/03. Human mutation, 42 (3) pp. 261-271. Peer-reviewed.
 
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.
Jerby-Arnon L., Neftel C., Shore M.E., Weisman H.R., Mathewson N.D., McBride M.J., Haas B., Izar B., Volorio A., Boulay G. et al., 2021/02. Nature medicine, 27 (2) pp. 289-300. Peer-reviewed.
Survival on four compared with three times per week haemodialysis in high ultrafiltration patients: an observational study.
Fotheringham J., Latimer N., Froissart M., Kronenberg F., Stenvinkel P., Floege J., Eckardt K.U., Wheeler D.C., 2021/02. Clinical kidney journal, 14 (2) pp. 665-672. Peer-reviewed.
The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies.
Boulay G., Cironi L., Garcia S.P., Rengarajan S., Xing Y.H., Lee L., Awad M.E., Naigles B., Iyer S., Broye L.C. et al., 2021/02. Life science alliance, 4 (2) pp. e202000808. Peer-reviewed.
AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data.
Quinodoz M., Peter V.G., Bedoni N., Royer Bertrand B., Cisarova K., Salmaninejad A., Sepahi N., Rodrigues R., Piran M., Mojarrad M. et al., 2021/01/22. Nature communications, 12 (1) p. 518. Peer-reviewed.
Ewing's Sarcoma.
Riggi N., Suvà M.L., Stamenkovic I., 2021/01/14. The New England journal of medicine, 384 (2) pp. 154-164. Peer-reviewed.
Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.
Claudinot S., Sakabe J.I., Oshima H., Gonneau C., Mitsiadis T., Littman D., Bonfanti P., Martens G., Nicolas M., Rochat A. et al., 2020/11/06. Nature communications, 11 (1) p. 5645. Peer-reviewed.
 
Measured glomerular filtration rate (GFR) significantly and rapidly decreases after radical cystectomy for bladder cancer.
Rouanne M., Gaillard F., Meunier M., Soorojebally Y., Phan H., Slimani-Thevenet H., Jannot A.S., Neuzillet Y., Friedlander G., Froissart M. et al., 2020/09/30. Scientific reports, 10 (1) p. 16145. Peer-reviewed.
 
Performance of Indexed and Nonindexed Estimated GFR.
Titan S., Miao S., Tighiouart H., Chen N., Shi H., Zhang L., Li Z., Froissart M., Rossing P., Grubb A. et al., 2020/09. American journal of kidney diseases, 76 (3) pp. 446-449. Peer-reviewed.
Attenuation of the pro-inflammatory signature of lung cancer-derived mesenchymal stromal cells by statins.
Galland S., Martin P., Fregni G., Letovanec I., Stamenkovic I., 2020/08/01. Cancer letters, 484 pp. 50-64. Peer-reviewed.
 
Correction to: Preclinical Evaluation and Dosimetry of [111In] CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
Cicone Francesco, Denoël Thibaut, Gnesin Silvano, Riggi Nicolo, Irving Melita, Jakka Gopinadh, Schaefer Niklaus, Viertl David, Coukos George, Prior John O., 2020/08. 1.
Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1).
Cicone F., Denoël T., Gnesin S., Riggi N., Irving M., Jakka G., Schaefer N., Viertl D., Coukos G., Prior J.O., 2020/08. Molecular imaging and biology, 22 (4) pp. 979-991. Peer-reviewed.
Hospitalization and mortality following non-attendance for hemodialysis according to dialysis day of the week: a European cohort study.
Fotheringham J., Smith M.T., Froissart M., Kronenberg F., Stenvinkel P., Floege J., Eckardt K.U., Wheeler D.C., 2020/06/09. BMC nephrology, 21 (1) p. 218. Peer-reviewed.
 
Cell-Cycle Arrest Biomarkers: Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants.
Bojan M., Pieroni L., Semeraro M., Froissart M., 2020/06. Pediatric critical care medicine, 21 (6) pp. 563-570. Peer-reviewed.
 
Traceable Impedance-Based Dispensing and Cloning of Living Single Cells.
Muller G., Bonzon D., Claudinot S., Rochat A., Renaud P., Barrandon Y., 2020/06. SLAS technology, 25 (3) pp. 215-221. Peer-reviewed.
 
Performance of creatinine-based equations for estimating glomerular filtration rate changes over time.
van Rijn MHC, Metzger M., Flamant M., Houillier P., Haymann J.P., van den Brand JAJG, Froissart M., Stengel B., 2020/05/01. Nephrology, dialysis, transplantation, 35 (5) pp. 819-827. Peer-reviewed.
LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma
Keskin T., Bakaric A., Waszyk P., Boulay G., Torsello M., Cornaz-Buros S., Chevalier N., Geiser T., Martin P., Volorio A. et al., 2020/04/14. Cell Reports.
Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression.
Galland S., Stamenkovic I., 2020/04. The Journal of pathology, 250 (5) pp. 555-572. Peer-reviewed.
LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability.
Keskin T., Bakaric A., Waszyk P., Boulay G., Torsello M., Cornaz-Buros S., Chevalier N., Geiser T., Martin P., Volorio A. et al., 2020/03/31. Cell reports, 30 (13) pp. 4567-4583.e5. Peer-reviewed.
 
Association of changes in bone mineral parameters with mortality in haemodialysis patients: insights from the ARO cohort.
Lamina C., Kronenberg F., Stenvinkel P., Froissart M., Forer L., Schönherr S., Wheeler D.C., Eckardt K.U., Floege J., 2020/03/01. Nephrology, dialysis, transplantation, 35 (3) pp. 478-487. Peer-reviewed.
 
Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.
Melms J.C., Vallabhaneni S., Mills C.E., Yapp C., Chen J.Y., Morelli E., Waszyk P., Kumar S., Deming D., Moret N. et al., 2020/02/15. Cancer research, 80 (4) pp. 798-810. Peer-reviewed.
 
Chronic Kidney Disease in Adolescents after Surgery for Congenital Heart Disease.
Bojan M., Pieroni L., Mirabile C., Froissart M., Bonnet D., 2020. Cardiorenal medicine, 10 (5) pp. 353-361. Peer-reviewed.
 
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
Neftel C., Laffy J., Filbin M.G., Hara T., Shore M.E., Rahme G.J., Richman A.R., Silverbush D., Shaw M.L., Hebert C.M. et al., 2019/08/08. Cell, 178 (4) pp. 835-849.e21. Peer-reviewed.
 
The continuous heart failure spectrum: moving beyond an ejection fraction classification.
Triposkiadis F., Butler J., Abboud F.M., Armstrong P.W., Adamopoulos S., Atherton J.J., Backs J., Bauersachs J., Burkhoff D., Bonow R.O. et al., 2019/07/01. European heart journal, 40 (26) pp. 2155-2163. Peer-reviewed.
Inhibition of the Hypoxia-Inducible Factor 1α-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease.
Mirtschink P., Bischof C., Pham M.D., Sharma R., Khadayate S., Rossi G., Fankhauser N., Traub S., Sossalla S., Hagag E. et al., 2019/06/11. Circulation, 139 (24) pp. 2778-2792. Peer-reviewed.
Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.
Gomes CPDC, Ágg B., Andova A., Arslan S., Baker A., Barteková M., Beis D., Betsou F., Wettinger S.B., Bugarski B. et al., 2019/03/29. Non-coding RNA, 5 (2). Peer-reviewed.
 
Low perfusion pressure is associated with renal tubular injury in infants undergoing cardiac surgery with cardiopulmonary bypass: A secondary analysis of an observational study.
Bojan M., Basto Duarte M.C., Lopez V., Tourneur L., Vicca S., Froissart M., 2018/08. European journal of anaesthesiology, 35 (8) pp. 581-587. Peer-reviewed.
Improving the prognosis of patients with severely decreased glomerular filtration rate (CKD G4+): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Eckardt K.U., Bansal N., Coresh J., Evans M., Grams M.E., Herzog C.A., James M.T., Heerspink HJL, Pollock C.A., Stevens P.E. et al., 2018/06. Kidney international, 93 (6) pp. 1281-1292. Peer-reviewed.
ALDH1A3 Is the Key Isoform That Contributes to Aldehyde Dehydrogenase Activity and Affects <i>in Vitro</i> Proliferation in Cardiac Atrial Appendage Progenitor Cells.
Puttini S., Plaisance I., Barile L., Cervio E., Milano G., Marcato P., Pedrazzini T., Vassalli G., 2018. Frontiers in cardiovascular medicine, 5 p. 90. Peer-reviewed.
Association of a Low-Protein Diet With Slower Progression of CKD.
Metzger M., Yuan W.L., Haymann J.P., Flamant M., Houillier P., Thervet E., Boffa J.J., Vrtovsnik F., Froissart M., Bankir L. et al., 2018/01. Kidney international reports, 3 (1) pp. 105-114. Peer-reviewed.
The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.
Micheletti R., Plaisance I., Abraham B.J., Sarre A., Ting C.C., Alexanian M., Maric D., Maison D., Nemir M., Young R.A. et al., 2017/06/21. Science translational medicine, 9 (395) p. 395. Peer-reviewed.
 
Proposed Confidence Scale and ID Score in the Identification of Known-Unknown Compounds Using High Resolution MS Data.
Rochat B., 2017/04. Journal of the American Society for Mass Spectrometry, 28 (4) pp. 709-723. Peer-reviewed.
New Lncs to mesendoderm specification.
Alexanian M., Pedrazzini T., Ounzain S., 2017/03. Journal of thoracic disease, 9 (Suppl 1) pp. S5-S8. Peer-reviewed.
A transcribed enhancer dictates mesendoderm specification in pluripotency.
Alexanian M., Maric D., Jenkinson S.P., Mina M., Friedman C.E., Ting C.C., Micheletti R., Plaisance I., Nemir M., Maison D. et al., 2017. Nature Communications, 8 (1) p. 1806. Peer-reviewed.
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