Department of Fundamental Oncology

Publications | Phd and Masters theses

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659 publications

... | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2003 | 2001 |
2015
The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors.
Romano E., Romero P., 2015. Journal For Immunotherapy of Cancer, 3 p. 15. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_20F437DAD8BC]
 
TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State.
Széles L., Meissner F., Dunand-Sauthier I., Thelemann C., Hersch M., Singovski S., Haller S., Gobet F., Fuertes Marraco S.A., Mann M. et al., 2015. Journal of Immunology, 195 (3) pp. 1025-1033. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_D509593DF5F7]
Toward a rational design of combination therapy in cancer.
Doucey M.A., Xenarios I., 2015. Oncoimmunology, 4 (11) pp. e1046674. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_4923BD9DFC25]
 
Tumor-infiltrating lymphocytes in triple-negative breast cancer: a biomarker for use beyond prognosis?
Tsoutsou P.G., Bourhis J., Coukos G., 2015. Journal of Clinical Oncology, 33 (11) pp. 1297-1298. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_0DCE380A0052]
Whole Tumor Antigen Vaccines: Where Are We?
Chiang C.L.L., Coukos G., Kandalaft L.E., 2015. Vaccines, 3 (2) pp. 344-372. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_CFA66AA4068A]
2014
Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels.
Bossard C., Dobay M.P., Parrens M., Lamant L., Missiaglia E., Haioun C., Martin A., Fabiani B., Delarue R., Tournilhac O. et al., 2014/11/06. Blood, 124 (19) pp. 2983-2986. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_DB6A51490542]
 
5P * MICROTUBULE-DEPOLYMERIZING AGENTS USED IN ANTIBODY-DRUG-CONJUGATES INDUCE ANTITUMOR ACTIVITY BY STIMULATION OF DENDRITIC CELLS
Speiser D. (eds.), 2014/11/01., 25 suppl 6 1, Oxford University Press (OUP).
[DOI][serval:BIB_3CA055922D53]
A novel bioinformatics pipeline to discover genes related to arbuscular mycorrhizal symbiosis based on their evolutionary conservation pattern among higher plants.
Favre P., Bapaume L., Bossolini E., Delorenzi M., Falquet L., Reinhardt D., 2014. Bmc Plant Biology, 14 (1) p. 333. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_707455FE39D2]
Adaptations of Natural Killer Cells to Self-MHC Class I.
Bessoles S., Grandclément C., Alari-Pahissa E., Gehrig J., Jeevan-Raj B., Held W., 2014. Frontiers in Immunology, 5 p. 349. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_BB450D1901CE]
 
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.
Kvistborg P., Philips D., Kelderman S., Hageman L., Ottensmeier C., Joseph-Pietras D., Welters M.J., van der Burg S., Kapiteijn E., Michielin O. et al., 2014. Science Translational Medicine, 6 (254) pp. 254ra128. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_69B53EDF0867]
Blocking Junctional Adhesion Molecule C Enhances Dendritic Cell Migration and Boosts the Immune Responses against Leishmania major.
Ballet R., Emre Y., Jemelin S., Charmoy M., Tacchini-Cottier F., Imhof B.A., 2014. PLoS Pathogens, 10 (12) pp. e1004550.
[URN][DOI][WoS][Pmid][serval:BIB_A5A7EF5ABB7B]
Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
Van't Hull E.F., Bron S., Henry L., Ifticene-Treboux A., Turrini R., Coukos G., Delaloye J.F., Doucey M.A., 2014. Oncoimmunology, 3 pp. e29080.
[URN][DOI][WoS][Pmid][serval:BIB_EFBCB71A50BF]
 
Cancer immunotherapy drives implementation science in oncology.
Speiser D.E., Flatz L., 2014. Human Vaccines and Immunotherapeutics, 10 (11) pp. 3107-3110.
[DOI][WoS][Pmid][serval:BIB_87B192022437]
Classification of current anticancer immunotherapies.
Galluzzi L., Vacchelli E., Bravo-San Pedro J.M., Buqué A., Senovilla L., Baracco E.E., Bloy N., Castoldi F., Abastado J.P., Agostinis P. et al., 2014. Oncotarget, 5 (24) pp. 12472-12508.
[URN][WoS][Pmid][serval:BIB_D59B3440A204]
Deciphering the unusual HLA-A2/Melan-A/MART-1-specific TCR repertoire in humans.
Romero P., Speiser D.E., Rufer N., 2014. European Journal of Immunology, 44 (9) pp. 2567-2570. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2573E29B94C8]
Differences in the transduction of canonical wnt signals demarcate effector and memory CD8 T cells with distinct recall proliferation capacity.
Boudousquié C., Danilo M., Pousse L., Jeevan-Raj B., Angelov G.S., Chennupati V., Zehn D., Held W., 2014. Journal of Immunology, 193 (6) pp. 2784-2791. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_1CEC9FA289EB]
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Toso A., Revandkar A., Di Mitri D., Guccini I., Proietti M., Sarti M., Pinton S., Zhang J., Kalathur M., Civenni G. et al., 2014. Cell Reports, 9 (1) pp. 75-89. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_8411D80B9994]
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab.
Meyer C., Cagnon L., Costa-Nunes C.M., Baumgaertner P., Montandon N., Leyvraz L., Michielin O., Romano E., Speiser D.E., 2014. Cancer Immunology, Immunotherapy : Cii, 63 (3) pp. 247-257. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_9606B044F312]
Inhibitory receptor-mediated regulation of natural killer cells.
Alari-Pahissa E., Grandclement C., Jeevan-Raj B., Held W., 2014. Critical Reviews in Immunology, 34 (6) pp. 455-465. Peer-reviewed.
[URN][WoS][Pmid][serval:BIB_4698362D418E]
iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine.
Corgnac S., Perret R., Zhang L., Mach J.P., Romero P., Donda A., 2014. Journal for Immunotherapy of Cancer, 2 (1) p. 39. Peer-reviewed.
[URN][DOI][Pmid][serval:BIB_4C145C87702F]
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
Jaworski M., Marsland B.J., Gehrig J., Held W., Favre S., Luther S.A., Perroud M., Golshayan D., Gaide O., Thome M., 2014. EMBO Journal, 33 (23) pp. 2765-2781.
[URN][DOI][WoS][Pmid][serval:BIB_9401281135B4]
 
Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function.
Zhang L., Tschumi B.O., Corgnac S., Rüegg M.A., Hall M.N., Mach J.P., Romero P., Donda A., 2014. Journal of Immunology, 193 (4) pp. 1759-1765.
[DOI][WoS][Pmid][serval:BIB_99C0A8A031A8]
miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan.
Schou J.V., Rossi S., Jensen B.V., Nielsen D.L., Pfeiffer P., Høgdall E., Yilmaz M., Tejpar S., Delorenzi M., Kruhøffer M. et al., 2014. Plos One, 9 (6) pp. e99886. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_B3039B1A6D65]
 
Overexpression of SMARCE1 is associated with CD8+ T-cell infiltration in early stage ovarian cancer.
Giannakakis A., Karapetsas A., Dangaj D., Lanitis E., Tanyi J., Coukos G., Sandaltzopoulos R., 2014. International Journal of Biochemistry and Cell Biology, 53 pp. 389-398.
[DOI][WoS][Pmid][serval:BIB_3EE5F8B4AE65]
Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains.
Balam S., Olugbile S., Servis C., Diakité M., D'Alessandro A., Frank G., Moret R., Nebie I., Tanner M., Felger I. et al., 2014. Malaria Journal, 13 p. 510.
[URN][DOI][WoS][Pmid][serval:BIB_2CED1904C6D2]
PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells.
Ragusa S., Cheng J., Ivanov K.I., Zangger N., Ceteci F., Bernier-Latmani J., Milatos S., Joseph J.M., Tercier S., Bouzourene H. et al., 2014. Cell Reports, 8 (6) pp. 1957-1973. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_E480EFD22557]
 
Pulmonary Sarcoid-like Granulomatosis after Multiple Vaccinations of a Long-term Surviving Patient with Metastatic Melanoma.
Bordry N., Costa-Nunes C.M., Cagnon L., Gannon P.O., Abed-Maillard S., Baumgaertner P., Murray T., Letovanec I., Lazor R., Bouchaab H. et al., 2014. Cancer Immunology Research, 2 (12) pp. 1148-1153.
[DOI][WoS][Pmid][serval:BIB_3CFC56A8F483]
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.
Fasnacht N., Huang H.Y., Koch U., Favre S., Auderset F., Chai Q., Onder L., Kallert S., Pinschewer D.D., MacDonald H.R. et al., 2014. Journal of Experimental Medicine, 211 (11) pp. 2265-2279.
[URN][DOI][WoS][Pmid][serval:BIB_AE262022BADB]
 
Successful engineering cancer immunotherapy
Romero Pedro, Coukos George, 2014. European Journal of Immunology. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_26E71B2FED52]
T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.
Melero I., Rouzaut A., Motz G.T., Coukos G., 2014. Cancer Discovery, 4 (5) pp. 522-526. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_C6457A27B855]
Test of four colon cancer risk-scores in formalin fixed paraffin embedded microarray gene expression data.
Di Narzo A.F., Tejpar S., Rossi S., Yan P., Popovici V., Wirapati P., Budinska E., Xie T., Estrella H., Pavlicek A. et al., 2014. Journal of the National Cancer Institute, 106 (10) pp. 1-8.
[URN][DOI][WoS][Pmid][serval:BIB_7FE48BDA06AD]
 
The role of the reporting framework MIATA within current efforts to advance immune monitoring.
Janetzki S., Britten C.M., MIATA Core Team, 2014. Journal of Immunological Methods, 409 pp. 6-8.
[DOI][WoS][Pmid][serval:BIB_E8E256448FAB]
 
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.
Di Mitri D., Toso A., Chen J.J., Sarti M., Pinton S., Jost T.R., D'Antuono R., Montani E., Garcia-Escudero R., Guccini I. et al., 2014. Nature, 515 (7525) pp. 134-137. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_23F6031897C7]
2013
 
Analysis, isolation and activation of antigen-specific CD4+ and CD8+ T cells by soluble MHC-peptide complexes
Schmidt J., Dojcinovic D., Guillaume P., Luescher I., 2013/07. Frontiers in Immunology, 4 (218). Peer-reviewed.
[DOI][serval:BIB_28570B87B9F2]
A dendritic cell vaccine pulsed with autologous hypochlorous Acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside.
Chiang C.L., Kandalaft L.E., Tanyi J., Hagemann A.R., Motz G.T., Svoronos N., Montone K., Mantia-Smaldone G.M., Smith L., Nisenbaum H.L. et al., 2013. Clinical Cancer Research, 19 (17) pp. 4801-4815. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_2509A0717B99]
Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules.
Bessoles S., Angelov G.S., Back J., Leclercq G., Vivier E., Held W., 2013. Journal of Immunology, 191 (10) pp. 5044-5051.
[URN][DOI][WoS][Pmid][serval:BIB_2B1B56B9E4B6]
 
Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids.
Chen S., Gfeller D., Buth S.A., Michielin O., Leiman P.G., Heinis C., 2013. Chembiochem, 14 (11) pp. 1316-1322. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_348A5320AF5C]
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.
Legat A., Speiser D.E., Pircher H., Zehn D., Fuertes Marraco S.A., 2013. Frontiers in Immunology, 4 p. 455.
[URN][DOI][WoS][Pmid][serval:BIB_6F1D514487FB]
Molecular insights for optimizing T cell receptor specificity against cancer.
Hebeisen M., Oberle S.G., Presotto D., Speiser D.E., Zehn D., Rufer N., 2013. Frontiers In Immunology, 4 p. 154.
[URN][DOI][WoS][Pmid][serval:BIB_5D02888E4E45]
 
Structure-Based, Rational Design of T Cell Receptors.
Zoete V., Irving M., Ferber M., Cuendet M.A., Michielin O., 2013. Frontiers in Immunology, 4 p. 268.
[DOI][WoS][Pmid][serval:BIB_CD515849E397]
2012
 
Conference scene: Immune signatures in the tumor and beyond.
Kandalaft L.E., Kalos M., Melief C.J., Speiser D.E., Coukos G., 2012. Immunotherapy, 4 (8) pp. 761-772.
[DOI][WoS][Pmid][serval:BIB_0447F37D562A]
 
Virus-like particles induce robust human T-helper cell responses.
Braun M., Jandus C., Maurer P., Hammann-Haenni A., Schwarz K., Bachmann M.F., Speiser D.E., Romero P., 2012. European Journal of Immunology, 42 (2) pp. 330-340.
[DOI][WoS][Pmid][serval:BIB_6CC8896DD5F6]
2011
 
Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities.
Bulliard Y., Narvaiza I., Bertero A., Peddi S., Röhrig U.F., Ortiz M., Zoete V., Castro-Díaz N., Turelli P., Telenti A. et al., 2011. Journal of Virology, 85 (4) pp. 1765-1776.
[DOI][WoS][Pmid][serval:BIB_512FB2191F5A]
 
Unique spectrum of activity of prosimian TRIM5alpha against exogenous and endogenous retroviruses.
Rahm N., Yap M., Snoeck J., Zoete V., Muñoz M., Radespiel U., Zimmermann E., Michielin O., Stoye J.P., Ciuffi A. et al., 2011. Journal of Virology, 85 (9) pp. 4173-4183.
[DOI][WoS][Pmid][serval:BIB_9D875230D1C1]
2010
 
Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.
Schmid D.A., Irving M.B., Posevitz V., Hebeisen M., Posevitz-Fejfar A., Sarria J.C., Gomez-Eerland R., Thome M., Schumacher T.N., Romero P. et al., 2010. Journal of Immunology, 184 (9) pp. 4936-4946. Peer-reviewed.
[URN][DOI][WoS][Pmid][serval:BIB_6F3E1D237CD2]
2009
 
Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent.
Lorusso G., Vannini N., Sogno I., Generoso L., Garbisa S., Noonan D.M., Albini A., 2009/05. European journal of cancer, 45 (8) pp. 1474-1484. Peer-reviewed.
[DOI][WoS][Pmid][serval:BIB_BC39EC8B10F4]
 
Anti-angiogenic Activity of a Novel Class of Chemopreventive Compounds: Oleanic Acid Terpenoids
Sogno Ilaria, Vannini Nicola, Lorusso Girieca, Cammarota Rosaria, Noonan Douglas M., Generoso Luca, Sporn Michael B., Albini Adriana, 2009. pp. 209-212 dans Cancer Prevention II, Springer Berlin Heidelberg.
[DOI][Pmid][serval:BIB_A1DFC14EE58F]
2008
Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
Liby Karen, Risingsong Renee, Royce Darlene B., Williams Charlotte R., Yore Mark M., Honda Tadashi, Gribble Gordon W., Lamph William W., Vannini Nicola, Sogno Ilaria et al., 2008/07/15. Clinical Cancer Research, 14 (14) pp. 4556-4563.
[URN][DOI][WoS][Pmid][serval:BIB_A4087E8CCF26]
 
Molecular Dynamics-based Free Energy Simulations
Cuendet M. A., Zoete V., Michielin O., 2008/05., WORLD SCIENTIFIC.
[DOI][serval:BIB_AAAC9CB47F2A]
 
Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
Noonan Douglas M., De Lerma Barbaro Andrea, Vannini Nicola, Mortara Lorenzo, Albini Adriana, 2008/03. Cancer and Metastasis Reviews, 27 (1) pp. 31-40.
[DOI][WoS][Pmid][serval:BIB_45BFF01C03E9]
 
Endothelial Cell Aging and Apoptosis in Prevention and Disease: E-Selectin Expression and Modulation As A Model
Noonan Douglas, Vannini Nicola, Pfeffer Ulrich, Lorusso Girieca, Albini Adriana, 2008/01/01. Current Pharmaceutical Design, 14 (3) pp. 221-225.
[DOI][Pmid][serval:BIB_BC46CFF85B9D]
2007
 
The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent
Vannini N., Lorusso G., Cammarota R., Barberis M., Noonan D. M., Sporn M. B., Albini A., 2007/12/07. Molecular Cancer Therapeutics, 6 (12) pp. 3139-3146.
[DOI][WoS][Pmid][serval:BIB_CFE35BD62923]
 
AKT/NF-κB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
Dell'Eva Raffaella, Ambrosini Claudia, Vannini Nicola, Piaggio Giovanna, Albini Adriana, Ferrari Nicoletta, 2007/11/01. Cancer, 110 (9) pp. 2007-2011.
[DOI][WoS][Pmid][serval:BIB_B18BB09C34A4]
 
Upstream promoter sequences and αCTD mediate stable DNA wrapping within the RNA polymerase–promoter open complex
Cellai Sara, Mangiarotti Laura, Vannini Nicola, Naryshkin Nikolai, Kortkhonjia Ekaterine, Ebright Richard H, Rivetti Claudio, 2007/03. EMBO reports, 8 (3) pp. 271-278.
[DOI][WoS][Pmid][serval:BIB_C36F3897C43C]
2003
 
Imaging transcription complexes with the Atomic Force Microscope.
Rivetti C., Vannini N., Cellai S., 2003/06. The Italian journal of biochemistry, 52 (2) pp. 98-103. Peer-reviewed.
[Pmid][serval:BIB_67D14D32770C]
2001
 
Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives.
Dermond O., Rüegg C., 2001. Drug Resistance Updates, 4 (5) pp. 314-321.
[DOI][WoS][Pmid][serval:BIB_EC453133C56F]
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